Neohesperidin Dihydrochalcone

Complete Technical Specification (98% Food Grade NHDC)

Unique Dual Function: High Sweetness + Powerful Bitterness Masking

Most common high-intensity sweeteners only deliver sweetness while leaving noticeable metallic aftertaste, herbal bitterness or sour irritation on the palate. NHDC is a citrus-derived high-potency sweetener with natural flavor-correcting properties. Its molecular structure binds to bitter taste receptors on the tongue to effectively suppress bitter, astringent, spicy and metallic off-notes, while releasing a clean, well-rounded natural citrus sweet aftertaste.

NHDC retains stable sweetness across a pH range of 2.0–8.0 and withstands temperatures up to 150 °C. No degradation or sweetness loss occurs during high-temperature baking, beverage UHT sterilization or tablet compression. It contains zero carbohydrates and will not spike blood glucose levels, making it suitable for diabetic, weight-management and oral care formulations. Being non-cariogenic, it avoids tooth decay issues associated with sucrose.

Core Functional Advantages:

• 300-fold sweetness relative to sucrose; ultra-low dosage sharply cuts raw material costs
• Excellent bitterness masking for herbal extracts, stevia, and off-notes in animal feed
• Boosts fruit and citrus aroma, improving thin flavor profiles in low-sugar products
• Heat and acid resistant, compatible with baking, UHT sterilization and acidic beverages
• Zero-calorie formulation fit for sugar-free, diabetic-friendly and children’s food lines
• Semi-natural citrus origin supports clean-label positioning vs fully synthetic sweeteners

Standard Production Process: Citrus Raw Material To Purified NHDC

Full Manufacturing Steps

1. Raw material extraction: Isolate neohesperidin flavonoids from bitter orange peel via ethanol reflux extraction
2. Catalytic alkaline hydrogenation: Convert neohesperidin into crude NHDC under high pressure using palladium catalyst
3. Neutralization & impurity removal: Eliminate residual heavy metal catalyst and citrus-derived impurities
4. Multi-stage recrystallization: Refine crude material to reach ≥98% HPLC food-grade purity
5. Low-temperature vacuum drying & fine milling: Form uniform white crystalline powder
6. Nitrogen-sealed packaging; full batch HPLC testing prior to shipment

100,000 class GMP closed purification workshop, strictly control residual solvent & heavy metal residue, fully comply with USP, European Pharmacopoeia Ph.Eur monograph standards, meet global food additive export audit requirements.

Factory Supply Capacity & Global Export Certifications

Specialized citrus flavonoid & high-intensity sweetener production base, annual comprehensive NHDC output reaches 30 tons food-grade powder. Year-round stable spot stock 1~3 tons, support small sample trial orders and large continuous bulk orders. Constant temperature nitrogen sealed warehouse to avoid moisture agglomeration and activity attenuation.

6 Core Competitive Advantages of  NHDC E959

Wide Temperature & pH Stability

No sweetness loss during high-temp baking, UHT sterilization, acidic juice & alkaline tablet pressing, wide formulation compatibility.

Safe Zero-Calorie Formula

Non-cariogenic, no blood sugar elevation, suitable for sugar-free, diabetic, weight-loss and children food series.

Full Global Export Certifications

FDA GRAS, EFSA E959, HALAL & KOSHER all available, support EU, US, Southeast Asia market product filing.

Semi-Natural Citrus Source

Derived from bitter orange peel flavonoid, cleaner label than fully synthetic sweeteners, widely accepted by premium clean-label food brands.

300-Fold Ultra-High Sweet Potency

Minimal inclusion levels achieve target sweetness, lowering overall formula costs compared to sucrose, stevia or erythritol.

Superior Bitterness Masking Capacity

Neutralizes bitter notes from herbal extracts, stevia and spicy feed ingredients; one single ingredient replaces separate flavor-masking additives.

Strict QC Testing & Complete Official Documents

OEM & Custom Formulation Service

Neohesperidin dihydrochalcone is a hydrogenated flavonoid derivative extracted from oranges and other citrus fruits. It is characterized by its sweetness, which is 300 times greater than that of sucrose, and its crisp, lasting aftertaste. It does not have the unpleasant aftertaste associated with saccharin or stevia.

NHDC not only improves the taste but also has a long-lasting sweetness. Combined with other sweeteners, it can be used to enhance taste, mask bitterness, and improve food and beverage quality. It also has excellent applications in the food, pharmaceutical, and feed industries.

Benefits And Potential Applications of Neohesperidin Dihydrochalcone (NHDC)

Antioxidant Properties

In recent years, many studies have shown that neohesperidin dihydrochalcone has a significant concentration-dependent scavenging activity on stable free radicals and reactive oxygen species (ROS).

In particular, NHDC has the most substantial inhibitory effect on H2O2 and HOCl, with scavenging rates of 93.5% and 73.5%, respectively.

What’s more, NHDC can inhibit protein degradation, cleavage of the plasmid DNA strand, protect the HIT-T15, and HUVEC cell death from HOCl attack.

The antioxidant activity of NHDC against various free radicals was examined. The results showed that NHDC could partially inhibit the browning effect of pigmentation caused by polyphenol oxidase.

In addition, NHDC can also significantly inhibit the up-regulation of matrix metalloproteinase (MMP-1) induced by infrared radiation. These results suggest that NHDC has the potential to protect human skin from premature aging caused by exposure to infrared radiation.

NHDC Application1

NHDC can act as an anti-browning additive and whitening agent.

Lower blood sugar and Lower Cholesterol

NHDC is an effective, non-toxic, low-calorie sweetener that satisfies people’s cravings for sweetness, reducing sugar intake overall.

Recent studies have discovered that NHDC can prevent α-amylase in mammals to a certain extent and consequently lower the body’s sugar intake, which then lowers blood sugar levels in the body. This is very important in the medical field, especially for diabetic patients.

NHDCApplication 2

NHDC can fulfil the role of a sugar-free, calorie-free sweetener. When used correctly, it has the potential to replace sucrose and lower human sucrose intake. It is appropriate for both obese and non-obese individuals.

Protect the liver

Studies have found that NHDC can reduce the levels of ALT, AST and hydroxyproline in liver tissue in CCI-induced liver fibrosis mice, and slow down cell degeneration, necrosis and liver fibrosis to varying degrees.

In addition, reduction of ALT and AST in serum can improve lipid metabolism and liver function, and inhibit fatty liver and endothelial plaque formation in major arteries. NHDC can also effectively alleviate CC1-induced oxidative damage and reduce inflammatory response and apoptosis.

NHDCApplication 3

The NHDC is hopeful that it will be useful as a hepatoprotective agent.

Prevent gastric ulcer

NHDC can hinder gastric acid secretion, so when mixed with other gastric acid inducers such as aluminum hydroxide gel, it can be used as an antacid to enhance the gastric acid resistance of the latter.

Suhrez et al found that NHDC significantly reduced the cold-restraint stress (CRS)-induced ulcer index. Its activity is comparable to that of ranitidine, which inhibits histamine activity, thereby significantly reducing gastric acid and pepsin secretion.

Regulating immunity

NHDC was added to feed not only for its pleasant taste and ability to increase appetite in animals, but also for the probiotic effects found by Daly et al.

Following the addition of NHDC to the piglet feed, the number of Lactobacilli at the entrance to the cecum of the piglets increased significantly with the increase in the lactic acid concentration in the intestinal lumen. Thereby affecting the intestinal symbiotic flora, regulating the body’s immunity, and reducing intestinal diseases.

NHDCApplication 4

Neohesperidin DC can be used as a feed additive. NHDC improves the palatability of feed, increases animal appetite, and improves intestinal bacteria, then stimulates their growth.

Neohesperidin dihydrochalcone (NHDC) recommended dose and Side effects.

• The desired dosage for desserts and dairy items is 10-35 ppm for sweeteners and 1-5 ppm for flavor enhancers.
• The dosage for Pharmaceutical Bitterness Masking is 10-30 ppm (sweetener) and 1-5 ppm (flavor enhancer).
• The maximum recommended dose is as follows: 30-35 mg NHDC/kg complete feed, 5 mg NHDC/L water, and 3-8 mg NHDC/L water for sucking and weaning pigs.

The amount used depends on the purpose, but any ingredient can become a danger to the human body if consumed in large quantities.

Studies have found that neohesperidin dihydrochalcone (NHDC) can lead to nausea and migraines when the concentration is 20 ppm or more. It is advised to wear surgical masks when working with pure NHDC.

Producer and manufacturers of Neohesperidin dihydrochalcone (NHDC)

FocusHerb has a long-standing production line of neohesperidin, and NHDC is one of the new products we developed for our customers. Years of experience guarantee the quality of our products and production processes.

Our neohesperidin and finished product manufacturing meets international quality standards. If you have any other questions about neohesperidin DC, please don’t hesitate to reach out to us. We would be happy to help you out!

Neohesperidin Dihydrochalcone Application

Neohesperidin Dihydrochalcone sees widespread usage in water-based, milk-based, and juice-based beverages, ice creams, wines, desserts, cakes, bakery products, candies, chewing gums, sauces, etc. It is an especially good fit for functional foods, health care products, and dietary supplements.

Sweetness Enhancer

NHDC has a crisp, persistent taste and is very sweet, and when used at the same time enhances the effects of other artificial sweeteners such as aspartame, saccharin, acesulfame potassium and cyclamate, and sugar alcohols such as xylitol.

This means less use of other sweeteners, which in turn reduces costs. NHDC is widely used in juice drinks, milk drinks, wine and bakery products.

Sweetener for Dietary supplements

NHDC is a low-calorie sweetener that also has some physiological benefits. It has antioxidant activity and can lower cholesterol and blood sugar levels. It is especially suitable for functional foods, health products and dietary supplements as a sweetener substitute.

Food Flavor/Flavor Enhancer

The flavor of NHDC is similar to maltol and ethyl maltol, and it produces a significant synergistic effect with other flavor ingredients. It is widely used in frozen milk products, candies, puddings, fruit juices, non-alcoholic beverages, condiments jams, chewing gums, and so on.

Why FocusHerb Neohesperidin Dihydrochalcone?

FocusHerb has been concentrating on the production and development of plant extracts for a long time. We offer the organic superfoods at inexpensive prices.

They are put through tough independent testing to guarantee that they are secure to consume globally.

How to buy Neohesperidin Dihydrochalcone?

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