Chamomile Extract

Chamomile is a natural plant flavonoid, which is the aglycone of some natural glycosides. Apigenin is widely found in leaves and stems of tropical vegetables.

As a known bioflavonoid, it has been shown to have various biological activities, including antioxidant, anti-inflammatory, anti-tumor, anti-genotoxic, anti-allergic, neuroprotective, cardioprotective and antibacterial, etc.

Apigenin function

Apigenin is a common dietary flavonoid widely found in many fruits, vegetables and medicinal herbs. It has various physiological functions, such as antioxidant, potent anti-inflammatory, antiviral activity, antibacterial, and blood pressure lowering.

Anti-tumor effect

Apigenin plays an important role in cancer prevention by inducing apoptosis in various cell lines.

ovarian cancer. Studies have found that apigenin can inhibit the growth, proliferation and metastasis of ca-ov3 (human ovarian cancer cells). Induces apoptosis in ca-ov3 cells by arresting cancer cells in G2/M phase. The effect it exerts is related to time and dosage.

Pancreatic cancer

Apigenin can inhibit the proliferation of pancreatic cancer cells. It starves tumors by reducing their source of glucose, the food cancer cells rely on to survive. In addition, apigenin can enhance the efficacy of the chemotherapy drug gemcitabine.

Chemo-sensitization

This study found that low levels of apigenin had low cytotoxic effects and were not effective in inducing apoptosis in human acute myeloid leukemia (hl-60) cells. However, apigenin combined with different concentrations of cisplatin (DDP) could enhance the inhibitory effect of cisplatin (DDP) on the proliferation of hl-60 cells.

Therefore, apigenin may have a chemosensitizing effect on hl-60 cells. Low concentrations of apigenin can also reduce the resistance of hl-60 cells to chemotherapy-induced apoptosis, which may be related to the downregulation of NF-κB and BCL-2.

Liver protection

The antioxidant properties of apigenin can help to reduce liver damage caused by ischemia-reperfusion. Apigenin can help to protect the liver by scavenging free radicals and reducing lipid peroxidation.

Apigenin has potent antioxidant and anti-inflammatory activities, which can reduce liver damage caused by oxidative stress.

Pharmacological experiments have proved that apigenin has obvious protective effects on alcoholic liver/hepatocyte injury, and its main mechanism is related to inhibiting the expression of CYP2E1 in liver/hepatocytes.

Prevent osteoporosis

Apigenin inhibits osteoblast formation, osteoclastogenesis, and prevents bone loss.

It protects bone tissue by reducing bone loss in the body.

Although more research is needed, some studies have found that apigenin may help promote osteoclast formation by inhibiting TNF-α and IFN-γ and inducing the secretion of several cytokines.

Apigenin also strongly inhibits the differentiation of 3T3-L1 preadipocytes into adipocytes, thus inhibiting differentiation concomitantly with the inhibition of adipocyte differentiation-induced IL-6, MCP-1, lectin production.

It has been shown to inhibit osteoclast differentiation and bone resorption. Additionally, it can induce apoptosis in osteoclasts. These effects make apigenin a potential therapeutic target for the treatment of osteoporosis and other bone diseases.

Anti-inflammatory and anti-oxidant activity

Apigenin inhibits the process of inflammation, increases IL-10 levels and normalizes parameters of oxidative stress.

It inhibits pro-inflammatory cytokines and induces the anti-inflammatory cytokine production.

Several literatures have shown that apigenin attenuates oxidative stress-induced tissue inflammation in tissues by modulating the expression of various oxidative stress markers, interleukins, blood enzyme markers, and several other related enzymes.

Apigenin can regulate blood sugar, treat thyroid insufficiency and control lipid peroxidation.

It was found that apigenin can increase insulin and thyroxine levels in diabetic animals, reduce blood sugar concentration and glucose-6-phosphorylase (G-6-Pase) activity.

Apigenin reversed the effects of alloxan-induced increases in serum cholesterol, hepatic lipid peroxidation (LPO), and decreased activity of antioxidants such as catalase (CAT) and superoxide dismutase (SOD) in animals.

In normoglycemic animals, apigenin can also reduce serum cholesterol and liver lipid peroxidation, and increase the activity of intracellular antioxidant substances.

Health Benefits of Apigenin

• Inhibit the growth of cancer cells.
• Lower blood pressure
• Protects the cardiovascular system
• Help sleep, calm nerves, eliminate irritability
• Resist inflammation
• Prevent osteoporosis
• Diuretic effect.
• Inhibit platelet aggregation.

Apigenin Dose

As we all know, apigenin is a powerful natural flavonoid. It has anti-cancer, anti-bacterial, anti-spasmodic, anti-inflammatory and other effects. Dosage may vary for different purposes.

For anxiolytic effects, apigenin doses of 3 mg/kg to 10 mg/kg were effective without sedative effects, and higher doses induced sedative effects in addition to reducing anxiety.

For general health, the preferred dosage range is 20-50 mg along with amino acids and vitamins.

Where To Buy Apigenin In Bulk?

FocusHerb is a professional manufacturer with over 15 years experience in the nutritional raw material. We now arrange a new production schedule for the Apigenin, which is our hot project for the health supplements.

FocusHerb Apigenin has a minimum specification of 98%, all high quality at an affordable price. If you have any interest, just send an email to admin@xafhbio.com, we will provide the price and technical documents, such as certificate of analysis, MSDS.