Devil’s Claw Extract: Benefits, Uses, Side Effects, and More

Feb 20 2023

Devil’s Claw has long been used to help with a variety of ailments and is now available in capsules, tablets, tinctures or tea. Common uses of devil’s claw extract include reducing pain and inflammation and aiding digestion.

In addition to traditional uses, recent research suggests that devil’s claw extract may have a variety of other health benefits, including lowering cholesterol levels, improving heart health, and even aiding in weight loss.

However, like any supplement, devil’s claw extract may have side effects and interact with certain medications. In this blog, we describe the history and efficacy of Leptospira extracts. In addition, its side effects and precautions for use are discussed.


The Historical and cultural significance of the Devil’s Claw Extract

Devil’s claw extract has a long history of use in traditional African medicine, especially in the Kalahari Desert region of southern Africa, where the plant is native. For centuries, the indigenous San people of the Kalahari Desert have used devil’s claw to treat a variety of health conditions, including arthritis, fever, and digestive problems.

The plant was first introduced to Europe in the early 1900s and quickly became popular for its potential health benefits. Today, devil’s claw extract is widely used as a natural supplement for its anti-inflammatory and pain-relieving properties.

In addition to its medicinal uses, devil’s claw extract has cultural significance in the spiritual and social practices of the San people. The San see plants as sacred symbols of power and strength, which play an important role in their traditional dances and rituals.

The Various Health Benefits of Devil’s Claw Extract

Devil’s claw grass (Harpagophytum procumbent) is a plant native to southern Africa. Its root extract has been traditionally used for its medicinal properties.

Here are some potential health benefits of devil’s claw extract:

Devil’s Claw Extract Harpagoside


While inflammation is a necessary and natural response to injury and infection, chronic inflammation can be detrimental to health. Various studies have linked chronic inflammation to heart disease, diabetes, and brain disease.

There are also diseases that are directly characterized by inflammation, such as inflammatory bowel disease (IBD), arthritis, and gout. Fortunately, there are natural remedies that can help to reduce inflammation and pain. One such remedy is devil’s claw extract, which has been shown to have anti-inflammatory properties.

Pain Relief

I believe that many people have experienced the pain of low back pain. Studies have shown that devil’s claw contains harpaglucoside, which is an active plant compound. Two clinical studies found that taking 50-100 grams of harpaglucoside per day was more effective in reducing low back pain than no treatment, but more research is needed to confirm these results.

Devil’s claw extract may help reduce pain by blocking certain enzymes in the body that cause inflammation and pain. It may be helpful for people with chronic pain such as fibromyalgia.

Improve Osteoarthritis

Osteoarthritis is a common form of arthritis that affects the joints and occurs when the protective covering (called cartilage) at the end of the bones in the joint wears away. It is characterized by joint pain, stiffness, and decreased mobility.

Devil’s claw extract has been shown to have anti-inflammatory effects by inhibiting the production of inflammatory cytokines and enzymes such as COX-2 and NF-kB. Additionally, it may help reduce the production of matrix metalloproteinases (MMPs), enzymes that cause cartilage breakdown in osteoarthritis.

Devil’s claw extract It has been shown to inhibit the production of substance P, a neuropeptide that plays a role in pain signaling. By reducing the production of substance P, devil’s claw extract may help reduce pain in people with osteoarthritis.

Skin Health

Inflammation is a common underlying factor in many skin conditions, such as acne, eczema, and psoriasis. Devil’s claw extract has been shown to have anti-inflammatory effects by inhibiting the production of inflammatory cytokines and enzymes such as COX-2 and NF-kB.

Devil’s Claw Extract also contains several antioxidants, such as harbacin and procambe, which help protect the skin from oxidative stress caused by UV radiation, pollution, and other environmental stressors.

Additionally, devil’s claw extract has analgesic properties that help relieve pain and discomfort associated with skin conditions such as itching, burning, and stinging.

Devil’s claw extract has anti-inflammatory, antioxidant, and analgesic properties and may have potential benefits for skin health. However, more research is needed to fully understand its effects on the skin and to determine its safety and effectiveness for topical use.

Blood sugar control

Devil’s claw extract may help lower blood sugar levels by inhibiting carbohydrate digestion, activating AMPK, modulating insulin signaling, and reducing oxidative stress and inflammation.

However, more research is needed to fully understand the mechanisms underlying the hypoglycemic effect of devil’s claw extract and to determine its safety and efficacy in people with diabetes.

Does Devil's Claw interact with other drugs?

Does Devil’s Claw interact with other drugs?

Although Devil’s Claw has many benefits, it may interact with certain medications.

Here are some examples of medications that may interact with Devil’s Claw:

Blood thinners: Devil’s claw might increase your risk of bleeding if taken with blood-thinning medications such as warfarin or aspirin.

Diabetes medicines: Devil’s claw might lower blood sugar levels, which may be problematic if taken with medicines that also lower blood sugar levels, such as insulin or oral diabetes medicines.

Blood pressure medicines: Devil’s claw may lower blood pressure, which can be a problem if taken with medicines that also lower blood pressure, such as ACE inhibitors or beta blockers.

Antacids: Devil’s claw may interfere with the absorption of antacids, so it’s best to avoid taking them together.

Immunosuppressants: Devil’s claw might stimulate the immune system and problems may occur if taken with drugs that suppress the immune system (such as corticosteroids or immunosuppressants).

Dosage and Preparation for Devil’s Claw Extract?

The dosage and preparation of Devil’s Claw extract may vary depending on the specific product and supplement form you use. Be sure to follow the dosing directions on the label or as prescribed by your healthcare provider.

Here are some general guidelines for the dosage and preparation of devil’s claw extract:

Capsules or tablets

Capsules or tablets

Devil’s claw extract is usually given in capsule or tablet form, usually in doses of 500 mg to 1000 mg per day. The exact dose may depend on your specific medical condition, age, and other factors. It is best to take devil’s claw extract with food to reduce the risk of an upset stomach.


Devil’s claw extract is also available in tincture form, which is an alcohol-based liquid extract. The dosage of the tincture may vary, but the usual recommended dose is 30-60 drops, taken 2 to 3 times a day. Tinctures should be diluted with water or fruit juice before consumption.


Devil’s claw extract is made into a tea by steeping 1-2 teaspoons of the dried root or extract in a cup of hot water for 10-15 minutes. Magic claw tea can be drunk up to 3 times a day.

Precautions When Using Devil’s Claw Extract

Devil’s claw extract is generally considered safe when taken in proper doses, but some precautions should be taken before using it.

Here are some precautions to keep in mind when using devil’s claw extract:

Allergic reactions: Some people may be allergic to devil’s claw extract, especially those who are sensitive to plants in the same family, such as daisies, ragweed, or calendula. Signs of an allergic reaction may include rash, itching, swelling, trouble breathing, or dizziness. If you experience any of these symptoms, stop using Devil’s Claw extract and seek medical attention.

Pregnancy and breastfeeding: There aren’t enough studies to determine the safety of devil’s claw extract during pregnancy and breastfeeding, so it’s best to avoid its use during these times.

Heart and circulation problems: Devil’s claw has the potential to interfere with heart rate, heartbeat, and blood pressure in individuals with cardiovascular conditions. Therefore, people diagnosed with circulatory problems should obtain medical advice before taking this supplement. Please consult your healthcare provider for more information.

Gallstones: Devil’s claw might increase bile production. For people with gallstones, this can be a problem. Avoid using Demon Claws.

Low sodium levels in the body: People with existing low sodium levels should exercise caution when taking Devil’s claw, as it may cause marked reductions in sodium levels. These effects might exacerbate existing symptoms of sodium deficiency. Therefore, close monitoring and management are recommended for those individuals at risk of hyponatremia.

Peptic ulcer disease: People with peptic ulcers should be cautious when using Demon Claws since it may increase the production of stomach acid, potentially exacerbating their condition. Therefore, people with peptic ulcer disease should avoid using this natural remedy.

Are There Any Side Effects?

When used according to recommended dosages, Devil’s Claw extract is generally safe. However, like any supplement, it may cause some adverse effects in certain individuals.

Potential side effects of Devil’s Claw extract include:

Headaches: Some people may experience headaches while taking devil’s claw extract.

Blood sugar changes: Devil’s claw extract may lower blood sugar levels, so it’s important to monitor your blood sugar levels closely if you have diabetes or are taking medications that lower blood sugar levels.

Diarrhea and indigestion, devil’s claw may also cause allergic skin reactions.

These side effects are relatively rare and most people can take devil’s claw extract without experiencing any side effects. However, if you experience any serious or persistent side effects while taking devil’s claw extract, discontinue use and consult your healthcare provider.

Additionally, it is important to purchase devil’s claw extract from a reputable source to ensure its safety and effectiveness.


Overall, devil’s claw extract may be a natural and effective supplement to consider for those looking to maintain their health. However, more research is needed to fully understand its effects on the body and to determine its safety and effectiveness for long-term use.

As with any supplement or medication, it’s important to consult a healthcare provider before adding devil’s claw extract to your regimen.

To learn more about herbal extracts, don’t hesitate to contact us via email at or by a phone call at 0086-29-88378803. We’d love to answer any questions you may have and provide further details about our products.

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