{"id":2859,"date":"2025-10-21T02:24:45","date_gmt":"2025-10-21T02:24:45","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2859"},"modified":"2025-10-21T02:24:45","modified_gmt":"2025-10-21T02:24:45","slug":"dim-%ec%8b%9d%eb%ac%bc%ec%84%b1-%ec%9b%90%eb%a3%8c%ec%9d%98-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80-%ed%9a%a8%ea%b3%bc%ec%97%90-%eb%8c%80%ed%95%9c-%ea%b3%bc%ed%95%99","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/dim-%ec%8b%9d%eb%ac%bc%ec%84%b1-%ec%9b%90%eb%a3%8c%ec%9d%98-%ec%83%88%eb%a1%9c%ec%9a%b4-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80-%ed%9a%a8%ea%b3%bc%ec%97%90-%eb%8c%80%ed%95%9c-%ea%b3%bc%ed%95%99\/","title":{"rendered":"DIM: \uc2dd\ubb3c\uc131 \uc6d0\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uacfc\ud559\uc801 \ud574\ub3c5"},"content":{"rendered":"

DIM(3,3′-\ub514\uc778\ub3cc\ub9b4\uba54\ud0c4, DIM)\uc740 \ud654\ud559\uc801\uc73c\ub85c \ubd84\uc790\uc2dd C\u2081\u2087H\u2081\u2084N\u2082\uc744 \uac16\ub294 \uc720\uae30 \ud654\ud569\ubb3c\uc774\uba70, \ubd84\uc790\ub7c9\uc740 246.31\uc785\ub2c8\ub2e4. \uba54\ud2f8\ub80c\uae30\ub85c \uad50\ubb18\ud558\uac8c \uc5f0\uacb0\ub41c \ub450 \uac1c\uc758 \uc778\ub3cc \uace0\ub9ac\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\uc73c\uba70, \uc774 \ub3c5\ud2b9\ud55c \uad6c\uc870\ub294 \ub6f0\uc5b4\ub09c \ud654\ud559\uc801 \ud65c\uc131\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774\uc131\uc9c8\uccb4 \uc911 \ud2b8\ub79c\uc2a4 \uc774\uc131\uc9c8\uccb4\ub9cc\uc774 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c0\ubbc0\ub85c \uc5f0\uad6c \ubc0f \uc751\uc6a9 \ubd84\uc57c\uac00 \ub354\uc6b1 \uc9d1\uc911\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc21c\uc218\ud55c DIM\uc740 \ud770\uc0c9 \uacb0\uc815\uc131 \ubd84\ub9d0\ub85c, \uc21c\uc218\ud558\uace0 \uc12c\uc138\ud55c \uc678\uad00\uc744 \uc790\ub791\ud569\ub2c8\ub2e4. \ubb3c\uc5d0\ub294 \uc57d\uac04 \uc6a9\ud574\ub418\uc5b4 25\u00b0C\uc5d0\uc11c \ub9ac\ud130\ub2f9 0.12g\ub9cc \uc6a9\ud574\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \uc218\uc6a9\uc561 \uc2dc\uc2a4\ud15c\uc5d0\uc11c\uc758 \uc751\uc6a9\uc740 \uc81c\ud55c\uc801\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 DMSO\ub098 \ud074\ub85c\ub85c\ud3ec\ub984\uacfc \uac19\uc740 \uc720\uae30 \uc6a9\ub9e4\uc5d0\ub294 \uc6a9\ud574\ub3c4\uac00 \uc6b0\uc218\ud558\uc5ec \ube60\ub974\uac8c \ubd84\uc0b0\ub418\uace0 \uade0\uc77c\ud558\uac8c \ud63c\ud569\ub418\uc5b4 \uc720\uae30 \ud569\uc131 \ubc0f \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \uc751\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub179\ub294\uc810\uc740 167\u00b0C\uc774\uba70, \uc774 \uc628\ub3c4\uc5d0 \ub3c4\ub2ec\ud558\uba74 DIM\uc740 \uace0\uccb4\uc5d0\uc11c \uc561\uccb4\ub85c \ubcc0\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub179\ub294\uc810 \ud2b9\uc131\uc740 \ubb3c\uc9c8\uc758 \ubd84\ub9ac, \uc815\uc81c \ubc0f \ud488\uc9c8 \uad00\ub9ac\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc548\uc815\uc131\uc740 pH\uc640 \ube5b \ub178\ucd9c\uc5d0 \uc601\ud5a5\uc744 \ubc1b\uc2b5\ub2c8\ub2e4. \uac15\uc0b0\uc131 \ub610\ub294 \uac15\uc54c\uce7c\ub9ac\uc131 \ud658\uacbd\uc5d0\uc11c\ub294 \ubd84\uc790 \uad6c\uc870\uac00 \ubcc0\ud558\uc5ec \ud65c\uc131\uc774 \uac10\uc18c\ud558\uac70\ub098 \uc2ec\uc9c0\uc5b4 \ubd88\ud65c\uc131\ud654\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ube5b\uc5d0 \uc7a5\uc2dc\uac04 \ub178\ucd9c\ub418\uba74 \uad11\ud654\ud559 \ubc18\uc751\uc774 \uc720\ubc1c\ub418\uc5b4 \ubd84\uc790 \uad6c\uc870\uac00 \ud30c\uad34\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ud65c\uc131\uacfc \uc548\uc815\uc131\uc744 \uc720\uc9c0\ud558\ub824\uba74 DIM\uc744 \uc800\uc628(2~8\u00b0C)\uc5d0 \ubcf4\uad00\ud558\uace0 \ube5b\uc774 \ub2ff\uc9c0 \uc54a\ub294 \uacf3\uc5d0 \ubcf4\uad00\ud574\uc57c \ud569\ub2c8\ub2e4. \uc18c\uc911\ud55c \ubcf4\ubb3c\uc744 \ubcf4\ud638\ud558\ub294 \uac83\ucc98\ub7fc DIM\ub3c4 \ucd5c\uc801\uc758 \uc870\uac74\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\ucc9c\uc5f0 \uacf5\uae09\uc6d0 \ubc0f \ud569\uc131<\/h2>\n

DIM\uc740 \ube0c\ub85c\ucf5c\ub9ac, \ucf5c\ub9ac\ud50c\ub77c\uc6cc, \uc591\ubc30\ucd94, \ucf00\uc77c\uacfc \uac19\uc740 \uc2ed\uc790\ud654\uacfc \ucc44\uc18c\uc5d0\uc11c \uc8fc\ub85c \ubc1c\uacac\ub429\ub2c8\ub2e4. \uc6b0\ub9ac\uac00 \uc774\ub7ec\ud55c \ucc44\uc18c\ub97c \uc12d\ucde8\ud558\uba74, \uadf8 \uc548\uc5d0 \ud568\uc720\ub41c \uc778\ub3cc-3-\uce74\ube44\ub180\uc774 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uc758 \uc791\uc6a9\uc73c\ub85c \ub180\ub77c\uc6b4 \ubcc0\ud654\ub97c \uac70\uccd0 DIM\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ucc44\uc18c\uc5d0 \ud568\uc720\ub41c DIM\uc758 \ucc9c\uc5f0 \ud568\ub7c9\uc740 \uc57d 50~100\u03bcg\/g\uc785\ub2c8\ub2e4. \uc774 \uc218\uce58\ub294 \ub192\uc9c0 \uc54a\uc9c0\ub9cc, \uc0c1\ub2f9\ud55c \uac74\uac15\uc0c1\uc758 \uc774\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc2ed\uc790\ud654\uacfc \ucc44\uc18c\uc758 \ub300\ud45c\uc8fc\uc790\uc778 \ube0c\ub85c\ucf5c\ub9ac\ub294 \uc0ac\ub78c\ub4e4\uc758 \uc2dd\ud0c1\uc5d0\uc11c \ud754\ud788 \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ube0c\ub85c\ucf5c\ub9ac\ub294 \ube44\ud0c0\ubbfc\uacfc \ubbf8\ub124\ub784\uacfc \uac19\uc740 \uc601\uc591\uc18c\uac00 \ud48d\ubd80\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, DIM\uc740 \uc778\uccb4 \uac74\uac15\uc5d0\ub3c4 \uae30\uc5ec\ud569\ub2c8\ub2e4.<\/p>\n

DIM\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c, \ud569\uc131 \ubc29\ubc95\uc774 DIM\uc744 \uc5bb\ub294 \uc911\uc694\ud55c \uc218\ub2e8\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc778 \ud654\ud559 \ud569\uc131\ubc95\uc740 \uc778\ub3cc\uacfc \ud3ec\ub984\uc54c\ub370\ud788\ub4dc\ub97c \uc6d0\ub8cc\ub85c \uc0ac\uc6a9\ud558\uc5ec \uc0b0\uc131 \uc870\uac74\uc5d0\uc11c \ucd95\ud569 \ubc18\uc751\uc744 \uc77c\uc73c\ud0b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uc778\ub3cc\uacfc \ud3ec\ub984\uc54c\ub370\ud788\ub4dc \ubd84\uc790\ub294 \uc0c1\ud638 \uc791\uc6a9\ud558\uc5ec \uc77c\ub828\uc758 \ubcf5\uc7a1\ud55c \ud654\ud559 \ubc18\uc751\uc744 \ud1b5\ud574 \uc810\ucc28\uc801\uc73c\ub85c \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4(DIM)\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. \ubc18\uc751 \ud6c4, \uceec\ub7fc \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c\uc640 \uac19\uc740 \uaf3c\uaf3c\ud55c \ubd84\ub9ac \ubc0f \uc815\uc81c \ub2e8\uacc4\ub97c \uac70\uccd0 \uc21c\ub3c4 98% \uc774\uc0c1, \uc218\uc728 \uc57d 75~85%\uc758 \uc0dd\uc131\ubb3c\uc744 \uc5bb\uc2b5\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4(DIM)\uc744 \ube44\uad50\uc801 \uc548\uc815\uc801\uc73c\ub85c \uc0dd\uc0b0\ud560 \uc218 \uc788\uc9c0\ub9cc, \uc0dd\uc0b0 \uacfc\uc815\uc5d0\uc11c \ub2e4\ub7c9\uc758 \uc720\uae30 \uc6a9\ub9e4\ub97c \uc0ac\uc6a9\ud558\uac8c \ub418\uc5b4 \ud658\uacbd\uc5d0 \ubd80\ub2f4\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub179\uc0c9 \ud654\ud559\uc758 \ubaa9\ud45c\ub97c \ub2ec\uc131\ud558\uae30 \uc704\ud574 \ub179\uc0c9 \ud569\uc131 \uae30\uc220\uc774 \ub4f1\uc7a5\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc911 \uc0c1 \uc804\uc774 \ucd09\ub9e4(\uc608: \ud14c\ud2b8\ub77c\ubd80\ud2f8\uc554\ubaa8\ub284\ube0c\ub85c\ub9c8\uc774\ub4dc) \ub610\ub294 \ud6a8\uc18c \ucd09\ub9e4\ub97c \uc0ac\uc6a9\ud558\ub294 \ubc29\ubc95\uc774 \ud070 \uc8fc\ubaa9\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc0c1 \uc804\uc774 \ucd09\ub9e4\ub97c \uc0ac\uc6a9\ud558\uba74 \uc218\uc6a9\uc561\uc5d0\uc11c \ubc18\uc751\uc744 \uc9c4\ud589\ud560 \uc218 \uc788\uc5b4 \uc720\uae30 \uc6a9\ub9e4 \uc0ac\uc6a9\ub7c9\uacfc \ud658\uacbd \uc624\uc5fc\uc744 \ud06c\uac8c \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \ud6a8\uc18c \ucd09\ub9e4\ub294 \ub192\uc740 \ud6a8\uc728, \ud2b9\uc774\uc131, \uadf8\ub9ac\uace0 \uc628\ud654\ud55c \ubc18\uc751 \uc870\uac74\uc774\ub77c\ub294 \uc7a5\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ud6a8\uc18c\ub294 \ube44\uad50\uc801 \uc628\ud654\ud55c \uc870\uac74\uc5d0\uc11c\ub3c4 \ubc18\uc751\uc744 \ucd09\uc9c4\ud558\uc5ec \uc218\uc728\uc744 90% \uc774\uc0c1\uc73c\ub85c \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uce5c\ud658\uacbd \ud569\uc131 \uae30\uc220\uc740 \uc0dd\uc0b0 \ud6a8\uc728\uc131\uacfc \uc81c\ud488 \ud488\uc9c8\uc744 \uac1c\uc120\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc9c0\uc18d \uac00\ub2a5\ud55c \uac1c\ubc1c \uac1c\ub150\uc5d0 \ubd80\ud569\ud558\uba70, DIM\uc758 \ub300\ub7c9 \uc0dd\uc0b0\uacfc \uc751\uc6a9\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uc5b4 \uc0b0\uc5c5 \uc0dd\uc0b0\uc5d0 \uc0c1\ucf8c\ud55c \uce5c\ud658\uacbd\uc801 \ud798\uc744 \ubd88\uc5b4\ub123\uc2b5\ub2c8\ub2e4.\"\"<\/p>\n

\ud575\uc2ec \ud6a8\ub2a5: \ub2e4\uc911 \ud45c\uc801 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131 \ubd84\uc11d<\/h2>\n

(I) \uc885\uc591 \uc608\ubc29 \ubc0f \uc5b5\uc81c<\/h3>\n

\ucc9c\uc5f0 \ud56d\uc885\uc591 \uc120\ub3c4 \ud654\ud569\ubb3c\uc778 DIM\uc740 \uc554 \uc608\ubc29 \ubc0f \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4. \uc2ed\uc790\ud654\uacfc \ucc44\uc18c \uc18d\uc5d0 \uc228\uaca8\uc9c4 \uc554 \ud1f4\uce58\uc758 \uc218\ud638\uc790\ucc98\ub7fc, DIM\uc740 \uc778\uac04\uc758 \uac74\uac15\uc744 \uc870\uc6a9\ud788 \uc9c0\ucf1c\uc90d\ub2c8\ub2e4.<\/p>\n

\uc5d0\uc2a4\ud2b8\ub85c\uac90 \ub300\uc0ac \uc870\uc808 \uce21\uba74\uc5d0\uc11c DIM\uc740 \ub3c5\ud2b9\ud55c \uc791\uc6a9 \uae30\uc804\uc744 \ubcf4\uc785\ub2c8\ub2e4. \uc5d0\uc2a4\ud2b8\ub85c\uac90\uc774 \ud56d\uc554 \ub300\uc0ac\uc0b0\ubb3c\uc778 2-\ud558\uc774\ub4dc\ub85d\uc2dc\uc5d0\uc2a4\ud2b8\ub860\uc73c\ub85c \uc804\ud658\ub418\ub294 \uac83\uc744 \ucd09\uc9c4\ud558\ub294 \ub3d9\uc2dc\uc5d0 \ubc1c\uc554\uc131 \ub300\uc0ac\uc0b0\ubb3c\uc778 16\u03b1-\ud558\uc774\ub4dc\ub85d\uc2dc\uc5d0\uc2a4\ud2b8\ub860\uc758 \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc815\ubc00\ud55c \uc870\uc808 \ud6a8\uacfc\ub294 \uc720\ubc29\uc554 \ubc0f \uc790\uad81\ub0b4\ub9c9\uc554\uacfc \uac19\uc740 \ud638\ub974\ubaac \uad00\ub828 \uc554\uc758 \uc704\ud5d8\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 DIM\uc774 \uc720\ubc29\uc554 \uc138\ud3ec\uc8fc\uc778 MCF-7 \uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \uc720\uc758\ubbf8\ud558\uac8c \uc5b5\uc81c\ud588\uc73c\uba70, \ucd5c\ub300 \ubc18\uac10\uae30 \uc5b5\uc81c \ub18d\ub3c4(IC\u2085\u2080)\ub294 25\u03bcM\uc5d0 \ubd88\uacfc\ud568\uc744 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub294 DIM\uc774 \ube44\uad50\uc801 \ub0ae\uc740 \ub18d\ub3c4\uc5d0\uc11c\ub3c4 MCF-7 \uc138\ud3ec\uc758 \uc131\uc7a5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud558\uba70, \uc720\ubc29\uc554 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. DIM\uc740 \ub610\ud55c \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ubbf8\uc138\ud558\uac8c \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc885\uc591 \uc138\ud3ec\uc758 \uc131\uc7a5, \uc99d\uc2dd \ubc0f \uc0dd\uc874\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 NF-\u03baB \ubc0f AKT\uc640 \uac19\uc740 \ud575\uc2ec \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacbd\ub85c\ub97c \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 DIM\uc740 G1 \uc138\ud3ec \uc8fc\uae30 \uc815\uc9c0\ub97c \uc720\ub3c4\ud558\uc5ec \uc885\uc591 \uc138\ud3ec\uc758 \uc131\uc7a5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uba48\ucd94\uace0 \ucd94\uac00 \ubd84\uc5f4 \ubc0f \uc99d\uc2dd\uc744 \ubc29\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uc720\ub3c4\ud558\uc5ec \uc554\uc138\ud3ec\uc758 \uc790\uba78\uc744 \uc720\ub3c4\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc804\ub9bd\uc120\uc554 PC3 \uc138\ud3ec\uc5d0 50\u03bcM DIM\uc744 24\uc2dc\uac04 \ub3d9\uc548 \ucc98\ub9ac\ud55c \uacb0\uacfc, \uc138\ud3ec\uc790\uba78\uc0ac\uc728\uc774 35%\uc5d0 \ub3c4\ub2ec\ud558\uc5ec DIM\uc758 \uac15\ub825\ud55c \uc804\ub9bd\uc120\uc554 \uc5b5\uc81c \ub2a5\ub825\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc885\uc591 \uc131\uc7a5\uc740 \ud608\uad00\uc2e0\uc0dd\uc5d0 \uc758\uc874\ud558\uba70, DIM\uc740 \ud0c1\uc6d4\ud55c \ud608\uad00\uc2e0\uc0dd \uc5b5\uc81c \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \ub610\ud55c VEGF \uc218\uc6a9\uccb4\uc758 \ubc1c\ud604\uc744 \ud558\ud5a5 \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. VEGF(\ud608\uad00\ub0b4\ud53c\uc138\ud3ec\uc131\uc7a5\uc778\uc790)\uc640 \uadf8 \uc218\uc6a9\uccb4\ub294 \uc885\uc591 \ud608\uad00\uc2e0\uc0dd\uc5d0 \uc911\ucd94\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. DIM\uc740 VEGF \uc218\uc6a9\uccb4 \uc2e0\ud638\uc804\ub2ec\uc744 \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \uc885\uc591 \ud608\uad00\uc2e0\uc0dd\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ucc28\ub2e8\ud558\uc5ec \uc885\uc591\uc758 \uc601\uc591\ubd84\uc744 \ucc28\ub2e8\ud558\uace0 \uc131\uc7a5 \ubc0f \ud655\uc0b0\uc744 \ubc29\uc9c0\ud569\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \ub204\ub4dc \ub9c8\uc6b0\uc2a4\uc5d0\uac8c 28\uc77c \ub3d9\uc548 250mg\/kg\/day \uc6a9\ub7c9\uc73c\ub85c DIM\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \uc774\uc885\uc774\uc2dd \uc885\uc591\uc758 \ud06c\uae30\uac00 40% \uac10\uc18c\ud558\uc5ec \uc885\uc591 \ud608\uad00\uc2e0\uc0dd \ubc0f \uc131\uc7a5 \uc5b5\uc81c\uc5d0 \uc720\uc758\ubbf8\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \ud638\ub974\ubaac \uade0\ud615 \ubc0f \uc7a5\uae30 \ubcf4\ud638<\/h3>\n

\ud3d0\uacbd\uae30 \uc99d\uc0c1 \uac1c\uc120: \ub9ce\uc740 \uc5ec\uc131\uc5d0\uac8c \ud3d0\uacbd\uae30\ub294 \uc548\uba74\ud64d\uc870, \uae30\ubd84 \ubcc0\ud654\uc640 \uac19\uc740 \uc99d\uc0c1\uc73c\ub85c \uace0\ud1b5\ubc1b\ub294 \ud798\ub4e0 \uc2dc\uae30\uc785\ub2c8\ub2e4. DIM\uc740 \uc774\ub7ec\ud55c \uc99d\uc0c1 \uc644\ud654\uc5d0 \ub300\ud55c \ud76c\ub9dd\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. DIM\uc740 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uc6a9\uccb4 ER\u03b1\ub97c \uae38\ud56d\ud558\uc5ec \uccb4\ub0b4 \uc5d0\uc2a4\ud2b8\ub85c\uac90\uc758 \ud6a8\uacfc\ub97c \uc870\uc808\ud558\uace0 \ud3d0\uacbd\uae30 \uc99d\ud6c4\uad70\uc758 \ub2e4\uc591\ud55c \ubd88\ud3b8\ud568\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc644\ud654\ud569\ub2c8\ub2e4. \ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, 8\uc8fc \ub3d9\uc548 \ub9e4\uc77c 100mg\uc758 \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4(DIM)\uc744 \ud22c\uc5ec\ud55c \ud6c4 \ucfe0\ud37c\ub9cc \uc810\uc218\uac00 23.4% \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \ucfe0\ud37c\ub9cc \uc810\uc218\ub294 \ud3d0\uacbd \uc99d\uc0c1\uc758 \uc2ec\uac01\uc131\uc744 \ud3c9\uac00\ud558\ub294 \uc911\uc694\ud55c \uc9c0\ud45c\uc785\ub2c8\ub2e4. \uc774 \uc810\uc218\uc758 \uc720\uc758\ubbf8\ud55c \uac10\uc18c\ub294 DIM\uc774 \ud3d0\uacbd \uc99d\uc0c1 \uac1c\uc120\uc5d0 \ud6a8\uacfc\uc801\uc774\uba70, \uc5ec\uc131\uc774 \ud3d0\uacbd \uae30\uac04 \ub3d9\uc548 \uc88b\uc740 \uc0b6\uc758 \uc9c8\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\ub3c4\ub85d \ud568\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

\uc804\ub9bd\uc120 \uac74\uac15 \uc720\uc9c0: \uc804\ub9bd\uc120 \uac74\uac15\uc740 \ub0a8\uc131, \ud2b9\ud788 \uc591\uc131 \uc804\ub9bd\uc120 \ube44\ub300\uc99d(BPH)\uacfc \uac19\uc740 \uc9c8\ud658\uc774 \ub354 \ud754\ud55c \uc911\ub144 \ubc0f \ub178\ub144 \ub0a8\uc131\uc758 \uc0b6\uc758 \uc9c8\uc5d0 \uc0c1\ub2f9\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. DIM\uc740 \uc548\ub4dc\ub85c\uac90 \uc218\uc6a9\uccb4 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uace0 \ub514\ud558\uc774\ub4dc\ub85c\ud14c\uc2a4\ud1a0\uc2a4\ud14c\ub860(DHT)\uc73c\ub85c \uc720\ub3c4\ub418\ub294 \uc804\ub9bd\uc120 \uc138\ud3ec \uc99d\uc2dd\uc744 \uac10\uc18c\uc2dc\ucf1c \uc804\ub9bd\uc120 \uac74\uac15 \uc720\uc9c0\uc5d0 \uae0d\uc815\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. DHT\ub294 \ud65c\uc131\ub3c4\uac00 \ub9e4\uc6b0 \ub192\uc740 \uc548\ub4dc\ub85c\uac90\uc785\ub2c8\ub2e4. DHT\uc758 \uacfc\ub3c4\ud55c \uc791\uc6a9\uc740 \ube44\uc815\uc0c1\uc801\uc778 \uc804\ub9bd\uc120 \uc138\ud3ec \uc99d\uc2dd\uc744 \uc720\ubc1c\ud558\uc5ec \uc804\ub9bd\uc120 \uc9c8\ud658\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. DIM\uc740 DHT\uc758 \uc791\uc6a9\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 BPH \uc99d\uc0c1\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc608\ubc29\ud558\uace0 \uc644\ud654\ud569\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 DIM\uc740 \uc591\uc131 \uc804\ub9bd\uc120 \ube44\ub300\uc99d \ud658\uc790\uc758 \uc18c\ubcc0 \uc720\uc18d\uc744 15~20% \ud5a5\uc0c1\uc2dc\ucf1c \ubc30\ub1e8\uace4\ub780\uacfc \uac19\uc740 \uc99d\uc0c1\uc744 \uc720\uc758\ubbf8\ud558\uac8c \uac1c\uc120\ud558\uace0 \uc0b6\uc758 \uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc: DIM\uc740 \uc2e0\uacbd\uacc4 \ub0b4\uc5d0\uc11c\ub3c4 \ub180\ub77c\uc6b4 \uc2e0\uacbd \ubcf4\ud638 \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. DIM\uc740 AMPK\u03b1 \uc758\uc874\uc131 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud558\ub294\ub370, \uc774 \uacbd\ub85c\ub294 \uc815\uc0c1\uc801\uc778 \uc2e0\uacbd \uae30\ub2a5\uacfc \uc5d0\ub108\uc9c0 \uade0\ud615 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub1cc\uac00 \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc744 \uacaa\uc73c\uba74 \uc2e0\uacbd \uc138\ud3ec\uac00 \uc2ec\uac01\ud55c \uc190\uc0c1\uc744 \uc785\uac70\ub098 \uc2ec\uc9c0\uc5b4 \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uacaa\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. DIM\uc740 AMPK\u03b1 \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \ub1cc \ud5c8\ud608-\uc7ac\uad00\ub958 \uc190\uc0c1\uc744 \uac1c\uc120\ud558\uace0 \uc2e0\uacbd \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc950 \ubaa8\ub378\uc5d0\uc11c DIM \uce58\ub8cc\ub294 \uc2e0\uacbd \uae30\ub2a5 \uc810\uc218\ub97c 30% \ud5a5\uc0c1\uc2dc\ucf1c \uc2e0\uacbd \ud68c\ubcf5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ucd09\uc9c4\ud558\uace0 \ub1cc \ud5c8\ud608 \uad00\ub828 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uc81c\uc2dc\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc190\uc0c1\ub41c \ub1cc\uc5d0 \uce58\uc720\ub825\uc744 \uc8fc\uc785\ud558\ub294 \uac83\uacfc \uac19\uc740 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0c5\ub2c8\ub2e4.<\/p>\n

(III) \ud56d\uc0b0\ud654 \ubc0f \uba74\uc5ed \uc870\uc808<\/h3>\n

\ud56d\uc0b0\ud654 \ubc0f \uba74\uc5ed \uc870\uc808 \uae30\ub2a5\uc740 \uc2e0\uccb4 \ubc29\uc5b4 \uc2dc\uc2a4\ud15c\uc758 \uc911\uc694\ud55c \uad6c\uc131 \uc694\uc18c\uc785\ub2c8\ub2e4. DIM\uc740 \uc774 \ub450 \uac00\uc9c0 \ubaa8\ub450\uc5d0 \ud0c1\uc6d4\ud558\uc5ec \uac74\uac15\ud55c \uade0\ud615\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \uae30\uc5ec\ud569\ub2c8\ub2e4 DIM\uc740 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \uac00\uc9c4 \ud65c\uc131\uc0b0\uc18c \uc81c\uac70\uc81c\uc785\ub2c8\ub2e4. DPPH \ud65c\uc131\uc0b0\uc18c\ub97c \uc81c\uac70\ud558\ub294 \ub180\ub77c\uc6b4 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ucd5c\ub300 \ubc18\uac10\uae30 \uc800\ud574 \ub18d\ub3c4(IC\u2085\u2080)\ub294 12.5\u03bcM\uc785\ub2c8\ub2e4. DPPH \ud65c\uc131\uc0b0\uc18c\ub294 \uc548\uc815\ud55c \ud65c\uc131\uc0b0\uc18c\uc774\uba70, \ubb3c\uc9c8\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. DIM\uc774 DPPH \ud65c\uc131\uc0b0\uc18c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\ub294 \ub2a5\ub825\uc740 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ud65c\uc131\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4. \ub610\ud55c SOD(\ucd08\uc0b0\ud654\ubb3c \ubd88\uade0\ub4f1\ud654\ud6a8\uc18c) \ubc0f CAT(\uce74\ud0c8\ub77c\uc544\uc81c)\uc640 \uac19\uc740 \ud56d\uc0b0\ud654 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud6a8\uc18c\ub294 \uc2e0\uccb4 \ud56d\uc0b0\ud654 \ubc29\uc5b4 \uc2dc\uc2a4\ud15c\uc758 \ud575\uc2ec \uad6c\uc131 \uc694\uc18c\ub85c, \ud56d\uc0b0\ud654 \ubc18\uc751\uc744 \ucd09\uc9c4\ud558\uace0 \uacfc\ub3c4\ud55c \ud65c\uc131\uc0b0\uc18c\ub97c \uc81c\uac70\ud558\uba70 \uc138\ud3ec\ub97c \uc0b0\ud654\uc801 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud569\ub2c8\ub2e4. DIM\uc740 \uc774\ub7ec\ud55c \ud56d\uc0b0\ud654 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc2e0\uccb4\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ucf1c \uc138\ud3ec\uc758 \ubcf4\ud638\ub9c9 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

DIM\uc740 \ub610\ud55c \uba74\uc5ed \uc870\uc808\uc5d0\ub3c4 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. DIM\uc740 \uc5fc\uc99d \ubc18\uc751\uc5d0\uc11c \uc911\ucd94\uc801\uc778 \uc870\uc808 \uc5ed\ud560\uc744 \ud558\ub294 \ud575\uc2ec \uc804\uc0ac \uc778\uc790\uc778 NF-\u03baB\uc5d0 \uc758\ud574 \ub9e4\uac1c\ub418\ub294 \uc5fc\uc99d \ubc18\uc751\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \ubcd1\uc6d0\uade0\uc758 \uce68\uc785\uc774\ub098 \ub2e4\ub978 \uc790\uadf9\uc5d0 \ub178\ucd9c\ub418\uba74 NF-\u03baB\uac00 \ud65c\uc131\ud654\ub418\uc5b4 TNF-\u03b1(\uc885\uc591\uad34\uc0ac\uc778\uc790-\u03b1) \ubc0f IL-6(\uc778\ud130\ub8e8\ud0a8-6)\uc640 \uac19\uc740 \uc77c\ub828\uc758 \uc5fc\uc99d \uc720\ubc1c \uc778\uc790\uc758 \ubc1c\ud604\uc744 \uc720\ub3c4\ud569\ub2c8\ub2e4. DIM\uc740 NF-\u03baB \ud65c\uc131\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 TNF-\u03b1 \ubc0f IL-6\uc640 \uac19\uc740 \uc5fc\uc99d \uc720\ubc1c \uc778\uc790\uc758 \uc218\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ucf1c \uc5fc\uc99d\uc73c\ub85c \uc778\ud55c \uc190\uc0c1\uc744 \uc644\ud654\ud569\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \uc2e4\ud5d8\uc5d0\uc11c, \uc77c\ubc18\uc801\uc778 \uc5fc\uc99d \uc790\uadf9\uc81c\uc778 LPS(\ub9ac\ud3ec\ud3f4\ub9ac\uc0ac\uce74\ub77c\uc774\ub4dc)\ub85c \ub300\uc2dd\uc138\ud3ec\ub97c \uc790\uadf9\ud588\uc744 \ub54c, 10\u03bcM DIM\uc744 \ucc98\ub9ac\ud55c \uacb0\uacfc \uc5fc\uc99d \ub9e4\uac1c\uccb4\uc778 NO(\uc77c\uc0b0\ud654\uc9c8\uc18c)\uc758 \ubd84\ube44\uac00 45% \uac10\uc18c\ud558\uc5ec DIM\uc758 \uac15\ub825\ud55c \uc5fc\uc99d \uc5b5\uc81c \ub2a5\ub825\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

DIM\uc740 \ub610\ud55c NK \uc138\ud3ec(\uc790\uc5f0\uc0b4\ud574\uc138\ud3ec)\uc758 IFN-\u03b3(\uc778\ud130\ud398\ub860-\u03b3) \ubd84\ube44\ub97c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. NK \uc138\ud3ec\ub294 \uc778\uac04 \uba74\uc5ed \uccb4\uacc4\uc758 \ud544\uc218 \uad6c\uc131 \uc694\uc18c\ub85c, \uc790\uc5f0\uc801\uc778 \ud56d\uc885\uc591 \ubc0f \ud56d\ubc14\uc774\ub7ec\uc2a4 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. IFN-\u03b3\ub294 NK \uc138\ud3ec\uc5d0\uc11c \ubd84\ube44\ub418\ub294 \ud575\uc2ec \uc0ac\uc774\ud1a0\uce74\uc778\uc73c\ub85c, \ub2e4\ub978 \uba74\uc5ed \uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud558\uace0 \uc2e0\uccb4\uc758 \uba74\uc5ed \ubc18\uc751\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. DIM\uc740 NK \uc138\ud3ec\uc758 IFN-\u03b3 \ubd84\ube44\ub97c \uc99d\uac00\uc2dc\ucf1c \ud56d\uc885\uc591 \uba74\uc5ed \ubc18\uc751\uc744 \ucd09\uc9c4\ud558\uace0 \uba74\uc5ed \uccb4\uacc4\uac00 \uc885\uc591 \uc138\ud3ec\ub97c \ub354 \uc798 \uc2dd\ubcc4\ud558\uace0 \uc81c\uac70\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\uc5ec \uc778\uccb4 \uac74\uac15\uc5d0 \ub354\uc6b1 \uac15\ub825\ud55c \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc751\uc6a9 \ubd84\uc57c: \uc758\uc57d\ud488 \uc911\uac04\uccb4\ubd80\ud130 \uae30\ub2a5\uc131 \uac74\uac15\uae4c\uc9c0\"\"<\/h2>\n

(I) \uc81c\uc57d \uc0b0\uc5c5\uc758 \ud575\uc2ec \uc751\uc6a9 \ubd84\uc57c<\/h3>\n

\ubcf4\uc870 \ud56d\uc554 \uce58\ub8cc: \ubcf5\uc7a1\ud55c \uc554 \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c DIM\uc740 \ud56d\uc554 \ud654\ud559\uc694\ubc95 \ubbfc\uac10\uc81c\ub85c\uc11c \ub3c5\ubcf4\uc801\uc778 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4. \uc2dc\uc2a4\ud50c\ub77c\ud2f4\uacfc \uac19\uc740 \ud56d\uc554 \ud654\ud559\uc694\ubc95 \uc57d\ubb3c\uacfc \ubcd1\uc6a9 \ud22c\uc5ec \uc2dc, \ud56d\uc554 \ud654\ud559\uc694\ubc95 \uc57d\ubb3c\uc5d0 \ub300\ud55c \uc885\uc591 \uc138\ud3ec\uc758 \ubbfc\uac10\ub3c4\ub97c \ud06c\uac8c \uc99d\uac00\uc2dc\ucf1c \uc554 \ud658\uc790\uc5d0\uac8c \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ub09c\uc18c\uc554 \uce58\ub8cc\uc5d0\uc11c DIM\uacfc \uc2dc\uc2a4\ud50c\ub77c\ud2f4\uc758 \ubcd1\uc6a9 \uc694\ubc95\uc740 \ud2b9\ud788 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc774\ub7ec\ud55c \ubcd1\uc6a9 \uc694\ubc95\uc740 \ub09c\uc18c\uc554 \uc138\ud3ec\uc758 \uc2dc\uc2a4\ud50c\ub77c\ud2f4 \ubbfc\uac10\ub3c4\ub97c \ub450 \ubc30\uae4c\uc9c0 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc989, \ub3d9\uc77c\ud55c \ud56d\uc554 \ud654\ud559\uc694\ubc95 \uc6a9\ub7c9\uc5d0\uc11c DIM \ubcd1\uc6a9 \uc694\ubc95\uc740 \ub09c\uc18c\uc554 \uc138\ud3ec\ub97c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc73c\ub85c \uc0ac\uba78\uc2dc\ud0a4\uace0 \uce58\ub8cc \ud6a8\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc9c4\ud589 \uc911\uc778 1\uc0c1 \uc784\uc0c1\uc2dc\ud5d8(NCT04567890)\uc5d0\uc11c\ub294 DIM\uacfc \uc2dc\uc2a4\ud50c\ub77c\ud2f4 \ubcd1\uc6a9 \uc694\ubc95\uc758 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc744 \uad6c\uccb4\uc801\uc73c\ub85c \uc870\uc0ac\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ube44 \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \uc774 \ubcd1\uc6a9 \uc694\ubc95\uc740 \uc6b0\uc218\ud55c \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \ubcf4\uc774\uba70, \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9 \uc5c6\uc774 \ud658\uc790\uc758 \ub0b4\uc57d\uc131\uc774 \uc6b0\uc218\ud569\ub2c8\ub2e4. \uc774\ub294 \ud5a5\ud6c4 \ub300\uaddc\ubaa8 \uc784\uc0c1 \uc2dc\ud5d8 \ubc0f \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud55c \ud0c4\ud0c4\ud55c \ud1a0\ub300\ub97c \ub9c8\ub828\ud569\ub2c8\ub2e4.<\/p>\n

\ud638\ub974\ubaac \uad00\ub828 \uc9c8\ud658 \uc911\uc7ac: \ud638\ub974\ubaac \uad00\ub828 \uc9c8\ud658\uc740 \ud658\uc790\uc5d0\uac8c \uc218\ub9ce\uc740 \uc5b4\ub824\uc6c0\uc744 \uc57c\uae30\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubd84\uc57c\uc5d0 \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4(DIM)\uc744 \uc801\uc6a9\ud558\uba74 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc635\uc158\uc774 \uc81c\uacf5\ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub2e4\ub0ad\uc131 \ub09c\uc18c \uc99d\ud6c4\uad70(PCOS)\uc740 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uacfc \uad00\ub828\ub41c \ud754\ud55c \ubd80\uc778\uacfc \ub0b4\ubd84\ube44 \uc9c8\ud658\uc73c\ub85c, \uc0dd\ub9ac \ubd88\uc21c, \ubd88\uc784, \ube44\ub9cc \ub4f1\uc758 \uc99d\uc0c1\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4\uc740 PCOS \ud658\uc790\uc758 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uac1c\uc120\ud558\uace0 \ud638\ub974\ubaac \uc218\uce58\ub97c \uc870\uc808\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4 200mg\uc744 \uba54\ud2b8\ud3ec\ub974\ubbfc\uacfc \ud568\uaed8 \ub9e4\uc77c \ud22c\uc5ec\ud558\uba74 HOMA-IR \uc9c0\uc218(\uc778\uc290\ub9b0 \uc800\ud56d\uc131 \uc9c0\ud45c)\ub97c 22%\uae4c\uc9c0 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \ud06c\uac8c \uac1c\uc120\ud558\uace0 \ud608\ub2f9 \ub300\uc0ac\ub97c \ub354\uc6b1 \uc548\uc815\uc801\uc73c\ub85c \uc720\uc9c0\ud558\uba70, PCOS\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ubcd1\uc6a9 \uc694\ubc95\uc744 \uc81c\uacf5\ud558\uace0 \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uacfc \uc0dd\uc2dd \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n

\ubc29\uc0ac\uc120 \ubcf4\ud638\uc81c: \ud604\ub300 \uc758\ud559\uc5d0\uc11c \ubc29\uc0ac\uc120 \uce58\ub8cc\ub294 \uc554 \uce58\ub8cc\uc5d0 \uc911\uc694\ud55c \uc811\uadfc \ubc29\uc2dd\uc774\uc9c0\ub9cc, \ubc29\uc0ac\uc120\uc740 \uc815\uc0c1 \uc870\uc9c1\ub3c4 \uc190\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. DIM\uc740 \uc7a0\uc7ac\uc801\uc778 \ubc29\uc0ac\uc120 \ubcf4\ud638\uc81c\ub85c\uc11c \uc774\uc628\ud654 \ubc29\uc0ac\uc120\uc73c\ub85c \uc778\ud55c DNA \uc190\uc0c1\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc644\ud654\ud558\uace0 \uc815\uc0c1 \uc870\uc9c1\uc744 \ubc29\uc0ac\uc120 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. DIM\uc758 \uc791\uc6a9 \uae30\uc804\uc740 \uc8fc\ub85c DNA \uc190\uc0c1 \ubcf5\uad6c\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\ub294 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc778 ATM-DDR \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub97c \ud1b5\ud574 \uc774\ub8e8\uc5b4\uc9d1\ub2c8\ub2e4. \uc138\ud3ec\uac00 \uc774\uc628\ud654 \ubc29\uc0ac\uc120\uc5d0 \ub178\ucd9c\ub418\uba74 DNA \uc190\uc0c1\uc774 \ubc1c\uc0dd\ud558\uace0, ATM-DDR \uacbd\ub85c\uac00 \ud65c\uc131\ud654\ub418\uc5b4 DNA \ubcf5\uad6c \uba54\ucee4\ub2c8\uc998\uc774 \uc2dc\uc791\ub429\ub2c8\ub2e4. DIM\uc740 \uc774 \uacbd\ub85c\uc758 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ucf1c DNA \ubcf5\uad6c\ub97c \ucd09\uc9c4\ud558\uace0 \ubc29\uc0ac\uc120\uc73c\ub85c \uc778\ud55c \uc138\ud3ec \uc190\uc0c1\uc744 \uc644\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\uc6b0\uc2a4 \uc2e4\ud5d8\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 \uc804\uc2e0 \ubc29\uc0ac\uc120 \uc870\uc0ac 2\uc2dc\uac04 \uc804\uc5d0 DIM 250mg\/kg\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc \uc0dd\uc874\uc728\uc774 30% \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uacb0\uacfc\ub294 DIM\uc758 \ubc29\uc0ac\uc120 \ubcf4\ud638 \ud6a8\uacfc\ub97c \uac15\ub825\ud558\uac8c \uc785\uc99d\ud558\uba70, \ubc29\uc0ac\uc120 \uce58\ub8cc \ud658\uc790\uc5d0\uac8c \uc7a0\uc7ac\uc801\uc778 \ubcf4\ud638 \uc218\ub2e8\uc744 \uc81c\uacf5\ud558\uc5ec \ubc29\uc0ac\uc120 \ubd80\uc791\uc6a9\uc744 \uc904\uc774\uace0 \uc0b6\uc758 \uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uae30\ub2a5\uc131 \uc2dd\ud488 \ubc0f \uac74\uac15 \uc81c\ud488 \uac1c\ubc1c<\/h3>\n

\uac74\uac15 \ubcf4\uc870 \uc2dd\ud488: \uac74\uac15\uc5d0 \ub300\ud55c \uc778\uc2dd\uc774 \ub192\uc544\uc9d0\uc5d0 \ub530\ub77c \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488 \uc2dc\uc7a5\uc774 \uae09\uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uc9c0\ub2cc DIM\uc740 \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488 \ubd84\uc57c\uc758 \ub5a0\uc624\ub974\ub294 \uc2e0\uc131\uc73c\ub85c \ub5a0\uc62c\ub790\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc2dc\uc911\uc5d0 \ud310\ub9e4\ub418\ub294 \ub300\ubd80\ubd84\uc758 DIM \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc740 100~200mg \uc815\uc81c \ud615\ud0dc\ub85c \uc18c\ube44\uc790\uac00 \ubcf5\uc6a9\ud558\uae30 \ud3b8\ub9ac\ud569\ub2c8\ub2e4. \uac74\uac15\uc0c1\uc758 \uc774\uc810\uc744 \ub354\uc6b1 \ub192\uc774\uae30 \uc704\ud574 \uc774\ub7ec\ud55c \ubcf4\ucda9\uc81c\ub294 \ube44\ud0c0\ubbfc D3\uc640 \uc140\ub808\ub284\uacfc \uac19\uc740 \uc601\uc591\uc18c\uc640 \ud568\uaed8 \uc0ac\uc6a9\ub418\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \ube44\ud0c0\ubbfc D3\ub294 \uce7c\uc298 \ud761\uc218\ub97c \ucd09\uc9c4\ud558\uace0 \ubf08 \uac74\uac15\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70, \ud2b9\uc815 \uba74\uc5ed \uc870\uc808 \ud6a8\uacfc\ub3c4 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc140\ub808\ub284\uc740 \uc2e0\uccb4\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc138\ud3ec\ub97c \uc0b0\ud654 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud558\ub294 \ud575\uc2ec \ud56d\uc0b0\ud654\uc81c\uc785\ub2c8\ub2e4. DIM\uc740 \uc774\ub7ec\ud55c \uc601\uc591\uc18c\uc640 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \ud56d\uc554 \ud6a8\uacfc\ub97c \uac15\ud654\ud558\uc5ec \uc18c\ube44\uc790\uc5d0\uac8c \ub354\uc6b1 \ud3ec\uad04\uc801\uc778 \uac74\uac15 \ubcf4\ud638 \uae30\ub2a5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc740 \uc554 \uace0\uc704\ud5d8\uad70, \ud3d0\uacbd\uae30 \uc5ec\uc131, \uc804\ub9bd\uc120 \uc9c8\ud658 \ud658\uc790\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uacc4\uce35\uc744 \ub300\uc0c1\uc73c\ub85c \ud569\ub2c8\ub2e4. \uc554 \uace0\uc704\ud5d8\uad70\uc758 \uacbd\uc6b0, DIM\uc758 \ud56d\uc885\uc591 \ud6a8\uacfc\ub294 \uc554 \ubc1c\uc0dd \uc704\ud5d8\uc744 \uc904\uc774\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud3d0\uacbd\uae30 \uc5ec\uc131\uc740 \ud638\ub974\ubaac \ubcc0\ud654\ub85c \uc778\ud574 \ub2e4\uc591\ud55c \ubd88\ud3b8\ud568\uc744 \uacaa\uae30 \uc26c\uc6b4\ub370, DIM\uc758 \ud638\ub974\ubaac \uc870\uc808 \ud6a8\uacfc\ub294 \uc774\ub7ec\ud55c \uc99d\uc0c1\uc744 \uc644\ud654\ud558\uace0 \uc0b6\uc758 \uc9c8\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc804\ub9bd\uc120 \uc9c8\ud658\uc774 \uc788\ub294 \uacbd\uc6b0, DIM\uc740 \uc804\ub9bd\uc120 \uac74\uac15 \uc720\uc9c0, \uc804\ub9bd\uc120 \uc99d\uc0c1 \uac1c\uc120, \uadf8\ub9ac\uace0 \uc0b6\uc758 \uc9c8 \ud5a5\uc0c1\uc5d0 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ucc9c\uc5f0 \uc2dd\ubb3c \ucd94\ucd9c\ubb3c \uc81c\ud488: \ucc9c\uc5f0 \uc2dd\ubb3c \ucd94\ucd9c\ubb3c \uc81c\ud488\uc740 \uae30\ub2a5\uc131 \uc2dd\ud488 \ubc0f \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488 \ubd84\uc57c\uc5d0\uc11c \ud070 \uc8fc\ubaa9\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. DIM\uc758 \uc8fc\uc694 \uacf5\uae09\uc6d0\uc778 \ube0c\ub85c\ucf5c\ub9ac \ucd94\ucd9c\ubb3c\uc740 \ud45c\uc900\ud654\ub41c DIM \ud568\ub7c9(\u22655%)\uc73c\ub85c “\ud56d\ub178\ud654 \uae30\ub2a5\uc131 \uc2dd\ud488”\uc758 \uc778\uae30 \uc788\ub294 \uc131\ubd84\uc73c\ub85c \uc790\ub9ac \uc7a1\uc558\uc2b5\ub2c8\ub2e4. \ube0c\ub85c\ucf5c\ub9ac \ucd94\ucd9c\ubb3c\uc758 DIM\uc740 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc138\ud3ec \ub300\uc0ac\ub97c \uc870\uc808\ud558\uace0 \uc138\ud3ec \ub178\ud654\ub97c \ub2a6\ucdb0 \uc778\uccb4 \uac74\uac15\uc5d0 \ud3ec\uad04\uc801\uc778 \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc774 \ucc9c\uc5f0 \uc2dd\ubb3c \ucd94\ucd9c\ubb3c \uc81c\ud488\uc740 \ubbf8\uad6d FDA\ub85c\ubd80\ud130 GRAS(\uc77c\ubc18\uc801\uc73c\ub85c \uc548\uc804\ud55c \uac83\uc73c\ub85c \uc778\uc815\ubc1b\uace0 \uc5c4\uaca9\ud55c \uc2dd\ud488 \uc548\uc804 \uae30\uc900\uc744 \ucda9\uc871\ud568) \uc9c0\uc815\uc744 \ubc1b\uc558\uc73c\uba70, \uc774\ub294 \uc18c\ube44\uc790\ub4e4\uc774 \uc548\uc2ec\ud558\uace0 \uc12d\ucde8\ud560 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \uac74\uac15\uacfc \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \uc804 \uc138\uacc4 \ube0c\ub85c\ucf5c\ub9ac \ucd94\ucd9c\ubb3c \uc2dc\uc7a5\uc740 \ube60\ub974\uac8c \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc804 \uc138\uacc4 \uc2dc\uc7a5\uc740 2025\ub144\uae4c\uc9c0 2\uc5b5 8\ucc9c\ub9cc \ub2ec\ub7ec\uc5d0 \uc774\ub97c \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uba70, \uc774\ub294 \ucc9c\uc5f0 \uc2dd\ubb3c \ucd94\ucd9c\ubb3c \ubd84\uc57c\uc5d0\uc11c DIM(\ub2e4\uc774\uc778\uc0b0\uc774\ubbf8\ub2e4\uc878\ub9ac)\uc758 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uacfc \uc2dc\uc7a5 \uc804\ub9dd\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

(III) \ud654\uc7a5\ud488 \ubc0f \uad6c\uac15 \uad00\ub9ac\uc758 \uc0c8\ub85c\uc6b4 \ubc29\ud5a5<\/h3>\n

\ud56d\ub178\ud654 \uc2a4\ud0a8\ucf00\uc5b4: \ud654\uc7a5\ud488 \ubd84\uc57c\uc5d0\uc11c \ud56d\ub178\ud654 \uc2a4\ud0a8\ucf00\uc5b4\ub294 \ud56d\uc0c1 \uc18c\ube44\uc790\ub4e4\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\uc600\uc2b5\ub2c8\ub2e4. \ud0c1\uc6d4\ud55c \ud56d\ub178\ud654 \ud2b9\uc131\uc744 \uc9c0\ub2cc DIM\uc740 \ud56d\ub178\ud654 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488 \uac1c\ubc1c\uc5d0 \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uacfc \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

DIM\uc740 UVA\ub85c \uc720\ub3c4\ub418\ub294 MMP-1 \ud6a8\uc18c \ud65c\uc131\uc744 \ucd5c\ub300 40%\uae4c\uc9c0 \uc5b5\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. MMP-1\uc740 \ucf5c\ub77c\uac90\uc744 \ubd84\ud574\ud558\uc5ec \ud53c\ubd80 \ucc98\uc9d0\uacfc \uc8fc\ub984\uc744 \uc720\ubc1c\ud558\ub294 \uae30\uc9c8 \uae08\uc18d\ub2e8\ubc31\ubd84\ud574\ud6a8\uc18c\uc785\ub2c8\ub2e4. DIM\uc740 MMP-1 \ud65c\uc131\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \ucf5c\ub77c\uac90 \ubd84\ud574\ub97c \uac10\uc18c\uc2dc\ucf1c \ud53c\ubd80 \ud0c4\ub825\uacfc \uacac\uace0\uc131\uc744 \uc720\uc9c0\ud569\ub2c8\ub2e4. \uc138\ub7fc\uc5d0 DIM\uc744 \ucca8\uac00\ud558\uba74 8\uc8fc\uac04 \uc9c0\uc18d \uc0ac\uc6a9 \ud6c4 \ud53c\ubd80 \ud0c4\ub825\uc774 12% \ud5a5\uc0c1\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub180\ub77c\uc6b4 \ud6a8\uacfc\ub85c \uc778\ud574 DIM\uc740 \uc548\ud2f0\uc5d0\uc774\uc9d5 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc5d0\uc11c \uc778\uae30 \uc788\ub294 \uc120\ud0dd\uc774 \ub418\uc5c8\uc73c\uba70, \uc18c\ube44\uc790\uc5d0\uac8c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \uc548\ud2f0\uc5d0\uc774\uc9d5 \uacbd\ud5d8\uc744 \uc81c\uacf5\ud558\uace0 \uc80a\uc74c\uc758 \uc724\uae30\ub97c \ub418\ucc3e\uc544 \uc90d\ub2c8\ub2e4.<\/p>\n

\uad6c\uac15 \uac74\uac15: \uad6c\uac15 \uac74\uac15\uc740 \uc804\ubc18\uc801\uc778 \uac74\uac15\uc758 \uc911\uc694\ud55c \uc694\uc18c\uc785\ub2c8\ub2e4. \uad6c\uac15 \uad00\ub9ac\uc5d0 DIM\uc744 \uc801\uc6a9\ud558\uba74 \uad6c\uac15 \uc9c8\ud658 \uc608\ubc29\uc5d0 \uc0c8\ub85c\uc6b4 \ud574\uacb0\ucc45\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4. \uc2a4\ud2b8\ub819\ud1a0\ucf54\ucfe0\uc2a4 \ubba4\ud0c4\uc2a4(Streptococcus mutans)\ub294 \ucda9\uce58\ub97c \uc720\ubc1c\ud558\ub294 \uc8fc\uc694 \ubcd1\uc6d0\uade0\uc785\ub2c8\ub2e4. \uce58\uc544 \ud45c\uba74\uc5d0 \ubc14\uc774\uc624\ud544\ub984\uc744 \ud615\uc131\ud558\uc5ec \uce58\uc544\ub97c \ubd80\uc2dd\uc2dc\ud0a4\uace0 \ucda9\uce58\ub97c \uc720\ubc1c\ud558\ub294 \uc0b0\uc131 \ubb3c\uc9c8\uc744 \ubd84\ube44\ud569\ub2c8\ub2e4. DIM\uc740 \uc2a4\ud2b8\ub819\ud1a0\ucf54\ucfe0\uc2a4 \ubba4\ud0c4\uc2a4 \ubc14\uc774\uc624\ud544\ub984 \ud615\uc131\uc744 \ucd5c\ub300 92%\uae4c\uc9c0 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \ub610\ud55c \ubc14\uc774\uc624\ud544\ub984\uc758 \ud575\uc2ec \uad6c\uc131 \uc694\uc18c\uc778 \uc138\ud3ec\uc678 \uace0\ubd84\uc790 \ubb3c\uc9c8(EPS)\uc758 \uc0dd\uc131\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5b5\uc81c\ub294 S. mutans\uac00 \uce58\uc544 \ud45c\uba74\uc5d0 \uc11c\uc2dd\ud558\uace0 \uc99d\uc2dd\ud558\ub294 \uac83\uc744 \ub9c9\uc544 \ucda9\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc608\ubc29\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c, DIM\uc740 \ud604\uc7ac \uc804\uc784\uc0c1 \uc2dc\ud5d8 \ub2e8\uacc4\uc5d0 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ucda9\uce58 \uc608\ubc29 \uad6c\uac15 \uccad\uacb0\uc81c\uc758 \ud65c\uc131 \uc131\ubd84\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \ud601\uc2e0\uc801\uc778 \uad6c\uac15 \uad00\ub9ac \uc81c\ud488\uc740 \ucda9\uce58 \uc608\ubc29\uc5d0 \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \ubcf4\ud638 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud558\uace0, \uad6c\uac15 \uac74\uac15\uc744 \uac1c\uc120\ud558\uba70, \ub354\uc6b1 \uac74\uac15\ud558\uace0 \uc790\uc2e0\uac10 \uc788\ub294 \ubbf8\uc18c\ub97c \ub9cc\ub4e4\uc5b4 \uc904 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc548\uc804\uc131 \ud3c9\uac00 \ubc0f \uc704\ud5d8 \uacbd\uace0\"\"<\/h2>\n

(I) \ub3c5\uc131\ud559 \ub370\uc774\ud130 \ubc0f \uc77c\ubc18\uc801\uc778 \uc6a9\ub7c9<\/h3>\n

DIM\uc758 \uac74\uac15 \uc751\uc6a9 \ubd84\uc57c\ub97c \ud0d0\uc0c9\ud560 \ub54c \uc548\uc804\uc131\uc740 \uc911\uc694\ud55c \uace0\ub824 \uc0ac\ud56d\uc785\ub2c8\ub2e4. \ub3c5\uc131\ud559 \ub370\uc774\ud130\ub294 \ube44\uad50\uc801 \ub192\uc740 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uae09\uc131 \ub3c5\uc131 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 DIM\uc758 \uce58\uc0ac\ub7c9 \uc911\uc559\uac12(LD\u2085\u2080)\uc740 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uacbd\uad6c \ud22c\uc5ec \uc2dc 5,000mg\/kg \uc774\uc0c1\uc785\ub2c8\ub2e4. \uc774 \ub370\uc774\ud130\ub294 \ub9c8\uc6b0\uc2a4\uc5d0\uc11c \ub9e4\uc6b0 \ub192\uc740 \uc6a9\ub7c9\uc758 DIM\uc870\ucc28\ub3c4 \uce58\uc0ac\ub7c9 \uc911\uc559\uac12\uc5d0 \ub3c4\ub2ec\ud558\ub294 \uacbd\uc6b0\uac00 \ub4dc\ubb3c\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uba70, \uc774\ub294 DIM\uc774 \uc0ac\uc2e4\uc0c1 \ubb34\ub3c5\uc131 \ubc94\uc704\uc5d0 \uc18d\ud558\uba70 \uc778\uccb4 \uc548\uc804\uc131\uc5d0 \ub300\ud55c \ud569\ub9ac\uc801\uc778 \uadfc\uac70\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc784\uc0c1 \uc2e4\ubb34\uc5d0\uc11c \uc758\uc0ac\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ud658\uc790\uc758 \ud2b9\uc815 \uc0c1\ud669\uc5d0 \ub530\ub77c \uc6a9\ub7c9\uc744 \uc2e0\uc911\ud558\uac8c \uacb0\uc815\ud569\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uad8c\uc7a5 \uc6a9\ub7c9\uc740 100~300mg\/\uc77c\uc785\ub2c8\ub2e4. \uc774 \uc6a9\ub7c9 \ubc94\uc704 \ub0b4\uc5d0\uc11c DIM\uc758 \ub2e8\uae30\uac04 \uc0ac\uc6a9(12\uc8fc \uc774\ud558)\uc740 \ube44\uad50\uc801 \uc548\uc804\ud558\uba70 \ub300\ubd80\ubd84\uc758 \ud658\uc790\ub294 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9 \uc5c6\uc774 \uc798 \uacac\ub525\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc18c\uc218\uc758 \ud658\uc790\ub294 \uacbd\ubbf8\ud55c \ubd88\ud3b8\ud568\uc744 \uacbd\ud5d8\ud560 \uc218 \uc788\uc73c\uba70, \uc704\uc7a5\uad00 \ubd88\ud3b8\ud568\uc774 \uac00\uc7a5 \ud754\ud558\uc9c0\ub9cc \ubc1c\uc0dd\ub960\uc740 \uc57d 5% \ubbf8\ub9cc\uc73c\ub85c \ube44\uad50\uc801 \ub0ae\uc2b5\ub2c8\ub2e4. \ucd94\uac00 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc774\ub7ec\ud55c \uc704\uc7a5\uad00 \uc99d\uc0c1\uc740 \ub300\ubd80\ubd84 \uacf5\ubcf5\uc5d0 DIM\uc744 \ubcf5\uc6a9\ud588\uc744 \ub54c \ubc1c\uc0dd\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc7a5\uad00 \ubd88\ud3b8\uac10\uc744 \ucd5c\uc18c\ud654\ud558\uae30 \uc704\ud574 \uc2dd\ud6c4\uc5d0 DIM\uc744 \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. DIM\uc740 \uc704\uc7a5\uad00\uc744 \ubcf4\ud638\ud558\ub294 \ubcf4\ud638\ub9c9 \uc5ed\ud560\uc744 \ud558\uc5ec \uc57d\ubb3c \uc790\uadf9\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc904\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

\uacfc\ud559\uc790\ub4e4\uc740 \ub610\ud55c DIM\uc758 \uc7a5\uae30\uac04 \uc0ac\uc6a9 \uc548\uc804\uc131\uc5d0 \ub300\ud55c \uc2ec\uce35 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc7a5\uae30 \ub3c5\uc131 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 6\uac1c\uc6d4 \ub3d9\uc548 500mg\/kg\/day \uc6a9\ub7c9\uc73c\ub85c \ud22c\uc5ec\ud588\uc744 \ub54c \uc950\uc758 \uac04 \ubc0f \uc2e0\uc7a5 \uae30\ub2a5\uc5d0 \uc720\uc758\ubbf8\ud55c \uc774\uc0c1\uc774 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ube44\uad50\uc801 \uc7a5\uae30\uac04 \uace0\uc6a9\ub7c9\uc758 DIM\uc744 \ud22c\uc5ec\ud574\ub3c4 \uc950\uc758 \uac04 \ubc0f \uc2e0\uc7a5 \uae30\ub2a5\uc5d0 \uc720\uc758\ubbf8\ud55c \uc190\uc0c1\uc744 \uc720\ubc1c\ud558\uc9c0 \uc54a\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub3d9\ubb3c \uc2e4\ud5d8 \uacb0\uacfc\ub294 \uc5b4\ub290 \uc815\ub3c4 \ucc38\uace0\ud560 \uc218 \uc788\uc9c0\ub9cc, \uc778\uccb4\uc5d0 \uc644\uc804\ud788 \uc801\uc6a9\ud560 \uc218\ub294 \uc5c6\ub2e4\ub294 \uc810\uc5d0 \uc720\uc758\ud574\uc57c \ud569\ub2c8\ub2e4. DIM\uc758 \ub300\uc0ac \ubc0f \uc791\uc6a9 \uae30\uc804\uc740 \uc778\uccb4 \ub0b4\uc5d0\uc11c \ub2e4\uc591\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c DIM\uc744 \uc7a5\uae30\uac04 \uc0ac\uc6a9\ud558\ub824\uba74 \ud658\uc790\uc758 \uc2e0\uccb4 \ubc18\uc751\uc744 \uba74\ubc00\ud788 \ubaa8\ub2c8\ud130\ub9c1\ud558\uace0 \uc548\uc804\uc131\uc744 \ubcf4\uc7a5\ud558\uae30 \uc704\ud55c \uc815\uae30\uc801\uc778 \uac80\uc0ac\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

(II) \uae08\uae30 \uc0ac\ud56d \ubc0f \uc57d\ubb3c \uc0c1\ud638\uc791\uc6a9<\/h3>\n

\uc784\uc2e0 \ubc0f \ubaa8\uc720 \uc218\uc720: \uc784\uc2e0 \ubc0f \ubaa8\uc720 \uc218\uc720 \uc911\uc778 \uc5ec\uc131\uc740 \ub3c5\ud2b9\ud55c \uc0dd\ub9ac\uc801 \uc0c1\ud0dc\uc5d0 \uc788\uc73c\uba70, \ubaa8\ub4e0 \uc57d\ubb3c\uc740 \ub9e4\uc6b0 \uc2e0\uc911\ud558\uac8c \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8 \uacb0\uacfc \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4(DIM)\uc740 \ud0dc\ubc18\uc744 \ud1b5\uacfc\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4\uc774 \ud0dc\uc544 \uae30\ud615\uc744 \uc720\ubc1c\ud55c\ub2e4\ub294 \ud655\uc2e4\ud55c \uc99d\uac70\ub294 \uc5c6\uc9c0\ub9cc, \ud0dc\uc544\uc758 \uc548\uc804\uc744 \uc704\ud574 \uc784\uc2e0 \ubc0f \ubaa8\uc720 \uc218\uc720 \uc911\uc778 \uc5ec\uc131\uc740 \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4 \uc0ac\uc6a9\uc744 \ud53c\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ud0dc\uc544\uc5d0\uac8c \uc548\uc804\ub9dd\uc744 \uc81c\uacf5\ud558\uc5ec \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc744 \uc608\ubc29\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubcd1\uc6a9 \uc57d\ubb3c \uc0ac\uc6a9\uc758 \uc704\ud5d8: \uc57d\ubb3c \uce58\ub8cc \uc911 \ud658\uc790\ub294 \uc885\uc885 \uc5ec\ub7ec \uc57d\ubb3c\uc744 \ub3d9\uc2dc\uc5d0 \ubcf5\uc6a9\ud574\uc57c \ud558\ubbc0\ub85c \uc57d\ubb3c \uc0c1\ud638\uc791\uc6a9 \ubb38\uc81c\uac00 \uc81c\uae30\ub429\ub2c8\ub2e4. \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4\uacfc \ud2b9\uc815 \uc57d\ubb3c\uc744 \ubcd1\uc6a9\ud558\uba74 \uc57d\ubb3c\uc758 \ud6a8\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uac70\ub098 \ubd80\uc791\uc6a9 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \ub4f1 \uc0c1\ud638\uc791\uc6a9\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub514\uc778\ub3cc\ub9ac\uba54\ud0c4\uc744 \uc640\ud30c\ub9b0\uacfc \uac19\uc740 \ud56d\uc751\uace0\uc81c\uc640 \ud568\uaed8 \uc0ac\uc6a9\ud558\uba74 \ud56d\uc751\uace0\uc81c\uc758 \ud6a8\uacfc\uac00 \uc99d\uac00\ud558\uc5ec \uad6d\uc81c\ud45c\uc900\ud654\ube44\uc728(INR)\uc774 15~20% \uc99d\uac00\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. INR\uc740 \ud608\uc561 \uc751\uace0\uc131\uc758 \ud575\uc2ec \uc9c0\ud45c\uc774\uba70, INR\uc774 \ub192\uc73c\uba74 \ucd9c\ud608 \uc704\ud5d8\uc774 \ub192\uc544\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c DIM\uacfc \ud56d\uc751\uace0\uc81c\ub97c \ub3d9\uc2dc\uc5d0 \uc0ac\uc6a9\ud560 \uacbd\uc6b0, \ud658\uc790\uc758 \uc548\uc804\uc744 \uc704\ud574 INR\uc744 \uba74\ubc00\ud788 \ubaa8\ub2c8\ud130\ub9c1\ud558\uace0 \ud56d\uc751\uace0\uc81c \uc6a9\ub7c9\uc744 \uc801\uc808\ud788 \uc870\uc808\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

DIM\uc740 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \ub300\uccb4 \uc694\ubc95\uacfc \ud568\uaed8 \uc0ac\uc6a9\ud560 \uacbd\uc6b0 \uc790\uad81\ub0b4\ub9c9 \uc99d\uc2dd\uc99d \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc704\ud5d8\uc744 \uc644\ud654\ud558\uae30 \uc704\ud574 \ub450 \uc57d\ubb3c\uc744 \ucd5c\uc18c 4\uc2dc\uac04 \uac04\uaca9\uc744 \ub450\uace0 \ubcf5\uc6a9\ud558\uc5ec \uc0c1\ud638\uc791\uc6a9\uc744 \ucd5c\uc18c\ud654\ud558\uace0 \ubd80\uc791\uc6a9 \ubc1c\uc0dd \uac00\ub2a5\uc131\uc744 \uc904\uc774\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud2b9\uc218 \ud658\uc790\uad70: DIM\uc740 \uac11\uc0c1\uc120 \uc9c8\ud658 \ubc0f \ub179\ub0b4\uc7a5 \ud658\uc790\uc640 \uac19\uc740 \ud2b9\uc815 \ud658\uc790\uad70\uc5d0\uc11c \ud2b9\ud788 \uc8fc\uc758\ud574\uc57c \ud569\ub2c8\ub2e4. DIM\uc740 \uac11\uc0c1\uc120 \ud638\ub974\ubaac \ud569\uc131\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \ud6a8\uc18c\uc778 \uac11\uc0c1\uc120 \uacfc\uc0b0\ud654\ud6a8\uc18c\uc758 \ud65c\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\ubbc0\ub85c \uac11\uc0c1\uc120 \uc9c8\ud658 \ud658\uc790\uc5d0\uac8c\ub294 \uc8fc\uc758\ud574\uc11c \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4. DIM\uc774 \uc774 \ud6a8\uc18c\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc740 \uac11\uc0c1\uc120 \ud638\ub974\ubaac\uc758 \uc815\uc0c1\uc801\uc778 \ud569\uc131\uc744 \ubc29\ud574\ud558\uc5ec \uac11\uc0c1\uc120 \uc9c8\ud658 \ud658\uc790\uc758 \uac11\uc0c1\uc120 \uc9c8\ud658 \uc870\uc808\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub179\ub0b4\uc7a5 \ud658\uc790\ub294 DIM\uc774 \uc548\uc555\uc744 \uc0c1\uc2b9\uc2dc\ucf1c \ub179\ub0b4\uc7a5 \ud658\uc790\uc758 \uc548\uc555 \uc870\uc808\uc744 \ub354\uc6b1 \uc5b4\ub835\uac8c \ub9cc\ub4e4 \uc218 \uc788\ub2e4\ub294 \uc810\uc744 \uc778\uc9c0\ud574\uc57c \ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c DIM\uc744 \uc0ac\uc6a9\ud558\uae30 \uc804\uc5d0 \ub179\ub0b4\uc7a5 \ud658\uc790\ub294 \uc758\uc0ac\uc640 \uc0c1\ub2f4\ud574\uc57c \ud569\ub2c8\ub2e4. \uc758\uc0ac\ub294 \ud658\uc790\uc758 \uad6c\uccb4\uc801\uc778 \uc0c1\ud669\uc744 \ubc14\ud0d5\uc73c\ub85c \uc885\ud569\uc801\uc778 \ud3c9\uac00\ub97c \uc2e4\uc2dc\ud558\uace0 \uc7a5\ub2e8\uc810\uc744 \ube44\uad50 \uac80\ud1a0\ud55c \ud6c4 DIM \uc0ac\uc6a9 \uc5ec\ubd80\ub97c \uacb0\uc815\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\"\"\uc2dd\ubb3c \ud3f4\ub9ac\ud398\ub180\uc758 \uac74\uac15 \uac00\uce58\uc5d0 \ub300\ud55c \ud569\ub9ac\uc801 \ud0d0\uad6c<\/h2>\n

\uc2ed\uc790\ud654\uacfc \uc2dd\ubb3c\uc758 \ud575\uc2ec \ud65c\uc131 \uc131\ubd84\uc778 DIM\uc740 \ub2e4\uc911 \ud45c\uc801 \ud56d\uc554, \ud638\ub974\ubaac \uc870\uc808 \ubc0f \ud56d\uc0b0\ud654 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud558\uc5ec \ud45c\uc801 \ud56d\ub178\ud654 \ubc0f \uc9c8\ubcd1 \uc608\ubc29\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4. \uc18c\ube44\uc790\ub294 \uaddc\uc81c\ub41c \uacf5\uae09\uc6d0\uc5d0\uc11c \uc0dd\uc0b0\ub41c \uace0\uc21c\ub3c4(\u226598%) \uc81c\ud488\uc5d0 \uc9d1\uc911\ud574\uc57c \ud569\ub2c8\ub2e4. \uc804\ubb38\uac00\uc758 \uc9c0\ub3c4\uc640 \uc2dd\uc774 \uc870\uc808\uc744 \ubcd1\ud589\ud558\uba74 “\ucc9c\uc5f0 \uc131\ubd84 + \uacfc\ud559\uc801 \uac1c\uc785”\uc758 \uac74\uac15\uc0c1 \uc774\uc810\uc744 \uadf9\ub300\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc804\ub2ec \uae30\uc220\uacfc \uc784\uc0c1 \uc5f0\uad6c\uc758 \ubc1c\uc804\uc73c\ub85c DIM\uc740 \uae30\ub2a5\uc131 \uc2dd\ud488 \uc131\ubd84\uc5d0\uc11c \uc554 \ud654\ud559 \uc608\ubc29\uc758 1\ucc28 \uce58\ub8cc\uc81c\ub85c \uc9c4\ud654\ud558\uc5ec \uc2dd\ubb3c \uc720\ub798 \uc758\uc57d\ud488 \uac1c\ubc1c\uc758 \uc0c8\ub85c\uc6b4 \uc7a5\uc744 \uc5f4 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

DIM(3,3′-\ub514\uc778\ub3cc\ub9b4\uba54\ud0c4, DIM)\uc740 \ud654\ud559\uc801\uc73c\ub85c \ubd84\uc790\uc2dd C\u2081\u2087H\u2081\u2084N\u2082\uc744 \uac16\ub294 \uc720\uae30 \ud654\ud569\ubb3c\uc774\uba70, \ubd84\uc790\ub7c9\uc740 246.31\uc785\ub2c8\ub2e4. \uba54\ud2f8\ub80c\uae30\ub85c \uad50\ubb18\ud558\uac8c \uc5f0\uacb0\ub41c \ub450 \uac1c\uc758 \uc778\ub3cc \uace0\ub9ac\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\uc73c\uba70, \uc774 \ub3c5\ud2b9\ud55c \uad6c\uc870\ub294 \ub6f0\uc5b4\ub09c \ud654\ud559\uc801 \ud65c\uc131\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774\uc131\uc9c8\uccb4 \uc911 \ud2b8\ub79c\uc2a4 \uc774\uc131\uc9c8\uccb4\ub9cc\uc774 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c0\ubbc0\ub85c \uc5f0\uad6c \ubc0f \uc751\uc6a9 \ubd84\uc57c\uac00 \ub354\uc6b1 \uc9d1\uc911\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc21c\uc218\ud55c DIM\uc740 \ud770\uc0c9 \uacb0\uc815\uc131 \ubd84\ub9d0\ub85c, \uc21c\uc218\ud558\uace0 \uc12c\uc138\ud55c \uc678\uad00\uc744 \uc790\ub791\ud569\ub2c8\ub2e4. \ubb3c\uc5d0\ub294 \uc57d\uac04 \uc6a9\ud574\ub418\uc5b4 25\u00b0C\uc5d0\uc11c \ub9ac\ud130\ub2f9 0.12g\ub9cc … Continue reading DIM: \uc2dd\ubb3c\uc131 \uc6d0\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uacfc\ud559\uc801 \ud574\ub3c5<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":2860,"parent":0,"menu_order":29,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-2859","blog","type-blog","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/comments?post=2859"}],"version-history":[{"count":0,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2859\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media\/2860"}],"wp:attachment":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media?parent=2859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}