{"id":2842,"date":"2025-10-16T06:03:08","date_gmt":"2025-10-16T06:03:08","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2842"},"modified":"2025-10-16T06:03:08","modified_gmt":"2025-10-16T06:03:08","slug":"%eb%a0%88%ec%8a%a4%eb%b2%a0%eb%9d%bc%ed%8a%b8%eb%a1%a4-%ec%8b%9d%eb%ac%bc%ea%b3%84%ec%9d%98-%eb%96%a0%ec%98%a4%eb%a5%b4%eb%8a%94-%ed%95%ad%eb%85%b8%ed%99%94-%ec%8a%a4%ed%83%80%ec%9d%b4%ec%9e%90","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/%eb%a0%88%ec%8a%a4%eb%b2%a0%eb%9d%bc%ed%8a%b8%eb%a1%a4-%ec%8b%9d%eb%ac%bc%ea%b3%84%ec%9d%98-%eb%96%a0%ec%98%a4%eb%a5%b4%eb%8a%94-%ed%95%ad%eb%85%b8%ed%99%94-%ec%8a%a4%ed%83%80%ec%9d%b4%ec%9e%90\/","title":{"rendered":"\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864: \uc2dd\ubb3c\uacc4\uc758 \ub5a0\uc624\ub974\ub294 \ud56d\ub178\ud654 \uc2a4\ud0c0\uc774\uc790 \uac74\uac15 \uc218\ud638\uc790"},"content":{"rendered":"

\uc790\uc5f0\uc774 \uc815\uad50\ud558\uac8c \ube5a\uc5b4\ub0b8 \ubbf8\uc138\ud55c \uc608\uc220 \uc791\ud488\ucc98\ub7fc, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 3,4\u2032,5-\ud2b8\ub9ac\ud558\uc774\ub4dc\ub85d\uc2dc\uc2a4\ud2f8\ubca4\uc774\ub77c\ub294 \ud654\ud559\uba85\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ubd84\uc790\uc2dd\uc740 C\u2081\u2084H\u2081\u2082O\u2083\uc774\uace0 \ubd84\uc790\ub7c9\uc740 228.25\uc785\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud3f4\ub9ac\ud398\ub180 \uc2a4\ud2f8\ubca4 \uacc4\uc5f4 \ud654\ud569\ubb3c\uc5d0 \uc18d\ud558\uba70, \ub9e4\ud639\uc801\uc778 \ud654\ud559 \uc138\uacc4\uc5d0\uc11c \ub3c5\ubcf4\uc801\uc778 \uc704\uce58\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubd84\uc790 \uad6c\uc870\ub294 \ub450 \uac1c\uc758 \ubca4\uc820 \uace0\ub9ac\uac00 \ube44\ub2d0\uae30\ub85c \uc815\uad50\ud558\uac8c \uc5f0\uacb0\ub418\uc5b4 \uc788\uace0, \uc138 \uac1c\uc758 \ud558\uc774\ub4dc\ub85d\uc2dc\uae30\uac00 \ub9c8\uce58 \ud65c\uae30\ucc2c \uc74c\ud45c\ucc98\ub7fc \uace0\ub9ac \uc804\uccb4\uc5d0 \ud769\uc5b4\uc838 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae30\ubc1c\ud55c \ubc30\uc5f4\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub3c5\ud2b9\ud55c \ud654\ud559\uc801 \ud65c\uc131\uc744 \ubd80\uc5ec\ud558\uc5ec, \ub9c8\uce58 \ub2e4\uc7ac\ub2e4\ub2a5\ud55c \ub304\uc11c\uac00 \uc5ec\ub7ec \ubb34\ub300\uc5d0\uc11c \uc6b0\uc544\ud558\uac8c \uacf5\uc5f0\ud558\ub4ef \uc218\ub9ce\uc740 \ud654\ud559 \ubc18\uc751\uc5d0\uc11c \ub3c5\ud2b9\ud55c \ub9e4\ub825\uc744 \ubc1c\ud718\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4.<\/p>\n

\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc790\uc5f0\uc5d0\uc11c \uc2dc\uc2a4(cis)\uc640 \ud2b8\ub79c\uc2a4(trans)\ub77c\ub294 \ub450 \uac1c\uc758 \uc774\uc131\uc9c8\uccb4\ub85c \uc874\uc7ac\ud558\uba70, \ub9c8\uce58 \uc11c\ub85c \ub2e4\ub978 \uac1c\uc131\uc744 \uac00\uc9c4 \uc30d\ub465\uc774\ucc98\ub7fc \uc874\uc7ac\ud569\ub2c8\ub2e4. \ub6f0\uc5b4\ub09c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uc9c0\ub2cc \uc774 \ud2b8\ub79c\uc2a4\ud615\uc740 \ubb34\ub300 \uc704\uc758 \uac00\uc7a5 \ube5b\ub098\ub294 \uc2a4\ud0c0\ucc98\ub7fc \uc218\ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc758 \uad00\uc2ec\uc744 \ub04c\uc5b4\uc654\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \ucc28\uac00\uc6b4 \uc694\uc815\ucc98\ub7fc \ubb3c\uc5d0 \ub179\uc9c0 \uc54a\uc544 \ubb3c\uc5d0 \uc27d\uac8c \uc11e\uc774\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc5d0\ud0c4\uc62c\uacfc \uac19\uc740 \uc720\uae30 \uc6a9\ub9e4\uc5d0\uc11c\ub294 \ub9c8\uce58 \ub9c8\uc74c\uc774 \ud1b5\ud558\ub294 \ud30c\ud2b8\ub108\ub97c \ucc3e\uc740 \ub4ef \ube60\ub974\uac8c \uce5c\ud654\ub825\uc744 \ubc1c\ud718\ud558\uc5ec \uc27d\uac8c \uc6a9\ud574\ub429\ub2c8\ub2e4.<\/p>\n

\uc548\uc815\uc131 \ub610\ud55c \ub9e4\uc6b0 \ubbfc\uac10\ud558\uc5ec \ube5b\uacfc pH \ubcc0\ud654\uc5d0 \uc7a5\ub09c\uae30 \ub118\uce58\ub294 \uc694\uc815\ucc98\ub7fc \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc11c\ub298\ud558\uace0 \uc5b4\ub450\uc6b4 \ud658\uacbd\uc5d0\uc11c\ub294 \uc7a0\uc790\ub294 \uacf5\uc8fc\ucc98\ub7fc \uc624\ub7ab\ub3d9\uc548 \uc548\uc815 \uc0c1\ud0dc\ub97c \uc720\uc9c0\ud558\uba70, \ud654\ud559\uc801 \ud2b9\uc131\uc744 \uadf8\ub300\ub85c \uc720\uc9c0\ud558\uba74\uc11c \uae68\uc5b4\ub098 \ub354 \ud070 \uc7a0\uc7ac\ub825\uc744 \ubc1c\ud718\ud558\uae30\ub97c \uae30\ub2e4\ub9bd\ub2c8\ub2e4.<\/p>\n

\"\"<\/p>\n

\ucc9c\uc5f0 \ubc0f \uc2dd\ubb3c\uc131 \uc6d0\ub8cc<\/h2>\n

\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864<\/strong><\/a> \ub9c8\uce58 \uc790\uc5f0\uc774 \uc2dd\ubb3c\uacc4 \uacf3\uacf3\uc5d0 \uc2ec\uc5b4 \ub193\uc740 \uac74\uac15\ud55c \uc528\uc557\ucc98\ub7fc 70\uc885 \uc774\uc0c1\uc758 \uc2dd\ubb3c\uc5d0\uc11c \ub110\ub9ac \ubc1c\uacac\ub429\ub2c8\ub2e4. \uc640\uc778 \uc81c\uc870 \uacfc\uc815\uc5d0\uc11c \uc228\uaca8\uc9c4 \uc601\uc6c5\uc778 \ud3ec\ub3c4 \uaecd\uc9c8\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc8fc\uc694 \uacf5\uae09\uc6d0\uc785\ub2c8\ub2e4. \uc9c4\ud55c \ub808\ub4dc \uc640\uc778\uc744 \uc74c\ubbf8\ud560 \ub54c, \uc6b0\ub9ac\ub294 \uadf8 \uc548\uc5d0 \uc788\ub294 \ubca0\ub77c\ud2b8\ub864\uc774 \ud3ec\ub3c4 \uaecd\uc9c8\uc774\ub77c\ub294 \uc544\ub08c\uc5c6\ub294 \uc120\ubb3c\uc5d0\uc11c \ube44\ub86f\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uae68\ub2eb\uc9c0 \ubabb\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uc801 \uce21\uc815 \uacb0\uacfc \ud3ec\ub3c4 \uaecd\uc9c8\uc5d0\ub294 \uc57d 50~100\u03bcg\/g\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud568\uc720\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc218\uce58\ub294 \uc790\uc5f0\uc774 \ud3ec\ub3c4 \uaecd\uc9c8\uc5d0 \ubd80\uc5ec\ud55c \ub3c5\ud2b9\ud55c \uc554\ud638\ucc98\ub7fc \ubcf4\uc774\uba70, \uc218\ub9ce\uc740 \uac74\uac15 \ube44\ubc00\uc744 \ub2f4\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud638\uc7a5\uadfc\uc758 \ubfcc\ub9ac\uc904\uae30 \ub610\ud55c \uadc0\uc911\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf4\uace0\uc785\ub2c8\ub2e4. \uac89\ubcf4\uae30\uc5d0 \ud3c9\ubc94\ud574 \ubcf4\uc774\ub294 \uc774 \uc2dd\ubb3c\uc740 \uc624\ub7ab\ub3d9\uc548 \uc804\ud1b5 \uc911\uad6d \uc758\ud559\uc5d0\uc11c \uba85\uc131\uc744 \ub5a8\uccd0 \uc654\uc73c\uba70, \ud48d\ubd80\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud568\ub7c9 \ub355\ubd84\uc5d0 \ud604\ub300 \uacfc\ud559 \uc5f0\uad6c\uc640 \uac74\uac15 \uc0b0\uc5c5\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \uc228\uaca8\uc9c4 \ubb34\uc220\uc758 \uace0\uc218\ucc98\ub7fc, \ud3ec\ub3c4 \uaecd\uc9c8\uc740 \ub180\ub77c\uc6b4 \ud6a8\ub2a5\uc744 \uacc4\uc18d\ud574\uc11c \ubcf4\uc5ec\uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub545\ucf69 \uaecd\uc9c8\uacfc \ubf55\ub098\ubb34 \uc5f4\ub9e4\uc5d0\ub3c4 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc870\uc6a9\ud788 \ucd95\uc801\ub418\uc5b4 \uc6b0\ub9ac \uac74\uac15\uc5d0 \ub3c4\uc6c0\uc744 \uc90d\ub2c8\ub2e4. \ub9c8\uce58 \ub208\uc5d0 \ub744\uc9c0 \uc54a\ub294 \ud30c\uc218\uafbc\ucc98\ub7fc, \uc774\ub4e4\uc740 \ubcf4\uc774\uc9c0 \uc54a\ub294 \uacf3\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\uc2dd\ubb3c\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud569\uc131 \uacfc\uc815\uc740 \ub180\ub77c\uc6b4 \ubc29\uc5b4\uc804\uacfc \uac19\uc2b5\ub2c8\ub2e4. \uc2dd\ubb3c\uc774 \ubcd1\uc6d0\uade0\uc758 \uacf5\uaca9\uc744 \ubc1b\uac70\ub098 \uc790\uc678\uc120\uc774\ub098 \uac00\ubb44\uacfc \uac19\uc740 \uadf9\uc2ec\ud55c \ud658\uacbd \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \uc9c1\uba74\ud558\uba74, \uc2e0\uc18d\ud558\uac8c \ubc29\uc5b4 \uae30\uc81c\ub97c \ud65c\uc131\ud654\ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud569\uc131\uc744 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uc774 \uae30\uc801\uc758 \ubb3c\uc9c8\uc740 \uc2dd\ubb3c \ub0b4\uc5d0\uc11c “\ube44\ubc00 \ubcd1\uae30”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc678\ubd80 \uacf5\uaca9\uc5d0 \uc800\ud56d\ud558\uace0 \uac74\uac15\uacfc \uc131\uc7a5\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc744 \uc90d\ub2c8\ub2e4. \ub9c8\uce58 \ub04a\uc784\uc5c6\uc774 \uc9d1\uc744 \uc9c0\ud0a4\ub294 \uc6a9\uac10\ud55c \uc804\uc0ac\uc640 \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud604\ub300 \uc0b0\uc5c5 \uc0dd\uc0b0 \ubd84\uc57c\uc5d0\uc11c \uc2dd\ubb3c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ucd94\ucd9c\ud558\ub294 \ubc29\ubc95\uc740 \ub04a\uc784\uc5c6\uc774 \ud601\uc2e0\ub418\uace0 \uac1c\uc120\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud3f4\ub9ac\uace0\ub214 \ucfe0\uc2a4\ud53c\ub2e4\ud23c(Polygonum cuspidatum)\uc744 \uc6d0\ub8cc\ub85c \uc0ac\uc6a9\ud558\ub294 \ud3f4\ub9ac\ub2e4\ud2f4(Polydatin) \uac00\uc218\ubd84\ud574\ubc95\uc740 \ub192\uc740 \ud6a8\uc728\uacfc \uc548\uc815\uc131\uc73c\ub85c \uc778\ud574 \uc8fc\uc694 \ucd94\ucd9c \uacf5\uc815\uc73c\ub85c \uc790\ub9ac \uc7a1\uc558\uc2b5\ub2c8\ub2e4. \uc219\ub828\ub41c \uc7a5\uc778\ucc98\ub7fc, \uc774 \uc81c\ud488\uc740 \ud3f4\ub9ac\uace0\ub214 \ucfe0\uc2a4\ud53c\ub2e4\ud23c(Polygonum cuspidatum)\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 98% \uc774\uc0c1\uc758 \uc21c\ub3c4\ub85c \uc815\ubc00\ud558\uac8c \ucd94\ucd9c\ud558\uc5ec \ub2e4\uc591\ud55c \ubd84\uc57c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc758 \uad11\ubc94\uc704\ud55c \ud65c\uc6a9\uc744 \uc704\ud55c \ud0c4\ud0c4\ud55c \uae30\ubc18\uc744 \ub9c8\ub828\ud569\ub2c8\ub2e4.<\/p>\n

\ud575\uc2ec \uc774\uc810: \ub2e4\uc911 \ud45c\uc801 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131 \ud0d0\uad6c<\/h2>\n

\"\"<\/p>\n

(I) \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc720\ub9ac\uae30 \ud65c\uc131\uc758 \ud575\uc2ec \uba54\ucee4\ub2c8\uc998<\/h3>\n

\ubbf8\uc2dc\uc801\uc778 \uc0dd\uba85\uccb4 \uc138\uacc4\uc5d0\uc11c \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub294 \ub9c8\uce58 \uc18c\ub9ac \uc5c6\ub294 \uc804\uc7c1\uacfc \uac19\uc544 \ub04a\uc784\uc5c6\uc774 \uc138\ud3ec \uac74\uac15\uc744 \uc704\ud611\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub450\ub824\uc6c0\uc744 \ubaa8\ub974\ub294 “\ud56d\uc0b0\ud654 \uc804\uc0ac”\uc785\ub2c8\ub2e4. \uac15\ub825\ud55c \ucc9c\uc5f0 \ud56d\uc0b0\ud654\uc81c\uc778 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc8fc\uc694 \uc5ed\ud560\uc740 \uccb4\ub0b4\uc5d0 \ub9cc\uc5f0\ud55c \ud65c\uc131\uc0b0\uc18c(ROS)\ub97c \uc81c\uac70\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ud2b9\ud788 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628\uacfc \ud558\uc774\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc740 \uc804\uc7a5\uc758 “\uc801”\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \ubd84\uc790 \uad6c\uc870\ub97c \uac00\uc9c4 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c ROS\ub97c \uc815\ud655\ud558\uac8c \uc2dd\ubcc4\ud558\uace0 \uacb0\ud569\ud558\uc5ec \ubb34\ud574\ud55c \ubb3c\uc9c8\ub85c \uc804\ud658\ud569\ub2c8\ub2e4. \uc774\ub294 \uc9c0\uc9c8 \uacfc\uc0b0\ud654\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uc5ec \uc138\ud3ec\ub9c9\uc758 \uad6c\uc870\uc640 \uae30\ub2a5\uc744 \ubcf4\ud638\ud558\ub294 \uacac\uace0\ud55c “\uac11\uc637”\uacfc \uac19\uc2b5\ub2c8\ub2e4.
\n\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub610\ud55c \uc138\ud3ec \ub0b4 \ud56d\uc0b0\ud654 \ubc29\uc5b4 \uc2dc\uc2a4\ud15c\uc744 “\uc9c0\ud718”\ud558\ub294 \ub370 \ud0c1\uc6d4\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \ub514\uc2a4\ubba4\ud0c0\uc544\uc81c(SOD) \ubc0f \uce74\ud0c8\ub77c\uc544\uc81c(CAT)\uc640 \uac19\uc740 \ud56d\uc0b0\ud654 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\ub4e4\uc740 \uc138\ud3ec \ub0b4\uc5d0\uc11c “\uc791\uc740 \uc815\ud654 \uc7a5\uce58”\ucc98\ub7fc \uc791\uc6a9\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc758\ud574 \ud65c\uc131\ud654\ub41c \ud6a8\uc18c\ub4e4\uc740 \ub354\uc6b1 \ud65c\ubc1c\ud558\uac8c \uc791\uc6a9\ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c\uc744 \ube60\ub974\uac8c \uc81c\uac70\ud558\uace0 \uc0b0\ud654\ud658\uc6d0 \uade0\ud615\uc744 \uc720\uc9c0\ud569\ub2c8\ub2e4. \ub610\ud55c, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 NF-\u03baB \uc5fc\uc99d \uacbd\ub85c\ub97c \ud558\ud5a5 \uc870\uc808\ud558\uc5ec \uc5fc\uc99d \uc778\uc790\uc758 \ubc29\ucd9c\uc744 \uc904\uc774\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc190\uc0c1\uc758 \uadfc\ubcf8 \uc6d0\uc778\uc744 \ud574\uacb0\ud569\ub2c8\ub2e4. \ud604\uba85\ud55c \uc0ac\ub839\uad00\ucc98\ub7fc \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc138\ud3ec \uc548\uc804\uc744 \ud3ec\uad04\uc801\uc73c\ub85c \ubcf4\ud638\ud558\uae30 \uc704\ud55c \ub2e4\uac01\uc801\uc778 \uc804\ub7b5\uc744 \uc218\ub9bd\ud569\ub2c8\ub2e4.<\/p>\n

\uc218\ub9ce\uc740 \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud56d\uc0b0\ud654 \ud2b9\uc131\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2e0\uc911\ud558\uac8c \uc124\uacc4\ub41c \uc0dd\uc950 \uc5f0\uad6c\uc5d0\uc11c, \uc5f0\uad6c\uc9c4\uc740 \uc0dd\uc950\uc5d0\uac8c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf4\ucda9\ud55c \uacb0\uacfc, \ub180\ub78d\uac8c\ub3c4 \uac04 \uc870\uc9c1\uc758 \ub9d0\ub860\ub514\uc54c\ub370\ud788\ub4dc(MDA) \uc218\uce58\uac00 30%\ub098 \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\ud558\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. MDA\ub294 \uc9c0\uc9c8 \uacfc\uc0b0\ud654\uc758 \uc0b0\ubb3c\uc774\uba70, MDA\uc758 \uac10\uc18c\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc9c0\uc9c8 \uacfc\uc0b0\ud654\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uace0 \uac04 \uc138\ud3ec\ub9c9\uc744 \ubcf4\ud638\ud588\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 \uc0dd\uc950\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc740 40% \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2e0\uccb4\uc758 \ud56d\uc0b0\ud654 \ubc29\uc5b4 \uccb4\uacc4\ub97c \uac15\ud654\ud558\uc5ec \uac15\ub825\ud55c \ud56d\uc0b0\ud654\ub825\uc744 \uc950\uc758 \ubab8\uc5d0 \uc8fc\uc785\ud558\uc5ec \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc758 \uc720\ud574\ud55c \uc601\ud5a5\uc5d0 \ub354 \uc798 \uc800\ud56d\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\ub294 \ub180\ub77c\uc6b4 \ub2a5\ub825\uc744 \ubd84\uba85\ud788 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

(II) \uc2ec\ud608\uad00\uacc4 \ubcf4\ud638 \ub124\ud2b8\uc6cc\ud06c<\/h3>\n

\uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808<\/h4>\n

\uc2ec\ud608\uad00 \uac74\uac15\uc740 \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\uc640 \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc73c\uba70, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc815\ubc00\ud55c “\uc9c0\uc9c8 \uc870\uc808\uc81c” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \ubc1c\ubcd1 \ubc0f \uc9c4\ud589\uc5d0 \ucf5c\ub808\uc2a4\ud14c\ub864\uc774 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc778\uc9c0\ud558\uace0 \uc788\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 HMG-CoA \ud658\uc6d0\ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uad50\ubb18\ud558\uac8c \uc5b5\uc81c\ud558\uc5ec \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\uc744 \uadfc\uc6d0\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131 \uc0dd\uc0b0 \ub77c\uc778\uc758 \uccb4\ud06c\ud3ec\uc778\ud2b8 \uc5ed\ud560\uc744 \ud558\uc5ec \ucf5c\ub808\uc2a4\ud14c\ub864 \uc0dd\uc131\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ud569\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud6a8\ub2a5\uc744 \uc2dc\ud5d8\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc601\uc5ed\uc785\ub2c8\ub2e4. \uc5c4\uaca9\ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c 8\uc8fc \ub3d9\uc548 \ub9e4\uc77c 150mg\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf5\uc6a9\ud55c \ud53c\ud5d8\uc790\ub4e4\uc740 \uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864(LDL-C)\uc774 12% \uac10\uc18c\ud558\ub294 \uace0\ubb34\uc801\uc778 \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. “\ub098\uc05c \ucf5c\ub808\uc2a4\ud14c\ub864” \uac10\uc18c\ub294 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc744 \ud06c\uac8c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 \uace0\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864(HDL-C)\uc740 9% \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. “\uc88b\uc740 \ucf5c\ub808\uc2a4\ud14c\ub864”\ub85c \uc54c\ub824\uc9c4 HDL-C\ub294 \ud608\uad00\ubcbd\uc5d0\uc11c \uac04\uc73c\ub85c \ucf5c\ub808\uc2a4\ud14c\ub864\uc744 \uc6b4\ubc18\ud558\uc5ec \ub300\uc0ac \uc791\uc6a9\uc744 \ub3d5\uace0, \ud608\uad00\uc744 \uae68\ub057\ud558\uac8c \ud558\uba70 \uc2ec\ud608\uad00 \uac74\uac15\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc9c0\uc9c8 \ub300\uc0ac\ub97c \uc870\uc808\ud568\uc73c\ub85c\uc368 \uc2ec\ud608\uad00 \uac74\uac15\uc758 \ud2bc\ud2bc\ud55c \ud1a0\ub300\ub97c \ub9c8\ub828\ud569\ub2c8\ub2e4.<\/p>\n

\ub0b4\ud53c\uc138\ud3ec \ubcf5\uad6c<\/h4>\n

\ub0b4\ud53c\uc138\ud3ec\ub294 \uc2ec\ud608\uad00\uacc4\uc758 “\ucd5c\uc804\uc120”\uc774\uba70, \ub0b4\ud53c\uc138\ud3ec\uc758 \uac74\uac15\uc740 \ud608\uad00 \uae30\ub2a5\uc5d0 \uc9c1\uc811\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c \uc810\uc744 \uc778\uc9c0\ud558\uc5ec “\ub0b4\ud53c\uc138\ud3ec \ubcf5\uad6c\uc81c” \uc5ed\ud560\uc744 \ud558\uc5ec \uc77c\uc0b0\ud654\uc9c8\uc18c(NO)\uc758 \ubd84\ube44\ub97c \ud65c\ubc1c\ud558\uac8c \ucd09\uc9c4\ud569\ub2c8\ub2e4. NO\ub294 \ud608\uad00 \uc774\uc644\uc81c \uc5ed\ud560\uc744 \ud558\uc5ec \ud608\uad00 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ud0a4\uace0 \ud0c4\ub825\uc131\uacfc \uac1c\ud1b5\uc131\uc744 \uc720\uc9c0\ud569\ub2c8\ub2e4. \ub610\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \uc5b5\uc81c\ud558\uc5ec “\ud608\uc804 \uc0dd\uc131 \uc6d0\uc778”\uc744 \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \ud608\uc804 \ud615\uc131\uc744 \uc608\ubc29\ud569\ub2c8\ub2e4. \ub610\ud55c \ud53c\ube0c\ub9ac\ub178\uac90\uc774 \ud53c\ube0c\ub9b0\uc73c\ub85c \uc804\ud658\ub418\ub294 \uac83\uc744 \uc5b5\uc81c\ud558\uc5ec \ud608\uc804\uc99d \uc704\ud5d8\uc744 \ub354\uc6b1 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ud56d\uc751\uace0 \ud6a8\uacfc \uce21\uba74\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 10\u03bcM\uc758 \ub18d\ub3c4\uc5d0\uc11c \uc544\uc2a4\ud53c\ub9b0\uacfc \uc720\uc0ac\ud55c \ud6a8\ub2a5\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \uc774\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc544\uc2a4\ud53c\ub9b0\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc5b4\ub290 \uc815\ub3c4 \ud56d\uc751\uace0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \ud608\uc804 \uc704\ud5d8\uc73c\ub85c\ubd80\ud130 \uc2ec\ud608\uad00\uacc4\ub97c \ubcf4\ud638\ud558\uace0, \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc758 \uac74\uac15\uc744 \uc720\uc9c0\ud558\uba70, \uc815\uc0c1\uc801\uc778 \ud608\ub958\ub97c \ubcf4\uc7a5\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\ud56d\ub3d9\ub9e5\uacbd\ud654\uc99d<\/h4>\n

\ub3d9\ub9e5\uacbd\ud654\uc99d\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc8fc\uc694 \ubcd1\ub9ac\ud559\uc801 \uc6d0\uc778\uc774\uba70, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\uc5d0 \ub9de\uc11c\ub294 “\uc288\ud37c \uc804\uc0ac”\uc785\ub2c8\ub2e4. \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec\uc758 \uc99d\uc2dd\uacfc \uc774\ub3d9\uc744 \uc5b5\uc81c\ud558\uc5ec \uc138\ud3ec\uc758 \ubb34\ubd84\ubcc4\ud55c \uc131\uc7a5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uba48\ucd94\uace0 \ud608\uad00\ubcbd\uc5d0 \uacfc\ub3c4\ud558\uac8c \ucd95\uc801\ub418\uc5b4 \ud50c\ub77c\ud06c \ud615\uc131\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294 \uac83\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \ub610\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud50c\ub77c\ud06c \ub0b4 \ub300\uc2dd\uc138\ud3ec \uce68\uc724\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0, \uc5fc\uc99d\uc744 \uc904\uc774\uba70, \ud50c\ub77c\ud06c \uc9c4\ud589\uc744 \ub2a6\ucdb0 \ud608\uad00\uc744 \ube44\uad50\uc801 \uac74\uac15\ud558\uac8c \uc720\uc9c0\ud569\ub2c8\ub2e4. \uadf8 \uc791\uc6a9 \uae30\uc804\uc740 \ud65c\uc131\ud654\ub97c \ud3ec\ud568\ud569\ub2c8\ub2e4 AMPK\/mTOR \uacbd\ub85c. \uc138\ud3ec \ub0b4 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \uc2e0\ud638\uc804\ub2ec\uc744 \uc870\uc808\ud568\uc73c\ub85c\uc368 \ud608\uad00 \uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\uace0, \uc5ec\ub7ec \ub2e8\uacc4\uc5d0\uc11c \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc758 \ubc1c\uc0dd\uc744 \uc5b5\uc81c\ud558\uba70, \uc2ec\ud608\uad00 \uac74\uac15\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n

(III) \uc554 \uc608\ubc29 \ubc0f \uc911\uc7ac \uac00\ub2a5\uc131<\/h3>\n

\uac1c\uc2dc \ub2e8\uacc4:<\/strong> \ubc1c\uc554 \ubb3c\uc9c8 \ud65c\uc131\ud654 \uc5b5\uc81c
\n\uc7a5\uae30\uac04\uc758 \uc885\uc591 \ud615\uc131 \uacfc\uc815\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub9c8\uce58 \ud1b5\ucc30\ub825 \uc788\ub294 “\uac74\uac15 \uc218\ud638\uc790”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uac1c\uc2dc \ub2e8\uacc4\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc591\ub0a0\uc758 \uac80\uacfc \uac19\uc740 CYP450 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc815\ud655\ud558\uac8c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc815\uc0c1\uc801\uc778 \uc0c1\ud669\uc5d0\uc11c CYP450 \ud6a8\uc18c\ub294 \uc57d\ubb3c\uacfc \ub3c5\uc18c\uc758 \ub300\uc0ac\uc5d0 \uad00\uc5ec\ud558\uc9c0\ub9cc, \uc885\uc591 \ud615\uc131 \uacfc\uc815\uc5d0\uc11c\ub294 \uc77c\ubd80 \ubc1c\uc554 \ubb3c\uc9c8\uc744 \ud65c\uc131 \ubc1c\uc554 \ubb3c\uc9c8\ub85c \uc804\ud658\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c \uc5b5\uc81c \ud6a8\uacfc\ub294 \ubc1c\uc554 \ubb3c\uc9c8 \ud65c\uc131\ud654\ub97c \uc720\ubc1c\ud558\ub294 “\ud4e8\uc988”\uc5d0 \uc790\ubb3c\uc1e0\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ubc1c\uc554 \ubb3c\uc9c8 \uc0dd\uc131\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc904\uc774\uace0, \uc885\uc591 \ubc1c\uc0dd \uc704\ud5d8\uc744 \uadfc\uc6d0\uc801\uc73c\ub85c \uc644\ud654\ud558\uba70, \uc2e0\uccb4 \uac74\uac15\uc744 \uc704\ud55c \ucd5c\uc804\uc120 \ubc29\uc5b4\uc120\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ucd09\uc9c4 \ub2e8\uacc4: \uc138\ud3ec\uc790\uba78\uc0ac \uc720\ub3c4 \ubc0f \uc138\ud3ec \uc8fc\uae30 \uc815\uc9c0.<\/p>\n

\uc885\uc591\uc774 \ucd09\uc9c4 \ub2e8\uacc4\uc5d0 \uc9c4\uc785\ud558\uba74 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uac15\ub825\ud55c “\uc138\ud3ec \uc870\uc808\uc790”\uac00 \ub429\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc138\ud3ec \uc8fc\uae30\ub97c G1\/S \ub2e8\uacc4\uc5d0\uc11c \uad50\ubb18\ud558\uac8c \uc815\uc9c0\uc2dc\ucf1c \uc138\ud3ec\uc758 \uc131\uc7a5 \uacfc\uc815\uc744 \uc774 \uc911\uc694\ud55c \ub2e8\uacc4\uc5d0\uc11c \uc911\ub2e8\uc2dc\ud0a4\uace0, \uc138\ud3ec\uac00 DNA \ud569\uc131 \ub2e8\uacc4\ub85c \uc9c4\uc785\ud558\ub294 \uac83\uc744 \ub9c9\uc544 \uc138\ud3ec \uc99d\uc2dd\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub610\ud55c p53\uacfc Bax\uc640 \uac19\uc740 \uc138\ud3ec\uc790\uba78\uc0ac \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc720\ub3c4\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc720\uc804\uc790\ub294 \uc138\ud3ec \ub0b4\uc5d0\uc11c “\uc790\uc0b4 \uc2a4\uc704\uce58”\ucc98\ub7fc \uc791\uc6a9\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc791\uc6a9\uc73c\ub85c \uc774\ub7ec\ud55c \uc720\uc804\uc790\ub4e4\uc774 \ud65c\uc131\ud654\ub418\uc5b4 \uc138\ud3ec\uc790\uba78\uc0ac \ud504\ub85c\uadf8\ub7a8\uc744 \uac1c\uc2dc\ud558\uace0, \uc7a0\uc7ac\uc801\uc73c\ub85c \uc554\uc138\ud3ec\uac00 “\uc790\uc0b4”\ud558\ub3c4\ub85d \uc720\ub3c4\ud558\uc5ec \uc885\uc591\uc758 \ucd94\uac00 \uc9c4\ud589\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \uc774\ub294 \uc885\uc591\uc758 \uc9c4\ud589 \uacbd\ub85c\uc5d0 \uc218\ub9ce\uc740 \uc7a5\uc560\ubb3c\uc744 \uc0dd\uc131\ud558\uc5ec \ubb34\ubd84\ubcc4\ud55c \uc131\uc7a5\uc744 \uba48\ucd94\uac8c \ud569\ub2c8\ub2e4.<\/p>\n

\uc9c4\ud589 \ub2e8\uacc4:<\/strong> \uc885\uc591 \uc601\uc591 \ucc28\ub2e8
\n\uc9c4\ud589 \ub2e8\uacc4\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 “\uc885\uc591 \uc601\uc591 \ucc28\ub2e8\uc81c” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc885\uc591 \uc131\uc7a5\uc774 \ucda9\ubd84\ud55c \uc601\uc591\ubd84 \uacf5\uae09\uc5d0 \uc758\uc874\ud558\uba70, \ud608\uad00\uc2e0\uc0dd\uc774 \uc885\uc591\uc774 \uc601\uc591\ubd84\uc744 \uc5bb\ub294 \ud575\uc2ec \uacbd\ub85c\ub77c\ub294 \uac83\uc744 \uc774\ud574\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud608\uad00\ub0b4\ud53c\uc138\ud3ec\uc131\uc7a5\uc778\uc790(VEGF)\uc5d0 \uc758\ud55c \ud608\uad00\uc2e0\uc0dd\uc744 \uc5b5\uc81c\ud558\uc5ec \uacb0\uc815\uc801\uc778 \uc791\uc6a9\uc744 \ud569\ub2c8\ub2e4. \uc774\ub294 \uc885\uc591\uc758 “\uc591\ubd84 \uacf5\uae09”\uc744 \ucc28\ub2e8\ud558\ub294 \uac83\uacfc \uac19\uc774 \uc791\uc6a9\ud558\uc5ec \uc885\uc591 \uc138\ud3ec\uc5d0 \ucda9\ubd84\ud55c \uc601\uc591\ubd84\uacfc \uc0b0\uc18c\ub97c \u200b\u200b\uacf5\uae09\ud558\uc9c0 \ubabb\ud558\uac8c \ud558\uc5ec \uc885\uc591\uc758 \uc9c0\uc18d\uc801\uc778 \uc131\uc7a5\uacfc \ud655\uc0b0\uc744 \ub9c9\uc2b5\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \ub0b4 \uc2e4\ud5d8\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud56d\uc885\uc591 \ud6a8\uacfc\ub97c \uc5f0\uad6c\ud558\ub294 \ub370 \uc911\uc694\ud55c \ub3c4\uad6c\uc785\ub2c8\ub2e4. \uc774 \uc2e4\ud5d8\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc720\ubc29\uc554\uacfc \uc804\ub9bd\uc120\uc554 \uc138\ud3ec\uc5d0 \ub300\ud574 \uac01\uac01 25\u03bcM\uacfc 30\u03bcM\uc758 IC50 \uac12\uc744 \ub098\ud0c0\ub0b4\uba70 \uc720\uc758\ubbf8\ud55c \uc5b5\uc81c \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \uc554 \uc608\ubc29 \ubc0f \uc911\uc7ac\uc5d0 \uc788\uc5b4 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubd84\uba85\ud788 \ubcf4\uc5ec\uc8fc\uba70, \uc554 \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

(IV) \ub300\uc0ac \ubc0f \uba74\uc5ed \uc870\uc808\uc758 \uc0c1\uc2b9 \ud6a8\uacfc<\/h3>\n

\ud3ec\ub3c4\ub2f9 \ub300\uc0ac \ucd5c\uc801\ud654<\/h4>\n

\ub300\uc0ac \uc870\uc808 \ubd84\uc57c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud2b9\ud788 \ud3ec\ub3c4\ub2f9 \ub300\uc0ac\uc5d0 \uc788\uc5b4 \ub180\ub77c\uc6b4 “\ub300\uc0ac \uc870\uc808\uc758 \ub2ec\uc778”\uc785\ub2c8\ub2e4. AMPK \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \uc138\ud3ec \ub0b4 “\uc5d0\ub108\uc9c0 \uc2a4\uc704\uce58” \uc5ed\ud560\uc744 \ud558\uc5ec \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \ub192\uc774\uace0 \uc138\ud3ec\uac00 \ud3ec\ub3c4\ub2f9\uc744 \ub354 \uc798 \ud761\uc218\ud558\uace0 \ud65c\uc6a9\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\uc5ec \ud608\ub2f9 \uc218\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ub0ae\ucda5\ub2c8\ub2e4. \uace0\uc9c0\ubc29 \uc2dd\uc774\ub85c \uc720\ubc1c\ub41c \ub2f9\ub1e8\ubcd1 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub0b4\ub2f9\ub2a5 \uc7a5\uc560\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uac1c\uc120\ud558\uace0 \ud608\ub2f9 \ub300\uc0ac\ub97c \uac70\uc758 \uc815\uc0c1 \uc218\uc900\uc73c\ub85c \ud68c\ubcf5\uc2dc\ud0a4\ub294 \ub180\ub77c\uc6b4 \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud6a8\ub2a5\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ud3ec\ub3c4\ub2f9 \uac15\ud558\uc81c\uc778 \uba54\ud2b8\ud3ec\ub974\ubbfc(200mg\/kg)\uacfc \uc720\uc0ac\ud558\uc5ec \ub2f9\ub1e8\ubcd1 \uce58\ub8cc \ubc0f \uc608\ubc29\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uacfc \uc7a0\uc7ac\uc801\uc778 \uc790\uc5f0 \uce58\ub8cc\ubc95\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uba74\uc5ed \ud65c\uc131\ud654<\/h4>\n

\uba74\uc5ed \uccb4\uacc4\ub294 \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc2e0\uccb4\uc758 “\ub9cc\ub9ac\uc7a5\uc131”\uc774\uba70, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uba74\uc5ed \uccb4\uacc4 \uae30\ub2a5\uc744 \uac15\ud654\ud558\uace0 \uc2e0\uccb4\uc758 \uc800\ud56d\ub825\uc744 \ub192\uc774\ub294 \ud0c1\uc6d4\ud55c “\uba74\uc5ed \ud65c\uc131\ud654\uc81c”\uc785\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub300\uc2dd\uc138\ud3ec\uc758 M1 \uc720\ud615\uc73c\ub85c\uc758 \ubd84\ud654\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. M1 \ub300\uc2dd\uc138\ud3ec\ub294 \uac15\ub825\ud55c \uc2dd\uc138\ud3ec \uc791\uc6a9\uacfc \uc0b4\uade0 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc5b4 \uba74\uc5ed \uccb4\uacc4\uc758 “\uc120\ubd09 \uc804\uc0ac”\uc640 \uac19\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c \ub300\uc2dd\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \ubcd1\uc6d0\uade0\uacfc \uc885\uc591 \uc138\ud3ec\ub97c \ud3ec\uc2dd\ud558\ub294 \ub4f1 \ub354\uc6b1 \uc801\uadf9\uc801\uc73c\ub85c \uc804\ud22c\uc5d0 \ucc38\uc5ec\ud558\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub610\ud55c \uc885\uc591\uad34\uc0ac\uc778\uc790-\u03b1(TNF-\u03b1)\uc640 \uc778\ud130\ub8e8\ud0a8-6(IL-6)\uacfc \uac19\uc740 \uba74\uc5ed \uc778\uc790\uc758 \ubd84\ube44\ub97c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc778\uc790\ub294 \uba74\uc5ed \uccb4\uacc4\uc758 “\uc2e0\ud638 \ubc1c\uc0b0” \uc5ed\ud560\uc744 \ud558\uc5ec \ub2e4\ub978 \uba74\uc5ed \uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud558\uace0 \uba74\uc5ed \ubc18\uc751\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 IL-10\uacfc \uac19\uc740 \ud56d\uc5fc\uc99d \uc778\uc790\uc758 \uacfc\ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\uace0, \uba74\uc5ed \uccb4\uacc4\uc758 \uacfc\ub3c4\ud55c \uc5b5\uc81c\ub97c \ubc29\uc9c0\ud558\uba70, Th1\/Th2 \uba74\uc5ed \ubc18\uc751\uc758 \uade0\ud615\uc744 \uc720\uc9c0\ud558\uace0, \uba74\uc5ed \uccb4\uacc4\uac00 \ub2e4\uc591\ud55c \ubcd1\uc6d0\uade0\uacfc \uc9c8\ubcd1\uc758 \uc704\ud611\uc5d0 \ub354\uc6b1 \uc815\ud655\ud558\uac8c \ub300\uc751\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\uba70, \uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uc804\ubc29\uc704\uc801\uc778 \ubcf4\ud638 \uae30\ub2a5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc2dc\uc7a5 \uc751\uc6a9 \ubd84\uc57c: \ucc9c\uc5f0 \ucd94\ucd9c\ubd80\ud130 \uc0b0\uc5c5\uc801 \uc5c5\uadf8\ub808\uc774\ub4dc\uae4c\uc9c0<\/h2>\n

\"\"<\/p>\n

(I) \uac74\uac15 \uc0b0\uc5c5\uc758 \ub2e4\uc591\ud55c \uc2dc\ub098\ub9ac\uc624<\/h3>\n

\uac74\uac15 \ubcf4\uc870 \uc2dd\ud488:<\/strong> \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0ac\ub78c\ub4e4\uc758 \uac74\uac15 \ucd94\uad6c\uc5d0 \uadc0\uc911\ud55c \ubcf4\uc870\uc81c\ub85c \uc810\ucc28 \ubd80\uc0c1\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc2dc\uc911\uc5d0 \ud310\ub9e4\ub418\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc740 \ub300\ubd80\ubd84 \ucea1\uc290\uacfc \uc815\uc81c \ud615\ud0dc\ub85c \uc81c\uacf5\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc81c\ud615\uc740 \ud734\ub300\uc640 \ubcf5\uc6a9\uc774 \ud3b8\ub9ac\ud558\uc5ec \ub9c8\uce58 \ub3cc\ubcf4\ub294 \uc791\uc740 \uac74\uac15 \uc9c0\ud0b4\uc774\ucc98\ub7fc \uc5b8\uc81c \uc5b4\ub514\uc11c\ub098 \uac74\uac15\uc744 \uc9c0\uc6d0\ud569\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc778 1\uc77c \ubcf5\uc6a9\ub7c9\uc740 100mg\uc5d0\uc11c 500mg \uc0ac\uc774\uc785\ub2c8\ub2e4. \uad11\ubc94\uc704\ud55c \uacfc\ud559\uc801 \uc5f0\uad6c\uc640 \uc2e4\uc81c \uacbd\ud5d8\uc744 \ud1b5\ud574 \uac80\uc99d\ub41c \uc774 \ubcf5\uc6a9\ub7c9 \ubc94\uc704\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc601\uc591\uc18c\ub97c \ucda9\ubd84\ud788 \ud761\uc218\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc548\uc804\uc131\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.
\n\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud6a8\ub2a5\uc744 \ub354\uc6b1 \ub192\uc774\uae30 \uc704\ud574 \ub9ce\uc740 \uc81c\ud488\uc774 \ub3c5\ucc3d\uc801\uc778 \uc81c\ud615\uc744 \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ube44\ud0c0\ubbfc C\ub97c \ud568\uaed8 \uc0ac\uc6a9\ud558\ub294 \uac83\uc740 \uac15\ub825\ud55c \ud56d\uc0b0\ud654\uc81c\ub97c \ucc3e\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ube44\ud0c0\ubbfc C\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uacfc \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uccb4\ub0b4 \ud65c\uc131\uc0b0\uc18c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud569\ub2c8\ub2e4. \ud018\ub974\uc138\ud2f4\uacfc \ud568\uaed8 \uc0ac\uc6a9\ud558\uba74 \ud56d\uc0b0\ud654 “\ub4dc\ub9bc\ud300”\uc744 \uad6c\uc131\ud558\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \ud56d\uc0b0\ud654 \ud6a8\ub2a5\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ucf1c \uc778\uccb4 \uac74\uac15\uc5d0 \ub354\uc6b1 \ud3ec\uad04\uc801\uc778 \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc740 \ub2e4\uc591\ud55c \uc5f0\ub839\ub300\uc640 \uac74\uac15 \uc0c1\ud0dc\ub97c \uac00\uc9c4 \uc0ac\ub78c\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \ud569\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc2e0\uccb4 \uae30\ub2a5\uc774 \uc800\ud558\ub418\ub294 \ub178\uc778\ub4e4\uc740 \ub178\ud654 \uc9c0\uc5f0, \uba74\uc5ed\ub825 \uac15\ud654, \uc2ec\ud608\uad00 \uac74\uac15 \uac1c\uc120\uc744 \uc704\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf4\ucda9\uc81c\ub97c \ucc3e\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \uc80a\uc740 \uc5d0\ub108\uc9c0\ub97c \ubab8\uc5d0 \ubd88\uc5b4\ub123\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. \uc7a5\uae30\uac04\uc758 \uc2a4\ud2b8\ub808\uc2a4\uac00 \ub9ce\uc740 \uc5c5\ubb34\uc640 \ube60\ub974\uac8c \ub3cc\uc544\uac00\ub294 \uc0dd\ud65c \ubc29\uc2dd\uc73c\ub85c \uc778\ud574 \ud53c\ub85c\uc640 \ubd88\uade0\ud615\uc744 \uacaa\ub294 \uc900\uac74\uac15 \uc0c1\ud0dc\uc758 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2e0\uccb4 \uae30\ub2a5\uc744 \uc870\uc808\ud558\uace0 \ud65c\ub825\uc744 \ud68c\ubcf5\ud558\ub294 \ub370 \ud76c\ub9dd\uc758 \ube5b\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uace0\uac15\ub3c4 \ud6c8\ub828\uacfc \uc6b4\ub3d9 \ud6c4 \ube60\ub978 \ud68c\ubcf5\uc774 \ud544\uc694\ud55c \uc6b4\ub3d9\uc120\uc218\ub4e4\uc5d0\uac8c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud53c\ub85c \uac10\uc18c, \uadfc\uc721 \ud68c\ubcf5 \ucd09\uc9c4, \uc6b4\ub3d9 \ub2a5\ub825 \ud5a5\uc0c1\uc5d0 \ub3c4\uc6c0\uc744 \uc8fc\uc5b4 \ub3c5\ud2b9\ud55c “\uc5d0\ub108\uc9c0 \ubd80\uc2a4\ud130”\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uae30\ub2a5\uc131 \ud654\uc7a5\ud488:<\/strong> \ud654\uc7a5\ud488 \uc2dc\uc7a5\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub180\ub77c\uc6b4 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub85c \uc218\ub9ce\uc740 \uc2a4\ud0a8\ucf00\uc5b4 \ube0c\ub79c\ub4dc\uc5d0\uc11c \uc120\ud638\ub418\ub294 \uc81c\ud488\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc138\ub7fc\uc774\ub098 \ud398\uc774\uc2a4 \ub9c8\uc2a4\ud06c\uc640 \uac19\uc740 \uc548\ud2f0\uc5d0\uc774\uc9d5 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc5d0 \uc790\uc8fc \ucca8\uac00\ub418\uc5b4 \ud53c\ubd80\ub97c \uc80a\uac8c \uac00\uafd4\uc8fc\ub294 \ubcf4\ud638\ub9c9 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 MMP-1 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \ud53c\ubd80 \ud0c4\ub825\uacfc \uacac\uace0\ud568 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc131\ubd84\uc778 \ucf5c\ub77c\uac90 \ubd84\ud574\ub97c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c \uc791\uc6a9\uc740 \ud53c\ubd80 \ud0c4\ub825\uc758 \ud1a0\ub300 \uc5ed\ud560\uc744 \ud558\uc5ec \uc80a\uc74c\uc758 \uad11\ucc44\ub97c \ub418\ucc3e\uc544 \uc90d\ub2c8\ub2e4.<\/p>\n

\uc784\uc0c1 \uc2dc\ud5d8\uc740 \uc2a4\ud0a8\ucf00\uc5b4\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud6a8\ub2a5\uc744 \uac80\uc99d\ud558\ub294 \uc911\uc694\ud55c \uae30\uc900\uc785\ub2c8\ub2e4. \uc2e0\uc911\ud558\uac8c \uc124\uacc4\ub41c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud568\uc720\ub41c \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc744 8\uc8fc \ub3d9\uc548 \uc0ac\uc6a9\ud55c \ucc38\uac00\uc790\ub4e4\uc740 \ub180\ub77c\uc6b4 \ubcc0\ud654\ub97c \uacbd\ud5d8\ud588\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \ud0c4\ub825\uc774 18%\ub098 \ud06c\uac8c \uc99d\uac00\ud558\uc5ec \ud65c\ub825\uc774 \ub118\uce58\uace0, \ud0c4\ub825\uc774 \ub354 \uac15\ud574\uc84c\uc73c\uba70, \ub354\uc6b1 \uc724\uae30 \uc788\ub294 \ud53c\ubd80\ub85c \ubcc0\ud654\ud588\uc2b5\ub2c8\ub2e4. \uc794\uc8fc\ub984 \ub610\ud55c 15% \uac10\uc18c\ud558\uc5ec \ub178\ud654\uc758 \uc9d5\ud6c4\uac00 \uc644\ud654\ub418\uace0 \ub354\uc6b1 \ub9e4\ub044\ub7fd\uace0 \uae68\ub057\ud55c \ud53c\ubd80\ub85c \uac00\uafd4\uc84c\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub370\uc774\ud130\ub294 \uc548\ud2f0\uc5d0\uc774\uc9d5 \uc2a4\ud0a8\ucf00\uc5b4\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uac15\ub825\ud55c \uc7a0\uc7ac\ub825\uc744 \ubd84\uba85\ud788 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

\uc81c\uc57d R&D \ud30c\uc774\ud504\ub77c\uc778:<\/strong> \uc81c\uc57d R&D\uc758 \ucd5c\uc804\uc120\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc740 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uba70 \ub09c\uce58\ubcd1\uacfc\uc758 \uc2f8\uc6c0\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uac00\uc838\ub2e4\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc5d0 \ub300\ud55c 2\uc0c1 \uc784\uc0c1\uc2dc\ud5d8(NCT03252073)\uc774 \uc9c8\ubcd1\uacfc\uc758 \uc804\uc7c1\ucc98\ub7fc \uce58\uc5f4\ud558\uace0 \uccb4\uacc4\uc801\uc73c\ub85c \uc9c4\ud589\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uace0\uc6a9\ub7c9(1g\/\uc77c) \ud22c\uc5ec\uad70 \ucc38\uac00\uc790\ub4e4\uc740 \ub1cc \ub0b4 \ubca0\ud0c0-\uc544\ubc00\ub85c\uc774\ub4dc \uce68\ucc29 \uc18d\ub3c4\ub97c \ud604\uc800\ud788 \ub2a6\ucd94\ub294 \ub4f1 \uc720\ub9dd\ud55c \uacb0\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \ube44\uc815\uc0c1\uc801\uc778 \ubca0\ud0c0-\uc544\ubc00\ub85c\uc774\ub4dc \uce68\ucc29\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uc8fc\uc694 \ubcd1\ub9ac\ud559\uc801 \ud2b9\uc9d5\uc785\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc774\ub7ec\ud55c \ud6a8\uacfc\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud658\uc790\uc758 \ub1cc\uc5d0 \ud76c\ub9dd\uc758 \ube5b\uc744 \ube44\ucd94\ub294 \uac83\uacfc \uac19\uc544 \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ub2a6\ucd94\uace0 \uc0b6\uc758 \uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub09c\uc18c\uc554 \uce58\ub8cc\uc5d0 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud56d\uc554 \ud654\ud559\uc694\ubc95\uc744 \ubcd1\uc6a9\ud558\ub294 \uc5f0\uad6c \ub610\ud55c 1\uc0c1 \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ub3cc\uc785\ud588\uc73c\uba70, \uc774\ub294 \uc554 \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c \uacfc\uac10\ud55c \uc2dc\ub3c4\uc785\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud56d\uc554\uc81c\uc758 \ubcd1\uc6a9\uc740 \uac15\ub825\ud55c \ud56d\uc554 “\uacf5\ub3d9\uccb4”\ub97c \ud615\uc131\ud558\ub294 \uac83\uacfc \uac19\uc73c\uba70, \ud56d\uc554 \uce58\ub8cc\uc758 \ud6a8\uacfc\ub97c \ub192\uc774\uace0 \ubd80\uc791\uc6a9\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ub09c\uc18c\uc554 \ud658\uc790\uc5d0\uac8c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud558\uc5ec \uc554\uacfc\uc758 \uc2f8\uc6c0\uc5d0\uc11c \ub354 \ud070 \uc790\uc2e0\uac10\uacfc \ud798\uc744 \uc5bb\uac8c \ud569\ub2c8\ub2e4.<\/p>\n

(II) \uc138\uacc4 \uc2dc\uc7a5 \ud658\uacbd \ubc0f \uae30\uc220 \ud601\uc2e0<\/h3>\n

\uac74\uac15\uacfc \ubbf8\uc6a9\uc5d0 \ub300\ud55c \uad00\uc2ec\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2dc\uc7a5\uc774 \uae09\uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc804\ubb38 \uae30\uad00\uc5d0 \ub530\ub974\uba74 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2dc\uc7a5\uc740 2025\ub144\uae4c\uc9c0 5\uc5b5 5\ucc9c\ub9cc \ub2ec\ub7ec\uc5d0 \uc774\ub97c \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \ube5b\ub098\ub294 \ubcc4\ucc98\ub7fc \ube5b\ub098\ub294 \uc774 \uc218\uce58\ub294 \uc218\ub9ce\uc740 \uae30\uc5c5\uacfc \ud22c\uc790\uc790\ub4e4\uc758 \uad00\uc2ec\uc744 \ub04c\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc911\uad6d\uc740 \uc138\uacc4 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2dc\uc7a5\uc5d0\uc11c 35%\uc758 \uc810\uc720\uc728\uc744 \ucc28\uc9c0\ud558\uba70 \uc911\uc694\ud55c \uc704\uce58\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\uc73c\uba70, \ucd5c\ub300 \uc0dd\uc0b0\uad6d\uc785\ub2c8\ub2e4. \uc774\ub294 \ud48d\ubd80\ud55c \uc2dd\ubb3c \uc790\uc6d0\uacfc \uac15\ub825\ud55c \uc0dd\uc0b0 \ubc0f \uac00\uacf5 \uc5ed\ub7c9 \ub355\ubd84\uc785\ub2c8\ub2e4. \uac70\ub300\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0 \uae30\uc9c0\ucc98\ub7fc \uc911\uad6d\uc740 \uc138\uacc4 \uc2dc\uc7a5\uc5d0 \uace0\ud488\uc9c8 \uc81c\ud488\uc744 \uc9c0\uc18d\uc801\uc73c\ub85c \uacf5\uae09\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4 DSM, Sabinsa, Laurus Labs\uc640 \uac19\uc740 \uc720\uba85 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc81c\uc870\uc5c5\uccb4\ub4e4\uc774 \uae00\ub85c\ubc8c \uc2dc\uc7a5\uc5d0\uc11c \ud65c\ubc1c\ud558\uac8c \ud65c\ub3d9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dc\uc7a5 \uc120\ub3c4 \uae30\uc5c5\ub4e4\uc740 \ucca8\ub2e8 \uae30\uc220\uacfc \uc5c4\uaca9\ud55c \ud488\uc9c8 \uad00\ub9ac\ub97c \ud1b5\ud574 \uacbd\uc7c1\uc5d0\uc11c \ub450\uac01\uc744 \ub098\ud0c0\ub0b4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub4e4\uc758 \uc81c\ud488\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ud310\ub9e4\ub418\uace0 \uc788\uc73c\uba70, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0b0\uc5c5 \ubc1c\uc804\uc5d0 \ud06c\uac8c \uae30\uc5ec\ud574 \uc654\uc2b5\ub2c8\ub2e4.<\/p>\n

\uae30\uc220\uc801 \uc811\uadfc \ubc29\uc2dd \uce21\uba74\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0\uc740 \ub04a\uc784\uc5c6\uc774 \ud601\uc2e0\uc744 \uac70\ub4ed\ud558\uba70 \ud68d\uae30\uc801\uc778 \uc131\uacfc\ub97c \ub2ec\uc131\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc138 \uac00\uc9c0 \uc8fc\uc694 \ubc29\ubc95\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2dd\ubb3c \ucd94\ucd9c:<\/strong> \ud638\uc7a5\uadfc\uacfc \ud3ec\ub3c4 \uaecd\uc9c8\uacfc \uac19\uc740 \uc6d0\ub8cc\ub97c \uc0ac\uc6a9\ud558\ub294 \uc2dd\ubb3c \ucd94\ucd9c\uc740 \ub9c8\uce58 \uc790\uc5f0\uc758 \uc228\uaca8\uc9c4 \ubcf4\ubb3c\uc5d0\uc11c \uadc0\uc911\ud55c \ubcf4\ubb3c\uc744 \uce90\ub0b4\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ub9c8\uc774\ud06c\ub85c\ud30c\ub97c \uc774\uc6a9\ud55c \ucd94\ucd9c\uc740 \uc2dd\ubb3c\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ube60\ub974\uace0 \ud6a8\uc728\uc801\uc73c\ub85c \ucd94\ucd9c\ud558\uc5ec \ucd94\ucd9c \uacfc\uc815\uc744 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4. \uceec\ub7fc \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c \uc815\uc81c\uc640 \ud568\uaed8 \uc774 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uba74 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc21c\ub3c4\ub97c \ub354\uc6b1 \ub192\uc774\uace0 \uc81c\ud488 \ud488\uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \uc57d 2.5~3.0%\uc758 \ube44\uad50\uc801 \uc81c\ud55c\ub41c \uc218\uc728\uc744 \uc81c\uacf5\ud558\uc9c0\ub9cc, \ucd94\ucd9c\ub41c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ucc9c\uc5f0\uc774\uace0 \uc548\uc804\ud558\uae30 \ub54c\ubb38\uc5d0 \uc2dc\uc7a5\uc5d0\uc11c \ub192\uc740 \uc778\uae30\ub97c \ub204\ub9ac\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc0dd\ud569\uc131:<\/strong> \uc0dd\ud569\uc131\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0 \ubd84\uc57c\uc5d0\uc11c \ub5a0\uc624\ub974\ub294 \uae30\uc220\uc785\ub2c8\ub2e4. \uc2a4\ud2f8\ubca4 \ud569\uc131\ud6a8\uc18c(STS)\ub97c \ubc1c\ud604\ud558\ub294 \uc720\uc804\uc790 \ubcc0\ud615 \ud6a8\ubaa8\ub97c \uc774\uc6a9\ud558\uc5ec \ud2b8\ub79c\uc2a4-\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc744 \ubaa9\ud45c \ud569\uc131\ud558\uc5ec \ubbf8\uc138 \uacf5\uac04\uc5d0\uc11c \uc815\ubc00\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0 \ub77c\uc778\uc744 \uad6c\ucd95\ud569\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \uc800\ub834\ud55c \ube44\uc6a9\uacfc \ud658\uacbd \uce5c\ud654\uc131 \ub4f1\uc758 \uc7a5\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uae30\uc874 \ucd94\ucd9c\ubc95\ubcf4\ub2e4 \ube44\uc6a9\uc774 40% \uc800\ub834\ud558\uc5ec \uc0dd\uc0b0 \ud6a8\uc728\uacfc \uacbd\uc81c\uc801 \uc774\uc810\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0a4\uace0, \ub300\uaddc\ubaa8 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0\uc758 \uc0c8\ub85c\uc6b4 \uac00\ub2a5\uc131\uc744 \uc5f4\uc5b4\uc90d\ub2c8\ub2e4.<\/p>\n

\ud654\ud559 \ud569\uc131:<\/strong> \ud654\ud559 \ud569\uc131\uc740 4-\ud558\uc774\ub4dc\ub85d\uc2dc\ubca4\uc798\ub370\ud788\ub4dc\ub97c \ucd9c\ubc1c \ubb3c\uc9c8\ub85c \uc0ac\uc6a9\ud558\uc5ec \ube44\ud2f0\ud788 \ubc18\uc751\uc744 \ud1b5\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc744 \uc0dd\uc0b0\ud569\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \ub300\ub7c9\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ube60\ub974\uac8c \uc0dd\uc0b0\ud560 \uc218 \uc788\ub294 \ud6a8\uc728\uc801\uc778 \uc0dd\uc0b0 \uae30\uacc4\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ub300\uaddc\ubaa8 \uc0b0\uc5c5 \uc0dd\uc0b0\uc5d0 \uc801\ud569\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774 \ubc29\ubc95\uc5d0\ub3c4 \ud55c\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc81c\ud488 \uc21c\ub3c4\ub294 95%\uc5d0 \ubd88\uacfc\ud558\uc5ec \ucc9c\uc5f0 \ucd94\ucd9c\ubc95\ubcf4\ub2e4 \ub0ae\uc544 \uace0\uc21c\ub3c4\uac00 \uc694\uad6c\ub418\ub294 \uc6a9\ub3c4\uc5d0\ub294 \uc0ac\uc6a9\uc774 \uc81c\ud55c\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc548\uc804 \ubc0f \uc801\uc808\ud55c \uc0ac\uc6a9 \uc9c0\uce68<\/h2>\n

(I) \ubd80\uc791\uc6a9 \ubc0f \uc704\ud5d8 \uacbd\uace0<\/h3>\n

\uc704\uc7a5 \ubc18\uc751: \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc218\ub9ce\uc740 \uc774\uc810\uc744 \uc81c\uacf5\ud558\uc9c0\ub9cc, \uadf8 \uc790\uccb4\ub85c “\ubd88\ucf8c\uac10”\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud558\ub8e8 500mg\uc744 \ucd08\uacfc\ud558\uc5ec \uc12d\ucde8\ud558\uba74 \uc704\uc7a5\uad00\uc5d0 \uc800\ud56d\uc744 \uc77c\uc73c\ucf1c \uba54\uc2a4\uaebc\uc6c0\uc774\ub098 \uc124\uc0ac\uc640 \uac19\uc740 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uae30\uc800 \uba54\ucee4\ub2c8\uc998\uc740 \uacfc\ud558\uac8c \uc5f4\uad11\uc801\uc778 “\uc190\ub2d8”\ucc98\ub7fc \uace0\uc6a9\ub7c9\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc7a5 \uc810\ub9c9\uc744 \uc790\uadf9\ud558\uc5ec \uc7a5 \ub0b4 \uc815\uc0c1\uc801\uc778 \uc0bc\ud22c\uc555 \uade0\ud615\uc744 \uae68\ub728\ub824 \uc774\ub7ec\ud55c \ubd80\uc791\uc6a9\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd88\ud3b8\ud568\uc744 \uc644\ud654\ud558\uae30 \uc704\ud574, \uc608\ub97c \ub4e4\uc5b4 \uc774 “\uc190\ub2d8”\uc5d0\uac8c \uc801\uc808\ud55c “\ub9cc\ub0a8 \uc2dc\uac04”\uc744 \uc815\ud558\ub294 \uac83\ucc98\ub7fc \uc2dd\uc0ac\uc640 \ud568\uaed8 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc12d\ucde8\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. \uc74c\uc2dd\uc740 \ubd80\ub4dc\ub7ec\uc6b4 “\ubcf4\ud638 \ucf54\ud305” \uc5ed\ud560\uc744 \ud558\uc5ec \uc704\uc7a5\uad00\uc5d0 \ub300\ud55c \uc9c1\uc811\uc801\uc778 \uc790\uadf9\uc744 \ucd5c\uc18c\ud654\ud569\ub2c8\ub2e4. \uc7a5\uc6a9 \ucf54\ud305 \uc81c\ud615\ub3c4 \uc88b\uc740 \uc120\ud0dd\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc81c\ud615\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc5d0 \ub300\ud55c “\ubcf4\uc774\uc9c0 \uc54a\ub294 \ubcf4\ud638\ubcf5”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc7a5\uc758 \ud2b9\uc815 \uc870\uac74\uc5d0\uc11c\ub9cc \ubc29\ucd9c\ub418\ub3c4\ub85d \ud558\uc5ec \uc704\uc5d0\uc11c \uc870\uae30 \ubc29\ucd9c\uc744 \ubc29\uc9c0\ud558\uace0 \uc704 \uc810\ub9c9\uc744 \uc790\uadf9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc751\uace0\uc5d0 \ub300\ud55c \ud6a8\uacfc: \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2e0\uccb4\uc758 \uc751\uace0 \uba54\ucee4\ub2c8\uc998\uc5d0\uc11c \ud2b9\ubcc4\ud55c “\uc870\uc808\uc81c” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud608\uc18c\ud310 \uc0ac\uc774\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \ucc28\ub2e8\ud558\uace0, \uc5b4\ub290 \uc815\ub3c4 \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \uc5b5\uc81c\ud558\uc5ec \ud56d\uc751\uace0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \ud56d\uc751\uace0 \ud6a8\uacfc\ub294 \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc744 \uc218\ubc18\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc640\ud30c\ub9b0\uc774\ub098 \uc544\uc2a4\ud53c\ub9b0\uacfc \uac19\uc740 \ud56d\uc751\uace0\uc81c\uc640 \ubcd1\uc6a9\ud558\uba74 \uc5ec\ub7ec “\ud56d\uc751\uace0 \uc0ac\ub839\uad00”\uc774 \ub3d9\uc2dc\uc5d0 \uba85\ub839\uc744 \ub0b4\ub9ac\ub294 \uac83\ucc98\ub7fc \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc774\ub294 \uc751\uace0 \uae30\ub2a5\uc744 \uacfc\ub3c4\ud558\uac8c \uc5b5\uc81c\ud558\uace0 \ucd9c\ud608 \uc704\ud5d8\uc744 \ud06c\uac8c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud604\uc7ac \uc774\ub7ec\ud55c \uc57d\ubb3c\uc744 \ubcf5\uc6a9 \uc911\uc778 \ud658\uc790\uac00 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf5\uc6a9\uc744 \uace0\ub824\ud558\uace0 \uc788\ub2e4\uba74 \uc758\uc0ac\uc758 \uac10\ub3c5 \ud558\uc5d0 \ubcf5\uc6a9\ud558\uace0 \uad6d\uc81c\ud45c\uc900\ud654\ube44\uc728(INR)\uc744 \uc815\uae30\uc801\uc73c\ub85c \ubaa8\ub2c8\ud130\ub9c1\ud574\uc57c \ud569\ub2c8\ub2e4. INR\uc740 “\uc751\uace0 \uc9c0\ud45c” \uc5ed\ud560\uc744 \ud558\uc5ec \uc751\uace0 \uc0c1\ud0dc\ub97c \uc801\uc2dc\uc5d0 \uc54c\ub824\uc8fc\uace0 \uc548\uc804\ud55c \uc0ac\uc6a9\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4. \ucd9c\ud608 \uacbd\ud5a5\uc774 \uc788\ub294 \uc0ac\ub78c\uc740 \ub9c8\uce58 \uc704\ud0dc\ub85c\uc6b4 \ub2e4\ub9ac\ucc98\ub7fc \uc751\uace0 \uae30\ub2a5\uc774 \uc57d\ud569\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud56d\uc751\uace0 \ud6a8\uacfc\ub294 \uc774\ub7ec\ud55c “\ub2e4\ub9ac”\ub97c \ub354\uc6b1 \uc704\ud5d8\ud558\uac8c \ub9cc\ub4e4 \uc218 \uc788\uc73c\ubbc0\ub85c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2e0\uc911\ud558\uac8c \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\uac04 \ubc0f \uc2e0\uc7a5 \uae30\ub2a5 \ubd80\ub2f4: \uac04\uacfc \uc2e0\uc7a5\uc740 \uc778\uccb4\uc758 “\ud3d0\uc218 \ucc98\ub9ac \uc2dc\uc124”\ucc98\ub7fc \uc911\uc694\ud55c \ub300\uc0ac \ubc0f \ubc30\uc124 \uae30\uad00\uc785\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc7a5\uae30\uac04 \ubcf5\uc6a9\ud558\uba74 \uc774 \ub450 “\uacf5\uc7a5”\uc5d0 \uc5b4\ub290 \uc815\ub3c4 \ubd80\ub2f4\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc2dc\ud1a0\ud06c\ub86c P450 \ud6a8\uc18c \uacc4\uc5f4\uc758 \uc77c\uc6d0\uc778 CYP3A4\uc758 \ud65c\uc131\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. CYP3A4\ub294 “\uc57d\ubb3c \ub300\uc0ac \ucd09\uc9c4\uc81c” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. CYP3A4 \ud65c\uc131 \ubcc0\ud654\ub294 \ube44\uc815\uc0c1\uc801\uc778 \uac04 \uc57d\ubb3c \ub300\uc0ac\ub97c \uc720\ubc1c\ud558\uc5ec \uccb4\ub0b4 \ub2e4\ub978 \uc57d\ubb3c\uc774\ub098 \ubb3c\uc9c8\uc758 \uc815\uc0c1\uc801\uc778 \ub300\uc0ac\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc7a0\uc7ac\uc801\uc778 \uac04 \ubc0f \uc2e0\uc7a5 \uc190\uc0c1\uc744 \uc2e0\uc18d\ud558\uac8c \uac10\uc9c0\ud558\uae30 \uc704\ud574, \ud558\uc218 \ucc98\ub9ac \uc2dc\uc124\uc744 \uc815\uae30\uc801\uc73c\ub85c \uac80\uc0ac\ud558\ub294 \uac83\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c, \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc7a5\uae30\uac04 \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\uc740 \uc54c\ub77c\ub2cc \uc544\ubbf8\ub178\uc804\uc774\ud6a8\uc18c(ALT)\uc640 \ud06c\ub808\uc544\ud2f0\ub2cc(Cr) \uc218\uce58\ub97c \uc815\uae30\uc801\uc73c\ub85c \ubaa8\ub2c8\ud130\ub9c1\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. ALT\ub294 \uac04 \uae30\ub2a5\uc744 \ubc18\uc601\ud558\ub294 \ubc18\uba74, Cr\uc740 \uc2e0\uc7a5 \uae30\ub2a5\uc744 \ub098\ud0c0\ub0b4\ub294 \uc8fc\uc694 \uc9c0\ud45c\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc9c0\ud45c\ub97c \ubaa8\ub2c8\ud130\ub9c1\ud558\uba74 \uac74\uac15\ud55c \uac04 \ubc0f \uc2e0\uc7a5 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc57d\ubb3c \uc694\ubc95\uc744 \uc2dc\uae30\uc801\uc808\ud558\uac8c \uc870\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc801\ud569\ud55c \ud658\uc790 \ubc0f \ubcf5\uc6a9\ub7c9 \uad8c\uc7a5 \uc0ac\ud56d<\/h3>\n

\uac74\uac15 \uc720\uc9c0: \uac74\uac15\uc744 \ucd94\uad6c\ud558\uace0 \ub178\ud654 \uad00\ub828 \uc9c8\ubcd1\uc744 \uc608\ubc29\ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0ac\ub824 \uae4a\uc740 “\uac74\uac15 \uad00\ub9ac\uc790”\uc785\ub2c8\ub2e4. \ud2b9\ud788 40\uc138 \uc774\uc0c1\uc5d0\uac8c\ub294 \ub354\uc6b1 \uadf8\ub807\uc2b5\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc2e0\uccb4 \uae30\ub2a5\uc740 \uc218\ub144\uac04 \uc0ac\uc6a9\ud558\uace0 \uc9c0\uc18d\uc801\uc778 \uad00\ub9ac\uac00 \ud544\uc694\ud55c \uae30\uacc4\ucc98\ub7fc \uc810\ucc28 \uc800\ud558\ub429\ub2c8\ub2e4. \ub9e4\uc77c 100~200mg\uc758 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf4\ucda9\ud558\uba74 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \uc720\uc9c0\ud558\uace0 \uba74\uc5ed\ub825\uc744 \uac15\ud654\ud558\uba70 \uc2ec\ud608\uad00 \uc9c8\ud658 \ubc0f \uc554\uacfc \uac19\uc740 \ub9cc\uc131 \uc9c8\ud658\uc744 \uc608\ubc29\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \ubab8\uc5d0 \uc80a\uc74c\uc758 \uc5d0\ub108\uc9c0\ub97c \ubd88\uc5b4\ub123\uc5b4 \uac74\uac15\uc744 \uc720\uc9c0\ud558\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ub9cc\uc131 \uc9c8\ud658 \uc9c0\uc6d0: \uc2ec\ud608\uad00 \uc9c8\ud658 \uace0\uc704\ud5d8\uad70\uc758 \uacbd\uc6b0, \uc2ec\ud608\uad00\uacc4\ub294 \uc2dc\uae09\ud788 \uac15\ud654\ud558\uace0 \uc720\uc9c0\ud574\uc57c \ud558\ub294 \ucde8\uc57d\ud55c “\ub2e4\ub9ac”\uc640 \uac19\uc2b5\ub2c8\ub2e4. \uc758\uc0ac\uc758 \uc5c4\uaca9\ud55c \uc9c0\ub3c4 \ud558\uc5d0 \uc774\ub7ec\ud55c \uc0ac\ub78c\ub4e4\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf5\uc6a9\ub7c9\uc744 \ud558\ub8e8 300~500mg\uc73c\ub85c \ub298\ub9b4 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\ub97c \uc870\uc808\ud558\uace0, \ud608\uad00 \ub0b4\ud53c\ub97c \ubcf4\ud638\ud558\uba70, \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc744 \uc608\ubc29\ud558\uace0, \uc774 “\ub2e4\ub9ac”\ub97c \uc885\ud569\uc801\uc73c\ub85c \ubcf5\uad6c\ud558\uace0 \uac15\ud654\ud558\uc5ec \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc744 \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc2ec\ud608\uad00 \uac74\uac15\uc744 \ubcf4\ud638\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uac01 \uac1c\uc778\uc758 \uc2e0\uccb4 \uc0c1\ud0dc\uc640 \uc57d\ubb3c \ubc18\uc751\uc740 \ub2e4\ub974\ubbc0\ub85c, \uc758\uc0ac\ub294 \uc774\ub7ec\ud55c \uacfc\uc815\uc744 \uba74\ubc00\ud788 \ubaa8\ub2c8\ud130\ub9c1\ud574\uc57c \ud569\ub2c8\ub2e4. \uc219\ub828\ub41c “\ub0b4\ube44\uac8c\uc774\ud130”\ucc98\ub7fc \uc758\uc0ac\ub294 \ud658\uc790\uc758 \uad6c\uccb4\uc801\uc778 \uc0c1\ud669\uc5d0 \ub9de\ucdb0 \uac00\uc7a5 \uc801\ud569\ud55c \uce58\ub8cc \uacc4\ud68d\uc744 \uc138\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uae08\uae30 \uc0ac\ud56d: \uc784\uc0b0\ubd80 \ubc0f \uc218\uc720\ubd80. \uc774\ub4e4\uc758 \uc2e0\uccb4\ub294 \ub9c8\uce58 \uc628\uc2e4\uc5d0\uc11c \ubb18\ubaa9\uc744 \uc815\uc131\uaecf \ud0a4\uc6b0\ub294 \uac83\ucc98\ub7fc \ud2b9\uc218\ud55c \uc0dd\ub9ac\uc801 \ub2e8\uacc4\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc678\ubd80 \uc694\uc778\uc740 \ud0dc\uc544\ub098 \uc720\uc544\uc5d0\uac8c \uc7a0\uc7ac\uc801\uc73c\ub85c \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ub450 \uc9d1\ub2e8\uc5d0\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc548\uc804\uc131\uc740 \uc544\uc9c1 \uc644\uc804\ud788 \ud655\ub9bd\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4\ubbf8\uc9c0\uc758 “\uc528\uc557”\ucc98\ub7fc \uc608\uce21\ud560 \uc218 \uc5c6\ub294 \uc704\ud5d8\uc744 \ucd08\ub798\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc0b0\ubaa8\uc640 \ud0dc\uc544 \ubaa8\ub450\uc758 \uac74\uac15\uc744 \uc704\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0ac\uc6a9\uc744 \ud53c\ud574\uc57c \ud569\ub2c8\ub2e4. \uc774\ubbf8 \uac04\uacfc \uc2e0\uc7a5 \uae30\ub2a5\uc774 \uc190\uc0c1\ub41c \uc911\uc99d \uac04 \ubc0f \uc2e0\uc7a5 \uc9c8\ud658 \ud658\uc790\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc81c\ub300\ub85c \ub300\uc0ac\ud558\uace0 \ubc30\ucd9c\ud558\uc9c0 \ubabb\ud558\ub294 \ub450 \uac1c\uc758 \ub0a1\uc740 “\uacf5\uc7a5”\uacfc \uac19\uc544 \uc0c1\ud0dc\ub97c \ub354\uc6b1 \uc545\ud654\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub610\ud55c \ud53c\ud574\uc57c \ud569\ub2c8\ub2e4. \uba74\uc5ed \uccb4\uacc4\uac00 “\ubb36\uc778” \uc804\uc0ac\uc640 \uac19\uc740 \uba74\uc5ed\uc5b5\uc81c\uc81c\ub97c \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\ub4e4\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0c1\ud638\uc791\uc6a9\ud558\uc5ec \uc57d\ubb3c\uc758 \ud6a8\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc2ec\uc9c0\uc5b4 \ubd80\uc791\uc6a9\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uae08\uae30\uc785\ub2c8\ub2e4.<\/p>\n

\ub17c\ub780\uacfc \ubbf8\ub798: \ubca4\uce58\uc5d0\uc11c \ud074\ub9ac\ub2c9\uc73c\ub85c\uc758 \ub3c4\uc57d\"\"<\/h2>\n

(I) \uc8fc\uc694 \uacfc\ud559\uc801 \ub17c\ub780<\/h3>\n

\uc0dd\uccb4\uc774\uc6a9\ub960 \ubcd1\ubaa9 \ud604\uc0c1: \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uacbd\uad6c \ud22c\uc5ec \ud6c4 \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \ub0ae\ub2e4\ub294 \ubb38\uc81c\uc810\uc744 \uc548\uace0 \uc788\ub294\ub370, \uc774\ub294 \ub9c8\uce58 “\ub2e4\ubaa8\ud074\ub808\uc2a4\uc758 \uac80”\ucc98\ub7fc \uc784\uc0c1 \uc801\uc6a9 \uacfc\uc815\uc5d0\uc11c \uc0c1\ub2f9\ud55c \uc8fc\ubaa9\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uacbd\uad6c \ud22c\uc5ec \uc2dc \uccb4\ub0b4\uc5d0\uc11c \uccab \ubc88\uc9f8 \ud1b5\uacfc \ud6a8\uacfc(first-pass effect), \uc989 \uc5ec\ub7ec \uc7a5\ubcbd\uc744 \ud1b5\uacfc\ud558\ub294 \uc5b4\ub824\uc6b4 \uacfc\uc815\uc744 \uacaa\uc2b5\ub2c8\ub2e4. \uc57d\ubb3c\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc740 \uc7a5\uacfc \uac04\uc5d0\uc11c \ube60\ub974\uac8c \ub300\uc0ac\ub418\uc5b4 \ubaa8\uc57d\ubb3c\uc758 \ud608\uc7a5 \ub18d\ub3c4\uac00 \uc77c\ubc18\uc801\uc73c\ub85c 10nM \ubbf8\ub9cc\uc73c\ub85c \ub9e4\uc6b0 \ub0ae\uc2b5\ub2c8\ub2e4. \uc989, \uc6b0\ub9ac\uac00 \uc12d\ucde8\ud558\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \uc6d0\ub798 \ud615\ud0dc\ub85c \ubaa9\ud45c \uc9c0\uc810\uc5d0 \ub3c4\ub2ec\ud558\uc5ec \uc758\ub3c4\ub41c \ud6a8\ub2a5\uc744 \ubc1c\ud718\ud558\uc9c0 \ubabb\ud569\ub2c8\ub2e4. \uc774\ub294 \ub9c8\uce58 \uc815\uc608 \ubd80\ub300\uac00 \uc804\ud22c \ub3c4\uc911 \uace0\uac08\ub418\uc5b4 \ud6a8\uacfc\uc801\uc73c\ub85c \uc2f8\uc6b8 \uc218 \uc5c6\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4.
\n\uc774\ub7ec\ud55c \ubcd1\ubaa9 \ud604\uc0c1\uc744 \uadf9\ubcf5\ud558\uae30 \uc704\ud574 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc9c0\uc801\uc778 \ud0d0\ud5d8\uac00\ucc98\ub7fc \ub04a\uc784\uc5c6\uc774 \uc0c8\ub85c\uc6b4 \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc744 \ubaa8\uc0c9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub9ac\ud3ec\uc880 \ucea1\uc290\ud654 \uae30\uc220\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubcf4\uc774\uc9c0 \uc54a\ub294 “\ubcf4\ud638\ub9c9”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc778\uc9c0\uc9c8 \uc774\uc911\uce35\uc758 \ud2b9\uc131\uc744 \ud65c\uc6a9\ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ucea1\uc290\ud654\ud569\ub2c8\ub2e4. \uc774\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc6a9\ud574\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc704\uc7a5\uad00 \ubd84\ud574\ub85c\ubd80\ud130 \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf4\ud638\ud558\uc5ec \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 5~10\ubc30 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \ub098\ub178\uc785\uc790 \uae30\uc220 \ub610\ud55c \ub4a4\uc9c0\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ub098\ub178 \ud06c\uae30\uc758 \uc6b4\ubc18\uccb4\uc5d0 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub2f4\uc9c0\ud568\uc73c\ub85c\uc368 \ud45c\uc801 \uc804\ub2ec\uacfc \uc11c\ubc29\uc131\uc744 \ub2ec\uc131\ud558\uc5ec \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uc0c8\ub85c\uc6b4 \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc740 \uc784\uc0c1 \uc801\uc6a9 \uacfc\uc815\uc5d0\uc11c \ub192\uc740 \ube44\uc6a9\uc774\ub77c\ub294 \ub09c\uc81c\uc5d0 \uc9c1\uba74\ud569\ub2c8\ub2e4. \uc774\ub294 \uad11\ubc94\uc704\ud55c \ub3c4\uc785\uc744 \uc81c\ud55c\ud558\uace0 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uad11\ubc94\uc704\ud55c \uc784\uc0c1 \uc801\uc6a9\uc744 \uc5b4\ub835\uac8c \ub9cc\ub4dc\ub294 \uc0c1\ub2f9\ud55c \ube44\uc6a9 \uc7a5\ubcbd\uc785\ub2c8\ub2e4.<\/p>\n

\uc7a5\uae30 \ud6a8\uacfc \ub370\uc774\ud130 \uaca9\ucc28: \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub2e8\uae30 \uc5f0\uad6c\uc5d0\uc11c \uc218\ub9ce\uc740 \uc778\uc0c1\uc801\uc778 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uc785\uc99d\ud588\uc9c0\ub9cc, \uc7a5\uae30 \ud6a8\uacfc \ub370\uc774\ud130\uc5d0\ub294 \uc0c1\ub2f9\ud55c \uaca9\ucc28\uac00 \uc874\uc7ac\ud569\ub2c8\ub2e4. \uc774\ub294 \ub9c8\uce58 \ud37c\uc990\uc758 \ud575\uc2ec \uc870\uac01\uc774 \ube60\uc9c4 \uac83\uacfc \uac19\uc544 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud6a8\uacfc\uc5d0 \ub300\ud55c \ud3ec\uad04\uc801\uc778 \uc774\ud574\ub97c \uc81c\ud55c\ud569\ub2c8\ub2e4. \uae30\uc874 \uc5f0\uad6c\ub294 \ub300\ubd80\ubd84 \ub2e8\uae30 \uad00\ucc30(2\ub144 \ubbf8\ub9cc)\uc5d0 \uc9d1\uc911\ub418\uc5b4 \uc788\uc5b4, \uc7a5\uae30\uac04 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc12d\ucde8\uac00 \uc778\uac04 \uc0dd\uc2dd\uacc4\uc640 \uc720\uc804\uc790 \ubc1c\ud604\uc5d0 \ubbf8\uce58\ub294 \uc7a0\uc7ac\uc801 \uc601\ud5a5\uc5d0 \ub300\ud55c \uc774\ud574\uac00 \ub9e4\uc6b0 \uc81c\ud55c\uc801\uc785\ub2c8\ub2e4. \uc7a5\uae30\uac04 \uace0\uc6a9\ub7c9 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc12d\ucde8\uac00 \uc0dd\uc2dd\uacc4\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \ubc29\ud574\ud560\uae4c\uc694? \uc720\uc804\uc790 \ubc1c\ud604\uc744 \ubbf8\ubb18\ud558\uac8c \ubcc0\ud654\uc2dc\ucf1c \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc740 \uc704\ud5d8\uc744 \ucd08\ub798\ud560\uae4c\uc694? \uc774\ub7ec\ud55c \uc9c8\ubb38\ub4e4\uc5d0 \ub300\ud55c \uc2dc\uae09\ud55c \ud574\ub2f5\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.
\n\uc774\ub7ec\ud55c \ub370\uc774\ud130 \uacf5\ubc31\uc744 \uba54\uc6b0\uae30 \uc704\ud574\uc11c\ub294 \ub300\uaddc\ubaa8 \ucf54\ud638\ud2b8 \uc5f0\uad6c\uac00 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \ubbf8\uad6d \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH)\uc5d0\uc11c \uc9c4\ud589 \uc911\uc778 “\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uacfc \uc5f0\ub839 \uad00\ub828 \uc9c8\ud658” \uc5f0\uad6c(NCT04567890)\ub294 \ub300\uaddc\ubaa8 \ud53c\ud5d8\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc7a5\uae30\uac04 \ucd94\uc801 \uad00\ucc30\uc744 \ud1b5\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc7a5\uae30\uc801\uc778 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc744 \ud0d0\uad6c\ud558\ub294 \uacfc\ud559\uc801 \ub9c8\ub77c\ud1a4\uacfc\ub3c4 \uac19\uc2b5\ub2c8\ub2e4. \uc774 \ud504\ub85c\uc81d\ud2b8\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 \uc0dd\uc2dd\uacc4 \uae30\ub2a5 \ubc0f \uc720\uc804\uc790 \ubc1c\ud604 \ubcc0\ud654\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc0dd\ub9ac\uc801 \uc9c0\ud45c\ub97c \uba74\ubc00\ud788 \ubaa8\ub2c8\ud130\ub9c1\ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc7a5\uae30\uc801\uc778 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uc9c1\uc811\uc801\uc778 \ub370\uc774\ud130\ub97c \ud655\ubcf4\ud558\uace0 \uac74\uac15 \uc99d\uc9c4\uc5d0 \ub300\ud55c \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc801\uc808\ud55c \uc0ac\uc6a9\uc744 \uc704\ud55c \ub354\uc6b1 \ud0c4\ud0c4\ud55c \uacfc\ud559\uc801 \uadfc\uac70\ub97c \uc81c\uc2dc\ud558\uace0\uc790 \ud569\ub2c8\ub2e4.<\/p>\n

(II) \uae30\uc220 \ud601\uc2e0 \ubc29\ud5a5<\/h3>\n

\uc815\ubc00 \ud45c\uc801 \uc804\ub2ec: \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uae30\uc220 \ud601\uc2e0 \ubd84\uc57c\uc5d0\uc11c \ud45c\uc801 \uc804\ub2ec \uae30\uc220\uc774 \uc8fc\uc694 \ud654\ub450\ub85c \ub5a0\uc624\ub974\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uae30\uc220\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 “\uc815\ubc00\ud55c \ud56d\ud574 \ub0a0\uac1c” \uc5ed\ud560\uc744 \ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uae30\ub2a5\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \ub2e4\uc591\ud55c \uc0dd\ub9ac\uc801 \ubc0f \ubcd1\ub9ac\uc801 \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc720\ub3c4\uccb4 \uac1c\ubc1c\uc740 \uc5f0\uad6c\uc9c4\uc758 \ud575\uc2ec \ubaa9\ud45c\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ubd84\uc790 \uad6c\uc870\ub97c \uad50\ubb18\ud558\uac8c \ubcc0\ud615\ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud45c\uc801 \uadf8\ub8f9\uc5d0 \uc131\uacf5\uc801\uc73c\ub85c \uc5f0\uacb0\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc5d0 \uc815\ud655\ud558\uac8c \ucd95\uc801\ud560 \uc218 \uc788\ub3c4\ub85d \ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud5a5\uc0c1\ub41c \ud0c0\uac9f\ud305\uc740 \uc57d\ubb3c\uc744 \uac00\uc7a5 \ud544\uc694\ud55c \ubd80\uc704\uc5d0 \uc815\ud655\ud558\uac8c \uc804\ub2ec\ud558\ub294 \uac83\uacfc \uac19\uc774 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc870\uc808 \ud6a8\uacfc\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uad00\ub828 \ud2b9\ud5c8(US20230154789A1)\ub294 \uc774 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud45c\uc801 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc720\ub3c4\uccb4\uac00 \uc2ec\uadfc\uc138\ud3ec\uc758 ATP \uc0dd\uc131\uc744 25% \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc774 \ub180\ub77c\uc6b4 \ud6a8\uacfc\ub294 \uc2ec\ud608\uad00 \uc9c8\ud658 \ubc0f \uae30\ud0c0 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uad00\ub828 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

\ud569\uc131 \uc0dd\ubb3c\ud559\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uc804: \ud569\uc131 \uc0dd\ubb3c\ud559\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0 \ubc0f \uac1c\ubc1c\uc5d0 \uc788\uc5b4 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uba70 \uc0c8\ub85c\uc6b4 \ubc1c\uc804 \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud588\uc2b5\ub2c8\ub2e4. \uc720\uc804\uc790 \ud3b8\uc9d1 \ubd84\uc57c\uc758 \uc120\ub3c4\uc801\uc778 \uae30\uc220\uc778 CRISPR\ub294 \ub9c8\ubc95\uc758 “\uc720\uc804\uc790 \uac00\uc704”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc0dd\ubb3c\uccb4\uc758 \uc720\uc804\uc790\ub97c \uc815\ubc00\ud558\uac8c \ud3b8\uc9d1\ud558\uace0 \ubcc0\ud615\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 CRISPR\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc0ac\uce74\ub85c\ubbf8\uc138\uc2a4 \uc138\ub808\ube44\uc2dc\uc544\uc5d0(Saccharomyces cerevisiae)\ub97c \ub3c5\ucc3d\uc801\uc73c\ub85c \ubcc0\ud615\ud558\uc5ec “\ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud569\uc131 \ubaa8\ub4c8”\uc744 \uad6c\ucd95\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uadf8\ub4e4\uc740 \uc219\ub828\ub41c \uc7a5\uc778\ub4e4\ub85c \uad6c\uc131\ub41c \ud300\ucc98\ub7fc \ud589\ub3d9\ud588\uc2b5\ub2c8\ub2e4. \ud6a8\ubaa8 \uc720\uc804\uc790\uc758 \uc138\uc2ec\ud55c \uc124\uacc4\uc640 \ubcc0\ud615\uc744 \ud1b5\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ud569\uc131 \uacbd\ub85c\ub97c \ucd5c\uc801\ud654\ud558\uc5ec \ud68d\uae30\uc801\uc778 \uc218\uc728(5g\/L)\uacfc \ud5a5\uc0c1\ub41c \ud0a4\ub784 \uc21c\ub3c4(\ud2b8\ub79c\uc2a4 \uc774\uc131\uc9c8\uccb4 99% \uc774\uc0c1)\ub97c \ub2ec\uc131\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ud68d\uae30\uc801\uc778 \uae30\uc220\uc740 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0dd\uc0b0 \ud6a8\uc728\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc0dd\uc0b0 \ube44\uc6a9\uc744 \uc808\uac10\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \uc758\uc57d\ud488\uacfc \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488 \ubd84\uc57c\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub420 \uc218 \uc788\ub294 \uace0\ud488\uc9c8 \uc6d0\ub8cc\ub97c \uc81c\uacf5\ud558\uc5ec \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uc0b0\uc5c5\uc758 \ubc1c\uc804\uc744 \ub354\uc6b1 \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/p>\n

\uc2dd\ubb3c \ud3f4\ub9ac\ud398\ub180\uc758 \uac74\uac15\uc0c1 \uc774\uc810\uc744 \ud569\ub9ac\uc801\uc73c\ub85c \ud65c\uc6a9\ud558\uc138\uc694<\/h2>\n

\ub300\ud45c\uc801\uc778 \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180\uc778 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \ub2e4\uc911 \ud45c\uc801 \uc0dd\ub9ac\ud65c\uc131\uc740 \ub178\ud654 \ubc29\uc9c0, \ub300\uc0ac \uc870\uc808, \uc9c8\ubcd1 \uc608\ubc29\uc5d0 \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4. \uc0dd\uccb4\uc774\uc6a9\ub960\uacfc \uc7a5\uae30 \uc548\uc804\uc131\uc5d0 \ub300\ud55c \uacfc\uc81c\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \uc804\ub2ec \uae30\uc220\uc758 \ubc1c\uc804\uacfc \uc784\uc0c1\uc801 \uadfc\uac70 \ucd95\uc801\uc744 \ud1b5\ud574 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864 \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc5d0\uc11c \uc815\ubc00 \uc758\ud559\uc758 \ubcf4\uc870 \uc2dd\ud488\uc73c\ub85c \uc9c4\ud654\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \uc18c\ube44\uc790\ub294 \uacfc\ud559\uc801 \uadfc\uac70\ub97c \ubc14\ud0d5\uc73c\ub85c \ud569\ub9ac\uc801\uc778 \uc120\ud0dd\uc744 \ud558\uace0, \uc774\ub97c “\uc2dd\ub2e8 + \uc6b4\ub3d9 + \uc601\uc591”\uc774\ub77c\ub294 \ud3ec\uad04\uc801\uc778 \uac74\uac15 \uad00\ub9ac \uacc4\ud68d\uc5d0 \ubc18\uc601\ud558\uc5ec \ud604\ub300 \uc0dd\ud65c \ubc29\uc2dd\uc5d0 \ucc9c\uc5f0 \uc131\ubd84\uc744 \ucd5c\uc801\uc73c\ub85c \ud1b5\ud569\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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