{"id":2891,"date":"2025-10-21T08:06:00","date_gmt":"2025-10-21T08:06:00","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2891"},"modified":"2025-10-21T08:06:00","modified_gmt":"2025-10-21T08:06:00","slug":"%ed%94%84%ed%85%8c%eb%a1%9c%ec%8a%a4%ed%8b%b0%eb%b2%a4-%ec%b2%9c%ec%97%b0-%ed%8f%b4%eb%a6%ac%ed%8e%98%eb%86%80%ec%97%90%ec%84%9c-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80%ec%9d%98-%ec%83%88%eb%a1%9c","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/%ed%94%84%ed%85%8c%eb%a1%9c%ec%8a%a4%ed%8b%b0%eb%b2%a4-%ec%b2%9c%ec%97%b0-%ed%8f%b4%eb%a6%ac%ed%8e%98%eb%86%80%ec%97%90%ec%84%9c-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80%ec%9d%98-%ec%83%88%eb%a1%9c\/","title":{"rendered":"\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4: \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180\uc5d0\uc11c \ub178\ud654 \ubc29\uc9c0\uc758 \uc0c8\ub85c\uc6b4 \uc778\uae30 \uc131\ubd84\uc73c\ub85c\uc758 \uacfc\ud559\uc801 \ud574\uc11d"},"content":{"rendered":"

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ud53c\ub85c\uac08\ub864 \uad6c\uc870\ub97c \uac00\uc9c4 \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180 \ud654\ud569\ubb3c\uc785\ub2c8\ub2e4. \ud654\ud559\uc801\uc73c\ub85c\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc758 \uba54\ud2f8\ud654\ub41c \uc720\ub3c4\uccb4\uc785\ub2c8\ub2e4. \uc774 \uc791\uc740 \ubcc0\ud654\ub97c \uacfc\uc18c\ud3c9\uac00\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud6a8\ub2a5\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uacbd\uad6c \uc0dd\uccb4\uc774\uc6a9\ub960\uc740 80%\uc5d0 \ub2ec\ud558\uba70, \uc774\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc758 4\ubc30\uc5d0 \ub2ec\ud558\ub294 \ub180\ub77c\uc6b4 \uc218\uce58\uc785\ub2c8\ub2e4. \uc989, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uad6c\uc870\uc801\uc73c\ub85c \uc12d\ucde8 \ud6c4 \uccb4\ub0b4\uc5d0\uc11c \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub418\uace0 \ud65c\uc6a9\ub418\uc5b4 \uc81c \uae30\ub2a5\uc744 \ubc1c\ud718\ud560 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ube14\ub8e8\ubca0\ub9ac, \ud3ec\ub3c4, \uc790\ub2e8\uacfc \uac19\uc740 \uc2dd\ubb3c\uc5d0\uc11c \ub110\ub9ac \ubc1c\uacac\ub429\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774\ub77c\ub294 \uc774\ub984 \ub610\ud55c \ub9e4\uc6b0 \uc720\uc11c \uae4a\uc740\ub370, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc18d \uc2dd\ubb3c\uc5d0\uc11c \ucd5c\ucd08\ub85c \ubd84\ub9ac\uc5d0 \uc131\uacf5\ud588\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \uc2dd\ubb3c\uc131 \uc5d0\uc2a4\ud2b8\ub85c\uac90\uacfc \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \ud2b9\uc131 \ub355\ubd84\uc5d0 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ucd5c\uadfc \uae30\ub2a5\uc131 \uc2dd\ud488 \ubc0f \uc758\uc57d\ud488 \ubd84\uc57c\uc758 \uc5f0\uad6c \ub300\uc0c1\uc73c\ub85c \uc790\ub9ac \uc7a1\uc558\uc73c\uba70, \uc218\ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \uadf8 \ube44\ubc00\uc744 \ub354\uc6b1 \uae4a\uc774 \ud30c\uace0\ub4e4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ube14\ub8e8\ubca0\ub9ac\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c, \ud575\uc2ec \ud56d\uc0b0\ud654\uc81c\uc778 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uacfc\uc77c\uc744 \uc0b0\ud654 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc774\ub97c \uc12d\ucde8\ud558\ub294 \uc0ac\ub78c\uc5d0\uac8c \uac74\uac15\uc0c1\uc758 \uc774\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\"\"<\/p>\n

\ud575\uc2ec \ud654\ud559\uc801 \ud2b9\uc131 \ubc0f \uc791\uc6a9 \uae30\uc804<\/h2>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4<\/strong><\/a>\uc758 \ubd84\uc790 \uad6c\uc870\ub294 \uc815\uad50\ud558\uac8c \uc124\uacc4\ub41c \uc815\ubc00 \uae30\uae30\uc640 \uc720\uc0ac\ud558\uba70, \ub514\uba54\ud1a1\uc2dc \uce58\ud658\uae30\uac00 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uad6c\uc870\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc9c0\uc9c8 \uc6a9\ud574\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud2b9\uc131\uc740 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 “\ub9c8\uc2a4\ud130 \ud0a4”\ub85c \ub9cc\ub4e4\uc5b4 \uc138\ud3ec\ub9c9\uc744 \uc27d\uac8c \ud1b5\uacfc\ud558\uc5ec \uc138\ud3ec \ub0b4\ubd80\ub85c \uce68\ud22c\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc77c\ub2e8 \uc138\ud3ec \ub0b4\ubd80\ub85c \uce68\ud22c\ud558\uba74, “\ud45c\uc801”\uc740 \uba85\ud655\ud574\uc9d1\ub2c8\ub2e4. \ubc14\ub85c \uc138\ud3ec\ud575\uc758 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uc6a9\uccb4(ER\u03b1\/ER\u03b2)\uc5d0 \uc9c1\uc811 \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc218\uc6a9\uccb4\uc5d0 \ud2b9\uc774\uc801\uc73c\ub85c \uacb0\ud569\ud568\uc73c\ub85c\uc368 \uc138\ud3ec \ub0b4 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc870\uc808 \uacfc\uc815\uc5d0 \ucc38\uc5ec\ud558\uc5ec \ub0b4\ubd84\ube44 \ud56d\uc0c1\uc131 \uc720\uc9c0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uc6a9\uccb4\uc5d0 \uc791\uc6a9\ud558\ub294 \uac83 \uc678\uc5d0\ub3c4 AMPK \ubc0f NF-\u03baB\ub97c \ud3ec\ud568\ud55c \uc138\ud3ec \ub0b4 \uc5ec\ub7ec \uc8fc\uc694 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc5d0\ub3c4 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 AMPK \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc5d0 \uc791\uc6a9\ud558\uc5ec \uad00\ub828 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \uc870\uc808\ud558\uace0, \uc138\ud3ec\uac00 \uc5d0\ub108\uc9c0\ub97c \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \ud65c\uc6a9\ud558\uace0 \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc5fc\uc99d \ubc18\uc751\uc5d0 \ubc18\uc751\ud558\uc5ec \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 NF-\u03baB \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud558\uace0, \uc5fc\uc99d \uad00\ub828 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uacfc \uc5fc\uc99d \uc778\uc790\uc758 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ubc1c\ud718\ud569\ub2c8\ub2e4. \ubd84\uc790 \uc218\uc900\uc5d0\uc11c \uc774\ub7ec\ud55c \uc870\uc808 \uacfc\uc815\uc740 \uad81\uadf9\uc801\uc73c\ub85c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \uc720\uc804\uc790 \ubc1c\ud604\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0\uc11c \ube44\ub86f\ub429\ub2c8\ub2e4. “\uc720\uc804\uc790 \uc0ac\ub839\uad00”\ucc98\ub7fc \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc2e0\uccb4\uc758 \ud544\uc694\uc5d0 \ub530\ub77c \uc720\uc804\uc790 \ubc1c\ud604 \uc218\uc900\uc744 \uc815\ubc00\ud558\uac8c \uc870\uc808\ud558\uc5ec \ud56d\uc5fc\uc99d, \ud56d\uc0b0\ud654, \ub300\uc0ac \uc870\uc808 \ub4f1 \ub2e4\uc591\ud55c \uc0dd\ub9ac \uae30\ub2a5\uc744 \ub2ec\uc131\ud558\uace0, \uc778\uccb4 \uac74\uac15\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \ubc29\uc5b4\ub825\uc744 \uc81c\uacf5\ud558\uba70, \ub2e4\uc911 \ud45c\uc801 \uac74\uac15 \uc911\uc7ac\uc5d0 \ub300\ud55c \ubd84\uc790\uc801 \uae30\ubc18\uc744 \ub9c8\ub828\ud569\ub2c8\ub2e4.<\/p>\n

\ud575\uc2ec \ud6a8\ub2a5: \ub2e4\uccb4\uacc4 \uac74\uac15 \uc911\uc7ac\uc758 \ubd84\uc790\uc801 \uae30\uc804\"\"<\/h2>\n

(I) \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d: \ub178\ud654\ub97c \uc704\ud55c \uc138\ud3ec \ubc29\uc5b4 \uc2dc\uc2a4\ud15c<\/h3>\n

\uc778\uccb4\uc5d0\uc11c \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5fc\uc99d \ubc18\uc751\uc740 \ub9c8\uce58 “\uc228\uaca8\uc9c4 \uc0b4\uc778\uc790”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ub04a\uc784\uc5c6\uc774 \uc138\ud3ec \uac74\uac15\uc744 \uc704\ud611\ud558\uace0 \ub178\ud654 \ubc0f \ub2e4\uc591\ud55c \ub9cc\uc131 \uc9c8\ud658\uc758 \ubc1c\ubcd1\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc6a9\uac10\ud55c “\uc218\ud638\uc790”\ucc98\ub7fc \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ub6f0\uc5b4\ub09c \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4.
\n\ud56d\uc0b0\ud654 \uad00\uc810\uc5d0\uc11c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc791\uc6a9 \uae30\uc804\uc740 \ub3c5\ucc3d\uc801\uc785\ub2c8\ub2e4. “\uae08\uc18d \uc774\uc628 \ud3ec\uc9d1\uae30” \uc5ed\ud560\uc744 \ud558\uc5ec \uae08\uc18d \uc774\uc628\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ud0ac\ub808\uc774\ud2b8\ud558\uace0, \uc790\uc720 \ub77c\ub514\uce7c \uc0dd\uc131\uc744 \uc6d0\ucc9c\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uae08\uc18d \uc774\uc628\uc740 \uccb4\ub0b4\uc5d0\uc11c \uc885\uc885 \ucd09\ub9e4 \uc5ed\ud560\uc744 \ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c \uc0dd\uc131\uc744 \ucd09\uc9c4\ud558\uae30 \ub54c\ubb38\uc5d0, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uae08\uc18d \uc774\uc628 \ud0ac\ub808\uc774\ud2b8\ud654\ub294 “\uc790\uc720 \ub77c\ub514\uce7c \uc0dd\uc131\uc758 \uc6d0\ucc9c”\uc774\uc790 \uc138\ud3ec \ub0b4 “\uccad\uc18c \uacbd\ube44\uc6d0” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. SOD\ub294 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628(O\u2082\u207b)\uc744 \uacfc\uc0b0\ud654\uc218\uc18c\ub85c \uc804\ud658\ud558\uace0, GSH-Px\ub294 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \ubb3c\ub85c \ud658\uc6d0\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\ub4e4\uc740 \uc138\ud3ec \ub0b4 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628(O\u2082\u207b), \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c(\u30fbOH) \ubc0f \uae30\ud0c0 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\uc5ec \uc9c0\uc9c8 \uacfc\uc0b0\ud654\ub97c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ube44\ud0c0\ubbfc C\ubcf4\ub2e4 10\ubc30 \uc774\uc0c1 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ud65c\uc131\uc744 \uac00\uc9c0\uace0 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ube14\ub8e8\ubca0\ub9ac\ub97c \ubcf4\uad00\ud558\ub294 \ub3d9\uc548 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc9c0\uc9c8 \uacfc\uc0b0\ud654\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uc5ec \ube14\ub8e8\ubca0\ub9ac\ub97c \ub354 \uc624\ub7ab\ub3d9\uc548 \uc2e0\uc120\ud558\uac8c \uc720\uc9c0\ud558\uace0 \ub9db\uc788\uace0 \uac74\uac15\ud55c \uacbd\ud5d8\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ub610\ud55c \uc5fc\uc99d \uacbd\ub85c \uc870\uc808\uc5d0 \ud0c1\uc6d4\ud569\ub2c8\ub2e4. NF-\u03baB \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc815\ud655\ud558\uac8c \ud45c\uc801\uc73c\ub85c \uc0bc\uc544 \uc5b5\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NF-\u03baB \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub294 \uc5fc\uc99d \ubc18\uc751\uc5d0\uc11c \ud575\uc2ec\uc801\uc778 \uc870\uc808 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud65c\uc131\ud654\ub418\uba74 IL-6 \ubc0f TNF-\u03b1\uc640 \uac19\uc740 \uc77c\ub828\uc758 \uc5fc\uc99d \uc720\ubc1c \uc0ac\uc774\ud1a0\uce74\uc778\uc758 \ubc29\ucd9c\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uace8\uad00\uc808\uc5fc \ubaa8\ub378\uc5d0\uc11c \uad00\uc808 \uc5f0\uace8\uc740 \uc5fc\uc99d\uc5d0 \uc758\ud574 \uce68\ubc94\ub418\uc5b4 MMP-13 \ud6a8\uc18c\uc758 \ubc1c\ud604\uc774 \uc99d\uac00\ud558\uc5ec \uc5f0\uace8 \ubcc0\uc131\uc774 \uac00\uc18d\ud654\ub429\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4(Pterostibene) \ud22c\uc5ec\ub294 \uad00\uc808 \uc5f0\uace8\uc758 MMP-13 \ubc1c\ud604\uc744 60% \uac10\uc18c\uc2dc\ucf1c \uc5f0\uace8 \ubcc0\uc131 \uc9c4\ud589\uc744 \ud604\uc800\ud788 \ub2a6\ucd94\uace0 \uace8\uad00\uc808\uc5fc \ud658\uc790\uc5d0\uac8c \ud76c\ub9dd\uc744 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc2ec\ud608\uad00 \ubcf4\ud638: \ud608\uad00 \uc7ac\uc0dd\uc758 \uc591\ubc29\ud5a5 \uc870\uc808<\/h3>\n

\uc2ec\ud608\uad00 \uc9c8\ud658\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc778\ub958 \uac74\uac15\uc5d0 \ub300\ud55c \uc8fc\uc694 \uc704\ud611\uc774 \ub418\uace0 \uc788\uc73c\uba70, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \uc2ec\ud608\uad00 \ubcf4\ud638\uc5d0 \ub300\ud574 \ubcf4\uc5ec\uc900 \uc7a0\uc7ac\ub825\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

\ub0b4\ud53c \uae30\ub2a5\uc740 \uc2ec\ud608\uad00\uacc4\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5 \uc720\uc9c0\uc5d0 \ud544\uc218\uc801\uc774\uba70, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ub0b4\ud53c \uae30\ub2a5 \ucd5c\uc801\ud654\uc5d0 \uc788\uc5b4 \uace0\uc720\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc0b0\ud654\uc9c8\uc18c \ud569\uc131\ud6a8\uc18c(eNOS)\uc758 \ud65c\uc131\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc0b0\ud654\uc9c8\uc18c\ub294 \ud608\uad00 \ud655\uc7a5\uc81c \uc5ed\ud560\uc744 \ud558\uc5ec \ud608\uad00 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ucf1c \ud608\uad00\uc744 \ud655\uc7a5\ud558\uace0 \ubbf8\uc138\uc21c\ud658\uc744 \uac1c\uc120\ud569\ub2c8\ub2e4. \ub610\ud55c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \ub0b4\ud53c \uc190\uc0c1\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uace0\ud638\ubaa8\uc2dc\uc2a4\ud14c\uc778\ud608\uc99d \ud658\uc790\uc758 \ud608\uad00 \ubcf4\ud638\uc5d0 \uad00\ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 Nrf2 \ub9e4\uac1c AMPK\/STAT3 \uacbd\ub85c\ub97c \uc870\uc808\ud558\uac70\ub098 PI3K\/Akt \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud558\uc5ec \ub0b4\ud53c\uc138\ud3ec\uc758 \uc0b0\ud654\uc9c8\uc18c \ud569\uc131\ud6a8\uc18c(eNOS) \uc778\uc0b0\ud654\ub97c \ub9e4\uac1c\ud568\uc73c\ub85c\uc368 \ub0b4\ud53c\uc138\ud3ec\ub97c \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud558\uc5ec \uc8fd\uc0c1\uacbd\ud654\ubc18 \ud615\uc131 \uc704\ud5d8\uc744 37% \uac10\uc18c\uc2dc\ud0a4\uace0 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\ube44\uc815\uc0c1\uc801\uc778 \uc9c0\uc9c8 \ub300\uc0ac\ub294 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc8fc\uc694 \uc704\ud5d8 \uc694\uc778\uc774\uba70, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc774\uc640 \uad00\ub828\ud558\uc5ec \ud0c1\uc6d4\ud55c \uc870\uc808 \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. “\uc9c0\uc9c8 \ub300\uc0ac \uc0ac\ub839\uad00” \uc5ed\ud560\uc744 \ud558\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 PPAR\u03b3 \uc218\uc6a9\uccb4\ub97c \ud65c\uc131\ud654\ud558\uace0, \uc9c0\ubc29\uc138\ud3ec \ubd84\ud654\ub97c \ucd09\uc9c4\ud558\uba70, \uc9c0\ubc29\uc138\ud3ec\uac00 \uc9c0\ubc29\uc744 \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uc800\uc7a5\ud558\uace0 \ub300\uc0ac\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ub610\ud55c \uac04 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\ud6a8\uc18c(HMG-CoA \ud658\uc6d0\ud6a8\uc18c)\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4(Pterostibene) 200mg\uc744 8\uc8fc \ub3d9\uc548 \ub9e4\uc77c \ubcf5\uc6a9\ud55c \uacb0\uacfc, LDL-C(\uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864, \ud754\ud788 “\ub098\uc05c \ucf5c\ub808\uc2a4\ud14c\ub864”\uc774\ub77c\uace0 \ud568) \uc218\uce58\uac00 12% \uac10\uc18c\ud558\uace0 HDL-C(\uace0\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864, \ud754\ud788 “\uc88b\uc740 \ucf5c\ub808\uc2a4\ud14c\ub864”\uc774\ub77c\uace0 \ud568) \uc218\uce58\uac00 9% \uc99d\uac00\ud558\ub294 \ub180\ub77c\uc6b4 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ud558\uace0 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

(III) \ub0b4\ubd84\ube44 \uc870\uc808: \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uade0\ud615\uc758 \uc815\ubc00\ud55c \uc870\uc808<\/h3>\n

\ub0b4\ubd84\ube44\uacc4\ub294 \uc2e0\uccb4\uc758 “\uc870\uc808 \uc911\ucd94”\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\uba70, \uc5d0\uc2a4\ud2b8\ub85c\uac90\uc740 \ud544\uc218\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc120\ud0dd\uc801 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uc6a9\uccb4 \uc870\uc808\uc81c(SERM)\uc778 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uce58\ub97c \uc815\ubc00\ud558\uac8c \uc870\uc808\ud558\uc5ec \uc2e0\uccb4 \uc5ec\ub7ec \ubd80\uc704\uc758 \uac74\uac15\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc5ec\uc131\uc758 \uacbd\uc6b0 \ub098\uc774\uac00 \ub4e4\uba74\uc11c \ubf08 \uac74\uac15\uc774 \ud2b9\ud788 \uc911\uc694\ud574\uc9c0\uba70, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ubf08 \uac74\uac15 \uc720\uc9c0\uc5d0 \ud0c1\uc6d4\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uace8\uc544\uc138\ud3ec \ubd84\ud654\ub97c \ucd09\uc9c4\ud558\uc5ec \uace8\uc544\uc138\ud3ec\uc5d0 “\ud65c\uc131\ud654\uc81c” \uc5ed\ud560\uc744 \ud558\uc5ec \uace8\uc544\uc138\ud3ec\uac00 \ubcf4\ub2e4 \uc801\uadf9\uc801\uc73c\ub85c \ubf08\ub97c \ud569\uc131\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4 \ub294 \uace8 \ud615\uc131\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ub610\ud55c \ud30c\uace8\uc138\ud3ec \ud65c\ub3d9\uc744 \uc5b5\uc81c\ud558\uace0 \uace8 \ud761\uc218\ub97c \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ud3d0\uacbd \ud6c4 \uc5ec\uc131\uc758 \uacbd\uc6b0, \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uc218\uce58 \uac10\uc18c\ub85c \uc778\ud574 \uace8 \uc190\uc2e4\uc774 \uac00\uc18d\ud654\ub418\uc5b4 \uace8\ub2e4\uacf5\uc99d \ubc1c\uc0dd \uc704\ud5d8\uc774 \ub192\uc544\uc9d1\ub2c8\ub2e4. \uace0\ubb34\uc801\uc778 \uac83\uc740 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4(Pterostibene) \ubcf4\ucda9\uc81c\ub97c 6\uac1c\uc6d4 \ub3d9\uc548 \ubcf5\uc6a9\ud55c \uacb0\uacfc, \uc624\uc2a4\ud14c\uc624\uce7c\uc2e0 \uc218\uce58\uac00 21%, \uc694\ucd94 \uace8\ubc00\ub3c4\uac00 1.8% \uc99d\uac00\ud588\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub294 \uace8\ub2e4\uacf5\uc99d \uac1c\uc120\uc5d0\ub3c4 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ub300\uc0ac \uc99d\ud6c4\uad70\uc5d0\ub3c4 \uc0c1\ub2f9\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uc5d0\uc2a4\ud2b8\ub85c\uac90\uc758 \ud6a8\uacfc\ub97c \ubaa8\ubc29\ud558\uc5ec \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \uc870\uc808\ud558\uc5ec \uc138\ud3ec\uac00 \uc778\uc290\ub9b0\uc5d0 \ub354 \uc798 \ubc18\uc751\ud558\uace0 \ud3ec\ub3c4\ub2f9\uc744 \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ud558\uace0 \ud65c\uc6a9\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ub300\uc0ac \uc99d\ud6c4\uad70 \ud658\uc790\uc5d0\uac8c\ub3c4 \ud6a8\uacfc\uac00 \uc788\uc2b5\ub2c8\ub2e4. (IV) \ud56d\uc554 \ud6a8\uacfc: \ub2e4\ub2e8\uacc4 \uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \ud45c\uc801
\n\ub450\ub824\uc6b4 \uc9c8\ubcd1\uc778 \uc554\uc740 \ud56d\uc0c1 \uc758\ud559 \uc5f0\uad6c\uc758 \uc8fc\uc694 \ud45c\uc801\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc \uba87 \ub144 \ub3d9\uc548 \uc785\uc99d\ub41c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud56d\uc554 \ud6a8\uacfc\ub294 \uc5f0\uad6c\uc790\uc640 \ud658\uc790\uc5d0\uac8c \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc548\uaca8\uc8fc\uc5c8\uc73c\uba70, \uc554 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uc5b4\uc904 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc885\uc591 \uc138\ud3ec \uc99d\uc2dd \uacfc\uc815\uc5d0\uc11c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 “\uc99d\uc2dd \ube0c\ub808\uc774\ud06c” \uc5ed\ud560\uc744 \ud558\uc5ec \uc138\ud3ec \uc8fc\uae30\ub97c G0\/G1 \ub2e8\uacc4\uc5d0\uc11c \ud6a8\uacfc\uc801\uc73c\ub85c \uc815\uc9c0\uc2dc\ud0b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud558\ud5a5 \uc870\uc808\uc740 \uc885\uc591 \uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \ub354\uc6b1 \uc57d\ud654\uc2dc\ud0b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc804\ub9bd\uc120\uc554 \ubc0f \uc720\ubc29\uc554 \uc138\ud3ec\uc8fc\uc5d0 \ub300\ud574 IC50 \uac12\uc774 5~10\u03bcM \uc815\ub3c4\ub85c \ub9e4\uc6b0 \ub0ae\uc544, \ube44\uad50\uc801 \ub0ae\uc740 \ub18d\ub3c4\uc5d0\uc11c\ub3c4 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \uc885\uc591 \uc138\ud3ec \uc99d\uc2dd\uc744 \uc720\uc758\ubbf8\ud558\uac8c \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc885\uc591 \uc138\ud3ec \uc99d\uc2dd\uc744 \uc5b5\uc81c\ud558\ub294 \uac83 \uc678\uc5d0\ub3c4 \ud734\uba74 \uc554\uc138\ud3ec\uc758 \ud65c\uc131\ud654\ub97c \uc870\uc808\ud558\ub294 \ub3c5\ud2b9\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc554 \uce58\ub8cc \uc911 \ud734\uba74 \uc554\uc138\ud3ec\ub294 \uc885\uc885 \uc885\uc591 \uc7ac\ubc1c\uc758 \uc6d0\uc778\uc774 \ub418\uba70, \uccb4\ub0b4\uc5d0 \uc228\uaca8\uc9c4 \uc2dc\ud55c\ud3ed\ud0c4\ucc98\ub7fc \uc5b8\uc81c\ub4e0 \ud65c\uc131\ud654\ub418\uc5b4 \uc885\uc591 \uc7ac\ubc1c\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 SOD2\ub97c \uc0c1\ud5a5 \uc870\uc808\ud558\uc5ec \ud734\uba74 \uc804\ub9bd\uc120\uc554 \uc138\ud3ec\uc758 \uc138\ud3ec\uc790\uba78\uc0ac\ub97c \uc720\ub3c4\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub294 \ud734\uba74 \uc138\ud3ec\uc5d0 “\uc0ac\ub9dd \uc120\uace0”\ub97c \ub0b4\ub9ac\uace0 \uadf8\ub4e4\uc758 \uc740\uc2e0\ucc98\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc18c\uba78\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \uce58\ub8cc\ub294 \uc720\uc758\ubbf8\ud55c \ubd80\uc791\uc6a9 \uc5c6\uc774 \uc885\uc591 \ubd80\ud53c\ub97c 42% \uac10\uc18c\uc2dc\ucf30\uc2b5\ub2c8\ub2e4. \uc774 \uacb0\uacfc\ub294 \uc554 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uc744 \uc81c\uacf5\ud558\uba70, \ud5a5\ud6c4 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uba70, \uc554 \ud658\uc790\uc758 \uc0dd\uc874\uc5d0 \ub300\ud55c \ub354 \ud070 \ud76c\ub9dd\uc744 \uc81c\uacf5\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n

\uc751\uc6a9 \uc2dc\ub098\ub9ac\uc624: \uc804\ud1b5 \uc758\ud559\uc5d0\uc11c \ud604\ub300 \uc815\ubc00 \uac1c\uc785\uae4c\uc9c0\"\"<\/h2>\n

(I) \ucc9c\uc5f0 \uc2dd\ud488\uc758 \ud6a8\uc728\uc801\uc778 \uc12d\ucde8<\/h3>\n

\uc6b0\ub9ac\uc758 \uc77c\uc0c1 \uc2dd\ub2e8\uc5d0\ub294 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud48d\ubd80\ud55c \ub2e4\uc591\ud55c \ucc9c\uc5f0 \uacf5\uae09\uc6d0\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dd\ud488\uc744 \uc801\uc808\ud788 \uc12d\ucde8\ud558\uba74 \ud14c\ub85c\uc2a4\ud2f0\ubca4 \uacf5\uae09\uc6d0\uc744 \ubcf4\ucda9\ud558\uace0 \uac74\uac15\uc0c1\uc758 \uc774\uc810\uc744 \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uacfc\uc77c\uc740 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc911\uc694\ud55c \uacf5\uae09\uc6d0\uc785\ub2c8\ub2e4. \ube14\ub8e8\ubca0\ub9ac\ub294 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ubcf4\uace0\ub85c, 1g\ub2f9 \uc57d 5~10\u03bcg\uc758 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ud568\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub9ce\uc740 \uacfc\uc77c \uc911\uc5d0\uc11c\ub3c4 \ube14\ub8e8\ubca0\ub9ac\ub294 \ub3c5\ud2b9\ud55c \ud48d\ubbf8\uc640 \ud48d\ubd80\ud55c \uc601\uc591 \uc131\ubd84\uc73c\ub85c \ub9ce\uc740 \uc0ac\ub791\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub300\ub85c \uba39\uac70\ub098 \ube14\ub8e8\ubca0\ub9ac \uc7bc\uc774\ub098 \uc694\uad6c\ub974\ud2b8\ub85c \ub9cc\ub4e4\uc5b4 \uba39\uc5b4\ub3c4 \ub9db\uc788\uace0 \uac74\uac15\ud55c \uc120\ud0dd\uc785\ub2c8\ub2e4. \ud3ec\ub3c4, \ud2b9\ud788 \uc790\uc0c9 \ud3ec\ub3c4 \uaecd\uc9c8\uc740 1g\ub2f9 3~8\u03bcg\uc758 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ud568\uc720\ud558\uace0 \uc788\uc5b4 \uc88b\uc740 \uacf5\uae09\uc6d0\uc785\ub2c8\ub2e4. \ud3ec\ub3c4\ub97c \uc12d\ucde8\ud560 \ub54c\ub294 \uaecd\uc9c8\uc9f8 \uba39\ub294 \uac83\uc774 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ucda9\ubd84\ud788 \ud761\uc218\ud558\ub294 \ub370 \uac00\uc7a5 \uc88b\uc2b5\ub2c8\ub2e4. \ubf55\ub098\ubb34 \uc5f4\ub9e4\uc5d0\ub3c4 1g\ub2f9 2~5\u03bcg\uc758 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud568\uc720\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ubf55\ucca0\uc5d0\ub294 \uc2e0\uc120\ud55c \ubf55\uc744 \ub530\uc11c \ub2ec\ucf64\ud558\uace0 \uc0c8\ucf64\ud55c \ub9db\uc744 \uc74c\ubbf8\ud558\ub294 \uac83\uc774 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ubcf4\ucda9\ud558\ub294 \uc88b\uc740 \ubc29\ubc95\uc785\ub2c8\ub2e4. \uc601\uc591\ud559\uc790\ub4e4\uc740 \ub9e4\uc77c 200~300g\uc758 \uc2e0\uc120\ud55c \ubf55\ub098\ubb34 \uc5f4\ub9e4\ub97c \uc12d\ucde8\ud560 \uac83\uc744 \uad8c\uc7a5\ud569\ub2c8\ub2e4. \uc774\ub294 \ubbf8\uac01\uc744 \ub9cc\uc871\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud48d\ubd80\ud55c \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc81c\uacf5\ud558\uc5ec \ub9db\uc788\ub294 \uc74c\uc2dd\uc744 \uc990\uae30\uba74\uc11c \uac74\uac15\uc5d0\ub3c4 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.<\/p>\n

\uc804\ud1b5 \ud55c\uc57d\uacfc \uae30\ub2a5\uc131 \uc2dd\ud488\uc744 \ud1b5\ud574 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc12d\ucde8\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc790\ub2e8 \ucd94\ucd9c\ubb3c\uc5d0\uc11c \ubc1c\uacac\ub418\uba70, \ud45c\uc900 \ud568\ub7c9\uc740 5% \uc774\uc0c1\uc785\ub2c8\ub2e4. \uc790\ub2e8 \ucd94\ucd9c\ubb3c\uc744 \uc0ac\uc6a9\ud560 \ub54c\ub294 \ud488\uc9c8\uacfc \uc548\uc804\uc131\uc744 \ubcf4\uc7a5\ud558\uae30 \uc704\ud574 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uacf5\uae09\uc6d0\uc758 \uc81c\ud488\uc744 \uc120\ud0dd\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4. \ucd9c\ucc98\uac00 \ubd88\ubd84\uba85\ud55c \uc911\uae08\uc18d \uc794\ub958\ubb3c\uacfc \uac19\uc740 \uc720\ud574\ud55c \uc601\ud5a5\uc744 \ud53c\ud558\uc2ed\uc2dc\uc624. \ub098\ud1a0\ud0a4\ub098\uc81c \ud654\ud569\ubb3c\uacfc \uac19\uc740 \ubc1c\ud6a8 \ucf69 \uc81c\ud488\uc5d0\ub3c4 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud568\uc720\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae30\ub2a5\uc131 \uc2dd\ud488\uc740 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc81c\uacf5\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ub098\ud1a0\ud0a4\ub098\uc81c\uac00 \ud608\uc804\uc744 \uc6a9\ud574\ud558\uace0 \uc2ec\ud608\uad00 \uac74\uac15\uc744 \uc99d\uc9c4\ud558\ub294 \ub370 \ub3c4\uc6c0\uc744 \uc8fc\ub294 \ub4f1 \ub2e4\ub978 \uac74\uac15\uc0c1\uc758 \uc774\uc810\ub3c4 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \ud488\uc9c8\uacfc \uc548\uc804\uc131\uc744 \ubcf4\uc7a5\ud558\uace0 \uc548\uc804\ud558\uac8c \uc12d\ucde8\ud560 \uc218 \uc788\ub3c4\ub85d \ud3c9\ud310\uc774 \uc88b\uc740 \uc81c\uc870\uc5c5\uccb4\uc758 \uc81c\ud488\uc744 \uc120\ud0dd\ud558\ub294 \uac83 \ub610\ud55c \uc911\uc694\ud569\ub2c8\ub2e4.<\/p>\n

(II) \ubcf4\ucda9\uc81c \uc0ac\uc6a9\uc758 \ud575\uc2ec \uc6d0\uce59<\/h3>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c\ub294 \uc77c\uc0c1\uc801\uc778 \uc2dd\ub2e8\uc5d0\uc11c \ucda9\ubd84\ud55c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc12d\ucde8\ud558\uc9c0 \ubabb\ud558\uac70\ub098 \ud2b9\uc815 \uac74\uac15\uc0c1\uc758 \ud544\uc694\uac00 \uc788\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ud3b8\ub9ac\ud55c \uc120\ud0dd\uc9c0\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc548\uc804\uc131\uacfc \ud6a8\uacfc\ub97c \ubcf4\uc7a5\ud558\uae30 \uc704\ud574\uc11c\ub294 \uacfc\ud559\uc801 \uc6d0\uce59\uc744 \uc900\uc218\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\uc801\ud569\ud55c \ub300\uc0c1\uc740 \uc8fc\ub85c \ub178\ud654 \ubc29\uc9c0 \uce58\ub8cc\ub97c \uc6d0\ud558\ub294 \uc911\ub144 \ubc0f \ub178\ub144\uce35\uc785\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc2e0\uccb4\uc758 \ub2e4\uc591\ud55c \uae30\ub2a5\uc774 \uc810\ucc28 \uc800\ud558\ub418\uace0 \ub178\ud654 \uc9d5\ud6c4\uac00 \ub354\uc6b1 \ub69c\ub837\ud574\uc9d1\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud2b9\uc131\uc740 \uc774\ub7ec\ud55c \uc0ac\ub78c\ub4e4\uc758 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \uba74\uc5ed\ub825\uc744 \uac15\ud654\ud558\uba70 \uc804\ubc18\uc801\uc778 \uac74\uac15\uc744 \uac1c\uc120\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub300\uc0ac \uc99d\ud6c4\uad70 \uc704\ud5d8\uc774 \ub192\uc740 \uc0ac\ub78c\ub4e4\ub3c4 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c\uc758 \uc801\ud569\ud55c \ud6c4\ubcf4\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc0ac\ub78c\ub4e4\uc740 \uc885\uc885 \uc778\uc290\ub9b0 \uc800\ud56d\uc131, \ube44\ub9cc, \uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d\uc744 \uc553\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \uc870\uc808\ud558\uace0, \ub0b4\uc7a5 \uc9c0\ubc29 \ucd95\uc801\uc744 \uc904\uc774\uba70, \ud608\uc911 \uc9c0\uc9c8\uc744 \uc870\uc808\ud558\uc5ec \ub300\uc0ac \uc99d\ud6c4\uad70 \uac1c\uc120\uc5d0 \uae0d\uc815\uc801\uc778 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ucd08\uae30 \ub958\ub9c8\ud2f0\uc2a4 \uad00\uc808\uc5fc\uacfc \uac19\uc740 \uacbd\ubbf8\ud55c \uc5fc\uc99d \uc9c8\ud658 \ud658\uc790\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c \ubcf5\uc6a9\uc744 \uace0\ub824\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub294 \uc5fc\uc99d\uc744 \uc904\uc774\uace0 \uc99d\uc0c1\uc744 \uc644\ud654\ud558\uba70 \uce58\ub8cc \ubc0f \ud68c\ubcf5\uc5d0 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c\uac00 \ubaa8\ub4e0 \uc0ac\ub78c\uc5d0\uac8c \uc801\ud569\ud55c \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4. \uc784\uc0b0\ubd80\uc640 \uc218\uc720\ubd80\ub294 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c\ub97c \ubcf5\uc6a9\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc2dd\ubb3c\uc131 \uc5d0\uc2a4\ud2b8\ub85c\uac90\uc73c\ub85c\uc11c \uc5d0\uc2a4\ud2b8\ub85c\uac90 \uade0\ud615\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uccd0 \ud0dc\uc544 \ubc1c\ub2ec \ubc0f \uc218\uc720\ubd80\uc758 \uac74\uac15\uc5d0 \uc545\uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \uc57d\ubb3c \uc0c1\ud638\uc791\uc6a9\uacfc \uad00\ub828\ud558\uc5ec, \uc640\ud30c\ub9b0\uacfc \uac19\uc740 \ud56d\uc751\uace0\uc81c\uc640 \ud568\uaed8 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ubcf5\uc6a9\ud560 \ub54c\ub294 \uc8fc\uc758\ud574\uc57c \ud569\ub2c8\ub2e4. \ucd9c\ud608\uc744 \uc608\ubc29\ud558\uae30 \uc704\ud574 \ubcf5\uc6a9 \uac04\uaca9\uc744 \ucd5c\uc18c 4\uc2dc\uac04 \uc774\uc0c1 \ub450\uc5b4\uc57c \ud569\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc640\ud30c\ub9b0 \ub300\uc0ac\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uccd0 \ud56d\uc751\uace0 \ud6a8\uacfc\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \ucd9c\ud608 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \ube44\uc7a5 \ubc0f \uc704 \uae30\ub2a5 \uc800\ud558\uac00 \uc788\ub294 \uc0ac\ub78c\ub3c4 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c \ubcf5\uc6a9 \uc2dc \uc124\uc0ac\uc640 \uac19\uc740 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\ubbc0\ub85c \uc8fc\uc758\ud574\uc57c \ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd84\ub4e4\uc740 \ud558\ub8e8 50mg\uc758 \uc800\uc6a9\ub7c9\uc73c\ub85c \uc2dc\uc791\ud558\uc5ec \uc810\ucc28\uc801\uc73c\ub85c \uc2e0\uccb4\uac00 \ubcf4\ucda9\uc81c\ub97c \uacac\ub51c \uc218 \uc788\ub3c4\ub85d \ud558\uace0 \ubc18\uc751\uc744 \uad00\ucc30\ud558\ub294 \uac83\uc774 \uc88b\uc2b5\ub2c8\ub2e4. \ubd88\ud3b8\ud568\uc774 \ubc1c\uc0dd\ud558\uba74 \uc6a9\ub7c9\uc744 \uc870\uc808\ud558\uac70\ub098 \uc989\uc2dc \ubcf5\uc6a9\uc744 \uc911\ub2e8\ud574\uc57c \ud569\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \ubcf4\ucda9\uc81c\ub97c \uc0ac\uc6a9\ud558\uae30 \uc804\uc5d0 \uc804\ubb38 \uc758\uc0ac \ub610\ub294 \uc601\uc591\uc0ac\uc640 \uc0c1\ub2f4\ud558\ub294 \uac83\uc774 \uac00\uc7a5 \uc88b\uc2b5\ub2c8\ub2e4. \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uc0ac\uc6a9\uc744 \ubcf4\uc7a5\ud558\uace0 \uac74\uac15\uc744 \ubcf4\ud638\ud558\uae30 \uc704\ud574 \uac1c\uc778\uc758 \uac74\uac15 \uc0c1\ud0dc\uc640 \uac74\uac15 \uc694\uad6c\uc5d0 \ub9de\ub294 \uac1c\uc778 \ub9de\ucda4\ud615 \ubcf4\ucda9\uc81c \ubcf5\uc6a9 \uacc4\ud68d\uc744 \uc218\ub9bd\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n

\ud504\ub7f0\ud2f0\uc5b4 \ud0d0\ud5d8: \ubd84\uc790 \uba54\ucee4\ub2c8\uc998\uc5d0\uc11c \uc0b0\uc5c5\uc758 \ubbf8\ub798\uae4c\uc9c0\"\"<\/h2>\n

(I) \ud56d\ub178\ud654 \ubd84\uc57c\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uacac<\/h3>\n

\ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\uace0 \uc80a\uc74c\uc758 \ud65c\ub825\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uacfc\ud559\uc790\ub4e4\uc740 \ub04a\uc784\uc5c6\uc774 \ud0d0\uad6c\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ud56d\ub178\ud654 \ubd84\uc57c\uc5d0\uc11c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4(Pterostibene)\uacfc \uad00\ub828\ub41c \uc77c\ub828\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uacac\uc740 \uc758\uc2ec\ud560 \uc5ec\uc9c0 \uc5c6\uc774 \uc774 \uc5ec\uc815\uc5d0 \uc0c8\ub85c\uc6b4 \ud65c\ub825\uc744 \ubd88\uc5b4\ub123\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

2022\ub144, \uc911\uad6d \uc758\uacfc\ub300\ud559 \uc5f0\uad6c\ud300\uc740 \uc8fc\ubaa9\ud560 \ub9cc\ud55c \uc131\uacfc\ub97c \ub2ec\uc131\ud588\uc2b5\ub2c8\ub2e4. \uc2ec\uce35 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud56d\ub178\ud654 \ubd84\uc57c\uc5d0\uc11c \ub3c5\ud2b9\ud55c \uc791\uc6a9 \uae30\uc804\uc744 \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \ud655\uc778\ud588\uc73c\uba70, \ud2b9\ud788 \uc5f0\uace8\uc138\ud3ec\uc758 \ub178\ud654 \uad00\ub828 \ubd84\ube44 \ud45c\ud604\ud615(SASP)\uc744 \uc5b5\uc81c\ud558\ub294 \ub370 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc774 \ud65c\uc131\ud654\ub418\uba74 \uad00\ub828 \uc138\ud3ec \ub0b4 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \uc815\ubc00\ud558\uac8c \uc870\uc808\ud558\uc5ec \ub178\ud654 \ub9c8\ucee4\uc778 p16\uacfc p21\uc5d0 \uc591\uc131 \ubc18\uc751\uc744 \ubcf4\uc774\ub294 \uc138\ud3ec\uc758 \ube44\uc728\uc744 48~53% \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc740 \uace8\uad00\uc808\uc5fc\uacfc \uac19\uc740 \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc911\uc7ac \uc804\ub7b5\uc744 \uc81c\uc2dc\ud558\uc5ec \ub9e4\uc6b0 \uc911\uc694\ud55c \uc758\ubbf8\ub97c \uc9c0\ub2d9\ub2c8\ub2e4. \ud754\ud55c \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc778 \uace8\uad00\uc808\uc5fc\uc740 \ud658\uc790\uc5d0\uac8c \uc2ec\uac01\ud55c \ud1b5\uc99d\uc744 \uc720\ubc1c\ud558\uace0 \uc0b6\uc758 \uc9c8\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc774\ub7ec\ud55c \ud6a8\uacfc\ub294 \uace8\uad00\uc808\uc5fc \ud658\uc790\uc5d0\uac8c \ud76c\ub9dd\uc758 \ucc3d\uc744 \uc81c\uacf5\ud558\uc5ec \ud1b5\uc99d\uc744 \uc644\ud654\ud558\uace0 \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ub2a6\ucd94\uba70 \uc815\uc0c1\uc801\uc778 \uc0dd\ud65c\ub85c \ubcf5\uadc0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uacfc AKG(\u03b1-\ucf00\ud1a0\uae00\ub8e8\ud0c0\ub974\uc0b0)\uc758 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \uac15\ub825\ud55c \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \ud2b8\ub9ac\uce74\ub974\ubcf5\uc2e4\uc0b0 \ud68c\ub85c\uc758 \ud575\uc2ec \uc911\uac04\uccb4\uc778 AKG\ub294 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \ub178\ud654 \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uacfc AKG\ub97c \ud568\uaed8 \uc0ac\uc6a9\ud558\uba74 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \ub180\ub77c\uc6b4 \ud654\ud559 \ubc18\uc751\uc744 \uc77c\uc73c\ud0b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc774\ub7ec\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 19%\uae4c\uc9c0 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc73c\uba70, \ud5a5\uc0c1\ub41c \uae30\ub2a5\uc740 \uc815\uc0c1\uc801\uc778 \uc138\ud3ec \ud65c\ub3d9\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc740 \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc810\ucc28 \uac10\uc18c\ud558\uba70, \uc774\ub294 \ub178\ud654\uc758 \uc8fc\uc694 \uc6d0\uc778\uc785\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uacfc AKG\uc758 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub294 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uac15\ud654\ud558\uc5ec \uc138\ud3ec\uc5d0 \ub354 \ub9ce\uc740 \uc5d0\ub108\uc9c0\ub97c \uacf5\uae09\ud558\uace0, \uacb0\uacfc\uc801\uc73c\ub85c \uc138\ud3ec \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc740 \uc774\uc911 “\ub300\uc0ac-\ud6c4\uc131\uc720\uc804\uc801” \ud56d\ub178\ud654 \uacbd\ub85c\uc758 \ud575\uc2ec \uc694\uc18c\uc785\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc740 \ud56d\ub178\ud654 \ubd84\uc57c\uc5d0 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5f4\uc5b4 \ub2e4\uc911 \uacbd\ub85c \uc2dc\ub108\uc9c0 \ud56d\ub178\ud654\uc758 \uc7a0\uc7ac\ub825\uc744 \uc785\uc99d\ud569\ub2c8\ub2e4. \uc774\ub294 \uc55e\uc73c\ub85c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc778 \ud56d\ub178\ud654 \uc81c\ud488 \uac1c\ubc1c\uc744 \ud1b5\ud574 \uc0ac\ub78c\ub4e4\uc774 \ub178\ud654 \uc9c0\uc5f0\uc774\ub77c\ub294 \uafc8\uc744 \uc2e4\ud604\ud560 \uc218 \uc788\ub3c4\ub85d \ub3c4\uc6b8 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4.<\/p>\n

(II) \uc0b0\uc5c5 \ubc1c\uc804 \ubc0f \uc2dc\uc7a5 \uc804\ub9dd<\/h3>\n

\uac74\uac15\uacfc \uc544\ub984\ub2e4\uc6c0\uc5d0 \ub300\ud55c \uc0ac\ub78c\ub4e4\uc758 \uad00\uc2ec\uc774 \ub354\uc6b1 \ucee4\uc9d0\uc5d0 \ub530\ub77c, \ub6f0\uc5b4\ub09c \ud6a8\ub2a5\uc744 \uc9c0\ub2cc \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc0b0\uc5c5 \ubc1c\uc804\uacfc \uc2dc\uc7a5 \uc804\ub9dd \ubaa8\ub450\uc5d0\uc11c \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uba70 \uac74\uac15 \uc0b0\uc5c5\uc758 \ube5b\ub098\ub294 \ubcc4\uc774 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2dc\uc7a5 \uaddc\ubaa8 \uce21\uba74\uc5d0\uc11c \ubcfc \ub54c, \uc804 \uc138\uacc4 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4 \uc2dc\uc7a5\uc740 \uae09\uc131\uc7a5\ud558\uace0 \uc788\uc73c\uba70 \uc5f0\ud3c9\uade0 9%\uc758 \uc131\uc7a5\ub960\uc744 \uae30\ub85d\ud558\uba70 \uafb8\uc900\ud788 \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uad00\ub828 \uc608\uce21\uc5d0 \ub530\ub974\uba74, 2029\ub144\uae4c\uc9c0 \uc2dc\uc7a5 \uaddc\ubaa8\ub294 5\ucc9c\ub9cc \uc704\uc548\uc5d0 \uc774\ub97c \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc131\uc7a5 \ucd94\uc138\ub294 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc5d0 \ub300\ud55c \ub192\uc740 \uc2dc\uc7a5 \uc778\uc9c0\ub3c4\uc640 \uac15\ub825\ud55c \uc218\uc694\ub97c \ubc18\uc601\ud558\uba70, \uc218\ub9ce\uc740 \uae30\uc5c5\ub4e4\uc774 \ud14c\ub85c\uc2a4\ud2f0\ubca4 \uad00\ub828 \uc81c\ud488\uc758 \uc5f0\uad6c \uac1c\ubc1c \ubc0f \uc0dd\uc0b0\uc5d0 \ud22c\uc790\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uae30\uc220 \uc5f0\uad6c \uac1c\ubc1c \uce21\uba74\uc5d0\uc11c\ub294 \ud604\uc7ac \ucc9c\uc5f0 \ucd94\ucd9c\uacfc \ud654\ud559 \ud569\uc131\uc774\ub77c\ub294 \ub450 \uac00\uc9c0 \uc8fc\uc694 \uc811\uadfc \ubc29\uc2dd\uc774 \uac1c\ubc1c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ube14\ub8e8\ubca0\ub9ac\ub098 \ud3ec\ub3c4 \uaecd\uc9c8\uacfc \uac19\uc740 \uc2dd\ubb3c\uc5d0\uc11c \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ucd94\ucd9c\ud558\ub294 \ucc9c\uc5f0 \ucd94\ucd9c\uc740 \ucc9c\uc5f0 \uc790\uc6d0\uc774\ub77c\ub294 \uc7a5\uc810\uacfc \ub192\uc740 \uc548\uc804\uc131\uc744 \uc81c\uacf5\ud558\uc5ec \uc18c\ube44\uc790\ub4e4\uc5d0\uac8c \ud070 \uc778\uae30\ub97c \uc5bb\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ucc9c\uc5f0 \uc2dd\ubb3c\uc5d0\uc11c \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud568\ub7c9\uc774 \uc0c1\ub300\uc801\uc73c\ub85c \ub0ae\uace0 \ucd94\ucd9c \ube44\uc6a9\uc774 \ub192\uc544 \ub300\ub7c9 \uc0dd\uc0b0\uc5d0 \uc81c\uc57d\uc774 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \ud654\ud559 \ud569\uc131\uc774 \ub4f1\uc7a5\ud588\uc73c\uba70, \ubbf8\uc0dd\ubb3c \ubc1c\ud6a8\uac00 \uc8fc\uc694 \uc5f0\uad6c \ubd84\uc57c\uc785\ub2c8\ub2e4. \ubbf8\uc0dd\ubb3c \ubc1c\ud6a8\ub294 \uc800\ube44\uc6a9, \uace0\uc218\uc728, \uc9c0\uc18d\uac00\ub2a5\uc131\uacfc \uac19\uc740 \uc7a5\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc720\uc804\uc790 \ubcc0\ud615 \ubbf8\uc0dd\ubb3c\uc744 \uc774\uc6a9\ud558\uba74 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud6a8\uc728\uc801\uc778 \ud569\uc131\uc774 \uac00\ub2a5\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc77c\ubd80 \uc5f0\uad6c\ud300\uc740 \ub300\uc7a5\uade0(Escherichia coli)\uacfc \uac19\uc740 \ubbf8\uc0dd\ubb3c\uc744 \uc774\uc6a9\ud558\uc5ec \ubc1c\ud6a8 \uc870\uac74 \ucd5c\uc801\ud654\uc640 \uc720\uc804\uc790 \uc870\uc791\uc744 \ud1b5\ud574 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4(Pterostibene)\uc758 \uc218\uc728\uacfc \uc21c\ub3c4\ub97c \uc131\uacf5\uc801\uc73c\ub85c \ud5a5\uc0c1\uc2dc\ucf1c \ub300\ub7c9 \uc0dd\uc0b0\uc758 \uae38\uc744 \uc5f4\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud6a8\ub2a5\uc744 \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud574 \uace0\uc21c\ub3c4(\u226599%) \ub098\ub178\ub9ac\ud3ec\uc880 \uc81c\ud615\uc774 \uc804\ub2ec \uc2dc\uc2a4\ud15c \uac1c\ubc1c\uc5d0 \uc788\uc5b4 \uc911\uc694\ud55c \ud654\ub450\uac00 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc218\uc6a9\uc131\uc774 \ub0ae\uace0 \uc7a5\uc5d0\uc11c \ucd08\ud68c \ud1b5\uacfc \ud6a8\uacfc(first-pass effect)\uac00 \ubc1c\uc0dd\ud558\uc5ec \uccb4\ub0b4 \ud761\uc218 \ubc0f \uc774\uc6a9\uc774 \uc81c\ud55c\ub429\ub2c8\ub2e4. \ub098\ub178\ub9ac\ud3ec\uc880 \uc81c\ud615\uc740 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc704\ud55c \ub9de\ucda4\ud615 “\uc804\ub2ec\uccb4”\uc640 \uac19\uc774 \uc774\ub7ec\ud55c \ubb38\uc81c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ud574\uacb0\ud569\ub2c8\ub2e4. \ub098\ub178\ub9ac\ud3ec\uc880\uc740 \ub6f0\uc5b4\ub09c \uc0dd\uccb4\uc801\ud569\uc131\uacfc \ud45c\uc801\ud654 \ud2b9\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc5b4 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ucea1\uc290\ud654\ud558\uace0 \uc218\uc6a9\uc131\uc744 \ub192\uc774\uba70 \uc7a5\uc5d0\uc11c\uc758 \ub300\uc0ac \ubc0f \ubd84\ud574\ub97c \ucd5c\uc18c\ud654\ud558\uc5ec \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, \ub098\ub178\ub9ac\ud3ec\uc880\uc740 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \uc815\ubc00\ud558\uac8c \uc804\ub2ec\ud558\uc5ec \uc138\ud3ec\uc640 \uc870\uc9c1\uc744 \ub354\uc6b1 \ud6a8\uacfc\uc801\uc73c\ub85c \ud45c\uc801\ud654\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4 \uce58\ub8cc \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4. \uc2dc\uc7a5 \uc801\uc6a9 \uce21\uba74\uc5d0\uc11c, \ub6f0\uc5b4\ub09c \ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d \ubc0f \ud56d\ub178\ud654 \ud2b9\uc131\uc744 \uc9c0\ub2cc \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ucf54\uc2a4\uba54\uc288\ud2f0\uceec\uacfc \uae30\ub2a5\uc131 \uc2dd\ud488 \ubd84\uc57c\uc5d0\uc11c \ub2e4\uc591\ud55c \uc0b0\uc5c5\uc5d0 \uac78\uccd0 \ud65c\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ucf54\uc2a4\uba54\uc288\ud2f0\uceec \ubd84\uc57c\uc5d0\uc11c\ub294 \uc8fc\ub984 \uac1c\uc120 \uc138\ub7fc\uc774 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc8fc\uc694 \ud65c\uc6a9 \ubd84\uc57c\ub85c \uc790\ub9ac \uc7a1\uc558\uc2b5\ub2c8\ub2e4. \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ucf5c\ub77c\uac90 \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uace0, \ud53c\ubd80 \ud0c4\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uba70, \uc8fc\ub984\uc744 \uc644\ud654\ud558\uace0, \ud53c\ubd80\ub97c \ub354\uc6b1 \ud0c4\ub825 \uc788\uace0 \ub9e4\ub044\ub7fd\uac8c \uac00\uafd4\uc90d\ub2c8\ub2e4. \ub9ce\uc740 \uc720\uba85 \ube0c\ub79c\ub4dc\uc5d0\uc11c \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc744 \ud568\uc720\ud55c \uc8fc\ub984 \uac1c\uc120 \uc138\ub7fc\uc744 \ucd9c\uc2dc\ud588\uc73c\uba70, \uc774\ub294 \uc18c\ube44\uc790\ub4e4\uc758 \uc5f4\ub82c\ud55c \uc9c0\uc9c0\ub97c \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uae30\ub2a5\uc131 \uc2dd\ud488 \ubd84\uc57c\uc5d0\uc11c\ub294 \uc11c\ubc29\ud615 \ucea1\uc290\uc774 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uc77c\ubc18\uc801\uc778 \uc81c\ud615\uc785\ub2c8\ub2e4. \uc11c\ubc29\ud615 \uae30\uc220\uc744 \ud1b5\ud574 \ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uccb4\ub0b4\uc5d0\uc11c \uc11c\uc11c\ud788 \ubc29\ucd9c\ub418\uc5b4 \uc9c0\uc18d \uc2dc\uac04\uc744 \uc5f0\uc7a5\ud558\uace0 \ud6a8\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud14c\ub85c\uc2a4\ud2f0\ubca4 \uc11c\ubc29\ud615 \ucea1\uc290\uc740 \ub178\uc778\uc774\ub098 \uc57c\uac04 \uadfc\ubb34\uc790\uc640 \uac19\uc774 \ud2b9\ubcc4\ud55c \uac74\uac15 \uad00\ub9ac\uac00 \ud544\uc694\ud55c \uc0ac\ub78c\ub4e4\uc5d0\uac8c \ud3b8\ub9ac\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc9c0\uc18d\uc801\uc778 \uae30\uc220 \ubc1c\uc804\uacfc \uc2dc\uc7a5 \ud655\ub300\ub97c \ud1b5\ud574 \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc55e\uc73c\ub85c \ub354 \ub9ce\uc740 \ubd84\uc57c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \uc218\ud589\ud558\uba70 \uc0ac\ub78c\ub4e4\uc758 \uac74\uac15\uacfc \ubbf8\uc6a9\uc5d0 \ub354\uc6b1 \ud765\ubbf8\ub85c\uc6b4 \uc774\uc810\uc744 \uac00\uc838\ub2e4\uc904 \uac83\uc73c\ub85c \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uc804\ud1b5\uc801\uc778 \uc57d\uc6a9 \uc2dd\ubb3c \ud65c\uc131 \uc131\ubd84\uc5d0\uc11c \ub2e4\ud559\uc81c\uc801 “\uc815\ubc00 \uac74\uac15 \uac1c\uc785 \ubd84\uc790”\ub85c \uc9c4\ud654\ud588\uc2b5\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \uac00\uce58\ub294 \ub2e8\uc77c \uc9c8\ubcd1\uc744 \uac1c\uc120\ud558\ub294 \ub370 \uadf8\uce58\uc9c0 \uc54a\uace0, \ud604\ub300 \uacfc\ud559\uc801 \ubd84\uc11d\uc744 \ud1b5\ud574 \ucc9c\uc5f0\ubb3c\uc774 \uacbd\ud5d8\uc801 \uc801\uc6a9\uc5d0\uc11c \uba85\ud655\ud55c \uba54\ucee4\ub2c8\uc998\uc73c\ub85c \ub3c4\uc57d\ud558\ub294 \uacfc\uc815\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc624\ub298\ub0a0 \uae09\uc18d\ud55c \uace0\ub839\ud654 \uc0ac\ud68c\uc5d0\uc11c \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud6a8\ub2a5 \ud55c\uacc4\ub97c \ud569\ub9ac\uc801\uc73c\ub85c \uc774\ud574\ud558\uace0 \uac1c\uc778\uc758 \uac74\uac15 \uc694\uad6c\uc640 \uc12d\ucde8\ub7c9\uc744 \uacfc\ud559\uc801\uc73c\ub85c \uade0\ud615 \uc788\uac8c \uc870\uc808\ud558\ub294 \uac83\uc740 \uc774 \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180\uc758 \uac74\uac15 \uc7a0\uc7ac\ub825\uc744 \uadf9\ub300\ud654\ud558\uace0 “\uc2dd\ubb3c \ud65c\uc131 \uc131\ubd84, \uc778\uccb4 \ud45c\uc801, \uadf8\ub9ac\uace0 \uc804\uc2e0 \uac74\uac15” \uac04\uc758 \uc815\ud655\ud55c \uc5f0\uad00\uc131\uc744 \uc99d\uc9c4\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

\ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ud53c\ub85c\uac08\ub864 \uad6c\uc870\ub97c \uac00\uc9c4 \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180 \ud654\ud569\ubb3c\uc785\ub2c8\ub2e4. \ud654\ud559\uc801\uc73c\ub85c\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc758 \uba54\ud2f8\ud654\ub41c \uc720\ub3c4\uccb4\uc785\ub2c8\ub2e4. \uc774 \uc791\uc740 \ubcc0\ud654\ub97c \uacfc\uc18c\ud3c9\uac00\ud574\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc758 \ud6a8\ub2a5\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uacbd\uad6c \uc0dd\uccb4\uc774\uc6a9\ub960\uc740 80%\uc5d0 \ub2ec\ud558\uba70, \uc774\ub294 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc758 4\ubc30\uc5d0 \ub2ec\ud558\ub294 \ub180\ub77c\uc6b4 \uc218\uce58\uc785\ub2c8\ub2e4. \uc989, \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \uad6c\uc870\uc801\uc73c\ub85c \uc12d\ucde8 \ud6c4 \uccb4\ub0b4\uc5d0\uc11c \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub418\uace0 \ud65c\uc6a9\ub418\uc5b4 \uc81c \uae30\ub2a5\uc744 \ubc1c\ud718\ud560 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4\uc740 \ube14\ub8e8\ubca0\ub9ac, \ud3ec\ub3c4, \uc790\ub2e8\uacfc \uac19\uc740 \uc2dd\ubb3c\uc5d0\uc11c \ub110\ub9ac \ubc1c\uacac\ub429\ub2c8\ub2e4. … Continue reading \ud504\ud14c\ub85c\uc2a4\ud2f0\ubca4: \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180\uc5d0\uc11c \ub178\ud654 \ubc29\uc9c0\uc758 \uc0c8\ub85c\uc6b4 \uc778\uae30 \uc131\ubd84\uc73c\ub85c\uc758 \uacfc\ud559\uc801 \ud574\uc11d<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":2892,"parent":0,"menu_order":26,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-2891","blog","type-blog","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/comments?post=2891"}],"version-history":[{"count":0,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2891\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media\/2892"}],"wp:attachment":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media?parent=2891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}