Food and Nutrition Ingredients
Nattokinase
Nattokinase is a potent fibrinolytic serine protease fermented from Bacillus Subtilis Natto with soybean medium. As professional nutraceutical enzyme manufacturer Focusherb, we supply standardized nattokinase powder with multiple FU activity grades, two formula options (with/without Vitamin K2), microcapsule stomach-resistant version available, tested by standard fibrin plate method for stable fibrinolytic activity.
We support bulk wholesale, private label capsule/tablet OEM, customized enzyme activity compound formula and full third-party lab testing. Our nattokinase raw materials serve global cardiovascular supplement factories, functional food brands and health nutrition manufacturers worldwide. Contact us to apply for free samples or technical support
FDA DSHEA Compliant
Halal Kosher
With/Without K2 Option
Full Batch FU COA
PRODUCT INTRODUCTION
| Product Name | Nattokinase Fibrinolytic Enzyme Powder |
| CAS Number | 133876-92-3 |
| Raw Material | Soybean fermented by Bacillus Subtilis Natto |
| Appearance | Off-white fine water-soluble powder |
| Standard FU Activity Options | 3000FU/g, 5000FU/g, 12000FU/g, 20000FU/g customizable |
| Formula Versions | With Vitamin K2 / Without Vitamin K2 for anticoagulant formulations |
| Bulk Packing | 1kg aluminum foil bag, 25kg light-proof food grade fiber drum; neutral export packaging available |
| Certifications | ISO22000, GMP, FDA DSHEA, Halal, Kosher, Third-party Fibrin Plate COA |
| MOQ | 1kg sample order / 25kg formal bulk wholesale |
| Shelf Life | 24 months sealed cool light-proof storage, microcapsule version retains 90% activity after 12 months |
Intelligent Deep Liquid Fermentation & Low-Temp Purification Process
We adopt full automatic closed deep liquid fermentation line with precise pH/temp/oxygen control, low-temperature ultrafiltration and vacuum freeze-drying to avoid nattokinase thermal deactivation, GMP clean workshop full production to guarantee consistent FU activity per batch.
- High-yield Bacillus Subtilis Natto strain seed activation & cultivation
- Constant 37℃ segmented deep liquid soybean medium fermentation
- Centrifugation & microfiltration remove bacterial residue & impurities
- Tangential flow ultrafiltration concentrate crude nattokinase enzyme
- -55℃ vacuum freeze-drying + optional microcapsule embedding for acid resistance
- Aseptic sifting, light-proof sealed bulk packaging & batch labeling
Our low-temp stabilization technology minimizes enzyme activity loss, contact us to nattokinase formulation application guide for capsule & powder formula design.

Factory Qualification, Monthly Output & Stable Warehouse Ready Stock
Our nutraceutical enzyme production plant passes ISO22000 & GMP global food safety audit, independent fermentation production workshop, every batch completes full fibrin plate FU activity test, heavy metal and microbial limit inspection before delivery.
Stable Production Capacity & Light-Proof Cold Storage Stock
- Monthly total fermentation output: 22 tons standardized nattokinase powder
- Permanent warehouse ready stock: 4–10 tons mixed FU grades, shipment within 3–7 working days
- Independent constant low-temp light-proof warehouse to prevent enzyme activity degradation
- Dual parallel automatic fermentation lines, support seasonal large bulk rush orders without stock shortage
- ISO22000 Global Food Safety Management System
- GMP 21 CFR Part 111 Standard Enzyme Production Workshop
- US FDA DSHEA Compliant Dietary Supplement Raw Material
- Halal & Kosher Global Export Religious Certification
- Independent third-party fibrin plate full batch FU testing system
Every shipment attaches official batch COA, fibrin plate test chromatogram, heavy metal report and SDS safety specification sheet.



Fibrin Plate FU Batch COA
Core Biological Functions & Cardiovascular Benefits
Powerful Fibrinolytic Activity
Directly degrade fibrin clot protein, activate body’s natural t-PA fibrinolytic system, core ingredient for circulation support supplements.
Support Healthy Blood Circulation
Reduce platelet aggregation and blood plasma viscosity, maintain smooth peripheral blood flow for middle-aged & elderly formulas.
Maintain Normal Blood Pressure Range
Inhibit ACE angiotensin-converting enzyme activity, assist stable blood pressure within normal healthy levels.
Long-Lasting In-Vivo Activity
Maintain effective fibrinolytic effect up to 8 hours after oral intake, far longer than short-acting clinical thrombolytic enzymes.
Mild & Safe Oral Tolerance
Natural fermented food-grade enzyme, no strong side effects, suitable for long-term daily nutritional supplementation.
Pet Cardiovascular Nutrition Additive
Improve pet blood circulation for senior dog & cat heart health supplementary powder formulas.
Have any questions?Let’s get in touch!
Contact us if your are thinking of purchasing highquality ingredients, develop new products, or justsolving a manufacturing challenge in your rawmaterials.
Core Biological Functions & Cardiovascular Benefits
Cardiovascular Supplement Capsule
Hard capsule, softgel, tablet OEM raw material for circulation & heart health series
Functional Solid Drink
Water-soluble nattokinase for heart health instant powder & compound meal blend
Middle-Aged Compound Nutrition Powder
Mix with red yeast rice, coq10, hawthorn extract for daily wellness blends
Senior Pet Heart Supplementary Raw Material
Pet circulation support powder additive for aging dogs and cats
Strict Quality Inspection & Batch COA Document
Each batch nattokinase completes comprehensive lab detection before shipment: fibrin plate FU activity assay, moisture, loss on drying, heavy metal (Pb, As, Hg, Cd), total aerobic bacteria, yeast & mold, coliform and salmonella negative test.
We provide independent third-party fibrin plate COA, full activity test report, MSDS safety data sheet and complete technical specification sheet for customs clearance and brand FDA registration upon customer request.
Full Batch Traceable QC System
Every bulk order matches exclusive batch number & complete fibrin plate activity lab record
OEM & Private Label Custom Service
Full Custom Support Range
- FU activity customization: 3000/5000/12000/20000FU/g adjustable per formula demand
- Dual formula selection: Nattokinase with Vitamin K2 / Without Vitamin K2
- Microcapsule stomach-resistant nattokinase version for acid-sensitive oral products
- Compound blending: mix with CoQ10, Red Yeast Rice, Hawthorn, Omega raw materials
- Finished capsule/tablet OEM, private label foil bag & fiber drum packaging design & printing
- Neutral export bulk packing without Focusherb logo for global distributors & brands
For customized bulk order cost budget, contact us to get tiered volume price reference.

What Is Nattokinase?
Nattokinase (NK), also known as subtilisin, is an enzyme extracted from natto, a fermented soybean made by combining boiled soybeans with specific bacteria. It is well known for its potential health benefits, especially in promoting cardiovascular health. The enzyme is thought to help break down fibrin, a protein involved in blood clotting, which may improve blood flow and reduce the risk of conditions such as deep vein thrombosis (DVT) or stroke.
Some studies suggest that nattokinase may help break down blood clots and improve blood circulation, acting as a natural anticoagulant. However, despite its promising potential, more research is needed to fully understand its efficacy and safety, especially for people with bleeding disorders or those taking blood-thinning medications.
Nattokinase is typically sold as a dietary supplement in capsule form and is often marketed for its potential to support heart health, lower blood pressure, and improve blood circulation.
Function of Kinase
Kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy molecules such as ATP (adenosine triphosphate) to specific substrates, usually proteins. This process is called phosphorylation, and it plays a vital role in regulating various cellular activities. The functions of kinases can be divided into the following key roles:
- Preventing and dissolving blood clots, protecting the cardiovascular system, and avoiding myocardial infarction and stroke.
- Lowering blood pressure, inhibiting enzymes that cause high blood pressure.
- Lowering cholesterol, effectively reducing total cholesterol and bad cholesterol.
- Preventing and treating osteoporosis and diabetes.
Application of Nattokinase
- Functional food. Promotes primary proteolysis in cheese as an exogenous proteolytic enzyme. This process increases the content of most free amino acids that can be used as substrates for many catabolic reactions to improve the flavor of the cheese.
- Health care products. Effectively remove blood clots in the human body, and are also effective in preventing high blood pressure, aging, stroke, muscle spasm, and cardiovascular and cerebrovascular injuries.
Dosage
The recommended dose of nattokinase is typically 2,000 mg per day. However, some people may take up to 5,000 mg per day depending on their health needs or as directed by their doctor. Always follow the dosing instructions on the supplement label or as directed by your healthcare provider. To ensure safety and effectiveness, do not exceed the recommended dose without consulting your doctor, especially if you are taking blood-thinning medication or have any underlying health conditions.
For optimal absorption, nattokinase should be taken with a glass of water, preferably on an empty stomach, unless otherwise directed.
How To Buy Nattokinase?
At Focusherb, we are committed to providing excellent support to ensure your experience is smooth and satisfying. Whether you need expert advice, product assistance, or have any specific questions about our services, we are here to help you every step of the way. Feel free to contact us at admin@xafhbio.com and our experienced team is ready to provide you with a quick response and guidance. Alternatively, you can easily submit an inquiry using the form at the bottom of the page and we will answer your question as soon as possible.
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Contact us if your are thinking of purchasing highquality ingredients, develop new products, or justsolving a manufacturing challenge in your rawmaterials.



















