{"id":2804,"date":"2025-10-11T08:42:42","date_gmt":"2025-10-11T08:42:42","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2804"},"modified":"2025-10-11T08:42:42","modified_gmt":"2025-10-11T08:42:42","slug":"nad-%ec%84%b8%ed%8f%ac-%ec%86%8d%ec%9d%98-%ec%83%9d%eb%aa%85%ec%9d%98-%ec%bd%94%eb%93%9c","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/nad-%ec%84%b8%ed%8f%ac-%ec%86%8d%ec%9d%98-%ec%83%9d%eb%aa%85%ec%9d%98-%ec%bd%94%eb%93%9c\/","title":{"rendered":"NAD: \uc138\ud3ec \uc18d\uc758 “\uc0dd\uba85\uc758 \ucf54\ub4dc”"},"content":{"rendered":"

NAD(\ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \uc544\ub370\ub2cc \ub2e4\uc774\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc)\ub294 \uc0dd\uba85\uccb4\uc5d0 \ud544\uc218\uc801\uc778 \ubcf4\uc870 \ud6a8\uc18c\ub85c \uc0dd\uba85 \ud65c\ub3d9\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. NAD\uc758 \ubc1c\uacac \uacfc\uc815\uc740 \uc218\ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc758 \uc9c0\ud61c\uc640 \ub178\uace0\uac00 \ub2f4\uae34 \uc6b0\uc5ec\uace1\uc808\ub85c \uc810\ucca0\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. 1904\ub144 NAD\uac00 \ubc1c\uacac\ub41c \uc774\ud6c4 100\ub144\uc774 \ub118\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

1904\ub144, \uc601\uad6d\uc758 \uc0dd\ud654\ud559\uc790 \uc544\uc11c \ud558\ub4e0 \uacbd\uc740 \ub9e5\uc8fc \ud6a8\ubaa8 \ucd94\ucd9c\ubb3c\uc744 \uc5f0\uad6c\ud558\ub358 \uc911 \uc608\uc0c1\uce58 \ubabb\ud55c \ubc1c\uacac\uc744 \ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ud6a8\ubaa8 \ucd94\ucd9c\ubb3c\uc744 \ubc18\ud22c\uacfc\uc131 \ub9c9\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9c4 \ubd09\uc9c0\uc5d0 \ub123\uace0 \uc21c\uc218\ud55c \ubb3c\uc5d0 \ub2f4\uac14\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ud765\ubbf8\ub85c\uc6b4 \ud604\uc0c1\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ud6a8\ubaa8 \ucd94\ucd9c\ubb3c\uc758 \uc791\uc740 \ubd84\uc790\ub294 \ub9c9\uc744 \ud1b5\uacfc\ud558\uc5ec \ubb3c\ub85c \uc774\ub3d9\ud588\uc9c0\ub9cc, \ud070 \ubd84\uc790\ub294 \ubd09\uc9c0\uc5d0 \uadf8\ub300\ub85c \ub0a8\uc544 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 \uc77c\ubc18\uc801\uc73c\ub85c \ub2f9\uc744 \ubc1c\ud6a8\uc2dc\ud0a4\ub294 \ud6a8\ubaa8 \ud6a8\uc18c\uc758 \ud65c\uc131\uc774 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ubd09\uc9c0\uc5d0\uc11c \uc2a4\uba70\ub098\uc628 \ubb3c\uc744 \ub2e4\uc2dc \ubd09\uc9c0\uc5d0 \ub123\uc5c8\ub354\ub2c8 \ud6a8\ubaa8 \ud6a8\uc18c\uc758 \ud65c\uc131\uc774 \uae30\uc801\uc801\uc73c\ub85c \ud68c\ubcf5\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucd94\uac00 \uc5f0\uad6c \ub05d\uc5d0 \ud558\ub4e0 \uacbd\uc740 \uc774 \uc791\uc740 \ubd84\uc790\uc5d0 \ub3c5\ud2b9\ud55c \ubb3c\uc9c8, \uc989 \ubcf4\uc870 \ud6a8\uc18c\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uace0, \uc774\ub294 \ub098\uc911\uc5d0 NAD+\ub85c \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc778\ub958 \uc5ed\uc0ac\uc0c1 \ucd5c\ucd08\ub85c \ucf54\uc5d4\uc790\uc784 \uc720\uc0ac \ubb3c\uc9c8\uc744 \ubc1c\uacac\ud55c \uac83\uc785\ub2c8\ub2e4. \uc774 \uc911\uc694\ud55c \ubc1c\uacac\uc73c\ub85c \ud558\ub4e0\uc740 1929\ub144 \ub178\ubca8 \ud654\ud559\uc0c1\uc744 \uc218\uc0c1\ud588\uc2b5\ub2c8\ub2e4. \ud6a8\ubaa8 \uc138\ud3ec \ub300\uc0ac\uc5d0\uc11c \uc5d0\ub108\uc9c0\ub97c \uacf5\uae09\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 NAD+\ub294 \uc218\ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc758 \uad00\uc2ec\uacfc \uc5f0\uad6c\ub97c \ub04c\uc5b4\ub0b4\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uadf8 \ud6c4 \uc218\uc2ed \ub144 \ub3d9\uc548 \uacfc\ud559\uc790\ub4e4\uc740 NAD\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uacc4\uc18d \uc2ec\ud654\ud588\uc2b5\ub2c8\ub2e4. 1920\ub144, \ub3c5\uc77c \ud654\ud559\uc790 \ud55c\uc2a4 \ud3f0 \uc624\uc77c\ub7ec-\ud5ec\ud540\uc740 \ud6a8\uc18c\ub97c \uc0ac\uc6a9\ud558\uc5ec NAD+\ub97c \ucd5c\ucd08\ub85c \ubd84\ub9ac \ubc0f \uc815\uc81c\ud558\ub294 \ub370 \uc131\uacf5\ud588\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \ub2e4\uc774\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc \uad6c\uc870\ub97c \ubc1c\uacac\ud558\uace0 \ud6a8\uc18c \ubd84\ub9ac \ubc0f \uc815\uc81c \uacfc\uc815\uc744 \ucd5c\uc801\ud654\ud558\uc5ec \uc774\ud6c4 NAD \uc5f0\uad6c\uc758 \ud0c4\ud0c4\ud55c \ud1a0\ub300\ub97c \ub9c8\ub828\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc73c\ub85c \ud558\ub4e0\uacfc \uc544\uc11c \ud558\ub4e0\uc740 1929\ub144 \ub178\ubca8 \ud654\ud559\uc0c1\uc744 \uacf5\ub3d9 \uc218\uc0c1\ud588\uc2b5\ub2c8\ub2e4. 1930\ub144, \ub3c5\uc77c \uacfc\ud559\uc790 \uc624\ud1a0 \ubc14\ub974\ubd80\ub974\ud06c\ub294 \ubb3c\uc9c8 \ubc0f \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc5d0\uc11c \ucf54\uc5d4\uc790\uc784\uc73c\ub85c\uc11c NAD+\uc758 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ucd5c\ucd08\ub85c \ubc1c\uacac\ud558\uc5ec NAD+\ub97c \uc0dd\uba85 \ub300\uc0ac\uc640 \ubc00\uc811\ud558\uac8c \uc5f0\uacb0\ud558\uace0 NAD+ \uc5f0\uad6c\ub97c \uc778\uac04 \uc758\ud559\uc73c\ub85c \ubc1c\uc804\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \uc774\ub4ec\ud574, \uadf8\ub294 \uc774 \ubc1c\uacac\uc73c\ub85c \ub178\ubca8 \uc758\ud559\uc0c1\uc744 \uc218\uc0c1\ud588\uc2b5\ub2c8\ub2e4. 1936\ub144, \ub6f0\uc5b4\ub09c \ub3c5\uc77c \uc0dd\ud654\ud559\uc790 \uc624\ud1a0 \ud558\uc778\ub9ac\ud788 \ubc14\ub974\ubd80\ub974\ud06c\ub294 \ubc1c\ud6a8 \ubc18\uc751\uc5d0\uc11c NAD+\uc758 \uae30\ub2a5\uc744 \ub354\uc6b1 \uba85\ud655\ud788 \ubc1d\ud600\ub0b4\uba70, \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \uc870\ud6a8\uc18c\uc778 NAD+\uac00 \uc138\ud3ec \ub300\uc0ac\uc640 \uc0dd\uba85 \uc720\uc9c0\uc5d0 \ud544\uc694\ud55c \uc5ec\ub7ec \ud654\ud559 \uacfc\uc815\uc5d0 \ud544\uc218\uc801\uc778 \uc218\uc18c\ud654\ubb3c \uc804\uc774 \ubc18\uc751\uc5d0 \ud544\uc218\uc801\uc784\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c NAD\uc758 \ubbf8\uc2a4\ud130\ub9ac\ub294 \uc810\ucc28 \ud480\ub838\uc2b5\ub2c8\ub2e4. 1938\ub144, \ucf58\ub77c\ud2b8 \uc5d8\ubca0\uc608\uc5e0\uc740 NAD\uc758 \ucd5c\ucd08\uc758 \ube44\ud0c0\ubbfc \uc804\uad6c\uccb4\uc778 “\ud56d\ud751\uc124\uc778\uc790(anti-black tongue factor)”\ub97c \ubc1c\uacac\ud558\uc5ec NAD \uc5f0\uad6c\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5f4\uc5c8\uc2b5\ub2c8\ub2e4. 1948\ub144, \uc544\uc11c \ucf58\ubc84\uadf8\ub294 \ucd5c\ucd08\uc758 NAD \uc0dd\ud569\uc131 \ud6a8\uc18c\ub97c \ubc1c\uacac\ud558\uace0, \ud6a8\ubaa8 \uc138\ud3ec\uc5d0\uc11c NAD+ \uc0dd\uc131 \ubc18\uc751\uc5d0 \ud544\uc694\ud55c \uc131\ubd84\uc744 \uc815\uc81c\ud588\uc73c\uba70, \ud654\ud559 \ubc18\uc751 \ud480\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc804\uad6c\uccb4 \ubd84\uc790\uc778 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \ubaa8\ub178\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc(NMN)\ub85c\ubd80\ud130 NAD+\ub97c \uc0dd\uc131\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. 1958\ub144, \uc7ad \ud504\ub77c\uc774\uc2a4\uc640 \ud544\ub9bd \ud578\ub4e4\ub7ec\ub294 \ub2c8\uc544\uc2e0\uc774 NAD+\ub85c \uc804\ud658\ub418\ub294 \uc138 \uac00\uc9c0 \uc0dd\ud654\ud559\uc801 \ub2e8\uacc4, \uc989 \ud504\ub77c\uc774\uc2a4-\ud578\ub4e4\ub7ec \uacbd\ub85c\ub97c \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ube44\ud0c0\ubbfc B3\uc778 \ub2c8\uc544\uc2e0\uc774 \uccb4\ub0b4\uc5d0\uc11c NAD+\ub85c \uc804\ud658\ub418\ub294 \uacfc\uc815\uc744 \ubc1d\ud600\ub0b4\uc5b4 NAD+\uc758 \uc2dd\uc774 \ud65c\uc6a9 \uc5f0\uad6c\ub97c \uc0c8\ub85c\uc6b4 \ucc28\uc6d0\uc73c\ub85c \ub04c\uc5b4\uc62c\ub838\uc2b5\ub2c8\ub2e4. 1963\ub144, \uc0f9\ubd09, \ubc14\uc77c, \uadf8\ub9ac\uace0 \ub9cc\ub378\uc740 NAD+\uac00 \uc8fc\uc694 \ud575 \ud6a8\uc18c\ub97c \ud65c\uc131\ud654\ud558\ub294 \ub370 \ud544\uc694\ud55c \uc5d0\ub108\uc9c0\ub97c \uc81c\uacf5\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubcf4\uace0\ud558\uc5ec DNA \ubcf5\uad6c \ud6a8\uc18c\uc778 PARP\uc5d0 \uad00\ud55c \uc77c\ub828\uc758 \ubc1c\uacac\uc758 \ud1a0\ub300\ub97c \ub9c8\ub828\ud588\uc2b5\ub2c8\ub2e4. PARP\ub294 DNA \uc190\uc0c1\uc744 \ubcf5\uad6c\ud558\uace0 \uc138\ud3ec \uc0ac\uba78\uc744 \uc870\uc808\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70, PARP\uc758 \ud65c\uc131 \ubcc0\ud654\ub294 \uc218\uba85 \ubcc0\ud654\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

21\uc138\uae30\uc5d0 \uacfc\ud559\uc790\ub4e4\uc740 NAD \uc5f0\uad6c\uc5d0\uc11c \ub354\uc6b1 \ud68d\uae30\uc801\uc778 \uc9c4\uc804\uc744 \uc774\ub8e8\uc5c8\uc2b5\ub2c8\ub2e4. 2000\ub144, MIT \uc0dd\ubb3c\ud559\uc790 \ub808\ub108\ub4dc \uacfc\ub80c\ud14c\ub294 SIR(\uce68\ubb35 \uc815\ubcf4 \uc870\uc808\uc790 2)\uacfc \uadf8 \uc0dd\uc950 \uc0c1\ub3d9\uccb4\uc778 SIRT1\uc774 \ubaa8\ub450 \ub2e8\ubc31\uc9c8 \ud0c8\uc544\uc138\ud2f8\ud654\ud6a8\uc18c \ud65c\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc2dc\ub974\ud22c\uc778 \ud6a8\uc18c\ub294 NAD\ub97c \uad6c\uc131 \uc694\uc18c\ub85c \ubd84\ud574\ud569\ub2c8\ub2e4. \ub610\ud55c, NAD+ \uc758\uc874\uc131 sir2 \ub2e8\ubc31\uc9c8\uc740 \uc591\uc870 \ud6a8\ubaa8\uc758 \uc218\uba85\uc744 \uc5f0\uc7a5\ud560 \uc218 \uc788\uc73c\uba70, NAD+ \uc758\uc874\uc131 sir2.1 \ub2e8\ubc31\uc9c8\uc740 \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9(Caenorhabditis elegans)\uc758 \uc218\uba85\uc744 \uac70\uc758 50%\uae4c\uc9c0 \uc5f0\uc7a5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. 2004\ub144, \uc138\uacc4\uc801\uc73c\ub85c \uc800\uba85\ud55c \ud654\ud559\uc790 \uc2a4\ud2f0\ube10 L. \ud5ec\ud310\ub4dc\uac00 \uc774\ub044\ub294 \uc5f0\uad6c\ud300\uc740 NAD+ \uc758\uc874\uc131 dsir2 \ub2e8\ubc31\uc9c8\uc774 \ucd08\ud30c\ub9ac\uc758 \uc218\uba85\uc744 \uc57d 10~20%\uae4c\uc9c0 \uc5f0\uc7a5\ud560 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. 2013\ub144, \uc6cc\uc2f1\ud134\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559\uc758 \uc2e0 \uc774\uce58\ub85c \uc774\ub9c8\uc774 \uad50\uc218\uac00 \uc9c4\ud589\ud55c \uc0dd\uc950 \uc5f0\uad6c\uc5d0\uc11c\ub294 NAD+ \uc218\uce58 \uc99d\uac00\uac00 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70, \ub1cc\uc5d0\uc11c NAD+ \uc758\uc874\uc131 SIRT1\uc758 \uacfc\ubc1c\ud604\uc774 \uc218\ucef7\uacfc \uc554\ucef7 \uc0dd\uc950 \ubaa8\ub450\uc758 \uc218\uba85\uc744 \ud06c\uac8c \uc5f0\uc7a5\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uac19\uc740 \ud574, \ud558\ubc84\ub4dc \uc758\ub300 \uc5f0\uad6c\ud300\uc740 22\uac1c\uc6d4 \ub41c \uc0dd\uc950(\uc778\uac04 \ub098\uc774\ub85c 60\uc138\uc5d0 \ud574\ub2f9)\uc5d0\uac8c NMN\uc744 1\uc8fc\uc77c \ub3d9\uc548 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud56d\uc0c1\uc131 \ubc0f \uadfc\uc721 \uac74\uac15\uacfc \uac19\uc740 \uc8fc\uc694 \uc9c0\ud45c\uac00 6\uac1c\uc6d4 \ub41c \uc0dd\uc950(\uc778\uac04 \ub098\uc774\ub85c 20\uc138\uc5d0 \ud574\ub2f9) \uc218\uc900\uc73c\ub85c \ud68c\ubcf5\ub418\uc5c8\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\ucc98\uc74c \uc6b0\uc5f0\ud788 \ubc1c\uacac\ub41c \uac83\ubd80\ud130 \uc5d0\ub108\uc9c0 \ub300\uc0ac, DNA \ubcf5\uad6c, \ub178\ud654, \uadf8\ub9ac\uace0 \uc9c8\ubcd1 \uc870\uc808\uacfc \uad00\ub828\ud558\uc5ec \uc0dd\uba85\uacfc\ud559\uc5d0\uc11c NAD\uc758 \uc911\uc694\uc131\uc740 \uc810\uc810 \ub354 \ucee4\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \uc5f4\uc1e0\ucc98\ub7fc NAD\ub294 \uc0dd\uba85\uc758 \ube44\ubc00\uc744 \ubc1d\ud600\ub0b4 \ub178\ud654\uc640 \uc9c8\ubcd1 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\uacfc \ud76c\ub9dd\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\"\"<\/p>\n

NAD: \uad6c\uc870 \ubc0f \ud2b9\uc131<\/h2>\n

\uace0\uc720 \ubd84\uc790 \uad6c\uc870<\/h3>\n

NAD\uc758 \ubd84\uc790 \uad6c\uc870\ub294 \uc815\uad50\ud558\uac8c \uad6c\uc131\ub41c “\ud654\ud559\uc801 \uad6c\uc870\ubb3c”\uacfc \uc720\uc0ac\ud558\uba70, \uadf8 \uae30\ubcf8 \uad6c\uc131 \uc694\uc18c\ub294 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc, \uc544\ub370\ub2cc, \ub9ac\ubcf4\uc2a4, \uc778\uc0b0\uc785\ub2c8\ub2e4. \ubbf8\uc2dc\uc801\uc73c\ub85c \ubcf4\uba74, \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc\uc640 \uc544\ub370\ub2cc\uc740 \uac01\uac01 \uace0\uc720\ud55c \ud654\ud559 \uadf8\ub8f9\uc73c\ub85c, \uc774 “\uad6c\uc870” \ub0b4\uc5d0\uc11c \ud575\uc2ec\uc801\uc778 \uc704\uce58\ub97c \ucc28\uc9c0\ud569\ub2c8\ub2e4. \ube44\ud0c0\ubbfc B3\uc758 \uc720\ub3c4\uccb4\uc778 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc\ub294 NAD \ubd84\uc790 \ub0b4\uc5d0\uc11c \uc0b0\ud654\ud658\uc6d0 \ubc18\uc751\uc5d0 \uad00\uc5ec\ud558\ub294 \ud575\uc2ec \ud65c\uc131 \ubd80\uc704\uc785\ub2c8\ub2e4. \ud575\uc0b0\uc758 \ud575\uc2ec \uc5fc\uae30\uc778 \uc544\ub370\ub2cc\uc740 \ub9ac\ubcf4\uc2a4\uc640 \uc778\uc0b0\uacfc \ud568\uaed8 \uc544\ub370\ub2cc \ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc\ub97c \ud615\uc131\ud569\ub2c8\ub2e4. \uc774 \ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc\ub294 \uc778\uc0b0\uae30\ub97c \ud1b5\ud574 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc\uc640 \uc815\uad50\ud558\uac8c \uc5f0\uacb0\ub418\uc5b4 NAD\uc758 \uace0\uc720\ud55c \ub2e4\uc774\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc \uad6c\uc870\ub97c \ud615\uc131\ud569\ub2c8\ub2e4. \uc774 \uad6c\uc870\ub294 \ubb34\uc791\uc704\uc801\uc778 \uc870\uac01\ub4e4\uc774 \uc544\ub2c8\ub77c, \uc624\ub79c \uc0dd\ubb3c\ud559\uc801 \uc9c4\ud654 \uacfc\uc815\uc744 \ud1b5\ud574 \ud615\uc131\ub41c \ucd5c\uc801\ud654\ub41c \uc870\ud569\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uad6c\uc131 \uc694\uc18c\ub4e4\uc758 \uc644\ubcbd\ud55c \ud611\ub825\uc740 NAD\uc5d0 \uac15\ub825\ud558\uace0 \uace0\uc720\ud55c \uc0dd\ubb3c\ud559\uc801 \uae30\ub2a5\uc744 \ubd80\uc5ec\ud569\ub2c8\ub2e4.<\/p>\n

\uc0b0\ud654\ud658\uc6d0\uc758 “\uc774\uc911\uc801 \ud2b9\uc131”<\/h3>\n

\uc138\ud3ec\uc758 \ubbf8\uc138\ud55c \uc138\uacc4\uc5d0\uc11c NAD\ub294 \uc0b0\ud654\ub41c \ud615\ud0dc(NAD+)\uc640 \ud658\uc6d0\ub41c \ud615\ud0dc(NADH)\uc758 \ub450 \uac00\uc9c0 \ud65c\uc131 \ud615\ud0dc\ub85c \uc874\uc7ac\ud569\ub2c8\ub2e4. \ub3d9\uc804\uc758 \uc591\uba74\ucc98\ub7fc, \uc774 \ub450 \ud615\ud0dc\ub294 \uc138\ud3ec \uc0b0\ud654\ud658\uc6d0 \ubc18\uc751\uc5d0\uc11c \uc911\uc694\ud558\uace0 \uc0c1\ud638 \ubcf4\uc644\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc138\ud3ec \ub0b4\uc5d0\uc11c \ub300\uc0ac \ubc18\uc751\uc774 \uc77c\uc5b4\ub0a0 \ub54c, NAD+\ub294 “\uc804\uc790 \uc218\uc6a9\uccb4” \uc5ed\ud560\uc744 \ud558\uba70, \ub300\uc0ac \uae30\uc9c8\ub85c\ubd80\ud130 \uc218\uc18c \uc774\uc628(\uc591\uc131\uc790 \ud558\ub098\uc640 \uc804\uc790 \ub450 \uac1c)\uc744 \uc801\uadf9\uc801\uc73c\ub85c \ubc1b\uc544\ub4e4\uc774\uba74\uc11c NADH\ub85c \ud658\uc6d0\ub429\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 NAD+\uac00 \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc5d0\uc11c \uc5d0\ub108\uc9c0 “\uc6d0\ub8cc”\ub97c \uc218\uc9d1\ud558\uc5ec \ub300\uc0ac \uae30\uc9c8\uc758 \ud654\ud559 \uc5d0\ub108\uc9c0\ub97c \uc218\uc18c \uc774\uc628\uc73c\ub85c \uc800\uc7a5\ud558\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc774\ud6c4, \uc138\ud3ec \ud638\ud761 \uacfc\uc815\uc5d0\uc11c NADH\ub294 “\uc804\uc790 \uacf5\uc5ec\uccb4”\ub85c \uc804\ud658\ub429\ub2c8\ub2e4. NADH\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub85c \ub4e4\uc5b4\uac00 \uc804\uc790 \uc804\ub2ec\uacc4\uc5d0 \ucc38\uc5ec\ud558\uc5ec, \uc800\uc7a5\ub41c \uc218\uc18c \uc774\uc628\uc5d0\uc11c \uc77c\ub828\uc758 \uc804\uc790 \uc804\ub2ec\uccb4\ub85c \uc804\uc790\ub97c \uc810\ucc28\uc801\uc73c\ub85c \ubc29\ucd9c\ud558\uba74\uc11c \uc0b0\ud654\ub418\uc5b4 \ub2e4\uc2dc NAD+\ub85c \uc804\ud658\ub429\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 \ub9c8\uce58 NADH\uac00 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc5d0\uc11c \uc218\uc9d1\ub41c \uc5d0\ub108\uc9c0 “\uc6d0\ub8cc”\ub97c \ucc98\ub9ac\ud558\uc5ec \uad81\uadf9\uc801\uc73c\ub85c \uc138\ud3ec\uac00 \uc9c1\uc811 \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 \uc5d0\ub108\uc9c0 \ud615\ud0dc\uc778 ATP\ub85c \uc804\ud658\ud558\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. NAD+\uc640 NADH \uc0ac\uc774\uc758 \uc774\ub7ec\ud55c \uc21c\ud658\uc740 \ub05d\uc5c6\ub294 “\uc5d0\ub108\uc9c0 \ub9b4\ub808\uc774 \uacbd\uc8fc”\uc640 \uac19\uc544 \ub2e4\uc591\ud55c \uc138\ud3ec \ud65c\ub3d9\uc5d0 \uc5d0\ub108\uc9c0\ub97c \uc9c0\uc18d\uc801\uc73c\ub85c \uacf5\uae09\ud558\uba70, \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ud575\uc2ec \uba54\ucee4\ub2c8\uc998\uc785\ub2c8\ub2e4.<\/p>\n

NAD: \uae30\ub2a5 \ubc0f \uba54\ucee4\ub2c8\uc998\"\"<\/h2>\n

\uc5d0\ub108\uc9c0 \ub300\uc0ac\uc758 “\ubd80\uc2a4\ud130”<\/h3>\n

\uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac “\uacf5\uc7a5”\uc5d0\uc11c NAD\ub294 \ub2e4\uc7ac\ub2e4\ub2a5\ud558\uace0 \uc911\uc694\ud55c “\uc77c\uafbc”\uc785\ub2c8\ub2e4. \ud574\ub2f9\uacfc\uc815, \ud2b8\ub9ac\uce74\ub974\ubcf5\uc2e4\uc0b0 \ud68c\ub85c, \uc0b0\ud654\uc801 \uc778\uc0b0\ud654\uc640 \uac19\uc740 \ud575\uc2ec \ub300\uc0ac \uacbd\ub85c\uc5d0 \uae4a\uc774 \uad00\uc5ec\ud558\uba70, \uc601\uc591\uc18c\ub97c \uc138\ud3ec\uac00 \uc0ac\uc6a9 \uac00\ub2a5\ud55c \uc5d0\ub108\uc9c0\uc778 ATP\ub85c \uc804\ud658\ud558\ub294 \ub370 \uc911\uc694\ud55c “\ubd80\uc2a4\ud130” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\uc138\ud3ec\uc9c8\uc5d0\uc11c \uc77c\uc5b4\ub098\ub294 \ud574\ub2f9\uacfc\uc815\uc740 \ud3ec\ub3c4\ub2f9 \ubd84\ud574 \ub300\uc0ac\uc758 \ucd08\uae30 \ub2e8\uacc4\ub85c, \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc758 “\uc804\uc870” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uae00\ub9ac\uc138\ub974\uc54c\ub370\ud788\ub4dc-3-\uc778\uc0b0 \ud0c8\uc218\uc18c\ud6a8\uc18c\ub294 “\uc804\ub3c4\uccb4” \uc5ed\ud560\uc744 \ud558\uc5ec \uae00\ub9ac\uc138\ub974\uc54c\ub370\ud788\ub4dc-3-\uc778\uc0b0\uc744 1,3-\ube44\uc2a4\ud3ec\uc2a4\ud3ec\uae00\ub9ac\uc138\ub974\uc0b0\uc73c\ub85c \uc804\ud658\ud558\ub294 \ucd09\ub9e4 \uc791\uc6a9\uc744 \ud558\uba70, NAD+\ub294 “\uc804\uc790 \uc218\uc9d1\uae30” \uc5ed\ud560\uc744 \ud558\uc5ec \ubc18\uc751 \uc911 \uc0dd\uc131\ub41c \uc218\uc18c \uc774\uc628\uc744 \ubc1b\uc544\ub4e4\uc5ec NADH\ub85c \ud658\uc6d0\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 \ud6c4\uc18d \ud574\ub2f9\uacfc\uc815 \ubc18\uc751\uc5d0 \ud544\uc694\ud55c \uc870\uac74\uc744 \uc81c\uacf5\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uace0\uc5d0\ub108\uc9c0 \uc804\uc790\ub97c \uc6b4\ubc18\ud558\ub294 NADH\ub97c \uc0dd\uc131\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc804\uc790\ub294 “\uc5d0\ub108\uc9c0 \uc6d0\ub8cc” \uc5ed\ud560\uc744 \ud558\uc5ec \uc774\ud6c4 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc758 \ud1a0\ub300\ub97c \ub9c8\ub828\ud569\ub2c8\ub2e4. \ud574\ub2f9\uacfc\uc815\uc5d0\uc11c \uc0dd\uc131\ub41c \ud53c\ub8e8\ube0c\uc0b0\uc774 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\uc9c8\ub85c \ub4e4\uc5b4\uac00\uba74 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc758 \ud575\uc2ec \uacfc\uc815\uc778 \ud06c\ub819\uc2a4 \ud68c\ub85c\uac00 \uc2dc\uc791\ub429\ub2c8\ub2e4. \ud06c\ub819\uc2a4 \ud68c\ub85c \ub0b4\uc5d0\uc11c \uc774\uc18c\uc2dc\ud2b8\ub974\uc0b0 \ud0c8\uc218\uc18c\ud6a8\uc18c\uc640 \u03b1-\ucf00\ud1a0\uae00\ub8e8\ud0c0\ub974\uc0b0 \ud0c8\uc218\uc18c\ud6a8\uc18c\uc640 \uac19\uc740 \ud6a8\uc18c\ub4e4\uc740 \uc219\ub828\ub41c \uc7a5\uc778\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec NAD+\uac00 \uc9c0\uc18d\uc801\uc73c\ub85c \uc218\uc18c \uc774\uc628\uc744 \ubc1b\uc544 NADH\ub85c \ubc18\ubcf5\uc801\uc73c\ub85c \ud658\uc6d0\ub418\ub294 \uc77c\ub828\uc758 \ubc18\uc751\uc744 \ucd09\ub9e4\ud569\ub2c8\ub2e4. \ud06c\ub819\uc2a4 \ud68c\ub85c\uc758 \uac01 \uc8fc\uae30\uc5d0\uc11c NAD+\ub294 \uc5ec\ub7ec \ubc18\uc751\uc5d0 \ucc38\uc5ec\ud558\uc5ec \ub2e4\ub7c9\uc758 “\uc5d0\ub108\uc9c0 \uc6d0\ub8cc”\ub97c \uc218\uc9d1\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc774\uc0b0\ud654\ud0c4\uc18c\uc640 \uc5ec\ub7ec \uace0\uc5d0\ub108\uc9c0 \uc911\uac04\uccb4\ub97c \uc0dd\uc131\ud558\uc5ec \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc704\ud55c \ud48d\ubd80\ud55c \ubb3c\uc9c8\uc801 \ud1a0\ub300\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

NADH\uac00 \uc6b4\ubc18\ud55c \uace0\uc5d0\ub108\uc9c0 \uc804\uc790\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub0b4\ub9c9\uc758 \uc804\uc790 \uc804\ub2ec\uacc4\ub85c \ub4e4\uc5b4\uac11\ub2c8\ub2e4. \uc774\ub294 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc758 \uc815\uc810\uc778 \uc0b0\ud654\uc801 \uc778\uc0b0\ud654 \uacfc\uc815\uc785\ub2c8\ub2e4. NADH\ub294 “\uc5d0\ub108\uc9c0 \uc804\ub2ec\uc790” \uc5ed\ud560\uc744 \ud558\uc5ec \uc804\uc790 \uc804\ub2ec \uc0ac\uc2ac\uc744 \ub530\ub77c \uc77c\ub828\uc758 \uc804\uc790 \uc218\uc1a1\uccb4\ub85c \uc804\uc790\ub97c \uc804\ub2ec\ud558\uace0, \uad81\uadf9\uc801\uc73c\ub85c \uc0b0\uc18c\ub85c \uc804\uc790\ub97c \uc804\ub2ec\ud558\uc5ec \ubb3c\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uc804\uc790 \uc804\ub2ec\ub85c \ubc29\ucd9c\ub41c \uc5d0\ub108\uc9c0\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\uc9c8\uc5d0\uc11c \ub9c9\uac04 \uacf5\uac04\uc73c\ub85c \uc591\uc131\uc790\ub97c \ud38c\ud551\ud558\ub294 \ub370 \uc0ac\uc6a9\ub418\uc5b4 \uc591\uc131\uc790 \uae30\uc6b8\uae30\ub97c \ud615\uc131\ud569\ub2c8\ub2e4. \uc774 \uc591\uc131\uc790 \uae30\uc6b8\uae30\ub294 “\uc5d0\ub108\uc9c0 \uc800\uc7a5\uc18c” \uc5ed\ud560\uc744 \ud558\uc5ec \ub9c9\ub300\ud55c \uc591\uc758 \uc5d0\ub108\uc9c0\ub97c \uc800\uc7a5\ud569\ub2c8\ub2e4. \uc591\uc131\uc790\uac00 ATP \ud569\uc131\ud6a8\uc18c\ub97c \ud1b5\ud574 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\uc9c8\ub85c \ub2e4\uc2dc \uc720\uc785\ub418\uba74, \uc591\uc131\uc790\uc758 \uc704\uce58 \uc5d0\ub108\uc9c0\ub294 ATP \ud569\uc131\ud6a8\uc18c\ub97c \uad6c\ub3d9\ud558\uc5ec ATP\ub97c \ud569\uc131\ud558\uace0, \uc591\uc131\uc790 \uae30\uc6b8\uae30\uc5d0 \uc800\uc7a5\ub41c \uc5d0\ub108\uc9c0\ub97c \uc138\ud3ec\uac00 \uc9c1\uc811 \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 ATP\ub85c \uc804\ud658\ud569\ub2c8\ub2e4. \uc774\ub807\uac8c \uc601\uc591\uc18c\uc758 \ud654\ud559 \uc5d0\ub108\uc9c0\uac00 ATP\uc758 \ud65c\uc131 \ud654\ud559 \uc5d0\ub108\uc9c0\ub85c \ucd5c\uc885 \uc804\ud658\ub429\ub2c8\ub2e4.<\/p>\n

DNA \ubcf5\uad6c\uc758 “\uc218\ud638\uc790”<\/h3>\n

\uc138\ud3ec\ub294 \uc790\uc678\uc120, \ud654\ud559\uc801 \uacf5\uaca9, \uc138\ud3ec \uc790\uccb4\uc758 \ub300\uc0ac \uacfc\uc815\uc5d0\uc11c \uc0dd\uc131\ub418\ub294 \ud65c\uc131 \uc0b0\uc18c\uc640 \uac19\uc740 \ub2e4\uc591\ud55c \ub0b4\uc678\ubd80 \uc694\uc778\uc758 \ub04a\uc784\uc5c6\ub294 \ub3c4\uc804\uc5d0 \uc9c1\uba74\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\ub4e4\uc740 DNA \ubd84\uc790\ub97c \uc190\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. NAD\ub294 \uc774 \uacfc\uc815\uc5d0\uc11c \ucda9\uc2e4\ud55c “\uc218\ud638\uc790” \uc5ed\ud560\uc744 \ud558\uba70, \uc138\ud3ec \ub0b4 DNA \ubcf5\uad6c \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ud544\uc218\uc801\uc785\ub2c8\ub2e4.<\/p>\n

\ud3f4\ub9ac(ADP-\ub9ac\ubcf4\uc2a4) \uc911\ud569\ud6a8\uc18c(PARP) \uacc4\uc5f4\uc740 DNA \ubcf5\uad6c \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c “\ubcf5\uad6c \ud300”\uc774\uba70, NAD\ub294 \uc774 \ud300\uc758 \ud65c\ub3d9\uc5d0 \ud544\uc218\uc801\uc778 “\uacf5\uae09\uc6d0”\uc785\ub2c8\ub2e4. \uc138\ud3ec\uc758 DNA\uac00 \uc190\uc0c1\ub418\uba74 NAD\ub294 “\uae34\uae09 \ubcf5\uad6c \uc2e0\ud638” \uc5ed\ud560\uc744 \ud558\uba70, PARP\uac00 \ud65c\uc131\ud654\ub429\ub2c8\ub2e4.<\/p>\n

NAD: \uc5f0\uad6c \ubc0f \uc751\uc6a9\"\"<\/h2>\n

\ud504\ub860\ud2f0\uc5b4 \uc5f0\uad6c \uacb0\uacfc<\/h3>\n

\ucd5c\uadfc \ub178\ud654 \ubc0f \uc9c8\ubcd1 \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c NAD \uc5f0\uad6c\ub294 \uc77c\ub828\uc758 \ub180\ub77c\uc6b4 \uc131\uacfc\ub97c \uac70\ub450\uba70 \uc778\uac04 \uac74\uac15\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uacfc \uac00\ub2a5\uc131\uc744 \uac00\uc838\uc654\uc2b5\ub2c8\ub2e4.
\n\ub178\ud654 \uc5f0\uad6c\uc5d0\uc11c \uc218\ub9ce\uc740 \uc5f0\uad6c\ub97c \ud1b5\ud574 NAD+ \uc218\uce58\uac00 \ub178\ud654 \uacfc\uc815\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc74c\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \ub178\ud654\uac00 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \uc778\uccb4\uc758 NAD+ \uc218\uce58\ub294 \uc810\ucc28 \uac10\uc18c\ud558\ub294\ub370, \uc774\ub294 \uc138\ud3ec \ub178\ud654\uc640 \uc2e0\uccb4 \uae30\ub2a5 \uc800\ud558\uc758 \uc8fc\uc694 \uc6d0\uc778\uc73c\ub85c \uc5ec\uaca8\uc9d1\ub2c8\ub2e4. \ubbf8\uad6d \uc6cc\uc2f1\ud134 \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559\uc758 \uacfc\ud559\uc790\ub4e4\uc740 NAD+ \uc804\uad6c\uccb4\uc778 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \ubaa8\ub178\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc(NMN)\ub97c \ubcf4\ucda9\ud558\uba74 \ub178\ud654\ub41c \uc0dd\uc950\uc758 NAD+ \uc218\uce58\uac00 \ud06c\uac8c \uc99d\uac00\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc774 \ud68c\ubcf5\ub418\uace0 \uadfc\ub825\uacfc \uc9c0\uad6c\ub825\uc774 \ud5a5\uc0c1\ub418\uba70, \uc77c\ubd80 \uc0dd\ub9ac\ud559\uc801 \uc9c0\ud45c\ub3c4 \uc80a\uc740 \uc0dd\uc950 \uc218\uc900\uc73c\ub85c \ud68c\ubcf5\ub420 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. Cell \uc800\ub110\uc5d0 \ubc1c\ud45c\ub41c \uc774 \uc5f0\uad6c\ub294 \uacfc\ud559\uacc4\uc758 \uad11\ubc94\uc704\ud55c \uad00\uc2ec\uc744 \ubd88\ub7ec\uc77c\uc73c\ucf30\uc73c\uba70 \ub178\ud654 \uc9c0\uc5f0 \uc5f0\uad6c\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5f4\uc5c8\uc2b5\ub2c8\ub2e4.
\nNAD\ub294 \uc9c8\ubcd1 \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c\ub3c4 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. 2020\ub144, \ub178\uc2a4\uc6e8\uc2a4\ud134 \ub300\ud559\uad50\uc758 Navdeep S. Chandel \uc5f0\uad6c\ud300\uc740 \ub1cc \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ubcf5\ud569\uccb4 I \uae30\ub2a5 \uc7a5\uc560 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \uc774\uc6a9\ud558\uc5ec NAD+ \uc7ac\uc0dd\uc774 \uc218\uba85\uc744 \uc5f0\uc7a5\ud560 \uc218 \uc788\uc9c0\ub9cc \uc6b4\ub3d9\uc2e4\uc870\ub294 \uc720\ubc1c\ud558\uc9c0 \uc54a\ub294\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. Cell Metabolism\uc5d0 \uac8c\uc7ac\ub41c \uc774 \uc5f0\uad6c\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ubcf5\ud569\uccb4 I \uae30\ub2a5 \uc7a5\uc560\uc640 \uad00\ub828\ub41c \ub1cc \uc9c8\ud658 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub610\ud55c, \uc0c1\ud558\uc774 \ud14c\ud06c \ub300\ud559\uad50\uc758 Fan \uc5f0\uad6c\ud300\uc740 \uc758\ud559 \uc6f9\uc0ac\uc774\ud2b8 BioRxiv\uc5d0 \ucd5c\uadfc \uc5f0\uad6c\ub97c \uac8c\uc7ac\ud558\uc5ec NAD+ \ubcf4\ucda9\uc774 \uc554\uc5d0 \ub300\ud55c \uba74\uc5ed \uc694\ubc95\uc758 \uce58\ub8cc \ud6a8\uacfc\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. CRISPR \uc2a4\ud06c\ub9ac\ub2dd\uacfc \uac19\uc740 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5f0\uad6c\uc9c4\uc740 NAD+ \uc218\uce58\uac00 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc744 \uc870\uc808\ud568\uc73c\ub85c\uc368 T \uc138\ud3ec\uc758 \ud65c\uc131\ud654\uc640 \uc885\uc591 \uc0ac\uba78 \ub2a5\ub825\uc744 \uc9c1\uc811\uc801\uc73c\ub85c \uc870\uc808\ud560 \uc218 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc740 \uc554 \uba74\uc5ed \uc694\ubc95\uc5d0 \uc801\uc6a9\ub418\uc5b4 \ub9c8\uc6b0\uc2a4\ub97c \ub300\uc0c1\uc73c\ub85c \uc2dc\ud5d8\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \uba74\uc5ed \uc694\ubc95\uacfc NAD+ \ubcf4\ucda9\uc744 \ubcd1\ud589\ud55c \uacb0\uacfc \ubaa8\ub4e0 \uc2e4\ud5d8 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc885\uc591\uc774 \uc131\uacf5\uc801\uc73c\ub85c \uc81c\uac70\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub294 NAD+ \ubcf4\ucda9\uacfc \uba74\uc5ed \uc694\ubc95\uc744 \ubcd1\ud589\ud558\ub294 \uac83\uc774 \uae30\uc874 \uc554 \uce58\ub8cc \uc804\ub7b5\uc5d0 \uc788\uc5b4 \uc911\uc694\ud55c \ub3cc\ud30c\uad6c\uac00 \ub420 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\uc758\ub8cc \ubd84\uc57c \uc751\uc6a9<\/h3>\n

NAD\ub294 \uc758\ub8cc \ubd84\uc57c\uc5d0\uc11c \ud3ed\ub113\uc740 \ud65c\uc6a9 \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \uc778\uac04\uc758 \uac74\uac15\uc744 \uc99d\uc9c4\ud558\ub294 \uac15\ub825\ud55c \ub3c4\uad6c\uac00 \ub420 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4. \ub178\ud654\uc5d0 \ub530\ub77c \uc2e0\uccb4\uc758 \ub300\uc0ac \uae30\ub2a5\uc740 \uc810\ucc28 \uc800\ud558\ub418\uc5b4 \ube44\ub9cc, \ub2f9\ub1e8\ubcd1, \uc2ec\ud608\uad00 \uc9c8\ud658\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \ub300\uc0ac \uc9c8\ud658\uc5d0 \ub354 \ucde8\uc57d\ud574\uc9d1\ub2c8\ub2e4. \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc758 \ud575\uc2ec \ubcf4\uc870 \ud6a8\uc18c\uc778 NAD\ub294 \ub300\uc0ac \ud56d\uc0c1\uc131 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 NAD+ \ubcf4\ucda9\uc740 \ub300\uc0ac \uae30\ub2a5\uc744 \uac1c\uc120\ud558\uace0, \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \ub192\uc774\uba70, \ud608\ub2f9 \uc218\uce58\ub97c \ub0ae\ucd94\uace0, \uc9c0\ubc29 \ucd95\uc801\uc744 \uac10\uc18c\uc2dc\ucf1c \ub300\uc0ac \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \ube44\ub9cc \ub9c8\uc6b0\uc2a4\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 NAD+ \uc804\uad6c\uccb4\uc778 NMN \ubcf4\ucda9\uc774 \uccb4\uc911\uacfc \uccb4\uc9c0\ubc29\ub960\uc744 \ud06c\uac8c \uac10\uc18c\uc2dc\ud0a4\uace0, \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \uac1c\uc120\ud558\uba70, \ub2f9 \ub0b4\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.
\nNAD\ub294 \ub610\ud55c \uc2e0\uccb4 \uae30\ub2a5 \ud5a5\uc0c1\uc5d0\ub3c4 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. NAD\ub294 \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc5d0 \uad00\uc5ec\ud558\uc5ec \uc138\ud3ec\uc5d0 \uc5d0\ub108\uc9c0\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc801\uc808\ud55c NAD+ \uc218\uce58\ub294 \uc138\ud3ec \uc5d0\ub108\uc9c0 \uacf5\uae09\uc744 \ubcf4\uc7a5\ud558\uace0 \uc138\ud3ec \uc7ac\uc0dd\uc744 \ucd09\uc9c4\ud558\uc5ec \uc9c0\uad6c\ub825, \ud53c\ub85c \uc800\ud56d\uc131, \uba74\uc5ed\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc6b4\ub3d9\uc120\uc218\ub098 \uace0\uac15\ub3c4 \uc6b4\ub3d9\uc744 \uaddc\uce59\uc801\uc73c\ub85c \ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c NAD+ \ubcf4\ucda9\uc81c\ub294 \uc6b4\ub3d9 \ub2a5\ub825 \ud5a5\uc0c1\uacfc \ud68c\ubcf5 \ucd09\uc9c4\uc5d0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubd80 \uc608\ube44 \uc778\uccb4 \uc2e4\ud5d8\uc5d0\uc11c NAD+ \ubcf4\ucda9\uc81c\ub294 \ub178\uc778\uc758 \uc6b4\ub3d9 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc2e0\uccb4 \ud65c\ub825\uc744 \uc99d\uc9c4\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

NAD\ub294 \ub610\ud55c \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uac1c\uc120\uc5d0 \uc0c1\ub2f9\ud55c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc55e\uc11c \uc5b8\uae09\ud588\ub4ef\uc774, NAD+ \uc218\uce58 \uac10\uc18c\ub294 \ub178\ud654\uc640 \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc73c\uba70, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1\uacfc \uac19\uc740 \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc2ec\ud608\uad00 \uc9c8\ud658 \ubc0f \uc554\uacfc \uac19\uc740 \ub9ce\uc740 \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc774 NAD+ \uc218\uce58 \uac10\uc18c\uc640 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. NAD+ \ubcf4\ucda9\uc81c\ub294 \uc774\ub7ec\ud55c \uc9c8\ud658\uc758 \ubc1c\ubcd1 \ubc0f \uc9c4\ud589\uc744 \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubd80 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 NAD+ \ubcf4\ucda9\uc81c\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \uc778\uc9c0 \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc99d\uc0c1\uc744 \uc644\ud654\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc2ec\ud608\uad00\uacc4\ub97c \ubcf4\ud638\ud558\uace0 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud654\uc7a5\ud488\uc758 \uc7a0\uc7ac\ub825<\/h3>\n

\ud654\uc7a5\ud488 \ubd84\uc57c\uc5d0\uc11c \ud56d\uc0b0\ud654 \ubc0f \ud56d\ub178\ud654 \ud6a8\uacfc\ub85c \uc778\ud574 NAD\ub294 \uc5f0\uad6c \ubc0f \uc751\uc6a9 \ubd84\uc57c\uc5d0\uc11c \ub728\uac70\uc6b4 \uad00\uc2ec\uc744 \ubc1b\uace0 \uc788\uc73c\uba70, \ud53c\ubd80 \uac74\uac15\uacfc \ubbf8\uc6a9\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uc194\ub8e8\uc158\uc744 \uc81c\uc2dc\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub178\ud654\uac00 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \ud53c\ubd80\uc758 NAD+ \uc218\uce58\uac00 \uc810\ucc28 \uac10\uc18c\ud558\uc5ec \ud53c\ubd80 \uc138\ud3ec\uc758 \uc2e0\uc9c4\ub300\uc0ac \ubc0f \ud68c\ubcf5 \uae30\ub2a5\uc774 \uc57d\ud654\ub429\ub2c8\ub2e4. \uc774\ub294 \ud53c\ubd80\uc758 \uc790\uac00 \ud68c\ubcf5 \ub2a5\ub825\uc744 \uc57d\ud654\uc2dc\ucf1c \uc8fc\ub984, \ucc98\uc9d0, \uac74\uc870\ud568, \uac70\uce60\uc5b4\uc9d0 \ub4f1 \ub2e4\uc591\ud55c \ub178\ud654 \uc99d\uc0c1\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc911\uc694\ud55c \uc870\ud6a8\uc18c\uc778 NAD+\ub294 \uc138\ud3ec \uae30\ub2a5 \uc870\uc808, DNA \ubcf5\uad6c, \uadf8\ub9ac\uace0 \ud56d\ub178\ud654\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud53c\ubd80\uc758 NAD+ \uc218\uce58 \uc99d\uac00 \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ud65c\uc131\ud654\ud558\uace0, \uc138\ud3ec \ud65c\ub825\uacfc \uc7ac\uc0dd \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \ud53c\ubd80 \uc9c8\uac10\uacfc \uc678\uad00\uc744 \uac1c\uc120\ud558\uace0 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc5d0 NAD+\ub97c \uc9c1\uc811 \uc801\uc6a9\ud558\ub294 \ub370\ub294 \uc218\ub9ce\uc740 \uc5b4\ub824\uc6c0\uc774 \uc788\uc2b5\ub2c8\ub2e4. NAD+ \ubd84\uc790\ub294 \ube44\uad50\uc801 \ud06c\uae30\uac00 \ucee4\uc11c \ud53c\ubd80 \ud45c\uba74\uc778 \uac01\uc9c8\uce35\uae4c\uc9c0 \uce68\ud22c\ud558\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \uacf5\uae30, \ube5b, \uae30\ud0c0 \ud658\uacbd \uc694\uc778\uc5d0 \ub178\ucd9c\ub418\uba74 \uc27d\uac8c \uc0b0\ud654\ub418\uc5b4 \ud65c\uc131\uc744 \uc783\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc81c\ud488 \uc548\uc815\uc131\uacfc \uc81c\ud615 \uc124\uacc4\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud55c \uacfc\uc81c\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \uacfc\ud559\uc790\ub4e4\uc740 NAD+ \uc804\uad6c\uccb4\uc5d0 \uc8fc\ubaa9\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc54c\ub824\uc9c4 NAD+ \uc804\uad6c\uccb4 \ubd84\uc790\ub294 \ud2b8\ub9bd\ud1a0\ud310(Trp), \ub2c8\uc544\uc2e0(NA), \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc(NAM), \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc \ub9ac\ubcf4\uc0ac\uc774\ub4dc(NR), \ub514\ud558\uc774\ub4dc\ub85c\ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc \ub9ac\ubcf4\uc0ac\uc774\ub4dc(NRH)\uc758 \ub2e4\uc12f \uac00\uc9c0\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc804\uad6c\uccb4\ub294 \ud53c\ubd80 \ub0b4 \ud6a8\uc18c \ubc18\uc751\uc744 \ud1b5\ud574 NAD+\ub85c \uc804\ud658\ub418\uc5b4 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \ud6a8\uacfc\ub97c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, NAM\uacfc NR\uc5d0\uc11c \ud569\uc131\ub41c \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \ubaa8\ub178\ub274\ud074\ub808\uc624\ud2f0\ub4dc(NMN)\ub294 \uc77c\ubc18\uc801\uc778 NAD+ \uc804\uad6c\uccb4\uc785\ub2c8\ub2e4. \uc77c\ubd80 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc740 \ud53c\ubd80\uc758 NAD+ \uc218\uce58\ub97c \ub192\uc774\uae30 \uc704\ud574 NMN\uc744 \ucca8\uac00\ud558\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub9ce\uc740 \ubdf0\ud2f0 \ud68c\uc0ac\ub4e4\ub3c4 NAD+ \uad00\ub828 \uc81c\ud488\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. 2024\ub144 \ucd08, \ub85c\ub808\uc54c\uc740 2023\ub144 \ub9d0\uc5d0 \uac1c\ubc1c\ub41c \ud601\uc2e0\uc801\uc778 \ube14\ub799\ubc14\uc774\uc624\uc2dc\uc2a4 \uc131\ubd84\uc744 \ud1b5\ud569\ud558\uc5ec \ub791\ucf64 \ube14\ub799 \uace8\ub4dc \ub77c\uc778\uc744 \ub300\ud3ed \uc5c5\ub370\uc774\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \ub791\ucf64 \uacf5\uc2dd \uc6f9\uc0ac\uc774\ud2b8\uc5d0 \ub530\ub974\uba74, \uc774 \uc131\ubd84\uc740 \uccb4\ub0b4\uc5d0\uc11c NAD+\ub97c \uadfc\uc6d0\uc801\uc73c\ub85c \ud65c\uc131\ud654\ud558\uc5ec \ud53c\ubd80 \uc138\ud3ec \uc7ac\uc0dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc6f9\uc0ac\uc774\ud2b8\uc5d0 \ub530\ub974\uba74, 0.5%\ub97c \ucca8\uac00\ud558\uba74 \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\ub97c 27%\uae4c\uc9c0 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud55c\uad6d\uc758 \ubdf0\ud2f0 \ub300\uae30\uc5c5 LG\uc0dd\ud65c\uac74\uac15 \ub610\ud55c \uc911\uc694\ud55c \ub3cc\ud30c\uad6c\ub97c \ub9c8\ub828\ud588\uc2b5\ub2c8\ub2e4. \uc21c\uc218 \ub9ac\ud3ec\uc880 \uae30\uc220\uc744 \ud1b5\ud574 \uae30\uc874 NAD+\uc758 \uc548\uc815\uc131\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ucf1c \ud53c\ubd80 \ud761\uc218\ub97c \uc6a9\uc774\ud558\uac8c \ud569\ub2c8\ub2e4. \ub85c\ub808\uc54c\uc740 \ud53c\ubd80 \ud56d\uc0b0\ud654 \ud6a8\ub2a5\uc744 136%, \ud53c\ubd80 \uc7ac\uc0dd \ud6a8\uacfc\ub97c 69%\uae4c\uc9c0 \ub192\uc77c \uc218 \uc788\ub294 “NAD \ub9ac\ub274\uc5bc 24″\ub97c \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4. NAD+\uc758 \uc791\uc6a9 \uae30\uc804\uc5d0 \ub300\ud55c \uc2ec\uce35\uc801\uc778 \uc5f0\uad6c\uac00 \uacc4\uc18d\ub418\uace0 \uae30\uc220 \ud601\uc2e0\uc774 \uc774\ub8e8\uc5b4\uc9d0\uc5d0 \ub530\ub77c, NAD+\ub294 \ud654\uc7a5\ud488 \ubd84\uc57c\uc5d0\uc11c \ub354\uc6b1 \ud68d\uae30\uc801\uc778 \ubc1c\uc804\uc744 \uc774\ub8e8\uc5b4 \uc18c\ube44\uc790\uc5d0\uac8c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \ud53c\ubd80 \uad00\ub9ac \uacbd\ud5d8\uc744 \uc81c\uacf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4.<\/p>\n

\"\"<\/p>\n

\uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ud65c\uc131\ud654\ud558\uace0, \uc138\ud3ec \ud65c\ub825\uacfc \uc7ac\uc0dd \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \ud53c\ubd80 \uc9c8\uac10\uacfc \uc678\uad00\uc744 \uac1c\uc120\ud558\uace0 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud604\uc7ac \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc5d0 NAD+\ub97c \uc9c1\uc811 \uc801\uc6a9\ud558\ub294 \ub370\ub294 \uc218\ub9ce\uc740 \uc5b4\ub824\uc6c0\uc774 \uc788\uc2b5\ub2c8\ub2e4. NAD+ \ubd84\uc790\ub294 \ube44\uad50\uc801 \ud06c\uae30\uac00 \ucee4\uc11c \ud53c\ubd80 \ud45c\uba74\uc778 \uac01\uc9c8\uce35\uae4c\uc9c0 \uce68\ud22c\ud558\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \uacf5\uae30, \ube5b, \uae30\ud0c0 \ud658\uacbd \uc694\uc778\uc5d0 \ub178\ucd9c\ub418\uba74 \uc27d\uac8c \uc0b0\ud654\ub418\uc5b4 \ud65c\uc131\uc744 \uc783\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc81c\ud488 \uc548\uc815\uc131\uacfc \uc81c\ud615 \uc124\uacc4\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud55c \uacfc\uc81c\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \uacfc\ud559\uc790\ub4e4\uc740 NAD+ \uc804\uad6c\uccb4\uc5d0 \uc8fc\ubaa9\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc54c\ub824\uc9c4 NAD+ \uc804\uad6c\uccb4 \ubd84\uc790\ub294 \ud2b8\ub9bd\ud1a0\ud310(Trp), \ub2c8\uc544\uc2e0(NA), \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc(NAM), \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc \ub9ac\ubcf4\uc0ac\uc774\ub4dc(NR), \ub514\ud558\uc774\ub4dc\ub85c\ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc \ub9ac\ubcf4\uc0ac\uc774\ub4dc(NRH)\uc758 \ub2e4\uc12f \uac00\uc9c0\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc804\uad6c\uccb4\ub294 \ud53c\ubd80 \ub0b4 \ud6a8\uc18c \ubc18\uc751\uc744 \ud1b5\ud574 NAD+\ub85c \uc804\ud658\ub418\uc5b4 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \ud6a8\uacfc\ub97c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, NAM\uacfc NR\uc5d0\uc11c \ud569\uc131\ub41c \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \ubaa8\ub178\ub274\ud074\ub808\uc624\ud2f0\ub4dc(NMN)\ub294 \uc77c\ubc18\uc801\uc778 NAD+ \uc804\uad6c\uccb4\uc785\ub2c8\ub2e4. \uc77c\ubd80 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc740 \ud53c\ubd80\uc758 NAD+ \uc218\uce58\ub97c \ub192\uc774\uae30 \uc704\ud574 NMN\uc744 \ucca8\uac00\ud558\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub9ce\uc740 \ubdf0\ud2f0 \ud68c\uc0ac\ub4e4\ub3c4 NAD+ \uad00\ub828 \uc81c\ud488\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. 2024\ub144 \ucd08, \ub85c\ub808\uc54c\uc740 2023\ub144 \ub9d0\uc5d0 \uac1c\ubc1c\ub41c \ud601\uc2e0\uc801\uc778 \ube14\ub799\ubc14\uc774\uc624\uc2dc\uc2a4 \uc131\ubd84\uc744 \ud1b5\ud569\ud558\uc5ec \ub791\ucf64 \ube14\ub799 \uace8\ub4dc \ub77c\uc778\uc744 \ub300\ud3ed \uc5c5\ub370\uc774\ud2b8\ud588\uc2b5\ub2c8\ub2e4. \ub791\ucf64 \uacf5\uc2dd \uc6f9\uc0ac\uc774\ud2b8\uc5d0 \ub530\ub974\uba74, \uc774 \uc131\ubd84\uc740 \uccb4\ub0b4\uc5d0\uc11c NAD+\ub97c \uadfc\uc6d0\uc801\uc73c\ub85c \ud65c\uc131\ud654\ud558\uc5ec \ud53c\ubd80 \uc138\ud3ec \uc7ac\uc0dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc6f9\uc0ac\uc774\ud2b8\uc5d0 \ub530\ub974\uba74, 0.5%\ub97c \ucca8\uac00\ud558\uba74 \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\ub97c 27%\uae4c\uc9c0 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud55c\uad6d\uc758 \ubdf0\ud2f0 \ub300\uae30\uc5c5 LG\uc0dd\ud65c\uac74\uac15 \ub610\ud55c \uc911\uc694\ud55c \ub3cc\ud30c\uad6c\ub97c \ub9c8\ub828\ud588\uc2b5\ub2c8\ub2e4. \uc21c\uc218 \ub9ac\ud3ec\uc880 \uae30\uc220\uc744 \ud1b5\ud574 \uae30\uc874 NAD+\uc758 \uc548\uc815\uc131\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ucf1c \ud53c\ubd80 \ud761\uc218\ub97c \uc6a9\uc774\ud558\uac8c \ud569\ub2c8\ub2e4. \ub85c\ub808\uc54c\uc740 \ud53c\ubd80 \ud56d\uc0b0\ud654 \ud6a8\ub2a5\uc744 136%, \ud53c\ubd80 \uc7ac\uc0dd \ud6a8\uacfc\ub97c 69%\uae4c\uc9c0 \ub192\uc77c \uc218 \uc788\ub294 “NAD \ub9ac\ub274\uc5bc 24″\ub97c \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4. NAD+\uc758 \uc791\uc6a9 \uae30\uc804\uc5d0 \ub300\ud55c \uc2ec\uce35\uc801\uc778 \uc5f0\uad6c\uac00 \uacc4\uc18d\ub418\uace0 \uae30\uc220 \ud601\uc2e0\uc774 \uc774\ub8e8\uc5b4\uc9d0\uc5d0 \ub530\ub77c, NAD+\ub294 \ud654\uc7a5\ud488 \ubd84\uc57c\uc5d0\uc11c \ub354\uc6b1 \ud68d\uae30\uc801\uc778 \ubc1c\uc804\uc744 \uc774\ub8e8\uc5b4 \uc18c\ube44\uc790\uc5d0\uac8c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \ud53c\ubd80 \uad00\ub9ac \uacbd\ud5d8\uc744 \uc81c\uacf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

NAD(\ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \uc544\ub370\ub2cc \ub2e4\uc774\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc)\ub294 \uc0dd\uba85\uccb4\uc5d0 \ud544\uc218\uc801\uc778 \ubcf4\uc870 \ud6a8\uc18c\ub85c \uc0dd\uba85 \ud65c\ub3d9\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. NAD\uc758 \ubc1c\uacac \uacfc\uc815\uc740 \uc218\ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc758 \uc9c0\ud61c\uc640 \ub178\uace0\uac00 \ub2f4\uae34 \uc6b0\uc5ec\uace1\uc808\ub85c \uc810\ucca0\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. 1904\ub144 NAD\uac00 \ubc1c\uacac\ub41c \uc774\ud6c4 100\ub144\uc774 \ub118\uc5c8\uc2b5\ub2c8\ub2e4. 1904\ub144, \uc601\uad6d\uc758 \uc0dd\ud654\ud559\uc790 \uc544\uc11c \ud558\ub4e0 \uacbd\uc740 \ub9e5\uc8fc \ud6a8\ubaa8 \ucd94\ucd9c\ubb3c\uc744 \uc5f0\uad6c\ud558\ub358 \uc911 \uc608\uc0c1\uce58 \ubabb\ud55c \ubc1c\uacac\uc744 \ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ud6a8\ubaa8 \ucd94\ucd9c\ubb3c\uc744 \ubc18\ud22c\uacfc\uc131 \ub9c9\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9c4 \ubd09\uc9c0\uc5d0 \ub123\uace0 \uc21c\uc218\ud55c \ubb3c\uc5d0 \ub2f4\uac14\uc2b5\ub2c8\ub2e4. … Continue reading NAD: \uc138\ud3ec \uc18d\uc758 “\uc0dd\uba85\uc758 \ucf54\ub4dc”<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":2805,"parent":0,"menu_order":33,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-2804","blog","type-blog","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/comments?post=2804"}],"version-history":[{"count":0,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2804\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media\/2805"}],"wp:attachment":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media?parent=2804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}