Arbutin is commercially used as a skin-whitening agent in cosmetic industry. It works by competitive inhibition of the enzyme, tyrosinase, a key enzyme in the synthesis of melanin. Depending on the spatial structure of the glycosidic linkage between glucose and hydroquinone, arbutin forms two epimers: Alpha Arbutin and Beta arbutin.
Recent research showed that Alpha-Arbutin has a 10-fold stronger inhibitory effect on the activity of tyrosinase from human malignant melanoma cells than that of Beta-Arbutin. The α-glucosidic bond found in Alpha-Arbutin offers higher stability than the β form found in the related Beta-Arbutin. Moreover, Alpha-Arbutin hardly inhibited cell growth at 1 mmol/L, while Beta-Arbutin inhibit it significantly at the same concentration. It is, therefore, considered that Alpha-Arbutin is an effective and safe ingredient for cosmetics.
Mechanism of Melanogenesis Inhibition
The enzyme tyrosinase, one of the key enzymes involved in melanin synthesis, is activated in melanocyte by the stimulation of free radicals induced from UV irradiation and stress. Its activation triggers melanogenesis, a complex series of enzymatic and chemical reactions, and finally leads to the formation of freckles and suntan. The inhibitory effect of α-Arbutin on melanogenesis is thought to be due to direct inhibition of melanosomal tyrosinase activity.
Function of Alpha /Beta Abrutin
Beta Arbutin powder will relieve and dispell chloasma, melanin, acne ect.
It has good effects of sterilization and relieving cough.
It is used to alleviate pain of burn and scald, enhancing immune fuction.
It can promote skin elasticity, retaining skin moisture and slowing down aging skin.
It has the function of restraining the activity of tyrosinase, preventing the formation of melanin.
Applied in cosmetic field, arbutin is mainly used in facial masks and esssence to whiten, eliminate wrinkles and dispelling spot.
Alpha arbutin application
Alpha arbutin is mainly used for advanced cosmetic as light toner and whitening agent ;Arbutin can be made into skin cream, medicated cream, senior pearl cream, etc., not only beauty, but also can diminish inflammation, fight excitant.
Alpha arbutin is a new type of burn medicine ingredient, characterized by rapid analgesic, anti-inflammatory, strong quickly eliminate the redness and swelling, heal quickly without leaving scars.
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