Cosmetic Ingredients
Wheat Germ Extract Spermidine
Spermidine (CAS 124-20-9) is a natural polyamine compound famous for triggering cellular autophagy, widely published in Nature and aging research papers. We supply two mainstream grades: 1% natural wheat germ spermidine extract and 99% high-purity synthetic spermidine powder. Natural grade fits clean-label consumer brands; 99% pure grade suits high-dose anti-aging, cognitive and liver health premium formulas.
Spermidine supports cell renewal, anti-oxidation, neuroprotection, cardiovascular health and immune balance. It is the hottest longevity ingredient in European, American and Japanese premium dietary supplements. All batches are HPLC tested, ISO/GMP/FSSC22000 certified, with complete COA, MSDS and third-party test reports. Support bulk wholesale, OEM customized blending and private label packaging.
ISO22000 GMP FSSC22000
Halal Kosher
HPLC Tested
Clean Label Available
Free Sample Support
Halal Kosher
HPLC Tested
Clean Label Available
Free Sample Support
PRODUCT INTRODUCTION
| Product Name | Spermidine Powder |
| CAS Number | 124-20-9 |
| Specifications | 0.2%,0.5%,1% Wheat Germ Extract |
| Appearance | 1%: Brown Yellow Fine Powder; |
| Test Method | HPLC |
| Molecular Formula | C7H19N3 |
| Function | Cell Autophagy, Anti-Aging, Cognitive Support, Liver & Cardiovascular Protection |
| Bulk Packing | 1kg/Aluminum Foil Bag, 25kg/Fiber Drum |
| MOQ | 1kg Sample Order, 25kg Bulk Order |
| Shelf Life | 24 Months Sealed, Cool & Dry Storage |
Extraction & Synthesis Purification Process
We provide two mature production lines: natural wheat germ low-temperature extraction process and high-purity synthetic recrystallization purification process. For 1% wheat germ spermidine, we adopt physical crushing, low-temperature ultrasonic extraction, membrane concentration and spray drying to retain natural active components without solvent residue. For 99% synthetic spermidine, multi-step purification and recrystallization ensure ultra-high purity, low impurity and stable batch consistency.
- Natural grade: pure physical extraction, clean label, no chemical addition
- Synthetic grade: high-precision synthesis, strict impurity control
- Full GMP closed workshop production
- Independent HPLC laboratory full batch detection
- Low temperature drying process to avoid active ingredient degradation
- Moisture-proof & light-proof sealed packaging
Stable batch difference, suitable for long-term stable formula supply for international premium anti-aging brands.
Factory Capacity, Certification & Warehouse Storage
Our spermidine production workshop complies with GMP, ISO22000, FSSC22000 food safety system. Annual output reaches 150 tons, with conventional spot inventory all year round, supporting fast delivery for bulk orders. All products pass heavy metal, microbial, solvent residue full inspection, meet EU/US/JP food ingredient standards.
Stable Supply Advantage
- Annual output: 150 tons dual-grade spermidine
- Ready stock: 8–12 tons permanent inventory
- Fast delivery: 3–7 working days
- Constant temperature moisture-proof professional warehouse
- ISO22000 / FSSC22000 / GMP Qualified
- Halal & Kosher Global Export Certification
- Third-party authoritative test report support
- Complete customs clearance documents: COA, MSDS, HPLC spectrum
Full Batch COA & HPLC Report
Core Functional Advantages & Selling Points
Activate Cellular Autophagy
Trigger the body’s natural cell renewal mechanism, clear damaged organelles and aging proteins, achieve cellular rejuvenation, core longevity mechanism verified by multiple academic studies.
Support Cognitive Health
Protect nerve cells, improve memory and concentration, delay age-related cognitive decline, suitable for brain health premium supplements.
Cardiovascular Protection
Improve vascular endothelial health, reduce vascular inflammation, assist in maintaining healthy blood lipid levels.
Anti-Inflammation & Antioxidation
Scavenge free radicals, reduce chronic low-grade inflammation in the body, delay overall aging progress.
Liver Metabolic Support
Promote liver cell repair, assist liver metabolism detoxification, widely used in liver care compound formulas.
Dual Grade Customization
Natural clean-label grade & high-purity high-dose grade optional, fully cover mass market and high-end premium product lines.
Have any questions?Let’s get in touch!
Contact us if your are thinking of purchasing highquality ingredients, develop new products, or justsolving a manufacturing challenge in your rawmaterials.
Free Sample
Main Application Fields
Anti-Aging Capsules
Longevity & cellular renewal premium daily supplement capsules
Anti-Aging Capsules
Longevity & cellular renewal premium daily supplement capsules
Anti-Aging Capsules
Longevity & cellular renewal premium daily supplement capsules
Anti-Aging Capsules
Longevity & cellular renewal premium daily supplement capsules
Strict QC Inspection & Complete Batch Documents
Every batch of spermidine undergoes full-item testing: HPLC content detection, appearance, fineness, moisture, heavy metal (Pb, As, Hg, Cd), solvent residue, total bacteria, yeast and mold, coliform and pathogenic bacteria detection. 100% meet global food additive standards.
We provide complete shipping documents: official batch COA, HPLC chromatogram spectrum, MSDS safety data sheet, third-party test report, certification files, to support customer customs clearance, product registration and supplier audit.
Full Batch Traceable System
Unique batch number for each order, full production & testing data permanently traceable
OEM & Customization Service
Full Custom Support
- Grade customization: 1% natural wheat germ / 99% high purity synthetic
- Compound pre-blend: cooperate with NMN, Resveratrol, CoQ10, PQQ anti-aging series
- Fine powder fineness customization for tablet/capsule/powder formulas
- Moisture-proof and anti-oxidation formula stabilization treatment
- Neutral export packaging & private label printing
Formula technical guidance and registration document support
Provide one-stop anti-aging raw material matching solution, long-term customized fixed-volume supply, support brand new product R&D and global market filing.
What’s Spermidine?
Spermidine is a naturally occurring polyamine characterized by the presence of two or more primary amino groups. It is widely found in ribosomes and living tissues and plays a vital role in cellular function and survival. Studies have shown that spermidine can extend lifespan in fungi, nematodes, insects, and rodents, highlighting its potential longevity benefits.
In humans, spermidine is synthesized from its precursor putrescine and is a key component in the production of spermine, another essential polyamine. It supports cellular health, growth, and maintenance and is essential for overall biological processes.
One of the most notable functions of spermidine is its role as a potent activator of autophagy – a natural cellular process that removes damaged components and promotes cell renewal. By stimulating autophagy, spermidine helps restore cellular activity and extend lifespan. Recent studies suggest that increasing dietary spermidine intake may reduce all-cause mortality, particularly by supporting cardiovascular health.
The Benefits of Spermidine
Spermidine has gained significant attention in recent years due to its potential health benefits. As a naturally occurring polyamine, it has been extensively studied for its role in various aspects of human health. However, while research is promising, it remains in the early stages, and many potential benefits have yet to be fully confirmed in humans.
Emerging evidence suggests that spermidine may support cardiovascular health, enhance fertility, and slow the aging process. It is known to activate autophagy, a cellular renewal process that helps extend lifespan, combat cellular aging, and maintain healthy cells, skin, and brain function.
Extend Life and Reduce Risk of Disease
Spermidine, much like fasting, activates protein deacetylation and autophagy, promoting healthy DNA function and the removal of senescent and toxic cells. Research suggests that spermidine supplementation may help lower the risk of various health conditions, including cancer, cardiovascular disease, metabolic disorders, and neurodegenerative diseases.
Notably, strong evidence links spermidine to improved cardiovascular health. Studies on aged mice have shown that spermidine supplementation enhances heart structure and function, contributing to better overall heart health. These benefits are further associated with metabolic improvements, as spermidine helps restore mitochondrial structure and function, optimizing energy production and cellular efficiency.
Anti-inflammatory and Immune-boosting Properties
Preclinical laboratory trials suggest that spermidine reduces inflammation and slows cellular and tissue aging. A 2017 study further demonstrated its antioxidant properties, showing that spermidine protects against oxidative stress by reducing the accumulation of reactive oxygen species (ROS) within cells. These harmful free radicals contribute to chronic inflammatory conditions such as rheumatoid arthritis, ischemic heart disease, and various lung, kidney, and liver diseases.
While autophagy activation remains spermidine’s primary mechanism for promoting longevity, research suggests additional benefits. Studies indicate that spermidine also exhibits anti-inflammatory properties and plays a role in lipid metabolism, cell growth, proliferation, and apoptosis (programmed cell death), further contributing to overall health and longevity.
Why Choose Focusherb Spermine Capsules?
Your cellular health directly impacts your overall well-being and disease risk. Incorporating spermidine-rich foods—such as wheat germ, whole grains, soybeans, cruciferous vegetables, nuts, beans, and peas—into your diet is a natural way to support cell function and longevity.
For additional support, spermidine supplements can help protect cells from age-related decline, promoting optimal energy levels and overall vitality as part of a healthy lifestyle.
Green Label
Vegan & cruelty-free
Maximum avoidance of any additives and excipients
If additives are used, only valuable natural substances
Maximum avoidance of chemical solvents in extracts
Filled in in pharmaceutical quality (GMP, ISO 22000:2018 and HACCP)
Only vegan capsule shells: 100% free of carrageenan and PEG
Packaging is free of plasticizers
Free of any unwanted additives such as magnesium stearate, gelatin, titanium dioxide, silicon dioxide, nanoparticles (without legal exceptions), genetic engineering, artificial colors and flavors, added sugar & sweeteners
Each batch is laboratory tested
Quality & Purity
Focusherb spermine capsules contain an ideal dose of a special wheat germ powder (Triticum sativum) and are produced in a pharmaceutical factory in Germany. These capsules are ultra-pure and 100% plant-based.
At Focusherb, we care deeply about the quality of our products. Our products are manufactured in carefully, rigorously tested facilities and meet the highest quality standards. When developing our products, we pay special attention to their tolerability and bioavailability.
Our Promise
Vegan& Hypoallergenic
We focus on the essentials, process only premium raw materials, and completely avoid unnecessary additives. All of our products are vegan and hypoallergenic. All raw materials are filled into vegan cellulose shells.
Raw Materials & Manufacturing
For our products, we search the world for the highest quality raw materials – free from contamination, rich in ingredients, and optimal in their effect. Only when our demands are fully met do we include a product in our range?
Pharmacy Quality
We do everything every day to ensure the product quality, purity, and safety of our products for you. Our products are carefully manufactured in strictly tested facilities in China. At all steps, we adhere to the strict HACCP quality standards.
FAQs
What is spermidine?
Spermidine is a natural polyamine found in all cells in the body.
What does autophagy mean?
Autophagy is the term used to describe the process in which old/damaged cells are broken down and reused to create new, healthy cells.
Does Spermidine contain actual sperm?
No – although it’s a common question. That being said, Spermidine is found in semen, as it is present in all body cells.
What is it good for?
Spermidine has been linked with multiple health benefits including prolonged lifespan due to its anti-inflammatory and antioxidant properties, as well as its ability to boost cell renewal and autophagy.
Which foods are highest in Spermidine?
There are many plant-derived foods with moderate to high levels of Spermidine; these include Soya beans, Wheatgerm, Vegetables (peas and mushrooms are both excellent sources) as well as cruciferous veg such as cauliflower or broccoli, Cheese (particularly cheddar, brie, parmesan, and gouda), Fruits (mangos and bananas particularly so).
Should I supplement with Spermidine?
Spermidine is a naturally occurring product so there are minimal risks associated with taking it in supplement form. Given the benefits it can have on the body and boosts cell renewal, immunity, and promotes antiaging, it’s certainly a recommended supplement on our list! That being said, if you have any doubts or existing health conditions, please check with your health provider first.
What is the recommended dosage for Spermidine?
6mg per day is an average dose, but it would be best to check with your health provider if you aren’t sure.
Does Spermidine have side effects?
There are no known side effects associated with taking Spermidine supplements.
Is Spermidine vegan friendly?
Yes, Spermidine is vegan-friendly.
How does spermidine work?
Spermidine has been characterized as a natural autophagy inducer. Autophagy is a process by which cells get rid of parts that are no longer needed or don’t work right, helping cells stay healthy and promoting longevity. Spermidine has been shown to block several enzymes that negatively control autophagy and may be as powerful as rapamycin, an FDA-approved immunosuppressant with strong autophagy-stimulating effects.
Have any questions?
Let's get in touch!
Contact us if your are thinking of purchasing highquality ingredients, develop new products, or justsolving a manufacturing challenge in your rawmaterials.
