{"id":2671,"date":"2025-09-23T07:15:35","date_gmt":"2025-09-23T07:15:35","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2671"},"modified":"2025-09-23T07:15:35","modified_gmt":"2025-09-23T07:15:35","slug":"%eb%94%94%ed%9e%88%eb%93%9c%eb%a1%9c%ed%80%98%eb%a5%b4%ec%84%b8%ed%8b%b4-%ec%9d%b8%ec%b2%b4%ec%97%90-%ec%9c%a0%ec%9d%b5%ed%95%9c-6%ea%b0%80%ec%a7%80-%ed%9a%a8%eb%8a%a5","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/%eb%94%94%ed%9e%88%eb%93%9c%eb%a1%9c%ed%80%98%eb%a5%b4%ec%84%b8%ed%8b%b4-%ec%9d%b8%ec%b2%b4%ec%97%90-%ec%9c%a0%ec%9d%b5%ed%95%9c-6%ea%b0%80%ec%a7%80-%ed%9a%a8%eb%8a%a5\/","title":{"rendered":"\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4: \uc778\uccb4\uc5d0 \uc720\uc775\ud55c 6\uac00\uc9c0 \ud6a8\ub2a5"},"content":{"rendered":"

\ub514\ud558\uc774\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc18c\ub098\ubb34, \ud3ec\ub3c4\uc528, \uc591\ud30c \ub4f1 \uc2dd\ubb3c\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uc778 \ud018\ub974\uc138\ud2f4\uc758 \uc218\uc18c\ud654 \uc720\ub3c4\uccb4\uc785\ub2c8\ub2e4. \ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d, \ub300\uc0ac \uc870\uc808 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ud604\uc7ac \uc2dd\ud488, \uac74\uac15 \ubcf4\uc870\uc2dd\ud488, \uc758\uc57d\ud488 \ub4f1\uc758 \uc6a9\ub3c4\ub85c \uc5f0\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.\"\"<\/p>\n

\ud56d\uc0b0\ud654 \ubc29\uc5b4: \uc790\uc720 \ub77c\ub514\uce7c \uc18c\uac70\uc758 \ud575\uc2ec \uba54\ucee4\ub2c8\uc998<\/h2>\n

\uc0dd\uccb4 \ub0b4\uc5d0\uc11c \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uc0dd\uc131\uacfc \uc18c\uac70\ub294 \uc5ed\ub3d9\uc801\uc778 \ud3c9\ud615 \uc0c1\ud0dc\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud3c9\ud615\uc774 \uae68\uc9c0\uba74 \uacfc\ub3c4\ud55c \uc790\uc720 \ub77c\ub514\uce7c\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc720\ubc1c\ud558\uc5ec \uc138\ud3ec\uc640 \uc870\uc9c1\uc744 \uc190\uc0c1\uc2dc\ud0a4\uace0 \uad81\uadf9\uc801\uc73c\ub85c \ub2e4\uc591\ud55c \uc9c8\ubcd1\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uac15\ub825\ud55c \ud56d\uc0b0\ud654\uc81c\uc778 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4<\/strong><\/a>\uc740 \uc2e0\uccb4\uc758 \uc0b0\ud654\ud658\uc6d0 \uade0\ud615\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774 \ud56d\uc0b0\ud654 \uba54\ucee4\ub2c8\uc998\uc740 \uc8fc\ub85c \ud398\ub180\uc131 \uc218\uc0b0\uae30\uc758 \uc790\uc720 \ub77c\ub514\uce7c \uc81c\uac70 \ub2a5\ub825\uacfc \ub3c5\ud2b9\ud55c \uace0\ub9ac\ud615 \ud56d\uc0b0\ud654 \ud65c\uc131\uc5d0 \uae30\ubc18\ud569\ub2c8\ub2e4.<\/p>\n

\ud398\ub180\uc131 \uc218\uc0b0\uae30\uc758 \uc790\uc720 \ub77c\ub514\uce7c \uc81c\uac70 \uae30\ub2a5<\/h3>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ubd84\uc790 \uad6c\uc870\uc5d0 5\uac1c\uc758 \ud398\ub180\uc131 \uc218\uc0b0\uae30\ub97c \ud3ec\ud568\ud558\uace0 \uc788\uc5b4 \uac15\ub825\ud55c \uc790\uc720 \ub77c\ub514\uce7c \uc81c\uac70 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud654\ud559\uc801 \uad00\uc810\uc5d0\uc11c \uc790\uc720 \ub77c\ub514\uce7c\uc740 \ud640\uc804\uc790\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \ubc18\uc751\uc131\uc774 \ub9e4\uc6b0 \ub192\uc2b5\ub2c8\ub2e4. \uc774\ub4e4\uc740 \uc138\ud3ec \ub0b4 \ub2e4\ub978 \ubd84\uc790\ub85c\ubd80\ud130 \uacf5\uaca9\uc801\uc73c\ub85c \uc804\uc790\ub97c \ud6d4\uccd0 DNA, \ub2e8\ubc31\uc9c8, \uc9c0\uc9c8\uacfc \uac19\uc740 \uc0dd\uccb4 \ubd84\uc790\ub97c \uacf5\uaca9\ud558\uace0 \ub2e4\uc591\ud55c \uc0b0\ud654\uc801 \uc190\uc0c1\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud398\ub180\uc131 \uc218\uc0b0\uae30\ub294 “\uc804\uc790 \uacf5\uc5ec\uccb4”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc218\uc18c \uc6d0\uc790\ub97c \uc801\uadf9\uc801\uc73c\ub85c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc790\uc720 \ub77c\ub514\uce7c\uc774 \uacf5\uaca9\ud558\uba74 \ud398\ub180\uc131 \uc218\uc0b0\uae30\uc758 \uc218\uc18c \uc6d0\uc790\ub294 \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uc9dd\uc9d3\uae30\ub418\uc9c0 \uc54a\uc740 \uc804\uc790\uc640 \uacb0\ud569\ud558\uc5ec \uc774\ub97c \uc548\uc815\ud654\uc2dc\ud0a4\uace0 \uc138\ud3ec \ub0b4 \ub2e4\ub978 \ubb3c\uc9c8\uc744 \ub354 \uc774\uc0c1 \uacf5\uaca9\ud558\uc9c0 \ubabb\ud558\ub3c4\ub85d \ub9c9\uc544 \uc790\uc720 \ub77c\ub514\uce7c\uc5d0 \uc758\ud574 \uc2dc\uc791\ub41c \uc5f0\uc1c4 \ubc18\uc751\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4.<\/p>\n

\uc608\ub97c \ub4e4\uc5b4, \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \ub77c\ub514\uce7c\uc740 \uc138\ud3ec \ud638\ud761 \uacfc\uc815\uc5d0\uc11c \uc0dd\uc131\ub418\ub294 \ud754\ud55c \uc790\uc720 \ub77c\ub514\uce7c\uc785\ub2c8\ub2e4. \ub2e4\ub7c9\uc73c\ub85c \ucd95\uc801\ub418\uba74 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9\uc758 \uc9c0\uc9c8\uc744 \uacf5\uaca9\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ubc29\ud574\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \ub77c\ub514\uce7c\uacfc \ube60\ub974\uac8c \ubc18\uc751\ud558\uc5ec \uc218\uc18c \uc6d0\uc790\ub97c \uacf5\uc5ec\ud558\uc5ec \ube44\uad50\uc801 \uc548\uc815\uc801\uc778 \uacfc\uc0b0\ud654\uc218\uc18c\ub85c \uc804\ud658\uc2dc\ucf1c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \ucd94\uac00 \uc190\uc0c1\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \ub610 \ub2e4\ub978 \uc608\ub85c\ub294 \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc740 DNA \uad6c\uc870\ub97c \uc9c1\uc811 \uc190\uc0c1\uc2dc\ud0a4\uace0 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\uc640 \uac19\uc740 \uc2ec\uac01\ud55c \uacb0\uacfc\ub97c \ucd08\ub798\ud560 \uc218 \uc788\ub294 \uace0\ub3c4\ub85c \uc0b0\ud654\uc131\uc778 \uc790\uc720 \ub77c\ub514\uce7c\uc785\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub610\ud55c \ud398\ub180\uc131 \ud788\ub4dc\ub85d\uc2e4\uae30\ub97c \ud1b5\ud574 \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uacfc \uacb0\ud569\ud558\uc5ec \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc774 DNA\ub97c \uc190\uc0c1\uc2dc\ud0a4\ub294 \uc704\ud5d8\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc904\uc774\uace0 \uc138\ud3ec \ub0b4 \ud544\uc218 \ubb3c\uc9c8\uc744 \ubcf4\ud638\ud558\ub294 \ubc29\ud328 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\uc9c0\uc18d\uc801\uc778 \uc21c\ud658 \ud56d\uc0b0\ud654 \ud65c\uc131<\/h3>\n

\ud55c \ubc88\ub9cc \uc12d\ucde8\ud558\ub294 \ub300\ubd80\ubd84\uc758 \ud56d\uc0b0\ud654\uc81c\uc640 \ub2ec\ub9ac, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uace0\uc720\ud55c \uc21c\ud658 \ud56d\uc0b0\ud654 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud398\ub180\uc131 \ud788\ub4dc\ub85d\uc2e4\uae30\uac00 \uc218\uc18c \uc6d0\uc790\ub97c \uc81c\uacf5\ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c\uacfc \uacb0\ud569\ud558\uba74 \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ubd88\uc548\uc815\ud558\uc5ec \uc0c8\ub85c\uc6b4 \uc0b0\ud654 \ubc18\uc751\uc744 \uacc4\uc18d \uc720\ubc1c\ud560 \uc218 \uc788\ub294 \ubc18\uba74, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uc740 \ub3c5\ud2b9\ud55c \uad6c\uc870\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \ub9e4\uc6b0 \uc548\uc815\uc801\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc548\uc815\uc131\uc740 \ubd84\uc790 \ub0b4 \uc804\uc790 \uacf5\uc561 \ud6a8\uacfc\uc5d0 \uae30\uc778\ud558\ub294\ub370, \uc774\ub294 \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uc758 \ube44\uacf5\uc720 \uc804\uc790\uac00 \uc804\uccb4 \ubd84\uc790 \uad6c\uc870 \ub0b4\uc5d0\uc11c \ube44\uad6d\uc7ac\ud654\ub418\uc5b4 \uc790\uc720 \ub77c\ub514\uce7c\uc758 \ud65c\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uc138\ud3ec \ub0b4 \uc218\uc6a9\uc561 \ud658\uacbd\uc5d0\uc11c \ubb3c \ubd84\uc790\ub294 \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uacfc \uc0c1\ud638 \uc791\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubb3c \ubd84\uc790\uc758 \uc218\uc18c \uc6d0\uc790\ub294 \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uacfc \uacb0\ud569\ud558\uc5ec \ud398\ub180\uc625\uc2e4 \ub77c\ub514\uce7c\uc774 \uc218\uc18c \uc6d0\uc790\ub97c \ub418\ucc3e\uc544 \uc6d0\ub798\uc758 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 \ubd84\uc790\ub85c \ub3cc\uc544\uac08 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc744 “\uc7ac\uc0dd” \ud56d\uc0b0\ud654 \ud65c\uc131\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. \uc774\ub294 \ub9c8\uce58 \uc804\ud22c\uc5d0\uc11c \uc5d0\ub108\uc9c0\ub97c \uc18c\ubaa8(\uc218\uc18c \uc6d0\uc790 \uc81c\uacf5)\ud558\ub354\ub77c\ub3c4 \ube60\ub974\uac8c \uc5d0\ub108\uc9c0\ub97c \ubcf4\ucda9(\uc218\uc18c \uc6d0\uc790 \ud68c\ubcf5)\ud558\uc5ec \uc804\ud22c\ub97c \uacc4\uc18d\ud560 \uc218 \uc788\ub294 \uad70\uc778\uacfc \uac19\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub9cc\uc131 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ubc18\uc751\ud558\uba74 \ube44\ud0c0\ubbfc C\uc640 \uac19\uc740 \ud56d\uc0b0\ud654\uc81c\uac00 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc81c\uac70\ud55c \ud6c4 \uace0\uac08\ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc9c0\uc18d\uc801\uc73c\ub85c \uc7ac\uc0dd\ub418\uc5b4 \uc9c0\uc18d\uc801\uc778 \ud56d\uc0b0\ud654 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub9cc\uc131 \uc5fc\uc99d \ubaa8\ub378\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc9c0\uc18d\uc801\uc778 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc740 \uc5fc\uc99d \uc870\uc9c1\uc758 \uc0b0\ud654\uc801 \uc190\uc0c1\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc904\uc774\uace0, \uc5fc\uc99d \ud574\uc18c\ub97c \ucd09\uc9c4\ud558\uba70, \ub354\uc6b1 \uc9c0\uc18d\uc801\uc778 \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2ec\ud608\uad00\uacc4 \ubcf4\ud638: \ud608\uad00\uc5d0\uc11c \uc2ec\uadfc\uae4c\uc9c0 \uc774\uc911 \ubcf4\ud638\"\"<\/h2>\n

\uc2e0\uccb4\uc758 “\uc0dd\uba85\uc120”\uc778 \uc2ec\ud608\uad00\uacc4\ub294 \uc0b6\uc758 \uc9c8\uacfc \uc218\uba85\uc5d0 \uc9c1\uacb0\ub429\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c4 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud608\uad00 \ud0c4\ub825 \uc720\uc9c0\ubd80\ud130 \uc2ec\uadfc \uc138\ud3ec \uac74\uac15 \ubcf4\ud638\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \uc2ec\ud608\uad00\uacc4 \ubcf4\ud638\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70, \uc2ec\ud608\uad00\uacc4\uc5d0 \ub2e4\ucc28\uc6d0\uc801\uc778 \ubc29\uc5b4 \uae30\ub2a5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ud608\uad00 \ud0c4\ub825 \uc720\uc9c0 \ubc0f \ubbf8\uc138\uc21c\ud658 \uac1c\uc120<\/h3>\n

\uc2ec\ud608\uad00\uacc4\uc5d0\uc11c \ub0b4\ud53c\uc138\ud3ec\ub294 \ud608\uc561\uacfc \ud608\uad00\ubcbd \uc0ac\uc774\uc758 \uc911\uc694\ud55c \uc7a5\ubcbd \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub0b4\ud53c\uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc740 \ud608\uad00 \uac74\uac15 \uc720\uc9c0\uc5d0 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud604\ub300 \uc0ac\ud68c\uc5d0\uc11c \uc7a5\uae30\uac04\uc758 \uace0\uc5fc\ubd84 \ubc0f \uace0\uc9c0\ubc29 \uc2dd\ub2e8, \uc6b4\ub3d9 \ubd80\uc871, \ud761\uc5f0, \ud658\uacbd \uc624\uc5fc\uacfc \uac19\uc740 \uac74\uac15\uc5d0 \ud574\ub85c\uc6b4 \uc0dd\ud65c \uc2b5\uad00\uc740 \ub0b4\ud53c\uc138\ud3ec\ub97c \uc190\uc0c1\uc2dc\ud0a4\uace0 \uc5fc\uc99d \ubc18\uc751\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5fc\uc99d \ubc18\uc751\uc774 \ud65c\uc131\ud654\ub418\uba74 \ub2e8\ud575\uad6c\uac00 \ub0b4\ud53c\uc138\ud3ec\uc5d0 \ubd80\ucc29\ub418\uc5b4 \uc810\ucc28\uc801\uc73c\ub85c \uc8fd\uc0c1\uacbd\ud654\ubc18\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc8fd\uc0c1\uacbd\ud654\ubc18\uc740 \ud608\uad00\ubcbd\uc744 \ub450\uaecd\uace0 \ub2e8\ub2e8\ud558\uac8c \ub9cc\ub4e4\uc5b4 \ud0c4\ub825\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc815\uc0c1\uc801\uc778 \ud608\ub958\ub97c \ubc29\ud574\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud575\uc778\uc790-\u03baB(NF-\u03baB) \uacbd\ub85c\uc640 \uac19\uc740 \uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \uc778\ud130\ub8e8\ud0a8-1\u03b2(IL-1\u03b2), \uc778\ud130\ub8e8\ud0a8-6(IL-6), \uc885\uc591\uad34\uc0ac\uc778\uc790-\u03b1(TNF-\u03b1)\uc640 \uac19\uc740 \uc5fc\uc99d \uc778\uc790\uc758 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc758 \uc5fc\uc99d \ubc18\uc751\uc744 \uc5b5\uc81c\ud558\uace0, \ub2e8\ud575\uad6c\uc758 \ubd80\ucc29\uc744 \ubc29\uc9c0\ud558\uba70, \uc8fd\uc0c1\uacbd\ud654\ubc18 \ud615\uc131\uc744 \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uace0\uc9c0\ud608\uc99d \ub3d9\ubb3c \ubaa8\ub378 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 \uce58\ub8cc\uac00 \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc758 \uc5fc\uc99d \uc778\uc790 \ubc1c\ud604\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uace0, \ub2e8\ud575\uad6c\uc758 \ub0b4\ud53c \ubd80\ucc29\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uba70, \uc8fd\uc0c1\uacbd\ud654\ubc18\uc758 \uba74\uc801\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub610\ud55c \ud608\uad00 \ud3c9\ud65c\uadfc\uc744 \ud655\uc7a5\ud558\ub294 \ud6a8\uacfc\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec\uc5d0 \uc791\uc6a9\ud558\uc5ec \uc77c\ub828\uc758 \uc138\ud3ec \ub0b4 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \ud608\uad00 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ud0b5\ub2c8\ub2e4. \ud2b9\ud788, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc5d0\uc11c \uc77c\uc0b0\ud654\uc9c8\uc18c(NO)\uc758 \ud569\uc131 \ubc0f \ubc29\ucd9c\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NO\ub294 \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec\ub85c \ube60\ub974\uac8c \ud655\uc0b0\ub418\uc5b4 \uad6c\uc544\ub2d0\uc0b0 \uace0\ub9ac\ud654\ud6a8\uc18c\ub97c \ud65c\uc131\ud654\ud558\uace0 \uc138\ud3ec \ub0b4 \uace0\ub9ac\ud615 \uad6c\uc544\ub178\uc2e0 \uc77c\uc778\uc0b0(cGMP) \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ucf1c \ud608\uad00 \ud3c9\ud65c\uadfc \uc774\uc644\uc744 \uc720\ub3c4\ud558\ub294 \uac15\ub825\ud55c \ud608\uad00 \ud655\uc7a5\uc81c\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud608\uad00 \ud655\uc7a5 \ud6a8\uacfc\ub294 \ud608\uad00 \uc800\ud56d\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ud0a4\uace0, \uad00\uc0c1\ub3d9\ub9e5 \ud608\ub958\ub97c \uc99d\uac00\uc2dc\ud0a4\uba70, \uc2ec\uc7a5\uc73c\ub85c\uc758 \ucda9\ubd84\ud55c \ud608\uc561 \uacf5\uae09\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4. \ub610\ud55c, \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc744 \uc7a5\uae30\uac04 \uc12d\ucde8\ud558\uba74 \ub0b4\ud53c \uc138\ud3ec\uc5d0\uc11c \uc77c\uc0b0\ud654\uc9c8\uc18c(NO) \uc0dd\uc131\uc774 \ud604\uc800\ud788 \uc99d\uac00\ud558\uace0, \ud608\uad00 \ud655\uc7a5 \uae30\ub2a5\uc774 \ud5a5\uc0c1\ub418\uba70, \ud608\uc555\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ub418\uc5b4 \uace0\ud608\uc555 \ubc0f \ub3d9\ub9e5\uacbd\ud654\uc99d\uacfc \uac19\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc608\ubc29\uc5d0 \uc0c1\ub2f9\ud55c \ud6a8\uacfc\uac00 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2ec\uadfc \uc138\ud3ec \ubcf4\ud638 \ubc0f \uc5d0\ub108\uc9c0 \ub300\uc0ac \ucd5c\uc801\ud654<\/h3>\n

\uc2ec\uadfc \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658, \ud2b9\ud788 \uad00\uc0c1\ub3d9\ub9e5 \uc9c8\ud658 \ud658\uc790\uc5d0\uac8c \ud754\ud558\uace0 \uc2ec\uac01\ud55c \ubb38\uc81c\uc785\ub2c8\ub2e4. \uad00\uc0c1\ub3d9\ub9e5\uc774 \ub9c9\ud788\uba74 \uc2ec\uadfc\uc138\ud3ec\uac00 \ud5c8\ud608\ub85c \uc778\ud574 \uc190\uc0c1\ub429\ub2c8\ub2e4. \ud608\uc561 \uad00\ub958\uac00 \ud68c\ubcf5\ub418\uba74 \ubcf5\uc7a1\ud55c \uc77c\ub828\uc758 \ubcd1\ud0dc\uc0dd\ub9ac\ud559\uc801 \ubc18\uc751\uc774 \uc720\ubc1c\ub418\uc5b4 \uc2ec\uadfc\uc138\ud3ec\uc758 \ucd94\uac00\uc801\uc778 \uc190\uc0c1\uacfc \uc2ec\uc9c0\uc5b4 \uc138\ud3ec\uc790\uba78\uc0ac\uae4c\uc9c0 \ucd08\ub798\ud558\uc5ec \uc2ec\uc7a5 \uae30\ub2a5\uc744 \uc2ec\uac01\ud558\uac8c \uc190\uc0c1\uc2dc\ud0a4\uace0 \uc2ec\uc7a5 \ub3cc\uc5f0\uc0ac\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc2ec\uadfc \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc5d0 \ub300\ud574 \ud0c1\uc6d4\ud55c \ubcf4\ud638 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc138\ud3ec\uc790\uba78\uc0ac \uacbd\ub85c\uc758 \uad00\uc810\uc5d0\uc11c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc138\ud3ec \ub0b4 \uc138\ud3ec\uc790\uba78\uc0ac \uad00\ub828 \ub2e8\ubc31\uc9c8\uc758 \ubc1c\ud604\uc744 \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc138\ud3ec \ub0b4\uc5d0\uc11c “\uc0dd\uba85 \uad6c\uc870\ub300”\ucc98\ub7fc \uc791\uc6a9\ud558\ub294 \ud56d\uc138\ud3ec\uc790\uba78\uc0ac \ub2e8\ubc31\uc9c8 Bcl-2\uc758 \ubc1c\ud604\uc744 \uc0c1\ud5a5\uc870\uc808\ud558\uc5ec \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc138\ud3ec\uc790\uba78\uc0ac \ucd09\uc9c4 \ub2e8\ubc31\uc9c8 Bax\uc758 \ubc1c\ud604\uc744 \ud558\ud5a5\uc870\uc808\ud558\uc5ec \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uc720\ub3c4\ud558\ub294 \uc778\uc790\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc2ec\uadfc\uc138\ud3ec\uc758 \uc138\ud3ec\uc790\uba78\uc0ac \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uace0 \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc774\ub77c\ub294 \uac00\ud639\ud55c \ud658\uacbd\uc5d0\uc11c \uc0dd\uc874\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4.<\/p>\n

\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc785\ub2c8\ub2e4. \uc5d0\ub108\uc9c0 \uc694\uad6c\ub7c9\uc774 \ub192\uc740 \uc2ec\uadfc\uc138\ud3ec\uc758 \uacbd\uc6b0, \uc801\uc808\ud55c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc740 \ud2b9\ud788 \uc911\uc694\ud569\ub2c8\ub2e4. \uc2ec\uadfc \ud5c8\ud608-\uc7ac\uad00\ub958 \ub3d9\uc548 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc190\uc0c1\ub418\uae30 \uc26c\uc6cc \uad6c\uc870\uc801 \ubb34\uacb0\uc131\uc774 \ud30c\uad34\ub418\uace0, \uc5d0\ub108\uc9c0 \ub300\uc0ac\uac00 \uc911\ub2e8\ub418\uba70, \uc2ec\uadfc\uc138\ud3ec\uc5d0 \ucda9\ubd84\ud55c ATP\ub97c \uacf5\uae09\ud558\uc9c0 \ubabb\ud558\uac8c \ub429\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub2e4\uc591\ud55c \ubc29\uc2dd\uc73c\ub85c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uad6c\uc870\uc801 \ubb34\uacb0\uc131\uc744 \ubcf4\ud638\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud56d\uc0b0\ud654 \uc791\uc6a9\uc744 \ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc8fc\ubcc0\uc758 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc81c\uac70\ud558\uace0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9\uc758 \uc0b0\ud654\uc801 \uc190\uc0c1\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \uc804\uc704\ub97c \uc870\uc808\ud558\uc5ec \uc815\uc0c1\uc801\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\uace0 \uc548\uc815\uc801\uc778 ATP \uacf5\uae09\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n

\uc218\ub9ce\uc740 \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc2ec\uc7a5 \ubcf4\ud638 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2ec\uadfc\uacbd\uc0c9 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 \uce58\ub8cc\ub294 \uacbd\uc0c9 \ud06c\uae30\ub97c \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\uc2dc\ud0a4\uace0 \uadfc\uc12c\uc720\uc758 \uc218\ucd95\uc744 \uac1c\uc120\ud588\uc2b5\ub2c8\ub2e4. \uc2ec\uadfc \uc218\ucd95\ub825. \uc774\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \uc2ec\uadfc\uc138\ud3ec \uc0ac\uba78\uc744 \uac10\uc18c\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \uae30\ub2a5 \ud68c\ubcf5\uc744 \ucd09\uc9c4\ud568\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc774\ub294 \uad00\uc0c1\ub3d9\ub9e5 \uc9c8\ud658 \ud658\uc790\uc758 \ubcf4\uc870 \uc694\ubc95\uc73c\ub85c\uc11c \ub9e4\uc6b0 \uc911\uc694\ud558\uba70, \uae09\uc131 \uc2ec\uc7a5\uc0ac \uc704\ud5d8 \uac10\uc18c\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc804\ub7b5\uacfc \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

\ub300\uc0ac \uc870\uc808: \ud608\ub2f9\uacfc \uc9c0\uc9c8 \uade0\ud615\"\"<\/h2>\n

\ud604\ub300 \uc0ac\ud68c\uc5d0\uc11c \ub2f9\ub1e8\ubcd1\uc774\ub098 \uace0\uc9c0\ud608\uc99d\uacfc \uac19\uc740 \ub300\uc0ac \uc9c8\ud658\uc758 \ubc1c\ubcd1\ub960\uc774 \uc99d\uac00\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub294 \uc778\uac04\uc758 \uac74\uac15\uc5d0 \uc2ec\uac01\ud55c \uc704\ud611\uc774 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c4 \ucc9c\uc5f0 \ud654\ud569\ubb3c\uc778 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud608\ub2f9\uacfc \uc9c0\uc9c8 \uc870\uc808\uc5d0 \uc788\uc5b4 \ub3c5\ubcf4\uc801\uc778 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b4\uba70, \ub300\uc0ac \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uacfc \ud76c\ub9dd\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4 \ud5a5\uc0c1 \ubc0f \ud3ec\ub3c4\ub2f9 \ub300\uc0ac \ucd5c\uc801\ud654<\/h3>\n

\uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uc870\uac74\uc5d0\uc11c \uc778\uc290\ub9b0\uc740 \ud608\ub2f9 \uc218\uce58\ub97c \uc870\uc808\ud558\ub294 \ud575\uc2ec \ud638\ub974\ubaac\uc785\ub2c8\ub2e4. \uc778\uc290\ub9b0\uc740 \ub9c8\uce58 “\uc5f4\uc1e0”\ucc98\ub7fc \uc138\ud3ec\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \uc704\ud55c “\ubb38”\uc744 \uc5f4\uc5b4 \ud608\uc561 \uc18d \ud3ec\ub3c4\ub2f9\uc774 \uc138\ud3ec\ub85c \ub4e4\uc5b4\uac00 \uc0dd\uba85 \ud65c\ub3d9\uc5d0 \ud544\uc694\ud55c \uc5d0\ub108\uc9c0\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub2f9\ub1e8\ubcd1, \ud2b9\ud788 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uacbd\uc6b0, \ub2e4\uc591\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 \uc138\ud3ec\uc758 \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\uac00 \uac10\uc18c\ud558\uc5ec “\uc5f4\uc1e0”\uac00 \ubb38\uc744 \uc5ec\ub294 \ub2a5\ub825\uc774 \uc57d\ud654\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ucda9\ubd84\ud55c \uc778\uc290\ub9b0\uc774 \ubd84\ube44\ub418\ub354\ub77c\ub3c4 \uc138\ud3ec\uac00 \ud3ec\ub3c4\ub2f9\uc744 \uc81c\ub300\ub85c \ud761\uc218\ud558\uc9c0 \ubabb\ud574 \ud608\ub2f9\uc774 \uc0c1\uc2b9\ud558\uace0 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc774 \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \uac1c\uc120\ud558\uace0 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\ub97c \ucd5c\uc801\ud654\ud558\ub294 \ub370 \uc911\uc694\ud55c \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc138\ud3ec \uc2e0\ud638\uc804\ub2ec \uad00\uc810\uc5d0\uc11c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 5′-AMP \ud65c\uc131\ud654 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c(AMPK) \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. AMPK\ub294 \uc138\ud3ec \ub0b4 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc758 \ud575\uc2ec \uc870\uc808\uc790\uc785\ub2c8\ub2e4. \uc138\ud3ec \ub0b4 \uc5d0\ub108\uc9c0 \uc218\uc900\uc774 \uac10\uc18c\ud558\uba74 AMPK\uac00 \ud65c\uc131\ud654\ub418\uc5b4 \uc138\ud3ec \ub0b4 “\uc5d0\ub108\uc9c0 \uacbd\ucc30” \uc5ed\ud560\uc744 \ud558\uba70, \uc77c\ub828\uc758 \ubc18\uc751\uc744 \ud1b5\ud574 \uc138\ud3ec \ub300\uc0ac \uacfc\uc815\uc744 \uc870\uc808\ud558\uace0 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uba70 \uc5d0\ub108\uc9c0 \uc18c\ube44\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 AMPK \ud65c\uc131\ud654\ub294 \uace8\uaca9\uadfc\uacfc \uc9c0\ubc29\uc138\ud3ec\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uace8\uaca9\uadfc \uc138\ud3ec\uc5d0\uc11c \ud65c\uc131\ud654\ub41c AMPK\ub294 \ud3ec\ub3c4\ub2f9 \uc218\uc1a1\uccb4 4(GLUT4)\uac00 \uc138\ud3ec \ub0b4 \uc800\uc7a5 \uc18c\ud3ec\uc5d0\uc11c \uc138\ud3ec\ub9c9 \ud45c\uba74\uc73c\ub85c \uc774\ub3d9\ud558\ub3c4\ub85d \ud569\ub2c8\ub2e4. GLUT4\ub294 \ud3ec\ub3c4\ub2f9\uc774 \uc138\ud3ec \ub0b4\ub85c \uc720\uc785\ub418\ub294 “\uc6b4\ubc18\uccb4” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. GLUT4 \uc218\uce58\uac00 \uc99d\uac00\ud558\uba74 \ud608\uc561\uc5d0\uc11c \uace8\uaca9\uadfc \uc138\ud3ec\ub85c \ud3ec\ub3c4\ub2f9\uc774 \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \uc6b4\ubc18\ub418\uc5b4 \ud608\ub2f9 \uc218\uce58\uac00 \ub0ae\uc544\uc9d1\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uac04\uc5d0\uc11c \uc8fc\uc694 \ud3ec\ub3c4\ub2f9\uc2e0\uc0dd \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uac04\uc758 \ud3ec\ub3c4\ub2f9 \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ucf1c \uacf5\ubcf5 \ud608\ub2f9 \uc218\uce58\ub97c \ub0ae\ucda5\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub3c4 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud608\ub2f9 \uac15\ud558 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc81c2\ud615 \ub2f9\ub1e8\ubcd1 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 50~100mg\uc744 \ub9e4\uc77c \ubcf4\ucda9\ud55c \uacb0\uacfc, \uc77c\uc815 \uae30\uac04 \ub3d9\uc548\uc758 \uce58\ub8cc \ud6c4 \ub2f9\ud654\ud608\uc0c9\uc18c \uc218\uce58\uac00 \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \ub2f9\ud654\ud608\uc0c9\uc18c\ub294 \uc9c0\ub09c 2~3\uac1c\uc6d4 \ub3d9\uc548\uc758 \ud3c9\uade0 \ud608\ub2f9 \uc218\uce58\ub97c \ub098\ud0c0\ub0b4\ub294 \uc911\uc694\ud55c \uc9c0\ud45c\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc218\uce58 \uac10\uc18c\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \uc7a5\uae30\uc801\uc73c\ub85c \ud608\ub2f9 \uc218\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ud558\uc5ec \ub2f9\ub1e8\ubcd1 \ud658\uc790\uc758 \uc0c1\ud0dc\ub97c \uac1c\uc120\ud558\uace0 \ub2f9\ub1e8\ubcd1 \uad00\ub9ac\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc790\uc5f0 \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808 \ubc0f \ucf5c\ub808\uc2a4\ud14c\ub864 \ud56d\uc0c1\uc131<\/h3>\n

\uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d\uc740 \ucf5c\ub808\uc2a4\ud14c\ub864, \uc911\uc131\uc9c0\ubc29, \uc9c0\ub2e8\ubc31\uc9c8\uacfc \uac19\uc740 \ud608\uc911 \uc9c0\uc9c8 \uc131\ubd84 \uc218\uce58\uac00 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uc99d\uac00\ud558\uac70\ub098 \uac10\uc18c\ud558\ub294 \uac83\uc744 \ub9d0\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d \ubc0f \uad00\uc0c1\ub3d9\ub9e5 \uc2ec\uc7a5 \uc9c8\ud658\uacfc \uac19\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc911\uc694\ud55c \uc704\ud5d8 \uc778\uc790\uc785\ub2c8\ub2e4. \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131, \uc6b4\ubc18, \uadf8\ub9ac\uace0 \ub300\uc0ac\ub294 \uc9c0\uc9c8 \ub300\uc0ac\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud56d\uc0c1\uc131\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \uc218\uc900\uc5d0\uc11c \uc9c0\uc9c8 \ub300\uc0ac\ub97c \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 3-\ud788\ub4dc\ub85d\uc2dc-3-\uba54\ud2f8\uae00\ub8e8\ud0c0\ub9b4 \ucf54\uc5d4\uc790\uc784 A(HMG-CoA) \ud658\uc6d0\ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. HMG-CoA \ud658\uc6d0\ud6a8\uc18c\ub294 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\uc758 \ud575\uc2ec \uc18d\ub3c4 \uc81c\ud55c \ud6a8\uc18c\ub85c, \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131 \uacfc\uc815\uc758 \ub9c8\uc2a4\ud130 \uc2a4\uc704\uce58 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 HMG-CoA \ud658\uc6d0\ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uba74 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131 \uacfc\uc815\uc774 \ubd80\ubd84\uc801\uc73c\ub85c \uc911\ub2e8\ub418\uc5b4 \uac04\uc5d0\uc11c \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\uc774 \uac10\uc18c\ud558\uace0 \ud608\uc911 \ucf5c\ub808\uc2a4\ud14c\ub864 \ub18d\ub3c4\uac00 \ub0ae\uc544\uc9d1\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub610\ud55c \uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31\uc9c8(LDL) \uc218\uc6a9\uccb4\uc758 \ubc1c\ud604\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. LDL \uc218\uc6a9\uccb4\ub294 \uc138\ud3ec \ud45c\uba74\uc5d0\uc11c “LDL \uc218\uc6a9\uccb4” \uc5ed\ud560\uc744 \ud558\uc5ec \ud608\uc561 \ub0b4 LDL\uc744 \uc778\uc2dd\ud558\uace0 \uacb0\ud569\ud558\uc5ec \uc138\ud3ec \ub0b4\ub85c \uc6b4\ubc18\ud558\uc5ec \ub300\uc0ac \ubd84\ud574\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 LDL \uc218\uc6a9\uccb4 \ubc1c\ud604\uc744 \ucd09\uc9c4\ud558\uba74 \uc138\ud3ec \ud45c\uba74\uc758 “LDL \uc218\uc6a9\uccb4” \uc218\uac00 \uc99d\uac00\ud558\uc5ec \ud608\uc561 \ub0b4 LDL\uc758 \ud761\uc218 \ud6a8\uc728\uc744 \ub192\uc774\uace0, \ud608\uc561\uc5d0\uc11c “\ub098\uc05c \ucf5c\ub808\uc2a4\ud14c\ub864”(LDL-C)\uc758 \uc81c\uac70\ub97c \ucd09\uc9c4\ud558\uba70, LDL-C \uc218\uce58\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\ud2b9\ud788, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud56d\uc0b0\ud654 \ud6a8\uacfc\ub294 \uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808\uc5d0\ub3c4 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud608\uc561 \ub0b4\uc5d0\uc11c LDL\uc740 \uc27d\uac8c \uc0b0\ud654\ub418\uace0 \ubcc0\ud615\ub418\uc5b4 \uc0b0\ud654 LDL(ox-LDL)\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. ox-LDL\uc740 \uc138\ud3ec\ub3c5\uc131\uc774 \ub9e4\uc6b0 \uac15\ud558\uba70 \ub300\uc2dd\uc138\ud3ec\uc5d0 \uc758\ud574 \ub300\ub7c9\uc73c\ub85c \ud761\uc218\ub418\uc5b4 \uac70\ud488 \uc138\ud3ec\ub85c \ubcc0\ud569\ub2c8\ub2e4. \uac70\ud488 \uc138\ud3ec\ub294 \ud608\uad00\ubcbd\uc5d0 \ucd95\uc801\ub418\uc5b4 \uc810\ucc28 \uc8fd\uc0c1\uacbd\ud654\ubc18\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. \ub514\ud558\uc774\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 LDL\uc758 \uc0b0\ud654\uc801 \ubcc0\ud615\uc744 \uc608\ubc29\ud558\uace0, ox-LDL\uc758 \ud615\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70, \ub3d9\ub9e5\uacbd\ud654\uc758 \uc2dc\uc791 \uc694\uc778\uc744 \uadfc\uc6d0\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uace0, \uc2ec\ud608\uad00\uacc4\ub97c \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4 \uc9c0\uc9c8 \uacfc\uc0b0\ud654 \uc0dd\uc131\ubb3c\ub85c \uc778\ud55c ge. \uc218\ub9ce\uc740 \ub3d9\ubb3c \ubc0f \uc138\ud3ec \uc5f0\uad6c\ub97c \ud1b5\ud574 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc9c0\uc9c8 \uc800\ud558 \ud6a8\uacfc\uac00 \ud655\uc778\ub418\uc5c8\uc73c\uba70, \uc774\ub294 \uace0\uc9c0\ud608\uc99d\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc744 \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \ud0c4\ud0c4\ud55c \uc774\ub860\uc801 \uadfc\uac70\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uac04 \ubcf4\ud638: \uc138\ud3ec \uc7ac\uc0dd\uc5d0\uc11c \uc12c\uc720\ud654 \uc911\uc7ac\uae4c\uc9c0\"\"<\/h2>\n

\uc778\uccb4\uc5d0\uc11c \uac00\uc7a5 \ud070 \uae30\uad00\uc778 \uac04\uc740 \uc2e0\uc9c4\ub300\uc0ac, \ud574\ub3c5, \uba74\uc5ed \uc870\uc808 \ub4f1 \uc218\ub9ce\uc740 \uc911\uc694\ud55c \uc0dd\ub9ac \uae30\ub2a5\uc744 \ub2f4\ub2f9\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud604\ub300 \uc0ac\ud68c\uc758 \uc74c\uc8fc, \uc57d\ubb3c \ub0a8\uc6a9, \ud658\uacbd \uc624\uc5fc, \uc798\ubabb\ub41c \uc2dd\uc2b5\uad00 \ub4f1 \uc5ec\ub7ec \uc694\uc778\ub4e4\uc774 \uac04\uc5d0 \uc2ec\uac01\ud55c \ubd80\ub2f4\uc744 \uc8fc\uc5b4 \ub2e4\uc591\ud55c \uac04 \uc9c8\ud658 \ubc1c\uc0dd\ub960\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c4 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uac04\uc138\ud3ec \uc7ac\uc0dd \ucd09\uc9c4\ubd80\ud130 \uac04 \uc12c\uc720\ud654 \uc9c4\ud589 \uc5b5\uc81c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \uac04 \ubcf4\ud638\uc5d0 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \ubcf4\uc774\uba70, \uac04 \uac74\uac15\uc744 \ud3ec\uad04\uc801\uc73c\ub85c \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n

\uac04\uc138\ud3ec \uc99d\uc2dd\uacfc \uc138\ud3ec\uc790\uba78\uc0ac \uade0\ud615 \uc870\uc808<\/h3>\n

\uac04\uc774 \uc190\uc0c1\ub418\uba74 \uac04\uc138\ud3ec \uc99d\uc2dd\uacfc \uc138\ud3ec\uc790\uba78\uc0ac \uade0\ud615\uc774 \uac04 \uae30\ub2a5 \ud68c\ubcf5\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc815\uc0c1\uc801\uc778 \uc0c1\ud669\uc5d0\uc11c \uac04\uc138\ud3ec\ub294 \ube44\uad50\uc801 \uc548\uc815\uc801\uc778 \uc0c1\ud0dc\ub97c \uc720\uc9c0\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uac04\uc774 \uc54c\ucf54\uc62c, \uc57d\ubb3c, \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uacfc \uac19\uc740 \uc678\ubd80 \uc694\uc778\uc5d0 \ub178\ucd9c\ub418\uba74 \uac04\uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc774 \uc190\uc0c1\ub418\uace0 \uc77c\ubd80 \uac04\uc138\ud3ec\ub294 \uc138\ud3ec\uc790\uba78\uc0ac \ub610\ub294 \uad34\uc0ac\ub97c \uacaa\uac8c \ub429\ub2c8\ub2e4. \uc774 \uc2dc\uc810\uc5d0\uc11c \uac04\uc740 \uc190\uc0c1\ub41c \uac04\uc138\ud3ec\ub97c \ubcf4\ucda9\ud558\uace0 \uc815\uc0c1\uc801\uc778 \uac04 \uad6c\uc870\uc640 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uac04\uc138\ud3ec \uc99d\uc2dd \uae30\uc804\uc744 \ud65c\uc131\ud654\ud574\uc57c \ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uac04\uc138\ud3ec \uc99d\uc2dd\uacfc \uc138\ud3ec\uc790\uba78\uc0ac \uc0ac\uc774\uc758 \uade0\ud615\uc744 \uc870\uc808\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc138\ud3ec\uc8fc\uae30 \ub2e8\ubc31\uc9c8\uc778 \uc0ac\uc774\ud074\ub9b0 D1\uc744 \ud65c\uc131\ud654\uc2dc\ucf1c \uac04\uc138\ud3ec\ub97c G1\uae30\uc5d0\uc11c S\uae30\ub85c \uc774\ub3d9\uc2dc\ud0a4\uace0 DNA \ubcf5\uc81c\uc640 \uc138\ud3ec \ubd84\uc5f4\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc138\ud3ec\uc8fc\uae30\ub294 \uc138\ud3ec \uc0dd\uba85\uc5d0 \uc911\uc694\ud55c \uacfc\uc815\uc785\ub2c8\ub2e4. G1\uae30\ub294 \uc138\ud3ec \uc131\uc7a5\uacfc DNA \ubcf5\uc81c \uc900\ube44 \ub2e8\uacc4\uc774\uba70, S\uae30\ub294 DNA \ubcf5\uc81c\uc5d0 \uc911\uc694\ud55c \uc2dc\uae30\uc785\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc5d0 \uc758\ud55c \uc0ac\uc774\ud074\ub9b0 D1 \ud65c\uc131\ud654\ub294 \uac04\uc138\ud3ec\uc5d0\uc11c \uac15\ub825\ud55c “\uc138\ud3ec\uc8fc\uae30 \uc5d4\uc9c4”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec DNA \ubcf5\uc81c\uae30\ub85c\uc758 \uc9c4\ud589\uc744 \uac00\uc18d\ud654\ud558\uace0, \uc774\ub97c \ud1b5\ud574 \uac04\uc138\ud3ec \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/p>\n

\ub3d9\uc2dc\uc5d0 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc138\ud3ec\uc790\uba78\uc0ac \ucd09\uc9c4 \ub2e8\ubc31\uc9c8\uc778 Bax\ub97c \ud558\ud5a5 \uc870\uc808\ud558\uc5ec \uac04\uc138\ud3ec\uc758 \uc608\uc815\ub41c \uc138\ud3ec\uc0ac\uba78\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. Bax\ub294 \uc138\ud3ec\uc790\uba78\uc0ac \ucd09\uc9c4 \ub2e8\ubc31\uc9c8\uc785\ub2c8\ub2e4. \ud65c\uc131\ud654\ub418\uba74 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub9c9 \ud22c\uacfc\uc131\uc744 \uc99d\uac00\uc2dc\ucf1c \uc2dc\ud1a0\ud06c\ub86c C\uc640 \uac19\uc740 \uc138\ud3ec\uc790\uba78\uc0ac \uc778\uc790\ub97c \ubc29\ucd9c\ud558\uace0, \uc774\ub294 \ub2e4\uc2dc \uc138\ud3ec\uc790\uba78\uc0ac \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uac04\uc138\ud3ec \uc790\uba78\uc0ac\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 Bax \ubc1c\ud604\uc744 \ud558\ud5a5 \uc870\uc808\ud568\uc73c\ub85c\uc368 \uac04\uc138\ud3ec \uc790\uba78\uc0ac\ub97c \ucc28\ub2e8\ud558\ub294 “\uc790\ubb3c\uc1e0” \uc5ed\ud560\uc744 \ud558\uc5ec \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uac04\uc138\ud3ec \uc7ac\uc0dd\uc5d0 \uc720\ub9ac\ud55c \ud658\uacbd\uc744 \uc870\uc131\ud569\ub2c8\ub2e4.<\/p>\n

\ub2e4\uc591\ud55c \ub3d9\ubb3c \uc5f0\uad6c\ub97c \ud1b5\ud574 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc774\ub7ec\ud55c \ud6a8\uacfc\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc54c\ucf54\uc62c\uc131 \uac04 \uc190\uc0c1 \ubaa8\ub378\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 \uce58\ub8cc\ub294 \uac04\uc138\ud3ec \uc99d\uc2dd \ud45c\uc9c0\uc790\uc778 PCNA\uc758 \ubc1c\ud604\uc744 40% \uc99d\uac00\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. PCNA\ub294 DNA \ud569\uc131\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\ub294 \ub2e8\ubc31\uc9c8\uc774\uba70, \ubc1c\ud604 \uc99d\uac00\ub294 \uac04\uc138\ud3ec \uc99d\uc2dd\uc774 \ucd09\uc9c4\ub418\uc5c8\uc74c\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc774 \uc2e4\ud5d8 \uacb0\uacfc\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \uac04 \uc870\uc9c1 \ubcf5\uad6c\ub97c \ud604\uc800\ud788 \uac00\uc18d\ud654\ud558\uace0 \uc190\uc0c1\ub41c \uac04\uc758 \ud68c\ubcf5\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc74c\uc744 \uac15\ub825\ud558\uac8c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

\ud56d\uc12c\uc720\ud654 \ubc0f \uc5fc\uc99d\uc131 \ubbf8\uc138\ud658\uacbd \uc870\uc808<\/h3>\n

\uac04 \uc12c\uc720\ud654\ub294 \ub2e4\uc591\ud55c \ub9cc\uc131 \uac04 \uc9c8\ud658\uc774 \uac04\uacbd\ubcc0\uc73c\ub85c \uc9c4\ud589\ub418\ub294 \ub370 \ud544\uc218\uc801\uc778 \ub2e8\uacc4\uc785\ub2c8\ub2e4. \uc774 \uc9c8\ud658\uc758 \uc8fc\uc694 \ud2b9\uc9d5\uc740 \uac04 \ub0b4 \uc138\ud3ec\uc678 \uae30\uc9c8(ECM)\uc758 \uacfc\ub3c4\ud55c \ucd95\uc801\uc73c\ub85c, \uac04 \uc870\uc9c1\uc758 \uad6c\uc870\uc801 \ud30c\uad34\uc640 \uae30\ub2a5 \uc7a5\uc560\ub97c \ucd08\ub798\ud569\ub2c8\ub2e4. \uac04 \uc131\uc0c1\uc138\ud3ec \ud65c\uc131\ud654\ub294 \uac04 \uc12c\uc720\ud654 \uc9c4\ud589\uc5d0 \uc911\ucd94\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uac04\uc774 \uc9c0\uc18d\uc801\uc73c\ub85c \uc190\uc0c1\ub418\uba74 \uac04 \uc131\uc0c1\uc138\ud3ec\uac00 \ud65c\uc131\ud654\ub418\uc5b4 \ud734\uba74 \uc0c1\ud0dc\uc5d0\uc11c \uc99d\uc2dd, \u200b\u200b\ud569\uc131, \ubd84\ube44\ub418\ub294 \ud65c\uc131 \uc0c1\ud0dc\ub85c \uc804\ud658\ub429\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ud615\uc9c8\uc804\ud658 \uc131\uc7a5 \uc778\uc790 \u03b2(TGF-\u03b2) \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \uac04 \uc131\uc0c1\uc138\ud3ec \ud65c\uc131\ud654\ub97c \ud45c\uc801\uc73c\ub85c \ud569\ub2c8\ub2e4. TGF-\u03b2\ub294 \uac04 \uc12c\uc720\ud654\uc758 \ud575\uc2ec \uc0ac\uc774\ud1a0\uce74\uc778\uc73c\ub85c, \uac04 \uc131\uc0c1\uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud558\uace0 ECM\uc758 \ud569\uc131\uacfc \ubd84\ube44\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 TGF-\u03b2 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \uac04 \uc131\uc0c1\uc138\ud3ec \ud65c\uc131\ud654\uc758 “\ud4e8\uc988” \uc5ed\ud560\uc744 \ud558\uc5ec 1\ud615 \ucf5c\ub77c\uac90\uacfc \uac19\uc740 ECM \uc131\ubd84\uc758 \ucd95\uc801\uc744 \uac10\uc18c\uc2dc\ucf1c \uc12c\uc720\ud654 \uacfc\uc815\uc744 \uc911\ub2e8\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uac04\uc758 \uc5fc\uc99d\uc131 \ubbf8\uc138\ud658\uacbd \ub610\ud55c \uac04 \uac74\uac15\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ud575\uc2ec \uc694\uc778\uc785\ub2c8\ub2e4. \uac04 \ub0b4 \ub300\uc2dd\uc138\ud3ec\uc778 \ucfe0\ud37c \uc138\ud3ec\ub294 \uc5fc\uc99d \ubc18\uc751\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uac04\uc774 \uc190\uc0c1\ub418\uba74 \ucfe0\ud37c \uc138\ud3ec\uac00 \ud65c\uc131\ud654\ub418\uc5b4 TNF-\u03b1\uc640 IL-6\uc640 \uac19\uc740 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc744 \ubd84\ube44\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc0ac\uc774\ud1a0\uce74\uc778\uc740 \uac04\uc758 \uc5fc\uc99d \ubc18\uc751\uc744 \ub354\uc6b1 \uc545\ud654\uc2dc\ucf1c \uac04\uc138\ud3ec\ub97c \uc190\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c \uac04 \uc131\uc0c1\uc138\ud3ec\uc758 \ud65c\uc131\ud654\ub97c \uc790\uadf9\ud558\uc5ec \uac04 \uc12c\uc720\ud654 \uc9c4\ud589\uc744 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ucfe0\ud37c \uc138\ud3ec\uc5d0\uc11c TNF-\u03b1\uc640 IL-6\uc640 \uac19\uc740 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \ubd84\ube44\ub97c \uc5b5\uc81c\ud558\uc5ec \uac04 \uc5fc\uc99d\uc744 \uc644\ud654\ud569\ub2c8\ub2e4. \uc774\ub294 \ub9c8\uce58 \uac04 \uc5fc\uc99d\uc758 “\ubd88\uaf43”\uc5d0 \ubb3c\uc744 \ubd93\ub294 \uac83\uacfc \uac19\uc740 \uc791\uc6a9\uc73c\ub85c \uac04\uc138\ud3ec \uc190\uc0c1\uc744 \uc904\uc774\uace0 \uac04\uc138\ud3ec\uc758 \ubcf5\uad6c \ubc0f \uc7ac\uc0dd\uc5d0 \uc720\ub9ac\ud55c \ubbf8\uc138\ud658\uacbd\uc744 \uc870\uc131\ud569\ub2c8\ub2e4. \uc774 \ub450\uc544\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ubcf4\ud638 \ud6a8\uacfc\ub294 \ub9cc\uc131 \uac04\uc5fc \ubc0f \uc9c0\ubc29\uac04 \ud658\uc790\uc5d0\uac8c \ub9e4\uc6b0 \uc911\uc694\ud558\uba70, \uac04\uacbd\ubcc0\uc73c\ub85c\uc758 \uc9c4\ud589\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uacfc \uc0dd\uc874\uc728\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uba74\uc5ed \uc870\uc808: \ud56d\uc5fc\uc99d, \ud56d\uade0 \ubc0f \uba74\uc5ed \ubc18\uc751 \ud5a5\uc0c1\"\"<\/h2>\n

\uba74\uc5ed \uc870\uc808\uc740 \uc778\uac04 \uba74\uc5ed \uccb4\uacc4\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc798 \ud6c8\ub828\ub41c \uad70\ub300\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ubcd1\uc6d0\uade0\uc73c\ub85c\ubd80\ud130 \uc2e0\uccb4\ub97c \ub04a\uc784\uc5c6\uc774 \ubcf4\ud638\ud569\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c4 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc815\ubc00\ud558\uac8c \uc5b5\uc81c\ud558\ub294 \uac83\ubd80\ud130 \uad11\ubc94\uc704\ud55c \ud56d\uade0 \ud65c\uc131\uc744 \ub098\ud0c0\ub0b4\uace0 \uba74\uc5ed \uc138\ud3ec \ubc18\uc751\uc744 \uac15\ud654\ud558\ub294 \uac83\uae4c\uc9c0 \uba74\uc5ed \uc870\uc808\uc5d0 \uc788\uc5b4 \ub2e4\uac01\uc801\uc778 \uc5ed\ud560\uc744 \uc218\ud589\ud558\uc5ec \uc778\uac04 \uba74\uc5ed \uccb4\uacc4\ub97c \ud3ec\uad04\uc801\uc73c\ub85c \uc9c0\uc6d0\ud569\ub2c8\ub2e4.<\/p>\n

\uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc758 \uc815\ubc00 \uc5b5\uc81c<\/h3>\n

\uc815\uc0c1\uc801\uc778 \uc0c1\ud669\uc5d0\uc11c \uc2e0\uccb4\uc758 \uc5fc\uc99d \ubc18\uc751\uc740 \uc790\uac00 \ubc29\uc5b4 \uae30\uc804\uc785\ub2c8\ub2e4. \uc2e0\uccb4\uac00 \ubcd1\uc6d0\uade0\uc758 \uce68\uc785\uc744 \ubc1b\uac70\ub098 \ubb3c\ub9ac\uc801 \ub610\ub294 \ud654\ud559\uc801 \uc190\uc0c1\uc744 \uc785\uc73c\uba74 \uba74\uc5ed \uccb4\uacc4\ub294 \ubcd1\uc6d0\uade0\uc744 \uc81c\uac70\ud558\uace0 \uc190\uc0c1\ub41c \uc870\uc9c1\uc744 \ubcf5\uad6c\ud558\uae30 \uc704\ud574 \uc2e0\uc18d\ud558\uac8c \uc5fc\uc99d \ubc18\uc751\uc744 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc5fc\uc99d \ubc18\uc751\uc774 \ud1b5\uc81c\ub418\uc9c0 \uc54a\uc73c\uba74 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \uacfc\uc789 \uc0dd\uc131\uc73c\ub85c \uc778\ud574 \uacfc\ub3c4\ud55c \uc5fc\uc99d \ubc18\uc751\uc774 \ubc1c\uc0dd\ud558\uc5ec \uc2e0\uccb4 \uc190\uc0c1\uc744 \uc720\ubc1c\ud558\uace0 \ub958\ub9c8\ud2f0\uc2a4 \uad00\uc808\uc5fc \ubc0f \uc5fc\uc99d\uc131 \uc7a5 \uc9c8\ud658\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \ub9cc\uc131 \uc5fc\uc99d\uc131 \uc9c8\ud658\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc5fc\uc99d \ubc18\uc751 \uc870\uc808\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\uba70, \ud575\uc778\uc790 \u03baB(NF-\u03baB)\uc640 \ubbf8\ud1a0\uac90 \ud65c\uc131\ud654 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c(MAPK) \uacbd\ub85c\ub97c \uc815\ud655\ud558\uac8c \uc5b5\uc81c\ud569\ub2c8\ub2e4. NF-\u03baB\ub294 \uc138\ud3ec \ub0b4 \uc5b4\ub514\uc5d0\ub098 \uc874\uc7ac\ud558\ub294 \uc804\uc0ac\uc778\uc790\uc785\ub2c8\ub2e4. \uc5fc\uc99d \ubc18\uc751 \uc2dc NF-\u03baB\ub294 “\uc0ac\ub839\uad00”\ucc98\ub7fc \uc791\uc6a9\ud569\ub2c8\ub2e4. \ud65c\uc131\ud654\ub418\uba74 \uc138\ud3ec\uc9c8\uc5d0\uc11c \ud575\uc73c\ub85c \uc774\ub3d9\ud558\uc5ec \uc77c\ub828\uc758 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \uc720\uc804\uc790 \uc804\uc0ac\ub97c \uac1c\uc2dc\ud558\uace0, \uc778\ud130\ub8e8\ud0a8-6(IL-6) \ubc0f \uc885\uc591\uad34\uc0ac\uc778\uc790-\u03b1(TNF-\u03b1)\uc640 \uac19\uc740 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \ub300\ub7c9 \ubc29\ucd9c\uc744 \uc720\ub3c4\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 NF-\u03baB \ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud558\uc5ec \uc138\ud3ec\uc9c8\uc5d0\uc11c \ud575\uc73c\ub85c\uc758 \uc774\ub3d9\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \uc774\ub294 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \ubc29\ucd9c\uc758 “\uc2e0\ud638\uc6d0”\uc744 \ube44\ud65c\uc131\ud654\ud558\uace0 \uc5fc\uc99d \ub9e4\uac1c\uccb4 \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4.
\nMAPK \uacbd\ub85c\ub294 \uc138\ud3ec\uc678 \uc2e0\ud638 \uc870\uc808 \ud0a4\ub098\uc544\uc81c(ERK), c-Jun N-\ub9d0\ub2e8 \ud0a4\ub098\uc544\uc81c(JNK), p38 MAPK\uc640 \uac19\uc740 \uc5ec\ub7ec \uac00\uc9c0 \uacbd\ub85c\ub97c \ud3ec\ud568\ud558\ub294 \uc5fc\uc99d \uc2e0\ud638\uc804\ub2ec\uc758 \ud575\uc2ec \uacbd\ub85c\uc774\uae30\ub3c4 \ud569\ub2c8\ub2e4. \uc138\ud3ec\uac00 \uc5fc\uc99d\uc5d0 \uc758\ud574 \uc790\uadf9\uc744 \ubc1b\uc73c\uba74 MAPK \uacbd\ub85c\uac00 \ud65c\uc131\ud654\ub429\ub2c8\ub2e4. \uc77c\ub828\uc758 \uc778\uc0b0\ud654 \uc5f0\uc1c4\ubc18\uc751\uc744 \ud1b5\ud574 \uc5fc\uc99d \uc2e0\ud638\uac00 \uc138\ud3ec\ud575\uc73c\ub85c \uc804\ub2ec\ub418\uc5b4 \uc5fc\uc99d \uad00\ub828 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 MAPK \uacbd\ub85c\uc758 \uc8fc\uc694 \ud0a4\ub098\uc544\uc81c \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec\uc744 \ucc28\ub2e8\ud558\uace0 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \ud569\uc131 \ubc0f \ubc29\ucd9c\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.
\n\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud56d\uc5fc\uc99d \ud6a8\uacfc\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub958\ub9c8\ud2f0\uc2a4 \uad00\uc808\uc5fc \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc744 \ub9e4\uc77c \ubcf4\ucda9\ud55c \uacb0\uacfc \uad00\uc808 \ubd80\uc885\uacfc \ud1b5\uc99d\uc774 \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\ud588\uc73c\uba70, IL-6 \ubc0f TNF-\u03b1\uc640 \uac19\uc740 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \ud608\uc911 \ub18d\ub3c4\ub3c4 \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud56d\uc5fc\uc99d \ud6a8\uacfc\uac00 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c(NSAID)\uc640 \uc720\uc0ac\ud558\uc9c0\ub9cc, NSAID\uc758 \uc77c\ubc18\uc801\uc778 \uc704\uc7a5\uad00 \ubd80\uc791\uc6a9\uc740 \uc5c6\uc5b4 \ub9cc\uc131 \uc5fc\uc99d\uc131 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \ub354 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \ucc9c\uc5f0 \ub300\uc548\uc744 \uc81c\uc2dc\ud568\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\uad11\ubc94\uc704 \ud56d\uade0 \ud6a8\uacfc \ubc0f \uba74\uc5ed \uc138\ud3ec \ud65c\uc131\ud654<\/h3>\n

\uc6b0\ub9ac\ub294 \uc77c\uc0c1\uc0dd\ud65c\uc5d0\uc11c \ubc15\ud14c\ub9ac\uc544, \ubc14\uc774\ub7ec\uc2a4, \uacf0\ud321\uc774\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \ubcd1\uc6d0\uade0\uc758 \uc704\ud611\uc5d0 \ub04a\uc784\uc5c6\uc774 \ub178\ucd9c\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uad11\ubc94\uc704 \ud56d\uade0 \ud65c\uc131\uc744 \ub098\ud0c0\ub0b4\uc5b4 \uc6b0\ub9ac \uac74\uac15\uc5d0 \uc911\uc694\ud55c \ubc29\uc5b4\uc120\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \ub0b4 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud669\uc0c9\ud3ec\ub3c4\uc0c1\uad6c\uade0, \ub300\uc7a5\uade0, \uce78\ub514\ub2e4 \uc54c\ube44\uce78\uc2a4\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \ud754\ud55c \ubcd1\uc6d0\uade0\uc5d0 \ub300\ud574 \uc720\uc758\ubbf8\ud55c \uc5b5\uc81c \ud6a8\uacfc\uac00 \uc785\uc99d\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc791\uc6a9 \uae30\uc804 \uce21\uba74\uc5d0\uc11c, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc8fc\ub85c \ubcd1\uc6d0\uade0 \uc138\ud3ec\ub9c9\uc758 \ubb34\uacb0\uc131\uc744 \ud30c\uad34\ud558\uace0 DNA \ud569\uc131\uc744 \ubc29\ud574\ud568\uc73c\ub85c\uc368 \ud56d\uade0 \ud65c\uc131\uc744 \ubc1c\ud718\ud569\ub2c8\ub2e4. \ud669\uc0c9\ud3ec\ub3c4\uc0c1\uad6c\uade0(Staphylococcus aureus)\uc758 \uacbd\uc6b0, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4(dihydroquercetin)\uc740 \uc138\ud3ec\ub9c9\uc758 \uc778\uc9c0\uc9c8 \ubd84\uc790\uc640 \uc0c1\ud638 \uc791\uc6a9\ud558\uc5ec \uc138\ud3ec\ub9c9 \uad6c\uc870\ub97c \ud30c\uad34\ud558\uace0 \ud22c\uacfc\uc131\uc744 \uc99d\uac00\uc2dc\ucf1c \uc138\ud3ec \ub0b4 \ubb3c\uc9c8\uc758 \uc720\ucd9c\uc744 \uc720\ub3c4\ud558\uace0 \uad81\uadf9\uc801\uc73c\ub85c \ubc15\ud14c\ub9ac\uc544 \uc0ac\uba78\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \ub300\uc7a5\uade0(Escherichia coli) \uc5f0\uad6c\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ubc15\ud14c\ub9ac\uc544 DNA \ubcf5\uc81c\uc5d0 \ud544\uc218\uc801\uc778 \ud6a8\uc18c\uc778 DNA \uc790\uc774\ub77c\uc81c(DNA gyrase)\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uba74 \ubc15\ud14c\ub9ac\uc544 DNA \ubcf5\uc81c\uac00 \uc815\uc0c1\uc801\uc73c\ub85c \uc9c4\ud589\ub418\uc9c0 \uc54a\uc544 \ubc15\ud14c\ub9ac\uc544\uc758 \uc131\uc7a5\uacfc \ubc88\uc2dd\uc774 \uc5b5\uc81c\ub429\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc9c1\uc811\uc801\uc778 \ud56d\uade0 \ud6a8\uacfc \uc678\uc5d0\ub3c4 T \ub9bc\ud504\uad6c \uc99d\uc2dd\uacfc \uc790\uc5f0\uc0b4\ud574\uc138\ud3ec(NK \uc138\ud3ec) \ud65c\uc131\uc744 \ucd09\uc9c4\ud558\uc5ec \uc2e0\uccb4\uc758 \uba74\uc5ed \ubc18\uc751\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \ubcd1\uc6d0\uade0 \uc81c\uac70 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. T \ub9bc\ud504\uad6c\ub294 \uc138\ud3ec \uba74\uc5ed\uc758 \ud575\uc2ec \uc138\ud3ec\uc785\ub2c8\ub2e4. \ubcd1\uc6d0\uade0\uc744 \uc778\uc2dd\ud558\uba74 \ud65c\uc131\ud654\ub418\uc5b4 \ube60\ub974\uac8c \uc99d\uc2dd\ud558\uace0 \ud6a8\uacfc\uae30 T \uc138\ud3ec\ub85c \ubd84\ud654\ud569\ub2c8\ub2e4. \uc774 \ud6a8\uacfc\uae30 T \uc138\ud3ec\ub294 \ubcd1\uc6d0\uade0\uc5d0 \uac10\uc5fc\ub41c \uc138\ud3ec\ub97c \uc9c1\uc811 \uacf5\uaca9\ud558\uc5ec \uc81c\uac70\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud558\uc774\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 T \ub9bc\ud504\uad6c \uc99d\uc2dd\uc5d0 \uc720\ub9ac\ud55c \ud658\uacbd\uc744 \uc81c\uacf5\ud558\uc5ec T \ub9bc\ud504\uad6c\uc758 \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4r \ubd84\uc5f4 \ubc0f \ubd84\ud654, \uadf8\ub9ac\uace0 \uc138\ud3ec \uba74\uc5ed \uac15\ud654.
\nNK \uc138\ud3ec\ub294 \uc2e0\uccb4 \uc120\ucc9c \uba74\uc5ed\uc758 \ud575\uc2ec \uc694\uc18c\ub85c, \ud56d\uc6d0\uc5d0 \ub178\ucd9c\ub418\uc9c0 \uc54a\uace0\ub3c4 \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc \uc138\ud3ec\uc640 \uc885\uc591 \uc138\ud3ec\ub97c \uc9c1\uc811 \uc0ac\uba78\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 NK \uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \ud65c\uc131\uc744 \ub192\uc774\uace0 \ud37c\ud3ec\ub9b0\uacfc \uadf8\ub79c\uc790\uc784\uacfc \uac19\uc740 \uc138\ud3ec\ub3c5\uc131 \ubb3c\uc9c8\uc744 \ub354 \ub9ce\uc774 \ubc29\ucd9c\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubb3c\uc9c8\uc740 \uac10\uc5fc\ub41c \uc138\ud3ec\uc758 \uc138\ud3ec\ub9c9\uc744 \ub6ab\uc5b4 \uc138\ud3ec \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uac10\uc5fc\ub41c \uc138\ud3ec\ub97c \uccb4\ub0b4\uc5d0\uc11c \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc774\ub7ec\ud55c \uba74\uc5ed \uc870\uc808 \ud6a8\uacfc\ub294 \uc778\ud50c\ub8e8\uc5d4\uc790\ub098 \ud5e4\ub974\ud398\uc2a4\uc640 \uac19\uc740 \ubc14\uc774\ub7ec\uc2a4\uc131 \uc9c8\ud658\uc5d0 \uc7a0\uc7ac\uc801\uc778 \uce58\ub8cc\uc801 \uac00\uce58\ub97c \uc9c0\ub2c8\uba70, \ud658\uc790\uc758 \uba74\uc5ed\ub825\uc744 \uac15\ud654\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc5d0 \ub354 \uc798 \ub300\ucc98\ud558\ub3c4\ub85d \ub3d5\uc2b5\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\ubbf8\ub7c9 \uc6d0\uc18c \uc2dc\ub108\uc9c0: \ud5a5\uc0c1\ub41c \uc131\ub2a5\uc744 \uc704\ud55c \ud669\uae08\ube5b \ud30c\ud2b8\ub108\uc2ed<\/h2>\n

\ubcf5\uc7a1\ud558\uace0 \uc12c\uc138\ud55c \uc778\uccb4\uc5d0\uc11c\ub294 \ub2e4\uc591\ud55c \uc601\uc591\uc18c\uac00 \ub3c5\ub9bd\uc801\uc73c\ub85c \uc874\uc7ac\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc624\ud788\ub824 \uc11c\ub85c \ud611\ub825\ud558\uace0 \uc601\ud5a5\uc744 \ubbf8\uccd0 \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc720\uc9c0\ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uacfc \ub2e4\uc591\ud55c \ubbf8\ub7c9 \uc6d0\uc18c\ub294 \ubc00\uc811\ud55c \uc2dc\ub108\uc9c0 \uad00\uacc4\ub97c \ubcf4\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud761\uc218 \ubc0f \uc774\uc6a9\uc744 \ucd09\uc9c4\ud558\uc5ec \uc778\uccb4 \uac74\uac15\uc5d0 \ud3ec\uad04\uc801\uc778 \uc774\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ub9c8\uadf8\ub124\uc298, \uc544\uc5f0, \ucca0\uc758 \uc2dc\ub108\uc9c0 \ud56d\uc0b0\ud654 \ub124\ud2b8\uc6cc\ud06c<\/h3>\n

\uc778\uccb4\uc758 \ud56d\uc0b0\ud654 \ubc29\uc5b4 \uc2dc\uc2a4\ud15c\uc5d0\uc11c \ub9c8\uadf8\ub124\uc298, \uc544\uc5f0, \ucca0\uacfc \uac19\uc740 \ubbf8\ub7c9 \uc6d0\uc18c\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uacfc \ub9e4\uc6b0 \ud6a8\uacfc\uc801\uc778 \uc2dc\ub108\uc9c0 \ud56d\uc0b0\ud654 \ub124\ud2b8\uc6cc\ud06c\ub97c \ud615\uc131\ud569\ub2c8\ub2e4. \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \ub514\uc2a4\ubba4\ud0c0\uc544\uc81c(SOD)\uc758 \uc911\uc694\ud55c \ubcf4\uc870 \uc778\uc790\uc778 \ub9c8\uadf8\ub124\uc298 \uc774\uc628\uc740 \ud56d\uc0b0\ud654 \uacfc\uc815\uc5d0\uc11c \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. SOD\ub294 \uc778\uccb4 \ud56d\uc0b0\ud654 \ud6a8\uc18c \uc2dc\uc2a4\ud15c\uc758 \ud575\uc2ec \uad6c\uc131\uc6d0\uc73c\ub85c, \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \ub77c\ub514\uce7c\uc744 \uacfc\uc0b0\ud654\uc218\uc18c\ub85c \uc804\ud658\ud558\ub294 \ucd09\ub9e4 \uc791\uc6a9\uc744 \ud1b5\ud574 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \ub77c\ub514\uce7c\uc744 \uccb4\ub0b4\uc5d0\uc11c \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\uace0 \uc138\ud3ec \uc190\uc0c1\uc744 \uc904\uc785\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \ub9c8\uadf8\ub124\uc298 \uc774\uc628\uacfc \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uba74 SOD \ud65c\uc131\uc774 \ud06c\uac8c \ud65c\uc131\ud654\ub418\uc5b4 \uc774 “\ud56d\uc0b0\ud654 \uc7a5\uce58”\uc5d0 \uac15\ub825\ud55c \ud65c\ub825\uc744 \ubd88\uc5b4\ub123\uc5b4 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uc81c\uac70\ud560 \uc218 \uc788\uac8c \ub429\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uacfc \ub9c8\uadf8\ub124\uc298 \uc774\uc628\uc758 \uacb0\ud569 \uc791\uc6a9\uc740 SOD \ud65c\uc131\uc744 30~50% \uc99d\uac00\uc2dc\ucf1c \uc2e0\uccb4\uc758 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628 \uc790\uc720 \ub77c\ub514\uce7c \uc81c\uac70 \ub2a5\ub825\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \uc138\ud3ec \uc190\uc0c1\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc544\uc5f0 \uc774\uc628 \ub610\ud55c \uc774\ub7ec\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ub0b4\ub294 \ud56d\uc0b0\ud654 \ub124\ud2b8\uc6cc\ud06c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc544\uc5f0 \uc774\uc628\uc740 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc138\ud3ec\ub9c9 \uacb0\ud569 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \uc138\ud3ec \ub0b4\ubd80\ub85c \ub354 \uc27d\uac8c \uce68\ud22c\ud558\uace0 \uc790\uc720 \ub77c\ub514\uce7c \uc81c\uac70 \ubc94\uc704\ub97c \ud655\uc7a5\ud569\ub2c8\ub2e4. \uc138\ud3ec\ub9c9\uc740 \uc911\uc694\ud55c \uc7a5\ubcbd\uc774\uc790 \uc790\uc720 \ub77c\ub514\uce7c \uacf5\uaca9\uc758 \uc8fc\uc694 \ud45c\uc801\uc785\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \uc138\ud3ec\ub9c9\uc5d0 \ub2e8\ub2e8\ud788 \uacb0\ud569\ud558\uba74 \uc138\ud3ec\ub9c9 \ud45c\uba74\uc5d0 “\ud56d\uc0b0\ud654 \ubc29\uc5b4\uc120”\uc744 \ud615\uc131\ud558\uc5ec \uce68\uc785\ud558\ub294 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc2e0\uc18d\ud558\uac8c \uc81c\uac70\ud558\uace0 \uc138\ud3ec\ub9c9\uc758 \ubb34\uacb0\uc131\uacfc \uae30\ub2a5\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4. \uc544\uc5f0 \uc774\uc628\uc740 \uae00\ub8e8\ud0c0\ud2f0\uc628 \ud37c\uc625\uc2dc\ub2e4\uc81c(GSH-Px)\uc640 \uac19\uc774 \ud56d\uc0b0\ud654 \ud65c\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \ud6a8\uc18c\ub97c \ud3ec\ud568\ud558\uc5ec \uc5ec\ub7ec \ud6a8\uc18c\uc758 \uad6c\uc131\uacfc \ud65c\uc131\uc744 \uc870\uc808\ud558\uc5ec \uc2e0\uccb4\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\ucca0 \uc774\uc628\uc740 \uc778\uccb4 \uc0dd\ub9ac \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc720\ub9ac \ucca0 \uc774\uc628\uc740 \ud39c\ud1a4 \ubc18\uc751\uc744 \ud1b5\ud574 \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc744 \uc0dd\uc131\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc740 \uc138\ud3ec\uc5d0 \ub9e4\uc6b0 \ud30c\uad34\uc801\uc778 \uace0\uc0b0\ud654\uc131 \uc720\ub9ac \ub77c\ub514\uce7c\uc785\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc720\ub9ac \ucca0\uc744 \ud0ac\ub808\uc774\ud2b8\ud558\uc5ec \uc548\uc815\ud55c \ubcf5\ud569\uccb4\ub97c \ud615\uc131\ud558\ub294 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ud39c\ud1a4 \ubc18\uc751 \ucc38\uc5ec\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 “\ucca0 \uad00\ub9ac\uc790” \uc5ed\ud560\uc744 \ud558\uc5ec \uc720\ub9ac \ucca0 \uc774\uc628\uc744 \uc801\uc808\ud558\uac8c “\ubcf4\ud638”\ud558\uace0 \uc720\ud574\ud55c \uc0b0\ud654 \ubc18\uc751\uc744 \uc720\ubc1c\ud558\uc9c0 \uc54a\ub3c4\ub85d \ubc29\uc9c0\ud558\uc5ec \uc138\ud3ec\ub97c \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \ub2e4\uc6d0\uc18c \ud611\ub825 “\ud56d\uc0b0\ud654 \ub9e4\ud2b8\ub9ad\uc2a4”\ub294 \uac01 \uc131\ubd84\uc758 \ud56d\uc0b0\ud654 \ud6a8\ub2a5\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub9c8\uadf8\ub124\uc298, \uc544\uc5f0, \ucca0\uacfc \uac19\uc740 \ubbf8\ub7c9 \uc6d0\uc18c\uc640 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud560 \ub54c \ub2e8\ub3c5\uc73c\ub85c \uc0ac\uc6a9\ud588\uc744 \ub54c\ubcf4\ub2e4 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc774 3~5\ubc30 \ub354 \ub192\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ub0b4\ub294 \ud56d\uc0b0\ud654 \ub124\ud2b8\uc6cc\ud06c\ub294 \ud658\uacbd \uc624\uc5fc\uc774\ub098 \uc790\uc678\uc120\uacfc \uac19\uc740 \uc678\ubd80 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc694\uc778\uc73c\ub85c\ubd80\ud130 \uc778\uccb4 \uc138\ud3ec\ub97c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf4\ud638\ud558\uc5ec \uc0b0\ud654\uc801 \uc190\uc0c1 \uc704\ud5d8\uc744 \uc904\uc774\uace0 \ub2e4\uc591\ud55c \ub9cc\uc131 \uc9c8\ud658\uc758 \ubc1c\ubcd1\uc744 \uc608\ubc29\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc601\uc591\uc18c \ud761\uc218 \ubc0f \uc0dd\uccb4\uc774\uc6a9\ub960 \ucd5c\uc801\ud654<\/h3>\n

\uc778\uac04\uc758 \uc601\uc591\uc18c \ud761\uc218 \uacfc\uc815\uc5d0\uc11c \ubbf8\ub7c9 \uc6d0\uc18c\uc640 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uae34\ubc00\ud558\uac8c \uc0c1\ud638 \uc791\uc6a9\ud558\uc5ec \uc601\uc591\uc18c \ud761\uc218 \ubc0f \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ud06c\uac8c \ucd5c\uc801\ud654\ud558\uace0 \ub354\uc6b1 \uc801\uc808\ud55c \uc601\uc591 \uc9c0\uc6d0\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ubbf8\ub7c9 \uc6d0\uc18c\ub294 \uc704\uc7a5 \uc810\ub9c9\uc744 \ud1b5\ud55c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud761\uc218\ub97c \ucd09\uc9c4\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc9c0\uc6a9\uc131\uacfc \uc218\uc6a9\uc131 \ubaa8\ub450\uc5d0 \uc6a9\ud574\ub418\ubbc0\ub85c \ud761\uc218\ub97c \uc704\ud574\uc11c\ub294 \ud2b9\uc218\ud55c \uc6b4\ubc18 \uba54\ucee4\ub2c8\uc998\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc544\uc5f0, \ucca0, \ub9c8\uadf8\ub124\uc298\uacfc \uac19\uc740 \ubbf8\ub7c9 \uc6d0\uc18c\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uacfc \uacb0\ud569\ud558\uc5ec \ubcf5\ud569\uccb4\ub97c \ud615\uc131\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubcf5\ud569\uccb4\ub294 \ubbf8\ub7c9 \uc6d0\uc18c \uc790\uccb4\uc758 \uc218\uc1a1\uccb4\ub97c \ud65c\uc6a9\ud558\uc5ec \uc704\uc7a5 \uc810\ub9c9\uc744 \ub354\uc6b1 \uc6d0\ud65c\ud558\uac8c \ud1b5\uacfc\ud558\uace0 \ud608\ub958\ub85c \uc720\uc785\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc544\uc5f0 \uc774\uc628\uc740 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uacfc \uc548\uc815\uc801\uc778 \ubcf5\ud569\uccb4\ub97c \ud615\uc131\ud558\uc5ec \uc7a5 \uc0c1\ud53c \uc138\ud3ec \ud45c\uba74\uc758 \uc544\uc5f0 \uc218\uc1a1\uccb4\ub97c \ud65c\uc6a9\ud558\uc5ec \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc744 \uc138\ud3ec \ub0b4\ub85c \uc6b4\ubc18\ud558\uace0 \ud761\uc218\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ubbf8\ub7c9 \uc6d0\uc18c\uc758 \uc0c1\uc2b9 \ud6a8\uacfc\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uc0dd\uccb4 \uc774\uc6a9\ub960\uc744 60% \uc774\uc0c1 \uc99d\uac00\uc2dc\ucf1c \uccb4\ub0b4 \ud6a8\ub2a5\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub610\ud55c \ubbf8\ub7c9 \uc6d0\uc18c\uc758 \ud761\uc218\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc7a5\ub0b4 \ubbf8\uc138 \ud658\uacbd\uc744 \uc870\uc808\ud558\uc5ec \ubbf8\ub7c9 \uc6d0\uc18c\uc758 \uc6a9\ud574\ub3c4\uc640 \uc874\uc7ac\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uccd0 \ud761\uc218\ub97c \ub354\uc6b1 \uc6a9\uc774\ud558\uac8c \ud569\ub2c8\ub2e4<\/p>\n

\"\"\"\"\uacb0\ub860: \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uacfc\ud559\uc801 \uc751\uc6a9 \ubc0f \ubbf8\ub798 \uc804\ub9dd<\/h2>\n

\ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c4 \ucc9c\uc5f0 \ud654\ud569\ubb3c\uc778 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub3c5\ud2b9\ud55c \ubd84\uc790 \uad6c\uc870\uc640 \ub2e4\uc911 \ud45c\uc801 \uba54\ucee4\ub2c8\uc998\uc744 \ud1b5\ud574 \ud56d\uc0b0\ud654, \ub300\uc0ac, \uc7a5\uae30 \ubc0f \uba74\uc5ed \uc870\uc808\uc5d0 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \ub098\ud0c0\ub0b4\uc5b4 \uc778\uccb4 \uac74\uac15\uc5d0 \ud3ec\uad04\uc801\uc778 \ub3c4\uc6c0\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ubd84\uc790 \uc218\uc900\uc758 \uc790\uc720 \ub77c\ub514\uce7c \uc18c\uac70\ubd80\ud130 \uc138\ud3ec \uc218\uc900\uc758 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c \uc870\uc808, \uadf8\ub9ac\uace0 \uad81\uadf9\uc801\uc73c\ub85c \uc804\ubc18\uc801\uc778 \uc7a5\uae30 \uae30\ub2a5 \uc720\uc9c0\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0, \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud6a8\uacfc\ub294 \uc778\uccb4 \uc0dd\ub9ac\uc758 \uc5ec\ub7ec \uce21\uba74\uc5d0 \uc2a4\uba70\ub4e4\uc5b4 \uc788\uc73c\uba70, \uadf8 \uc911\uc694\uc131\uc740 \uc790\uba85\ud569\ub2c8\ub2e4.<\/p>\n

2021\ub144 \uc911\uad6d \uad6d\uac00\uc704\uc0dd\uac74\uac15\uc704\uc6d0\ud68c\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4(\uc21c\ub3c4 \u226595%)\uc744 \uc0c8\ub85c\uc6b4 \uc2dd\ud488 \uc6d0\ub8cc\ub85c \uc2b9\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc911\uc694\ud55c \ubcc0\ud654\ub294 \uc2dd\ud488 \ubc0f \uac74\uac15 \ubd84\uc57c\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \uad11\ubc94\uc704\ud55c \uc751\uc6a9\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uc5b4\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uae30\ub2a5\uc131 \uc2dd\ud488 \ubd84\uc57c\uc5d0\uc11c \ub6f0\uc5b4\ub09c \ud56d\uc0b0\ud654 \ubc0f \uac74\uac15 \uc99d\uc9c4 \ud6a8\uacfc\ub97c \uc9c0\ub2cc \ub514\ud788\ub4dc\ub85c\ucf00\ub974\uc138\ud2f4\uc740 \ucc28\uc138\ub300 \uae30\ub2a5\uc131 \uc2dd\ud488\uc758 \ud575\uc2ec \uc131\ubd84\uc73c\ub85c \uc790\ub9ac\ub9e4\uae40\ud558\uc5ec \uc18c\ube44\uc790\uc5d0\uac8c \ub354\uc6b1 \uac74\uac15\ud558\uace0 \uae30\ub2a5\uc131\uc774 \uac15\ud654\ub41c \uc2dd\ud488\uc744 \uc81c\uacf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc74c\ub8cc, \ubc1c\ud6a8\uc720, \ucf54\ucf54\uc544 \uc81c\ud488 \ubc0f \uae30\ud0c0 \uc2dd\ud488\uc5d0 \ub514\ud788\ub4dc\ub85c\ucf00\ub974\uc138\ud2f4\uc744 \ucca8\uac00\ud558\uba74 \uc601\uc591\uac00\ub97c \ub192\uc77c \ubfd0\ub9cc \uc544\ub2c8\ub77c \uace0\uc720\ud55c \uac74\uac15 \ud6a8\ub2a5\uc744 \ubd80\uc5ec\ud558\uc5ec \uac74\uac15\uc2dd\ud488\uc5d0 \ub300\ud55c \uc18c\ube44\uc790\uc758 \uc218\uc694\ub97c \ucda9\uc871\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ucf00\ub974\uc138\ud2f4\uc740 \uc81c\uc57d \ubc0f \uc758\ub8cc \ubd84\uc57c\uc5d0\uc11c\ub3c4 \uc720\ub9dd\ud55c \ud65c\uc6a9 \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac74\uac15\uc5d0 \ub300\ud55c \ub300\uc911\uc758 \uc778\uc2dd\uc774 \ub192\uc544\uc9d0\uc5d0 \ub530\ub77c \ucc9c\uc5f0\uc758 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uac74\uac15 \uc81c\ud488\uc5d0 \ub300\ud55c \uc218\uc694 \ub610\ud55c \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ucc9c\uc5f0 \uc0dd\ub9ac\ud65c\uc131 \ubb3c\uc9c8\uc778 \ub514\ud788\ub4dc\ub85c\ucf00\ub974\uc138\ud2f4\uc740 \ub3c5\uc131\uacfc \ubd80\uc791\uc6a9\uc774 \ub0ae\uc544 \ud604\ub300 \uc18c\ube44\uc790\uc758 \uac74\uac15 \uc81c\ud488 \uc120\ud638\ub3c4\ub97c \ucda9\uc871\ud569\ub2c8\ub2e4. \ud5a5\ud6c4 \ucea1\uc290, \uc815\uc81c, \uacbd\uad6c\uc6a9\uc561 \ub4f1 \ub2e4\uc591\ud55c \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc73c\ub85c \uac1c\ubc1c\ub418\uc5b4 \uc77c\uc0c1\uc801\uc778 \uac74\uac15 \uc720\uc9c0\uc5d0 \uac15\ub825\ud55c \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \ub354\uc6b1\uc774, \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \uc788\uc5b4\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ub2e4\uc911 \ud45c\uc801 \uc791\uc6a9 \uae30\uc804\uc740 \ub2e4\uc591\ud55c \uc9c8\ubcd1 \uce58\ub8cc\ub97c \uc704\ud55c \uc7a0\uc7ac\uc801 \uc120\ub3c4 \ud654\ud569\ubb3c\ub85c \uc791\uc6a9\ud558\uc5ec \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uacfc \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4. \uc55e\uc73c\ub85c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4 \uc5f0\uad6c\ub294 \uc5ec\uc804\ud788 \ub9ce\uc740 \uc720\ub9dd\ud55c \ud0d0\uad6c \uc601\uc5ed\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc554 \uc608\ubc29 \ubd84\uc57c\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc774 \ub2e4\uc591\ud55c \uc554\uc138\ud3ec\uc5d0 \ub300\ud55c \uc5b5\uc81c \ud6a8\uacfc\ub97c \ubcf4\uc774\ub294 \uac83\uc73c\ub85c \uc5f0\uad6c\ub418\uc5c8\uc9c0\ub9cc, \uc885\uc591\uc758 \ubc1c\uc0dd, \uc9c4\ud589 \ubc0f \uc804\uc774 \uacfc\uc815\uc5d0\uc11c \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud2b9\uc815 \uc791\uc6a9 \uae30\uc804\uc744 \uc774\ud574\ud558\uace0 \ud45c\uc801\uc744 \uba85\ud655\ud788 \ud558\uc5ec \uc554 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \ub300\ud55c \ub354\uc6b1 \ud0c4\ud0c4\ud55c \uc774\ub860\uc801 \ud1a0\ub300\ub97c \ub9c8\ub828\ud558\uae30 \uc704\ud55c \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uc2e0\uacbd \ubcf4\ud638 \ubd84\uc57c\uc5d0\uc11c\ub294 \uc778\uad6c \uace0\ub839\ud654\uc640 \ud568\uaed8 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ubc0f \ud30c\ud0a8\uc2a8\ubcd1\uacfc \uac19\uc740 \uc2e0\uacbd \ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \ubc1c\ubcd1\ub960\uc774 \ub9e4\ub144 \uc99d\uac00\ud558\uc5ec \uc0ac\ud68c\uc640 \uac00\uc871\uc5d0\uac8c \ud070 \ubd80\ub2f4\uc744 \uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc2e0\uacbd\uacc4 \ubcf4\ud638\uc5d0 \uc720\ub9dd\ud55c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ud5a5\ud6c4 \uc5f0\uad6c\ub294 \uc2e0\uacbd \uc138\ud3ec \ubcf4\ud638 \uae30\uc804, \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8 \uc870\uc808, \uadf8\ub9ac\uace0 \uc2e0\uacbd \uc5fc\uc99d \uc5b5\uc81c \ud6a8\uacfc\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0\uc758 \uc751\uc6a9\uc744 \ubaa8\uc0c9\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n

\uacfc\ud559\uae30\uc220\uc758 \uc9c0\uc18d\uc801\uc778 \ubc1c\uc804\uacfc \ud568\uaed8 \uc815\ubc00 \uc758\ud559\uc740 \uc758\ud559 \ubc1c\uc804\uc758 \ud575\uc2ec \ud2b8\ub80c\ub4dc\ub85c \uc790\ub9ac \uc7a1\uc558\uc2b5\ub2c8\ub2e4. \ucc9c\uc5f0 \ud65c\uc131 \uc131\ubd84\uc778 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc815\ubc00 \uc758\ud559\uacfc \uae34\ubc00\ud558\uac8c \ud1b5\ud569\ub420 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac1c\uc778 \uc720\uc804\ud559 \ubc0f \ub2e8\ubc31\uc9c8\uccb4\ud559\uc744 \ud3ec\ud568\ud55c \ub2e4\uc911 \uc624\ubbf9\uc2a4 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud568\uc73c\ub85c\uc368, \uac1c\uc778\ubcc4 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud6a8\uacfc\uc640 \ucd5c\uc801 \uc6a9\ub7c9\uc744 \uc815\ud655\ud558\uac8c \ud30c\uc545\ud558\uc5ec \uac1c\uc778 \ub9de\ucda4\ud615 \uac74\uac15 \uad00\ub9ac \ubc0f \uc9c8\ubcd1 \uce58\ub8cc\ub97c \uac00\ub2a5\ud558\uac8c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc758 \ud6a8\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \uac74\uac15 \uc99d\uc9c4 \ud6a8\uacfc\ub97c \uadf9\ub300\ud654\ud558\uc5ec \uc778\uac04 \uac74\uac15\uc5d0 \ub354\uc6b1 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uc194\ub8e8\uc158\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \ub9e4\uc6b0 \uc720\ub9dd\ud55c \ucc9c\uc5f0 \ud654\ud569\ubb3c\ub85c\uc11c \uc5ec\ub7ec \ubd84\uc57c\uc5d0\uc11c \uc0c1\ub2f9\ud55c \uac00\uce58\ub97c \uc785\uc99d\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uc9c0\uc18d\uc801\uc778 \uc2ec\uce35 \uc5f0\uad6c\uc640 \uc751\uc6a9 \ubd84\uc57c \ud655\ub300\ub97c \ud1b5\ud574 \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc778\uac04 \uac74\uac15\uc5d0 \ub354\uc6b1 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \uc218\ud589\ud558\uc5ec \ub354 \ud070 \uc774\uc810\uc744 \uc81c\uacf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\ub514\ud558\uc774\ub4dc\ub85c\ud018\ub974\uc138\ud2f4\uc740 \uc18c\ub098\ubb34, \ud3ec\ub3c4\uc528, \uc591\ud30c \ub4f1 \uc2dd\ubb3c\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uc778 \ud018\ub974\uc138\ud2f4\uc758 \uc218\uc18c\ud654 \uc720\ub3c4\uccb4\uc785\ub2c8\ub2e4. \ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d, \ub300\uc0ac \uc870\uc808 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ud604\uc7ac \uc2dd\ud488, \uac74\uac15 \ubcf4\uc870\uc2dd\ud488, \uc758\uc57d\ud488 \ub4f1\uc758 \uc6a9\ub3c4\ub85c \uc5f0\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud56d\uc0b0\ud654 \ubc29\uc5b4: \uc790\uc720 \ub77c\ub514\uce7c \uc18c\uac70\uc758 \ud575\uc2ec \uba54\ucee4\ub2c8\uc998 \uc0dd\uccb4 \ub0b4\uc5d0\uc11c \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uc0dd\uc131\uacfc \uc18c\uac70\ub294 \uc5ed\ub3d9\uc801\uc778 \ud3c9\ud615 \uc0c1\ud0dc\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud3c9\ud615\uc774 \uae68\uc9c0\uba74 \uacfc\ub3c4\ud55c \uc790\uc720 \ub77c\ub514\uce7c\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc720\ubc1c\ud558\uc5ec \uc138\ud3ec\uc640 … Continue reading \ub514\ud788\ub4dc\ub85c\ud018\ub974\uc138\ud2f4: \uc778\uccb4\uc5d0 \uc720\uc775\ud55c 6\uac00\uc9c0 \ud6a8\ub2a5<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":2672,"parent":0,"menu_order":46,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-2671","blog","type-blog","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/comments?post=2671"}],"version-history":[{"count":0,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2671\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media\/2672"}],"wp:attachment":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media?parent=2671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}