{"id":2921,"date":"2025-10-30T07:01:38","date_gmt":"2025-10-30T07:01:38","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2921"},"modified":"2025-10-30T07:01:38","modified_gmt":"2025-10-30T07:01:38","slug":"nr%ec%9d%80-%ec%83%9d%eb%a6%ac%ec%a0%81-%eb%85%b8%ed%99%94%eb%a5%bc-%ec%a7%80%ec%97%b0%ec%8b%9c%ed%82%b5%eb%8b%88%eb%8b%a4-%ea%b3%bc%ed%95%99%ec%a0%81-%ec%9b%90%eb%a6%ac%ec%97%90%ec%84%9c-%eb%85%b8","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/nr%ec%9d%80-%ec%83%9d%eb%a6%ac%ec%a0%81-%eb%85%b8%ed%99%94%eb%a5%bc-%ec%a7%80%ec%97%b0%ec%8b%9c%ed%82%b5%eb%8b%88%eb%8b%a4-%ea%b3%bc%ed%95%99%ec%a0%81-%ec%9b%90%eb%a6%ac%ec%97%90%ec%84%9c-%eb%85%b8\/","title":{"rendered":"NR\uc740 \uc0dd\ub9ac\uc801 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0b5\ub2c8\ub2e4: \uacfc\ud559\uc801 \uc6d0\ub9ac\uc5d0\uc11c \ub178\ud654 \ubc29\uc9c0 \uc2e4\ucc9c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ud3ec\uad04\uc801\uc778 \ubd84\uc11d"},"content":{"rendered":"

\uc0b6\uc758 \uacfc\uc815\uc5d0\uc11c \ub178\ud654\ub294 \ud53c\ud560 \uc218 \uc5c6\ub294 \ud669\ud63c\ucc98\ub7fc \uc870\uc6a9\ud788 \ucc3e\uc544\uc635\ub2c8\ub2e4. \uadf8\ub807\ub2e4\uba74 \ub178\ud654\ub780 \uc815\ud655\ud788 \ubb34\uc5c7\uc77c\uae4c\uc694? \uc138\ud3ec\uc640 \ubd84\uc790 \uc218\uc900\uc744 \uae4a\uc774 \ub4e4\uc5ec\ub2e4\ubcf4\uba74, \ub178\ud654\uc758 \ubcf8\uc9c8\uc740 NAD+ \uc218\uce58 \uac10\uc18c\ub85c \ucd09\ubc1c\ub418\ub294 \ub3c4\ubbf8\ub178 \ud6a8\uacfc\ub77c\ub294 \uac83\uc744 \uc54c \uc218 \uc788\uc2b5\ub2c8\ub2e4. NAD+, \uc989 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \uc544\ub370\ub2cc \ub514\ub274\ud074\ub808\uc624\ud2f0\ub4dc\ub294 \uc0dd\uc18c\ud558\uac8c \ub4e4\ub9b4\uc9c0 \ubaa8\ub974\uc9c0\ub9cc, \uc6b0\ub9ac \ubab8\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac, DNA \ubcf5\uad6c, \uadf8\ub9ac\uace0 \uc7a5\uc218 \ub2e8\ubc31\uc9c8 \ud65c\uc131\ud654\uc5d0 \ud544\uc218\uc801\uc778 \uc870\ud6a8\uc18c\uc785\ub2c8\ub2e4. \uac04\ub2e8\ud788 \ub9d0\ud574, NAD+\ub294 \uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \ud654\ud3d0\uc640 \uac19\uc2b5\ub2c8\ub2e4. NAD+\uac00 \uc5c6\uc73c\uba74 \ub2e4\uc591\ud55c \uc138\ud3ec \uc0dd\ub9ac \ud65c\ub3d9\uc774 \uc81c\ub300\ub85c \uae30\ub2a5\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \uc138\ud3ec\ub97c \ubd84\uc8fc\ud55c \uacf5\uc7a5\uc73c\ub85c, NAD+\ub97c \uacf5\uc7a5\uc744 \uac00\ub3d9\ud558\ub294 \uc804\uae30\ub77c\uace0 \uc0dd\uac01\ud574 \ubcf4\uc138\uc694. \uc804\uae30\uac00 \ubd80\uc871\ud558\uba74 \uacf5\uc7a5\uc758 \uc0dd\uc0b0 \ud6a8\uc728\uc774 \uae09\uaca9\ud788 \ub5a8\uc5b4\uc9c0\uace0 \uc2ec\uc9c0\uc5b4 \ub9c8\ube44\uae4c\uc9c0 \ucd08\ub798\ud569\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc6b0\ub9ac \ubab8\uc758 NAD+ \uc218\uce58\ub294 \ub9c8\uce58 \uc0c8\ub294 \ubc30\ud130\ub9ac\ucc98\ub7fc \uae09\uaca9\ud788 \uac10\uc18c\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 30\uc138\uacbd\ubd80\ud130 \uc2e0\uccb4\uc758 NAD+ \ud568\ub7c9\uc740 20\ub144\ub9c8\ub2e4 \uc57d 50%\uc529 \uac10\uc18c\ud569\ub2c8\ub2e4. 60\uc138\uac00 \ub418\uba74 NAD+ \uc218\uce58\ub294 \uc80a\uc5c8\uc744 \ub54c\uc758 25%\uc5d0 \ubd88\uacfc\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae09\uaca9\ud55c \uac10\uc18c\ub294 \uc77c\ub828\uc758 \uc5f0\uc1c4 \ubc18\uc751\uc744 \uc77c\uc73c\ud0b5\ub2c8\ub2e4. \uc138\ud3ec\uc758 “\ubc1c\uc804\uc18c”\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc138\ud3ec \ud65c\ub3d9\uc5d0 \ud544\uc694\ud55c \uc5d0\ub108\uc9c0\ub97c \uc0dd\uc131\ud569\ub2c8\ub2e4. NAD+ \uc218\uce58\uac00 \ub5a8\uc5b4\uc9c0\uba74 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud638\ud761 \uc0ac\uc2ac\uc758 \ud6a8\uc728\uc774 \ub5a8\uc5b4\uc838 \ucda9\ubd84\ud55c \uc5d0\ub108\uc9c0\ub97c \uc0dd\uc131\ud560 \uc218 \uc5c6\uac8c \ub418\uace0, \uc774\ub294 \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc7a5\uc560\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \ud53c\ub85c\uac10\uacfc \uccb4\ub825 \uc800\ud558\ub97c \ub69c\ub837\ud558\uac8c \ub290\ub07c\uac8c \ub429\ub2c8\ub2e4. \ud55c\ub54c \uc26c\uc6e0\ub358 \uc77c\uc0c1 \ud65c\ub3d9\uc774 \uc5b4\ub824\uc6cc\uc9c0\uace0, \uacc4\ub2e8 \uba87 \uce35\uc744 \uc624\ub974\ub294 \uac83\uc870\ucc28 \uc228\uc774 \ucc28\uba70, \uc57d\uac04\uc758 \uc6b4\ub3d9\ub9cc\uc73c\ub85c\ub3c4 \ud0c8\uc9c4\ud558\uac8c \ub429\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c DNA \uc190\uc0c1\ub3c4 \ucd95\uc801\ub429\ub2c8\ub2e4. NAD+\ub294 DNA \ubcf5\uad6c \ud6a8\uc18c\uc778 PARP(poly-ADP-ribose polymerase)\uc758 \ud544\uc218 \uae30\uc9c8\uc785\ub2c8\ub2e4. NAD+\uac00 \ubd80\uc871\ud558\uba74 PARP \ud65c\ub3d9\uc774 \uc81c\ud55c\ub418\uc5b4 \uc190\uc0c1\ub41c DNA\ub97c \ud6a8\uacfc\uc801\uc774\uace0 \uc2e0\uc18d\ud558\uac8c \ubcf5\uad6c\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \ubc29\uc0ac\uc120, \uc624\uc5fc, \uadf8\ub9ac\uace0 \uc77c\uc0c1\uc801\uc778 \uc2e0\uc9c4\ub300\uc0ac \uacfc\uc815\uc5d0\uc11c \uc0dd\uc131\ub418\ub294 \ud65c\uc131\uc0b0\uc18c\ub294 \ubaa8\ub450 DNA\ub97c \uc190\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc190\uc0c1\uc774 \uc81c\ub54c \ubcf5\uad6c\ub418\uc9c0 \uc54a\uc73c\uba74 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc774\uc5b4\uc838 \uc554\uc774\ub098 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uac19\uc740 \ub178\ud654 \uad00\ub828 \uc9c8\ubcd1\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc138\ud3ec\uc790\uba78\uc0ac(Apoptosis)\uac00 \uac00\uc18d\ud654\ub429\ub2c8\ub2e4. \uc815\uc0c1\uc801\uc778 \uc0c1\ud669\uc5d0\uc11c \uc138\ud3ec\uc790\uba78\uc0ac\ub294 \uc815\uc0c1\uc801\uc778 \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\ub294 \uc138\ud3ec \uc0ac\uba78\uc758 \uc9c8\uc11c \uc788\ub294 \uacfc\uc815\uc785\ub2c8\ub2e4. \uadf8\ub7ec\ub098 NAD+ \uc218\uce58\uac00 \uac10\uc18c\ud558\uba74 \uc138\ud3ec\uc790\uba78\uc0ac \uc870\uc808 \uae30\uc804\uc758 \ubd88\uade0\ud615\uc774 \ubc1c\uc0dd\ud558\uc5ec \uc870\uae30 \uc138\ud3ec \uc0ac\uba78\uacfc \uadf8\uc5d0 \ub530\ub978 \uc870\uc9c1 \ubc0f \uc7a5\uae30 \uae30\ub2a5 \uc800\ud558\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 \ud53c\ubd80\ub294 \ud0c4\ub825\uc744 \uc783\uace0 \uc8fc\ub984\uc9c0\uace0 \ucc98\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uba74\uc5ed \uccb4\uacc4\uac00 \uc57d\ud654\ub418\uba74 \ubcd1\uc6d0\uade0\uc5d0 \ub354 \ucde8\uc57d\ud574\uc838 \uc7a6\uc740 \uc9c8\ubcd1\uacfc \ub290\ub9b0 \ud68c\ubcf5\uc73c\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\"\"NR \ud575\uc2ec \uc791\uc6a9 \uae30\uc804: \uc138 \uac00\uc9c0 \uc8fc\uc694 \ub178\ud654 \uacbd\ub85c \ud45c\uc801<\/h2>\n

\uc7a5\uc218 \ub2e8\ubc31\uc9c8 \uc2dc\ub974\ud22c\uc778 \ud65c\uc131\ud654<\/h3>\n

\uacfc\ud559\uc790\ub4e4\uc5d0\uac8c “\uc7a5\uc218 \ub2e8\ubc31\uc9c8”\ub85c \uc54c\ub824\uc9c4 \uc2dc\ub974\ud22c\uc778 \uacc4\uc5f4\uc740 NAD+ \uc218\uce58\uc640 \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. NAD+\uc758 \ud575\uc2ec \uc804\uad6c\uccb4\uc778 NR\uc740 \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ucf1c \uc2dc\ub974\ud22c\uc778\uc744 \ud65c\uc131\ud654\ud569\ub2c8\ub2e4.<\/p>\n

\uc2dc\ub974\ud22c\uc778\uc740 \ud65c\uc131\ud654\ub418\uba74 \uc720\uc804\uc790\ub97c \ubd80\uc9c0\ub7f0\ud788 \uc9c0\ud0a4\ub294 \uc218\ud638\uc790\ucc98\ub7fc \ub180\ub77c\uc6b4 \uae30\ub2a5\uc744 \uc218\ud589\ud569\ub2c8\ub2e4. \uc190\uc0c1\ub41c DNA\ub97c \ubcf5\uad6c\ud558\uace0 \uc720\uc804 \uc815\ubcf4\uc758 \uc815\ud655\ud55c \uc804\ub2ec\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4. \ub610\ud55c, \uc2dc\ub974\ud22c\uc778\uc740 \ud154\ub85c\ubbf8\uc5b4\uc758 \ub2e8\ucd95\uc744 \ub2a6\ucd9c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5fc\uc0c9\uccb4 \ub05d\ubd80\ubd84\uc758 \ucea1\ucc98\ub7fc \ud154\ub85c\ubbf8\uc5b4\ub294 \uc138\ud3ec \ubd84\uc5f4\uacfc \ud568\uaed8 \uc9e7\uc544\uc9d1\ub2c8\ub2e4. \ud154\ub85c\ubbf8\uc5b4\uac00 \uc77c\uc815 \uc218\uc900\uae4c\uc9c0 \uc9e7\uc544\uc9c0\uba74 \uc138\ud3ec\ub294 \ubd84\uc5f4\uc744 \uba48\ucd94\uace0 \ub178\ud654 \uc0c1\ud0dc\uc5d0 \ub4e4\uc5b4\uac11\ub2c8\ub2e4. \uc2dc\ub974\ud22c\uc778\uc740 \ud154\ub85c\ubbf8\uc5b4 \ub2e8\ucd95\uc744 \ub2a6\ucda4\uc73c\ub85c\uc368 \uc720\uc804\uc790 \uc218\uc900\uc5d0\uc11c \uc138\ud3ec\uc758 \uc80a\uc74c\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4. \ud558\ubc84\ub4dc \uc758\uacfc\ub300\ud559 \uc5f0\uad6c\ud300\uc740 \ub178\ub839 \uc950\uc5d0\uac8c NR\uc744 \ubcf4\ucda9\ud558\ub294 \uc2e4\ud5d8\uc744 \uc218\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \uc0dd\uc950\uc758 \uc2dc\ub974\ud22c\uc778 \ud65c\uc131\uc774 \ud06c\uac8c \uc99d\uac00\ud558\uace0, DNA \uc190\uc0c1\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf5\uad6c\ub418\uc5c8\uc73c\uba70, \ud154\ub85c\ubbf8\uc5b4 \uae38\uc774\uac00 \uc99d\uac00\ud588\uace0, \uc5ec\ub7ec \uc0dd\ub9ac \uc9c0\ud45c\uac00 \uc720\uc758\ubbf8\ud558\uac8c \uac1c\uc120\ub418\uc5b4 \ub9c8\uce58 \uc0dd\uc950\uac00 \uc80a\uc740 \ud65c\ub825\uc744 \ub418\ucc3e\uc740 \uac83\ucc98\ub7fc \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc7ac\uac74<\/h3>\n

\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uac74\uac15\uc740 \uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0 \uacf5\uae09 \ubc0f \uc804\ubc18\uc801\uc778 \uae30\ub2a5\uacfc \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \ud68c\ubcf5\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc740 NR\uc785\ub2c8\ub2e4.<\/p>\n

NR\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud638\ud761 \uc0ac\uc2ac\uc758 \ud6a8\uc728\uc131\uc744 \ud5a5\uc0c1\uc2dc\ucf1c \uc774\ub7ec\ud55c “\ubc1c\uc804\uc18c”\uc758 \ud6a8\uc728\uc131\uc744 \ud68c\ubcf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub0b4 \uc804\uc790 \uc804\ub2ec \uc0ac\uc2ac\uc758 \uc801\uc808\ud55c \uae30\ub2a5\uc744 \ucd09\uc9c4\ud558\uc5ec \uc0b0\uc18c\uc640 \uc601\uc591\uc18c\ub97c ATP\ub85c \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uc804\ud658\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ub610\ud55c NR\uc740 \ud65c\uc131\uc0b0\uc18c \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ud65c\uc131\uc0b0\uc18c\ub294 \uc138\ud3ec \ub300\uc0ac \uacfc\uc815\uc5d0\uc11c \uc0dd\uc131\ub418\ub294 \uc720\ud574 \ubb3c\uc9c8\uc785\ub2c8\ub2e4. \ud65c\uc131\uc0b0\uc18c\ub294 \uc0b0\ud654\ub825\uc774 \ub9e4\uc6b0 \uac15\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc640 \ub2e4\ub978 \uc138\ud3ec \uad6c\uc870\ub97c \uacf5\uaca9\ud558\uc5ec \uc138\ud3ec \uc190\uc0c1\uacfc \ub178\ud654\ub97c \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NR\uc740 NAD+ \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub0b4 \ud56d\uc0b0\ud654 \ud6a8\uc18c \uc2dc\uc2a4\ud15c\uc744 \ud65c\uc131\ud654\ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc911\ud654\ud558\uace0 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uc190\uc0c1\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub178\uc778\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c NR \ubcf4\ucda9\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \ud06c\uac8c \uac1c\uc120\ud558\uace0, \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uba70, \uc9c0\uad6c\ub825\uacfc \ud65c\ub825\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ucf1c \ud53c\ub85c\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \ubc0f \uc5fc\uc99d \uc870\uc808<\/h3>\n

\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5fc\uc99d\uc740 \ub178\ud654 \uacfc\uc815\uc758 \ub450 \uac00\uc9c0 \uc8fc\uc694 \uc6d0\uc778\uc73c\ub85c, \uc11c\ub85c \uc0c1\ud638 \uc791\uc6a9\ud558\uc5ec \ub178\ud654 \uacfc\uc815\uc744 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4. NR\uc740 \uc6a9\uac10\ud55c \uc804\uc0ac\ucc98\ub7fc \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5fc\uc99d\uc744 \ubaa8\ub450 \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ud569\ub2c8\ub2e4.<\/p>\n

NR\uc758 \uccb4\ub0b4 \ub300\uc0ac\uc0b0\ubb3c\uc740 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ud2b9\uc131\uc744 \uac00\uc9c4 \uace0\uc804\uc790 \ubc00\ub3c4 \uad6c\uc870\ub97c \ud615\uc131\ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc911\ud654\ud558\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \uc138\ud3ec \uc190\uc0c1\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c \uc138\ud3ec\ub9c9, \ub2e8\ubc31\uc9c8, DNA\uc640 \uac19\uc740 \uc0dd\uccb4 \uace0\ubd84\uc790\ub97c \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uacf5\uaca9\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud569\ub2c8\ub2e4. NR\uc740 \ub610\ud55c \uc5fc\uc99d \uc778\uc790\uc758 \uc0dd\uc131\uacfc \ubc29\ucd9c\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. TNF-\u03b1 \ubc0f IL-6\uc640 \uac19\uc740 \uc5fc\uc99d \uc778\uc790\ub294 \ub9cc\uc131 \uc5fc\uc99d\uc744 \uc720\ubc1c\ud558\uace0 \uc870\uc9c1\uacfc \uc7a5\uae30\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \ubc29\ud574\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NR\uc740 SIRT1\uacfc \uac19\uc740 \ub2e8\ubc31\uc9c8\uc744 \ud65c\uc131\ud654\ud558\uace0 NF-\u03baB \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \uc5fc\uc99d \uc778\uc790\uc758 \ubc1c\ud604\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc5fc\uc99d \ubc18\uc751\uc744 \uc644\ud654\ud569\ub2c8\ub2e4. \ub9cc\uc131 \uc5fc\uc99d\uc131 \uc9c8\ud658 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 NR \ubcf4\ucda9\uc740 \uc5fc\uc99d \uc9c0\ud45c \uc218\uce58\ub97c \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uace0, \ud608\uad00 \ubc0f \uac04\uacfc \uac19\uc740 \uc7a5\uae30\uc758 \ub178\ud654 \uad00\ub828 \uc190\uc0c1\uc744 \uac1c\uc120\ud558\uba70, \uc804\ubc18\uc801\uc778 \uac74\uac15\uc744 \uc99d\uc9c4\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

NR\uc758 \ud56d\ub178\ud654 \ud6a8\uacfc\uc5d0 \ub300\ud55c \uc99d\uac70: \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uc784\uc0c1\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294 \uc911\uc694\ud55c \ub3cc\ud30c\uad6c\"\"<\/h2>\n

(I) \ub3d9\ubb3c \uc2e4\ud5d8: \ud6a8\ubaa8\uc5d0\uc11c \ud3ec\uc720\ub958\ub85c\uc758 \uc218\uba85 \uc5f0\uc7a5 \uc99d\uac70<\/h3>\n

\ud6a8\ubaa8 \ubaa8\ub378:<\/strong> 2000\ub144, \ubbf8\uc2dc\uc138\uacc4\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \ud1b5\ud574 NR\uc758 \ud56d\ub178\ud654 \uc5f0\uad6c\uac00 \uc2dc\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \ub178\ud654\uc758 \ube44\ubc00\uc744 \uac04\uc9c1\ud55c \ub2e8\uc21c\ud558\uc9c0\ub9cc \ub180\ub77c\uc6b4 \ub2e8\uc138\ud3ec \uc0dd\ubb3c\uc778 \ud6a8\ubaa8\uc5d0 \uc8fc\ubaa9\ud588\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc2e4\ud5d8\uc744 \ud1b5\ud574 \ud6a8\ubaa8 \uc138\ud3ec\uc5d0\uc11c NAD+ \ud569\uc131\ud6a8\uc18c(\uae00\ub8e8\ud0c0\ubbfc \uac00\uc218\ubd84\ud574\ud6a8\uc18c)\ub97c \uc81c\uac70\ud588\uc744 \ub54c, \ub9c8\uce58 \uc138\ud3ec\uac00 \uc6d0\ub3d9\ub825\uc744 \uc783\uc740 \uac83\ucc98\ub7fc \uc138\ud3ec \uc131\uc7a5\uc774 \uc2ec\uac01\ud558\uac8c \uc5b5\uc81c\ub41c\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ub180\ub78d\uac8c\ub3c4 NR\uc744 \ucca8\uac00\ud558\uc790 \uc774\uc804\uc5d0 \uc815\uccb4\ub418\uc5c8\ub358 \ud6a8\ubaa8 \uc138\ud3ec\uac00 \ud65c\ub825\uc744 \ub418\ucc3e\uc544 \uc131\uc7a5 \ub2a5\ub825\uc744 \ud68c\ubcf5\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ubc1c\uacac\uc740 \ub9c8\uce58 \ud55c \uc904\uae30 \ube5b\ucc98\ub7fc NR\uc758 \uc218\uba85 \uc870\uc808\uc5d0 \ub300\ud55c \uac1c\uc785 \uacbd\ub85c\ub97c \ubc1d\ud600\ub0c8\uace0, \uc138\ud3ec \uc0dd\uba85\uc744 \uc720\uc9c0\ud558\uace0 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\ub294 NR\uc758 \uc5c4\uccad\ub09c \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ub9c8\uc6b0\uc2a4 \uc2e4\ud5d8:<\/strong> \ud6a8\ubaa8 \uc2e4\ud5d8\uc774 NR \ud56d\ub178\ud654 \uc5f0\uad6c\uc758 \uc2dc\uc791\uc774\uc5c8\ub2e4\uba74, \ub9c8\uc6b0\uc2a4 \uc2e4\ud5d8\uc744 \ud1b5\ud574 \uc774 \uc528\uc557\uc774 \ud2bc\ud2bc\ud55c \uc5b4\ub9b0 \ub098\ubb34\ub85c \uc790\ub784 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. 2012\ub144, \ub85c\uc794\uc5d0 \uc788\ub294 \uc2a4\uc704\uc2a4 \uc5f0\ubc29 \uacf5\uacfc\ub300\ud559(EPFL)\uc758 \ud55c \uc5f0\uad6c\ud300\uc740 \ube44\ub9cc \uc0dd\uc950\uc5d0 \uc8fc\ubaa9\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc0dd\uc950\ub4e4\uc740 \uc2dd\uc774 \uc694\uc778\uc744 \ube44\ub86f\ud55c \uc5ec\ub7ec \uc694\uc778\uc73c\ub85c \uc778\ud574 \ub9c8\uce58 \uae30\uacc4\uac00 \uace0\uc7a5 \ub09c \uac83\ucc98\ub7fc \ub300\uc0ac \uc7a5\uc560\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uc0dd\uc950\ub4e4\uc5d0\uac8c NR\uc744 \ubcf4\ucda9\ud588\uace0, \uc77c\uc815 \uae30\uac04 \ud6c4 \ub180\ub77c\uc6b4 \uc77c\uc774 \uc77c\uc5b4\ub0ac\uc2b5\ub2c8\ub2e4. \uc0dd\uc950\uc758 \ub300\uc0ac \uc9c0\ud45c\uac00 \ub208\uc5d0 \ub744\uac8c \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uc804\uc5d0 \ub192\uc558\ub358 \ud608\ub2f9\uacfc \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\uac00 \uac10\uc18c\ud558\uae30 \uc2dc\uc791\ud588\uace0, \ub9c8\uce58 \uae30\uacc4 \ubd80\ud488\ub4e4\uc774 \uc7ac\uc870\uc815\ub418\uc5b4 \ub354 \uc6d0\ud65c\ud558\uac8c \uc791\ub3d9\ud558\ub294 \uac83\ucc98\ub7fc \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\uac00 \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. 2014\ub144\uc5d0\ub294 \ubbf8\uad6d\uc758 \ud55c \uc5f0\uad6c\ud300\ub3c4 \uc774 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \uac04\uc554 \uc0dd\uc950\uc5d0\uac8c NR\uc744 \ubcf4\ucda9\ud588\uc744 \ub54c \uc885\uc591 \uc131\uc7a5\uc774 \uc5b5\uc81c\ub418\uace0 \uc0dd\uc950\uc758 \uac74\uac15\ud55c \uc218\uba85\uc774 \uc5f0\uc7a5\ub418\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc0dd\uc950\uc758 \ud65c\ub825\ub3c4 \ub208\uc5d0 \ub744\uac8c \uc99d\uac00\ud558\uc5ec \uc9c8\ubcd1\uc73c\ub85c \uc778\ud574 \uacbd\ud5d8\ud588\ub358 \ubb34\uae30\ub825\ud568\uc744 \ub354 \uc774\uc0c1 \ubcf4\uc774\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc774\ub294 NR\uc774 \uc9c8\ubcd1\uacfc \uc2f8\uc6b0\uace0 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \ub370 \uc720\uc758\ubbf8\ud55c \ud6a8\ub2a5\uc774 \uc788\uc74c\uc744 \ub354\uc6b1 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc778\uccb4 \uc784\uc0c1 \uc2dc\ud5d8: \uc870\uae30 \ub178\ud654 \ubc0f \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc744 \ud0c0\uae43\uc73c\ub85c \ud55c \ud68d\uae30\uc801\uc778 \uc5f0\uad6c<\/h3>\n

\ubca0\ub974\ub108 \uc99d\ud6c4\uad70 \uc911\uc7ac:<\/strong> 2023\ub144, \uc77c\ubcf8 \uce58\ubc14\ub300\ud559\uad50 \uc5f0\uad6c\ud300\uc740 \ud765\ubbf8\ub85c\uc6b4 \uc18c\uc2dd\uc744 \uc804\ud588\uc2b5\ub2c8\ub2e4. \ubc14\ub85c \ubca0\ub974\ub108 \uc99d\ud6c4\uad70 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \uc2dc\ud5d8\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ubca0\ub974\ub108 \uc99d\ud6c4\uad70\uc740 \ud76c\uadc0 \uc870\uae30 \ub178\ud654 \uc9c8\ud658\uc785\ub2c8\ub2e4. 20\ub300 \ud658\uc790\ub4e4\uc740 \ud770\uba38\ub9ac, \ub300\uba38\ub9ac, \ubc31\ub0b4\uc7a5\uacfc \uac19\uc740 \ub178\ud654 \uad00\ub828 \uc99d\uc0c1\uc744 \ubcf4\uc785\ub2c8\ub2e4. \uc0b6\uc758 \uc18d\ub3c4\uac00 \ube68\ub77c\uc9c0\uace0 \ub2e4\uc591\ud55c \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc774 \uc870\uae30\uc5d0 \ubc1c\uc0dd\ud558\uc5ec \uc0b6\uc758 \uc9c8\uacfc \uc218\uba85\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4.<\/p>\n

\uc774 \uc2dc\ud5d8\uc5d0\uc11c \ud658\uc790\ub4e4\uc740 \ub9e4\uc77c NR(\ub178\ud654\ubc29\uc9c0\uc81c)\uc744 \ubcf5\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc\ub294 \ub180\ub77c\uc6e0\uc2b5\ub2c8\ub2e4. \ub9c8\uce58 \ub9c8\ub978 \uac15\ubb3c\uc5d0 \uc2e0\uc120\ud55c \ubb3c\uc744 \uc8fc\uc785\ud55c \uac83\ucc98\ub7fc \ud608\uc911 NAD+ \uc218\uce58\uac00 40% \uc99d\uac00\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\ub9e5 \uacbd\uc9c1\ub3c4\uac00 \ud06c\uac8c \uac10\uc18c\ud558\uc5ec \uc774\uc804\uc5d0 \uacbd\uc9c1\ub418\uc5c8\ub358 \ud608\uad00\uc774 \ud0c4\ub825\uc744 \ub418\ucc3e\uace0 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc774 \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uada4\uc591\uc774 \ub354 \ube68\ub9ac \uce58\uc720\ub418\uc5c8\uace0, \uc624\ub7ab\ub3d9\uc548 \uce58\uc720\ud558\uae30 \uc5b4\ub824\uc6e0\ub358 \uc0c1\ucc98\uac00 \uc544\ubb3c\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \uc2e0\uc7a5 \uae30\ub2a5\ub3c4 \uac1c\uc120\ub418\uc5c8\uace0, \uc2e0\uccb4\uc758 \ud574\ub3c5 \ubc0f \uae30\ud0c0 \uae30\ub2a5\ub3c4 \ud68c\ubcf5\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc778\uac04 \uc870\ub85c\uc99d\uc5d0 \ub300\ud55c NR\uc758 \uce58\ub8cc\uc801 \uc7a0\uc7ac\ub825\uc744 \ucc98\uc74c\uc73c\ub85c \uc785\uc99d\ud55c \uac83\uc73c\ub85c, \uc774\ub7ec\ud55c \ud658\uc790\ub4e4\uc5d0\uac8c \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4.<\/p>\n

\uac74\uac15\ud55c \ub178\ud654\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5:<\/strong> \uc5f0\uad6c\ud300\uc740 40~65\uc138 \uc0ac\ub78c\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \ub300\uc870 \uc2dc\ud5d8\uc744 \uc9c4\ud589\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\ub839\ub300\uc758 \uc0ac\ub78c\ub4e4\uc740 \uc5d0\ub108\uc9c0 \uac10\uc18c, \uc218\uba74\uc758 \uc9c8 \uc800\ud558, \uc778\uc9c0 \uae30\ub2a5 \uc800\ud558 \ub4f1 \ub2e4\uc591\ud55c \ub178\ud654 \uc9d5\ud6c4\ub97c \ubcf4\uc774\uae30 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ucc38\uac00\uc790\ub4e4\uc5d0\uac8c 60\uc77c \ub3d9\uc548 \ub9e4\uc77c 300mg\uc758 NR\uc744 \ubcf4\ucda9\ud558\ub3c4\ub85d \ud588\uc2b5\ub2c8\ub2e4. 60\uc77c \ud6c4, \uae30\uc801\uc774 \uc77c\uc5b4\ub0ac\uc2b5\ub2c8\ub2e4. \ucc38\uac00\uc790\ub4e4\uc758 \ud608\uccad NAD+\/NADH \ube44\uc728\uc774 38% \uc99d\uac00\ud588\uace0, \uc2e0\uccb4\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac \ud6a8\uc728\uc774 \ud5a5\uc0c1\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadfc\ub825\uc774 \uc99d\uac00\ud588\uace0, \ud55c\ub54c \ubd88\uac00\ub2a5\ud574 \ubcf4\uc600\ub358 \ubb34\uac70\uc6b4 \ubb3c\uac74\uc744 \ub4e4\uc5b4 \uc62c\ub9ac\ub294 \uac83\ub3c4 \uc774\uc81c\ub294 \uc27d\uac8c \ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc218\uba74\uc758 \uc9c8\uc774 \ud06c\uac8c \uac1c\uc120\ub418\uc5b4 \ub354 \ud3b8\uc548\ud55c \ubc24\uacfc \ub354 \ub9d1\uc740 \ub0a0\uc744 \ubcf4\ub0bc \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc778\uc9c0 \uae30\ub2a5 \ub610\ud55c \uac1c\uc120\ub418\uc5b4 \uae30\uc5b5\ub825\uc774 \ud5a5\uc0c1\ub418\uace0 \uc0ac\uace0\ub825\uc774 \uc608\ub9ac\ud574\uc84c\uc73c\uba70, \ub9c8\uce58 \uc80a\uc74c\uc744 \ub418\ucc3e\uc740 \uac83\ucc98\ub7fc \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

\uae30\uc220 \ud601\uc2e0: “\ube44\ud6a8\uc728\uc801\uc778 \ubcf4\ucda9”\uc5d0\uc11c “\uc815\ubc00\ud55c \ub178\ud654 \ubc29\uc9c0”\ub85c: \uc0b0\uc5c5 \ud601\uc2e0<\/h2>\n

(I) \uae30\uc874 NR \ud65c\uc6a9\uc758 \ubcd1\ubaa9 \ud604\uc0c1: \uc704\uc7a5\uad00 \ub300\uc0ac \ubc0f \uc138\ud3ec \uce68\ud22c<\/h3>\n

NR\uc740 \uc790\uc5f0\uc5d0 \ub110\ub9ac \uc874\uc7ac\ud558\uc9c0\ub9cc, \ub9c8\uce58 \uad11\ud65c\ud55c \ubc14\ub2e4\uc5d0 \uc228\uaca8\uc9c4 \ubcf4\ubb3c\ucc98\ub7fc \uadf8 \ud568\ub7c9\uc740 \uadf9\ud788 \ub0ae\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc6b0\uc720\uc5d0\uc11c \ud544\uc694\ud55c NR\uc744 \uc5bb\uc73c\ub824\uba74 \ubb34\ub824 10\ub9cc \ucef5\uc758 \uc6b0\uc720\uac00 \ud544\uc694\ud55c\ub370, \uc774\ub294 \uc2e4\ud604 \ubd88\uac00\ub2a5\ud55c \uc804\ub9dd\uc785\ub2c8\ub2e4. \ub354\uc6b1\uc774, NR \uacbd\uad6c \uc12d\ucde8\ub97c \ud1b5\ud574 NAD+\ub97c \ubcf4\ucda9\ud558\ub824\ub294 \uc2dc\ub3c4\ub294 \uc218\ub9ce\uc740 \ub09c\uad00\uc5d0 \uc9c1\uba74\ud569\ub2c8\ub2e4.<\/p>\n

NR\uc740 \uacbd\uad6c \ud22c\uc5ec \ud6c4 \uc778\uccb4\uc5d0 \ucc98\uc74c \ub3c4\ucc29\ud558\ub294 \uacf3\uc5d0\uc11c \uac15\ub825\ud55c “\uc801”\uc778 \uc704\uc7a5\uad00\uacfc \ub9c8\uc8fc\uce69\ub2c8\ub2e4. \uc0ac\ub098\uc6b4 “\uc0ac\ub0e5\uafbc”\ucc98\ub7fc \uc704\uc7a5 \ud6a8\uc18c\ub294 NR\uc744 \uacf5\uaca9\ud558\uc5ec \uad6c\uc870\ub97c \ud30c\uad34\ud569\ub2c8\ub2e4. NR\uc774 \uc704\uc7a5 \ud6a8\uc18c\ub97c \ud1b5\uacfc\ud558\uc5ec \uac04\uc73c\ub85c \ub4e4\uc5b4\uac00\uba74 \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc\ub85c \ub300\uc0ac\ub429\ub2c8\ub2e4. \ub2c8\ucf54\ud2f4\uc544\ub9c8\uc774\ub4dc\ub294 NAD+ \ud569\uc131 \uacbd\ub85c\uc5d0\ub3c4 \uad00\uc5ec\ud558\uc9c0\ub9cc, \uadf8 \ud65c\uc131\uacfc \ud6a8\ub2a5\uc740 NR\uc5d0 \ube44\ud574 \ud604\uc800\ud788 \ub5a8\uc5b4\uc9d1\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 NR\uc774 \uc190\uc0c1\ub418\uc9c0 \uc54a\uace0 \ud6a8\uacfc\uc801\uc778 \ud615\ud0dc\ub85c \uc138\ud3ec\uc5d0 \uce68\ud22c\ud558\uc9c0 \ubabb\ud574 \ubcf8\ub798\uc758 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc9c0 \ubabb\ud558\uac8c \ub429\ub2c8\ub2e4.<\/p>\n

\ucd08\uae30 NR \ubcf4\ucda9\uc81c\ub294 \ub300\ubd80\ubd84 \ub2e8\uc77c \uc81c\ud615\uc744 \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub2e8\uc21c\ud55c \uc124\uacc4\ub85c \uc778\ud574 \uccb4\ub0b4 NR \uc804\ud658\uc728\uc740 15% \ubbf8\ub9cc\uc73c\ub85c \ub9e4\uc6b0 \ub0ae\uc558\uc2b5\ub2c8\ub2e4. \uc774\ucc98\ub7fc \ub0ae\uc740 \uc804\ud658\uc728\uc740 \ub9c8\uce58 \ub9f9\ub82c\ud558\uac8c \ud0c0\uc624\ub974\ub294 \ub178\ud654\uc758 \ubd88\uaf43\uc5d0 \ubb3c \uba87 \ubc29\uc6b8\uc744 \ubfcc\ub9ac\ub294 \uac83\uacfc \uac19\uc544 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub294 \ubbf8\ubbf8\ud558\uace0, \ub178\ud654 \uc9c0\uc5f0\uc774\ub77c\ub294 \uc808\uc2e4\ud55c \uc694\uad6c\ub97c \ucda9\uc871\uc2dc\ud0a4\uc9c0 \ubabb\ud569\ub2c8\ub2e4.<\/p>\n

(II) \ud601\uc2e0\uc801\uc778 \uae30\uc220 \uac15\ud654: \ubcf4\ud638\uae30\uc5d0\uc11c \ud65c\uc131 \uc720\ud669\uc73c\ub85c\uc758 \uc774\uc911 \ud601\uc2e0<\/h3>\n

NR \uc751\uc6a9 \ubd84\uc57c\uac00 \uc5b4\ub824\uc6c0\uc744 \uacaa\ub358 \uc2dc\uae30\uc5d0 \ubbf8\uad6d \uc758\uc0dd\uba85\uacf5\ud559\uc5f0\uad6c\uc18c(AIME)\uc758 \uc6ec\uc900 \uc6ec(Wen-jun Wen)\uc774 \uc774\ub044\ub294 \ud300\uc740 \ud601\uc2e0\uc801\uc778 TOPIA\u00ae \uae30\uc220\uc744 \ub3c4\uc785\ud558\uc5ec NR\uc758 \ud6a8\uc728\uc801\uc778 \ud65c\uc6a9\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubcf4\ud638\uae30 \ubcc0\ud615:<\/strong> \uc774 \ud601\uc2e0\uc740 NR\uc5d0 \ud2bc\ud2bc\ud55c “\uac11\uc637”\uc744 \uc785\ud788\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4. NR \ubd84\uc790 \ud45c\uba74\uc5d0 \ubcf4\ud638\ub9c9\uc744 \ud615\uc131\ud558\uc5ec \uc704\uc7a5\uad00 \ub0b4 \ub2e4\uc591\ud55c \u200b\u200b\ud6a8\uc18c\uc5d0 \uc758\ud55c \ubd84\ud574\ub97c \ubc29\uc9c0\ud569\ub2c8\ub2e4. \ub9c8\uce58 \uc801\uc758 \uacf5\uaca9\uc5d0\ub3c4 \ub450\ub824\uc6c0 \uc5c6\uc774 \ubd88\uad74\uc758 \ubc29\ud328\ub97c \ub4e0 \uc804\uc0ac\uc640 \uac19\uc2b5\ub2c8\ub2e4. NR\uc740 \uc628\uc804\ud55c \ud615\ud0dc\ub85c \ud608\ub958\uc5d0 \ud761\uc218\ub418\uc5b4 \uccb4\ub0b4 \uc548\uc815\uc131\uacfc \uc0dd\uccb4 \uc774\uc6a9\ub960\uc744 \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubcc0\ud654\ub294 NR\uc758 \uc804\ud658\uc728\uc744 70% \uc774\uc0c1\uc73c\ub85c \ub192\uc5ec NR\uc758 \ud56d\ub178\ud654 \uacfc\uc815\uc5d0 \uac15\ub825\ud55c \ud65c\ub825\uc744 \ubd88\uc5b4\ub123\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud65c\uc131 \uc720\ud669 \uc2dc\ub108\uc9c0:<\/strong> \uc774\ub294 TOPIA\u00ae \uae30\uc220\uc758 \ub610 \ub2e4\ub978 \ud575\uc2ec \uae30\uc220\uc785\ub2c8\ub2e4. \ud65c\uc131 \uc720\ud669\uc740 \ub9c8\ubc95\uc758 \uc5f4\uc1e0\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc138\ud3ec\ub9c9 \ucc44\ub110\uc744 \ud65c\uc131\ud654\ud558\uace0 \uc77c\uc2dc\uc801\uc73c\ub85c \ud655\uc7a5\uc2dc\ud0b5\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 NR\uc740 \ub9c8\uce58 \ubb3c\uace0\uae30\uac00 \ubb3c\uc18d\uc744 \ud5e4\uc5c4\uce58\ub4ef \uc138\ud3ec \ub0b4\ub85c \ud6a8\uc728\uc801\uc73c\ub85c \uce68\ud22c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \ud65c\uc131 \uc720\ud669\uc740 NR\uc774 \ub9e4\uc6b0 \uce5c\uc804\uc790\uc131 \uad6c\uc870\ub97c \ud615\uc131\ud558\uc5ec \ub6f0\uc5b4\ub09c \uc790\uc720 \ub77c\ub514\uce7c \uc18c\uac70 \ub2a5\ub825\uc744 \uac00\uc9c4 \uac15\ub825\ud55c “\uccad\uc18c\uae30” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774\ub294 \uc138\ud3ec \ub0b4 \uc790\uc720 \ub77c\ub514\uce7c\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\uc5ec \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub85c \uc778\ud55c \uc190\uc0c1\uc744 \uc904\uc77c \ubfd0\ub9cc \uc544\ub2c8\ub77c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc640 DNA \ubcf5\uad6c \ud6a8\uc728\uc744 \ub3d9\uc2dc\uc5d0 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc774 \ub354\uc6b1 \uac15\ud654\ub418\uc5b4 \uc5d0\ub108\uc9c0 \uc0dd\uc0b0 \ud6a8\uc728\uc774 \ub354\uc6b1 \ub192\uc544\uc9d1\ub2c8\ub2e4. DNA \ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \ub610\ud55c \ud65c\uc131\ud654\ub418\uc5b4 \uc190\uc0c1\ub41c \uc720\uc804\uc790\ub97c \uc2e0\uc18d\ud558\uac8c \ubcf5\uad6c\ud558\uace0, \ub2e4\ub2e8\uacc4\uc801\uc73c\ub85c \uc138\ud3ec \uc80a\uc74c\uc744 \uc704\ud55c \ud3ec\uad04\uc801\uc778 \ubcf4\ud638 \uae30\ub2a5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

(III) \ubca4\uce58\ub9c8\ud06c \uc81c\ud488 NOVIS\uc758 \ud0c4\uc0dd: \uacfc\ud559\uc801 \ud574\uc11d\uc758 \uc774\uc815\ud45c<\/h3>\n

TOPIA\u00ae \uae30\uc220\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uc804\uc744 \ubc14\ud0d5\uc73c\ub85c NOVIS\ub294 NR \ud56d\ub178\ud654 \ubd84\uc57c\uc758 \ube5b\ub098\ub294 \uc2a4\ud0c0\ub85c \ub5a0\uc62c\ub790\uc2b5\ub2c8\ub2e4. \ubbf8\uad6d FDA\uc5d0 \ub4f1\ub85d\ub41c \ucd5c\ucd08\uc758 \ubcf5\ud569 NR \ubcf4\ucda9\uc81c\ub85c, \uc774\ub294 NOVIS\uc758 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc5d0 \ub300\ud55c \uad8c\uc704 \uc788\ub294 \uc778\uc815\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4.
\nNOVIS\uc758 \uc815\uad50\ud558\uac8c \uc124\uacc4\ub41c \ud3ec\ubbac\ub77c\ub294 \ud558\ub8e8 \ub450 \ucea1\uc290\ub9cc\uc73c\ub85c NAD+ \uc218\uce58\ub97c 60%\uae4c\uc9c0 \ud06c\uac8c \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. NOVIS\ub294 NAD+ \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc2dc\ub974\ud22c\uc778\uc758 \ud65c\uc131\uc744 \uc815\ubc00\ud558\uac8c \uc870\uc808\ud569\ub2c8\ub2e4. \ud65c\uc131\ud654\ub418\uba74 \uc2dc\ub974\ud22c\uc778\uc774 \uac15\ub825\ud55c \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \uadfc\uc721 \uc7ac\uc0dd\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc57d\ud654\ub41c \uadfc\uc721\uc740 \uc810\ucc28 \ud0c4\ub825\uacfc \ud798\uc744 \ud68c\ubcf5\ud558\uc5ec \uc6b4\ub3d9\uacfc \uc77c\uc0c1\uc0dd\ud65c\uc744 \ub354\uc6b1 \uc27d\uac8c \uc218\ud589\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ud608\uad00 \ud0c4\ub825\uc131 \ub610\ud55c \ud68c\ubcf5\ub418\uc5b4 \uc774\uc804\uc5d0 \ubee3\ubee3\ud588\ub358 \ud608\uad00\uc744 \ubd80\ub4dc\ub7fd\uace0 \uc720\uc5f0\ud558\uac8c \ub9cc\ub4e4\uc5b4 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \uc778\uc9c0 \uae30\ub2a5 \ub610\ud55c \ud5a5\uc0c1\ub418\uc5b4 \uae30\uc5b5\ub825\uc774 \ud5a5\uc0c1\ub418\uace0 \uc0ac\uace0\ub825\uc774 \ubbfc\ucca9\ud574\uc838 \ub9c8\uce58 \ub1cc\uac00 \ud65c\ub825\uc744 \ub418\ucc3e\uc740 \uac83\ucc98\ub7fc \ub290\uaef4\uc9d1\ub2c8\ub2e4. NOVIS\uc758 \ud0c1\uc6d4\ud55c \uc131\ub2a5\uc740 \uad6d\uc81c \uc5b8\ub860\uc73c\ub85c\ubd80\ud130 “\ud56d\ub178\ud654 \ubd84\uc57c\uc758 \ud68d\uae30\uc801\uc778 \uc81c\ud488”\uc774\ub77c\ub294 \ucc2c\uc0ac\ub97c \ubc1b\uc73c\uba70 \ub192\uc740 \ud3c9\uac00\ub97c \ubc1b\uc558\uc2b5\ub2c8\ub2e4. NOVIS\uc758 \ucd9c\uc2dc\ub294 \uacfc\ud559 \uc5f0\uad6c \ubd84\uc57c\uc5d0\uc11c \uc911\uc694\ud55c \uc131\uacfc\ub97c \uac70\ub458 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \uac74\uac15\uacfc \uc80a\uc74c\uc744 \ucd94\uad6c\ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc2e4\uc9c8\uc801\uc778 \ud76c\ub9dd\uc744 \uc548\uaca8\uc8fc\uba70 \ud56d\ub178\ud654\uc758 \uae38\ub85c \ub098\uc544\uac00\ub294 \ub4e0\ub4e0\ud55c \ubc1c\uac78\uc74c\uc744 \ub0b4\ub51b\uac8c \ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

NR\uc758 \uc0dd\ub9ac \uc9c0\ud45c \ub2e4\ucc28\uc6d0 \uac15\ud654: \ub178\ud654 \uc9c0\uc5f0\uc758 \ud575\uc2ec \uc99d\uac70\"\"<\/h2>\n

(I) \ub300\uc0ac \ubc0f \uc5d0\ub108\uc9c0 \uc2dc\uc2a4\ud15c: \uc138\ud3ec\uc758 “\ud65c\ub825 \uc5d4\uc9c4” \uc7ac\uac00\ub3d9
\n\ud608\ub2f9 \ubc0f \uc9c0\uc9c8: NR\uc740 \uc2e0\uccb4 \ub300\uc0ac\uc758 “\ub611\ub611\ud55c \uad00\ub9ac\uc790”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ud608\ub2f9 \ubc0f \uc9c0\uc9c8 \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud608\ub2f9\uc758 \uacbd\uc6b0, NR\uc740 \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \ud06c\uac8c \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc778\uc290\ub9b0\uc740 \uc138\ud3ec\uc758 “\ubb38”\uc744 \uc5ec\ub294 “\uc5f4\uc1e0”\uc640 \uac19\uc544 \ud608\uc561 \uc18d \ud3ec\ub3c4\ub2f9\uc774 \uc138\ud3ec \uc548\uc73c\ub85c \ub4e4\uc5b4\uac00 \uc5d0\ub108\uc9c0\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\uac00 \ud5a5\uc0c1\ub418\uba74 \uc138\ud3ec\ub294 \uc778\uc290\ub9b0\uc5d0 \ub354 \ubbfc\uac10\ud558\uac8c \ubc18\uc751\ud558\uace0 \ud3ec\ub3c4\ub2f9\uc740 \uc138\ud3ec\uc5d0 \uc758\ud574 \ub354 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub418\uace0 \ud65c\uc6a9\ub420 \uc218 \uc788\uc5b4 \ud608\ub2f9 \uc218\uce58\ub97c \ub0ae\ucd9c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub2f9\ub1e8\ubcd1 \uc804\ub2e8\uacc4 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 NR \ubcf4\ucda9 \ud6c4 \ud53c\ud5d8\uc790\ub4e4\uc740 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc774 \ud06c\uac8c \uac10\uc18c\ud588\uc73c\uba70, \uacf5\ubcf5 \ud608\ub2f9\uacfc \uc2dd\ud6c4 \ud608\ub2f9\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \uc870\uc808\ub418\uc5b4 \ub9c8\uce58 \ud608\ub2f9 \ud3ed\uc8fc\uc5d0 “\ube0c\ub808\uc774\ud06c\ub97c \ubc1f\ub294” \uac83\ucc98\ub7fc \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

NR\uc740 \ub610\ud55c \uc9c0\uc9c8 \uc870\uc808\uc5d0\ub3c4 \ub9e4\uc6b0 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \ud608\uc911 \uc9c0\uc9c8\uc758 \uc911\uc694\ud55c \uad6c\uc131 \uc694\uc18c\uc778 \uc911\uc131\uc9c0\ubc29 \uc218\uce58\ub97c \ub0ae\ucd9c \uc218 \uc788\uc73c\uba70, \uacfc\ub3c4\ud558\uac8c \ub192\uc740 \uc911\uc131\uc9c0\ubc29\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. NR\uc740 \uc9c0\uc9c8 \ub300\uc0ac \uad00\ub828 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc870\uc808\ud558\uc5ec \uc911\uc131\uc9c0\ubc29 \ud569\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \ubd84\ud574 \ubc0f \ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uc5ec \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\ub97c \uac74\uac15\ud55c \ubc94\uc704\ub85c \uc720\uc9c0\ud569\ub2c8\ub2e4. \uc7a5\uae30\uac04 NR\uc744 \uc12d\ucde8\ud558\uba74 \ub300\uc0ac \uc99d\ud6c4\uad70\uc758 \uc9c4\ud589\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ub2a6\ucd94\uace0, \ub2f9\ub1e8\ubcd1 \ubc0f \uc2ec\ud608\uad00 \uc9c8\ud658\uacfc \uac19\uc740 \ub300\uc0ac \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 \uc904\uc774\uba70, \uac15\ub825\ud55c \uac74\uac15 \ubc29\uc5b4\ub825\uc744 \uad6c\ucd95\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5: \uc138\ud3ec \ub0b4 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\ub294 \uc2e0\uccb4\uc758 \uc5d0\ub108\uc9c0 \uacf5\uae09\uacfc \ud65c\ub825\uc5d0 \uc9c1\uc811\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. NR\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uac1c\uc120\uc5d0 \ud0c1\uc6d4\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc774\uba70, ATP \uc0dd\uc131 \ud6a8\uc728\uc744 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. ATP\ub294 \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \ud654\ud3d0”\uc640 \uac19\uc740 \uc9c1\uc811\uc801\uc778 \uc5d0\ub108\uc9c0\uc6d0\uc774\uba70, \ucda9\ubd84\ud55c ATP\ub294 \ub2e4\uc591\ud55c \uc0dd\ub9ac \ud65c\ub3d9\uc758 \uc6d0\ud65c\ud55c \uc9c4\ud589\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n

NR\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub0b4 \uc8fc\uc694 \ud6a8\uc18c\ub97c \ud65c\uc131\ud654\ud558\uc5ec \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ud638\ud761 \uc0ac\uc2ac\uc758 \uc804\uc790 \uc804\ub2ec \uacfc\uc815\uc744 \ucd5c\uc801\ud654\ud558\uace0, \uc0b0\uc18c\uc640 \uc601\uc591\uc18c\uac00 ATP\ub85c \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uc804\ud658\ub418\ub3c4\ub85d \ud558\uc5ec \uc138\ud3ec\uc5d0 \ucda9\ubd84\ud55c \uc5d0\ub108\uc9c0\ub97c \uacf5\uae09\ud569\ub2c8\ub2e4. \ub610\ud55c NR\uc740 \uc816\uc0b0 \ucd95\uc801\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6b4\ub3d9\uc774\ub098 \uace0\uac15\ub3c4 \ud65c\ub3d9 \uc911 \uc138\ud3ec\ub294 \ubb34\uc0b0\uc18c \ud638\ud761\uc744 \ud1b5\ud574 \uc816\uc0b0\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4. \uacfc\ub3c4\ud55c \uc816\uc0b0\uc774 \ucd95\uc801\ub418\uba74 \uadfc\uc721\ud1b5\uc774\ub098 \ud53c\ub85c\uc640 \uac19\uc740 \ubd88\ud3b8\ud568\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NR\uc740 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uc758 \uc720\uc0b0\uc18c \ub300\uc0ac \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ubb34\uc0b0\uc18c \ud638\ud761\uc744 \uac10\uc18c\uc2dc\ucf1c \uc816\uc0b0 \uc0dd\uc131\uc744 \uac10\uc18c\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 NR\uc740 \uc816\uc0b0 \uc81c\uac70 \ubc0f \ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uc5ec \uc2e0\uccb4\uac00 \ud53c\ub85c\uc5d0\uc11c \ub354 \ube68\ub9ac \ud68c\ubcf5\ud558\ub3c4\ub85d \ud569\ub2c8\ub2e4. NR\uc744 \ubcf4\ucda9\ud55c \ub9ce\uc740 \uc6b4\ub3d9\uc120\uc218\ub4e4\uc740 \uc9c0\uad6c\ub825\uacfc \ud53c\ub85c \uc800\ud56d\ub825\uc774 \ud06c\uac8c \ud5a5\uc0c1\ub418\uc5b4 \ub9c8\uce58 \ubb34\ud55c\ud55c \uc5d0\ub108\uc9c0\uc6d0\uc744 \uac00\uc9c4 \uac83\ucc98\ub7fc \ud6c8\ub828\uacfc \uacbd\uae30\uc5d0\uc11c \ub354 \ub098\uc740 \uc131\uc801\uc744 \uac70\ub450\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc7a5\uae30 \ubc0f \uc2dc\uc2a4\ud15c \ud68c\ucd98: \ub0b4\ubd80\uc5d0\uc11c \uc678\ubd80\ub85c \ub178\ud654 \uc5ed\uc804<\/h3>\n

\uc2ec\ud608\uad00\uacc4: \uc2ec\ud608\uad00\uacc4: \uc2ec\ud608\uad00\uacc4\ub294 \uc2e0\uccb4\uc758 “\uc6b4\uc1a1\ub9dd”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc2e0\uccb4\uc758 \ubaa8\ub4e0 \ubd80\uc704\uc5d0 \ud608\uc561\uc744 \uacf5\uae09\ud569\ub2c8\ub2e4. NR\uc740 \uc2ec\ud608\uad00 \uac74\uac15\uc744 \ubcf4\ud638\ud558\uace0 \uc2ec\ud608\uad00 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\ub3d9\ub9e5 \uacbd\uc9c1\uc740 \uc2ec\ud608\uad00 \ub178\ud654\uc758 \uc911\uc694\ud55c \uc9c0\ud45c\ub85c, \ud608\uc555 \uc0c1\uc2b9, \uc2ec\uc7a5 \ubd80\ud558 \uc99d\uac00, \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8 \uc99d\uac00\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \ub178\ub974\uc5d0\ud53c\ub124\ud504\ub9b0(NR)\uc740 \ub3d9\ub9e5 \uacbd\uc9c1\uc744 \uac10\uc18c\uc2dc\ucf1c \ud608\uad00 \ud0c4\ub825\uc744 \ud68c\ubcf5\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc5d0\uc11c \uc0b0\ud654\uc9c8\uc18c \ud569\uc131\ud6a8\uc18c(eNOS)\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc0b0\ud654\uc9c8\uc18c(NO) \ubc29\ucd9c\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. NO\ub294 \ud608\uad00\uc758 “\uc724\ud65c\uc81c” \uc5ed\ud560\uc744 \ud558\uc5ec \ud608\uad00 \ud3c9\ud65c\uadfc\uc744 \uc774\uc644\uc2dc\ud0a4\uace0, \ud608\uad00\uc744 \ud655\uc7a5\ud558\uba70, \ud608\uad00 \uc800\ud56d\uc744 \uac10\uc18c\uc2dc\ucf1c \ub3d9\ub9e5\uc744 \ub354\uc6b1 \uc720\uc5f0\ud558\uace0 \ud0c4\ub825 \uc788\uac8c \ub9cc\ub4ed\ub2c8\ub2e4.<\/p>\n

\ub0b4\ud53c \uae30\ub2a5\uc740 \uc2ec\ud608\uad00 \uac74\uac15 \uc720\uc9c0\uc5d0\ub3c4 \uc911\uc694\ud569\ub2c8\ub2e4. \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\ub294 \ud608\uc561\uacfc \uc870\uc9c1 \uc0ac\uc774\uc758 \uc7a5\ubcbd \uc5ed\ud560\uc744 \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud608\uad00 \uc218\ucd95\uacfc \ud655\uc7a5\uc744 \uc870\uc808\ud558\uace0, \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \uc5b5\uc81c\ud558\uba70, \ud608\uc804 \ud615\uc131\uc744 \uc608\ubc29\ud558\ub294 \ub2e4\uc591\ud55c \uc0dd\ub9ac\ud65c\uc131 \ubb3c\uc9c8\uc744 \ubd84\ube44\ud569\ub2c8\ub2e4. \ub178\ub974\uc5d0\ud53c\ub124\ud504\ub9b0(NR)\uc740 \ub0b4\ud53c \uae30\ub2a5\uc744 \uac1c\uc120\ud558\uace0 \ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\ub97c \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5fc\uc99d\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub0b4\ud53c \uc138\ud3ec\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0, \ub0b4\ud53c \uc138\ud3ec\uc5d0 \ub300\ud55c \uc790\uc720 \ub77c\ub514\uce7c\uc758 \uacf5\uaca9\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70, \ub3d9\uc2dc\uc5d0 \uc5fc\uc99d \uc778\uc790\uc758 \ubc29\ucd9c\uc744 \uc5b5\uc81c\ud558\uc5ec \uc5fc\uc99d \ubc18\uc751\uc73c\ub85c \uc778\ud55c \ub0b4\ud53c \uc138\ud3ec \uc190\uc0c1\uc744 \uc644\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 \ub3d9\ubb3c\uc5d0\uac8c NR\uc744 \ubcf4\ucda9\ud588\uc744 \ub54c \ud608\uad00 \ub0b4\ud53c \uae30\ub2a5\uc774 \uc720\uc758\ubbf8\ud558\uac8c \ud5a5\uc0c1\ub418\uace0, \uc815\uc0c1\uc801\uc778 \ud608\uad00 \ud655\uc7a5 \ubc0f \uc218\ucd95\uc774 \ud68c\ubcf5\ub418\uc5c8\uc73c\uba70, \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc8fd\uc0c1\uacbd\ud654\ubc18 \ud615\uc131\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc8fc\uc694 \ubcd1\ub9ac\ud559\uc801 \uc6d0\uc778 \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. NR\uc740 \uc5fc\uc99d \ubc18\uc751\uacfc \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc5b5\uc81c\ud558\uace0, \ud608\uad00\ubcbd\uc758 \uc9c0\uc9c8 \uce68\ucc29\uc744 \uc904\uc774\uba70, \ud50c\ub77c\ud06c \ud615\uc131 \ubc0f \ubc1c\ub2ec\uc744 \uc608\ubc29\ud568\uc73c\ub85c\uc368 \uc8fd\uc0c1\uacbd\ud654\ubc18 \ud615\uc131\uc744 \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0, NR\uc740 \ud608\uad00 \ud3c9\ud65c\uadfc \uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uc99d\uc2dd\uacfc \ubd84\ud654\ub97c \ucd09\uc9c4\ud558\uace0, \ud608\uad00\ubcbd\uc758 \uad6c\uc870\uc801 \ubc0f \uae30\ub2a5\uc801 \uc548\uc815\uc131\uc744 \uc720\uc9c0\ud558\uba70, \ub2e4\ubc29\uba74\uc5d0\uc11c \uc2ec\ud608\uad00 \uac74\uac15\uc744 \ubcf4\ud638\ud558\uc5ec “\uad50\ud1b5\ub9dd”\uc758 \uc6d0\ud65c\ud55c \ud750\ub984\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n

\uc2e0\uacbd\uacc4: \uc2e0\uacbd\uacc4\ub294 \uc2e0\uccb4\uc758 “\uc9c0\ud718 \uc13c\ud130”\ub85c\uc11c \ub2e4\uc591\ud55c \uc0dd\ub9ac \ud65c\ub3d9\uc744 \uc81c\uc5b4\ud558\uace0 \uc870\uc808\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc2e0\uacbd\uacc4\ub294 \uc810\ucc28 \uc545\ud654\ub418\uc5b4 \uc778\uc9c0 \uae30\ub2a5 \uc800\ud558, \uae30\uc5b5\ub825 \uac10\ud1f4, \uae30\ubd84 \ubcc0\ud654\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc2e0\uacbd\uc601\uc591\uc778\uc790(NR)\ub294 \uc2e0\uacbd\uacc4\ub97c \ubcf4\ud638\ud558\uace0 \uc2e0\uacbd \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

\uc2e0\uacbd\uc138\ud3ec\ub294 \uc2e0\uacbd\uacc4\uc758 \uae30\ubcf8 \uad6c\uc131 \uc694\uc18c\ub85c, \ub9e4\uc6b0 \ucde8\uc57d\ud558\uace0 \uc0b0\ud654\uc801 \uc190\uc0c1\uc5d0 \uc27d\uac8c \uc601\ud5a5\uc744 \ubc1b\uc2b5\ub2c8\ub2e4. NR\uc740 \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0, \ud56d\uc0b0\ud654 \ud6a8\uc18c \uc2dc\uc2a4\ud15c\uc744 \ud65c\uc131\ud654\ud558\uace0, \uc790\uc720 \ub77c\ub514\uce7c\uc744 \uc911\ud654\uc2dc\ud0a4\uace0, \uc2e0\uacbd\uc138\ud3ec\uc5d0 \ub300\ud55c \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc758 \uacf5\uaca9\uc744 \uc904\uc784\uc73c\ub85c\uc368 \uc2e0\uacbd\uc138\ud3ec\ub97c \uc0b0\ud654\uc801 \uc190\uc0c1\uc73c\ub85c\ubd80\ud130 \ubcf4\ud638\ud569\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 NR\uc740 \uc2e0\uacbd \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uc5ec \uc2e0\uacbd\uc758 \ud65c\ub825\uacfc \uc190\uc0c1 \uc800\ud56d\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1\uacfc \uac19\uc740 \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c<\/p>\n

NR \ubcf4\ucda9\uc740 \uc2e0\uacbd \uc190\uc0c1\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc77c\uc815 \uc218\uc900\uc758 \uc2e0\uacbd \uae30\ub2a5 \ud68c\ubcf5\uc744 \ub2ec\uc131\ud588\uc2b5\ub2c8\ub2e4. \ub1cc\uc720\ub798 \uc2e0\uacbd\uc601\uc591\uc778\uc790(BDNF)\ub294 \uc2e0\uacbd\uacc4 \uae30\ub2a5\uc758 \ubc1c\ub2ec \ubc0f \uc720\uc9c0\uc5d0 \ud544\uc218\uc801\uc778 \ub2e8\ubc31\uc9c8\uc785\ub2c8\ub2e4. BDNF\ub294 \uc2e0\uacbd \uc138\ud3ec\uc758 \uc131\uc7a5, \ubd84\ud654, \uc0dd\uc874\uc744 \ucd09\uc9c4\ud558\uace0, \uc2e0\uacbd \uc138\ud3ec \uac04\uc758 \uc5f0\uacb0\uc744 \uac15\ud654\ud558\uba70, \ud559\uc2b5 \ubc0f \uae30\uc5b5 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. NR\uc740 \uad00\ub828 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud558\uace0 BDNF \ud569\uc131 \ubc0f \ubc29\ucd9c\uc744 \ucd09\uc9c4\ud558\uc5ec BDNF \uc218\uce58\ub97c \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc7a5\uae30\uac04 NR\uc744 \ubcf4\ucda9\ud55c \uc0ac\ub78c\ub4e4\uc740 \ub1cc\uc758 BDNF \uc218\uce58\uac00 \ud604\uc800\ud788 \ub192\uace0, \uc778\uc9c0 \uae30\ub2a5, \uae30\uc5b5\ub825, \uc0ac\uace0\ub825, \uac10\uc815\uc774 \uac1c\uc120\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc73c\uba70, \ub9c8\uce58 “\uc0ac\ub839\ubd80”\uc5d0 \uc0c8\ub85c\uc6b4 \ud65c\ub825\uc744 \ubd88\uc5b4\ub123\ub294 \uac83\uacfc \uac19\uc2b5\ub2c8\ub2e4.<\/p>\n

\uba74\uc5ed \uccb4\uacc4: \uba74\uc5ed \uccb4\uacc4\ub294 \ubcd1\uc6d0\uade0\uc758 \uce68\uc785\uc5d0 \uc800\ud56d\ud558\uace0 \uc9c8\ubcd1\uc73c\ub85c\ubd80\ud130 \uc2e0\uccb4\ub97c \ubcf4\ud638\ud558\ub294 \uc2e0\uccb4\uc758 “\ubc29\uc5b4\ub825”\uc785\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uba74\uc5ed \uccb4\uacc4\ub294 \uc810\ucc28 \uc57d\ud574\uc9c0\uace0, \uba74\uc5ed \uc138\ud3ec\uc758 \uae30\ub2a5\uc740 \uc800\ud558\ub418\uba70, \ubcd1\uc6d0\uade0\uc5d0 \ub300\ud55c \uc800\ud56d\ub825\uc774 \uc57d\ud574\uc9c0\uace0, \ub2e4\uc591\ud55c \uac10\uc5fc\uc131 \uc9c8\ud658\uc758 \ubc1c\uc0dd \uac00\ub2a5\uc131\uc774 \ub192\uc544\uc9d1\ub2c8\ub2e4.<\/p>\n

NR\uc740 \uba74\uc5ed \uccb4\uacc4\ub97c \uc870\uc808\ud558\uace0 \uba74\uc5ed \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. CD38 \ud6a8\uc18c\ub294 NAD+\ub97c \uc18c\ubaa8\ud558\ub294 \ud6a8\uc18c\uc785\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c CD38 \ud6a8\uc18c\uc758 \ud65c\uc131\uc774 \uc99d\uac00\ud558\uc5ec \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\uac00 \uac10\uc18c\ud558\uace0, \uc774\ub294 \uba74\uc5ed \uc138\ud3ec\uc758 \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. NR\uc740 CD38 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc870\uc808\ud558\uc5ec NAD+ \uc18c\ubaa8\ub97c \uc904\uc774\uace0 \uc138\ud3ec \ub0b4 NAD+ \uc218\uce58\ub97c \uc548\uc815\uc801\uc73c\ub85c \uc720\uc9c0\ud569\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uba74\uc5ed \uc138\ud3ec\ub294 \ucda9\ubd84\ud55c \uc5d0\ub108\uc9c0\uc640 \ubb3c\uc9c8 \uacf5\uae09\uc744 \ud655\ubcf4\ud558\uace0 \uc591\ud638\ud55c \uae30\ub2a5 \uc0c1\ud0dc\ub97c \uc720\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

T \uc138\ud3ec\ub294 \uba74\uc5ed \uccb4\uacc4\uc758 \uc911\uc694\ud55c \uad6c\uc131\uc6d0\uc73c\ub85c, \ubcd1\uc6d0\uade0\uc744 \uc778\uc2dd\ud558\uace0 \uc81c\uac70\ud558\uace0 \uba74\uc5ed \ubc18\uc751\uc744 \uc870\uc808\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. NR\uc740 T \uc138\ud3ec\uc758 \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0, \uc99d\uc2dd\uacfc \ud65c\uc131\ud654\ub97c \ucd09\uc9c4\ud558\uba70, \ubcd1\uc6d0\uade0\uc744 \uc778\uc2dd\ud558\uace0 \uacf5\uaca9\ud558\ub294 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 NR\uc740 T \uc138\ud3ec\uc758 \ubd84\ud654\uc640 \uae30\ub2a5\uc801 \uade0\ud615\uc744 \uc870\uc808\ud558\uc5ec \uba74\uc5ed \uccb4\uacc4\uc758 \uc804\ubc18\uc801\uc778 \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 NR\uc744 \ubcf4\ucda9\ud55c \ub178\uc778\ub4e4\uc740 T \uc138\ud3ec \ud65c\ub3d9\uc774 \ud06c\uac8c \uc99d\uac00\ud558\uace0, \uc778\ud50c\ub8e8\uc5d4\uc790 \ubc14\uc774\ub7ec\uc2a4\uc640 \uac19\uc740 \ubcd1\uc6d0\uade0\uc5d0 \ub300\ud55c \uc800\ud56d\ub825\uc774 \ud5a5\uc0c1\ub418\uba70, \uac10\uc5fc \uc704\ud5d8\uc774 \uac10\uc18c\ud558\uc5ec “\ubc29\uc5b4\ub825”\uc774 \uac15\ud654\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

(III) \uc5d0\ud53c\uc5d0\uc774\uc9d5 \uc9c0\ud45c: \ub208\uc5d0 \ub744\ub294 \ud68c\ucd98 \ubcc0\ud654<\/h3>\n

NR\uc740 \uccb4\ub0b4 \uc0dd\ub9ac \uc9c0\ud45c\uc640 \uc7a5\uae30 \uccb4\uacc4\uc5d0 \uae0d\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce60 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \uc5d0\ud53c\uc5d0\uc774\uc9d5 \ub2e8\uacc4\uc5d0\uc11c\ub3c4 \ub208\uc5d0 \ub744\ub294 \ud68c\ucd98 \ubcc0\ud654\ub97c \uac00\uc838\uc62c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \ub178\ud654 \uacfc\uc815\uc5d0\uc11c \ud770\uba38\ub9ac\uac00 \ub298\uc5b4\ub098\ub294 \ubb38\uc81c\uc5d0 \uc9c1\uba74\ud558\ub294\ub370, \uc774\ub294 \uc678\ubaa8\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc2dc\uac04\uc758 \ud750\ub984\uae4c\uc9c0 \ub290\ub07c\uac8c \ud569\ub2c8\ub2e4. \uc784\uc0c1 \uad00\ucc30 \uacb0\uacfc, 6~12\uac1c\uc6d4 \ub3d9\uc548 \uc9c0\uc18d\uc801\uc73c\ub85c NR\uc744 \ubcf4\ucda9\ud558\uba74 \ubaa8\ubc1c \uc0c9\uc18c \uce68\ucc29\uc744 \ud06c\uac8c \uac1c\uc120\ud558\uace0 \ud770\uba38\ub9ac \ubc1c\uc0dd\uc744 \uc904\uc77c \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae30\uc800 \uc6d0\ub9ac\ub294 NR\uc758 NAD+ \uc218\uce58 \uc99d\uac00 \ub2a5\ub825\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. NAD+\ub294 \ubaa8\ub0ad \ub0b4 \uba5c\ub77c\ub2cc \uc138\ud3ec\uc758 \ub300\uc0ac \uacfc\uc815\uc5d0 \uad00\uc5ec\ud569\ub2c8\ub2e4. \ucda9\ubd84\ud55c NAD+\ub294 \uba5c\ub77c\ub2cc \uc138\ud3ec\uc758 \uc815\uc0c1\uc801\uc778 \uae30\ub2a5\uc744 \uc720\uc9c0\ud558\uace0, \uba5c\ub77c\ub2cc \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uba70, \ubaa8\ubc1c\uc744 \uc6d0\ub798\uc758 \uac80\uace0 \uc724\uae30 \uc788\ub294 \uc0c1\ud0dc\ub85c \ud68c\ubcf5\uc2dc\ucf1c \uc90d\ub2c8\ub2e4. \ub9c8\uce58 \uba38\ub9ac\uce74\ub77d\uc758 “\ud314\ub808\ud2b8”\uc5d0 \uc0c9\uc744 \ub2e4\uc2dc \uc8fc\uc785\ud558\ub294 \uac83\uacfc \uac19\uc544 \uc80a\uc740 \uba38\ub9ac\uce74\ub77d \uc0c9\uae54\uc774 \ub2e4\uc2dc \ub098\ud0c0\ub098\ub3c4\ub85d \ud569\ub2c8\ub2e4. \ud53c\ubd80\ub294 \uc778\uccb4\uc5d0\uc11c \uac00\uc7a5 \ud070 \uae30\uad00\uc774\uc790 \ub178\ud654\uac00 \uac00\uc7a5 \uc27d\uac8c \ub098\ud0c0\ub098\ub294 \ubd80\uc704\uc785\ub2c8\ub2e4.<\/p>\n

\ub098\uc774\uac00 \ub4e4\uba74\uc11c \ud53c\ubd80\ub294 \uc810\ucc28 \ud0c4\ub825\uc744 \uc783\uc5b4 \uc8fc\ub984, \ucc98\uc9d0, \uae30\ud0c0 \uc5ec\ub7ec \ubb38\uc81c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. NR\uc740 \ud53c\ubd80 \ud0c4\ub825 \uac1c\uc120\uc5d0 \uc0c1\ub2f9\ud55c \ud6a8\uacfc\ub97c \ubc1c\ud718\ud569\ub2c8\ub2e4. \ucf5c\ub77c\uac90 \ud569\uc131\uc744 \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ucf5c\ub77c\uac90\uc740 \ud53c\ubd80\uc758 \uc8fc\uc694 \uad6c\uc870 \ub2e8\ubc31\uc9c8\ub85c, \ud53c\ubd80\uc758 “\uac15\ucca0 \ub9c9\ub300”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ud53c\ubd80\uc5d0 \ud0c4\ub825\uacfc \uacac\uace0\ud568\uc744 \ubd80\uc5ec\ud569\ub2c8\ub2e4. NR\uc740 \uad00\ub828 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud558\uc5ec \uc12c\uc720\uc544\uc138\ud3ec\uc758 \ucf5c\ub77c\uac90 \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uace0 \ud53c\ubd80\uc758 \ucf5c\ub77c\uac90 \ud568\ub7c9\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, NR\uc740 \ud53c\ubd80 \uc138\ud3ec\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0, \ud65c\uc131\uc0b0\uc18c\ub85c \uc778\ud55c \ud53c\ubd80 \uc190\uc0c1\uc744 \uc904\uc774\uba70, \ud53c\ubd80 \ub178\ud654 \uacfc\uc815\uc744 \ub2a6\ucdb0\uc90d\ub2c8\ub2e4. NR\uc744 \uc77c\uc815 \uae30\uac04 \uafb8\uc900\ud788 \uc12d\ucde8\ud558\uba74 \ud53c\ubd80\uac00 \ub354\uc6b1 \ud0c4\ub825 \uc788\uace0 \ud0c4\ub825 \uc788\uc5b4\uc9c0\uba70, \ub9c8\uce58 \uc2dc\uac04\uc744 \ub418\ub3cc\ub9b0 \ub4ef \uc8fc\ub984\uc774 \uc810\ucc28 \uc605\uc5b4\uc9c0\uace0, \uc80a\uc74c\uc758 \uad11\ucc44\ub97c \ub418\ucc3e\ub294 \ub180\ub77c\uc6b4 \uacbd\ud5d8\uc744 \ud558\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4. \uad00\uc808\uc758 \uc720\uc5f0\uc131 \ub610\ud55c \ub178\ud654\uc758 \uc815\ub3c4\ub97c \uce21\uc815\ud558\ub294 \uc911\uc694\ud55c \uc9c0\ud45c \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uad00\uc808 \uc5f0\uace8\uc740 \uc810\ucc28 \ub9c8\ubaa8\ub418\uace0, \uad00\uc808 \uc8fc\ubcc0 \uc870\uc9c1\uc740 \uc5fc\uc99d \u200b\u200b\ubc18\uc751\uc744 \uc77c\uc73c\ucf1c \uad00\uc808 \ud1b5\uc99d, \uacbd\uc9c1, \uc6b4\ub3d9 \uc81c\ud55c\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. NR\uc740 \uc5fc\uc99d \uc778\uc790\uc758 \uc0dd\uc131\uacfc \ubd84\ube44\ub97c \uc5b5\uc81c\ud558\uc5ec \uad00\uc808 \uc5fc\uc99d\uc744 \uc904\uc774\uace0, \uad00\uc808 \uc870\uc9c1\uc758 \uc5fc\uc99d \uc190\uc0c1\uc744 \uc904\uc785\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 NR\uc740 \uad00\uc808 \uc5f0\uace8 \uc138\ud3ec\uc758 \uc2e0\uc9c4\ub300\uc0ac\uc640 \ud68c\ubcf5\uc744 \ucd09\uc9c4\ud558\uace0, \ud65c\uc561 \ubd84\ube44\ub97c \uc99d\uac00\uc2dc\ucf1c \uad00\uc808\uc744 \uc724\ud65c\ud558\uace0 \ubcf4\ud638\ud569\ub2c8\ub2e4. \uad00\uc808 \ubb38\uc81c\uac00 \uc788\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 NR \ubcf4\ucda9\uc81c\ub97c \uc12d\ucde8\ud55c \ud6c4 \uad00\uc808 \ud1b5\uc99d\uc774 \uc0c1\ub2f9\ud788 \uc904\uc5b4\ub4e4\uace0 \uc720\uc5f0\uc131\uc774 \ud06c\uac8c \ud5a5\uc0c1\ub418\ub294 \uac83\uc744 \uacbd\ud5d8\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \uc77c\uc0c1 \ud65c\ub3d9\uc744 \ub354 \uc790\uc720\ub86d\uac8c \uc218\ud589\ud558\uace0 \uc790\uc720\uc640 \ud65c\ub825\uc744 \ub418\ucc3e\uc744 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\ubbf8\ub798 \uc804\ub9dd: NR \ud56d\ub178\ud654 \ubd84\uc57c\uc758 \uae30\ud68c\uc640 \uacfc\uc81c\"\"<\/h2>\n

(I) \uc0b0\uc5c5\ud654 \uc804\ub9dd: \uc218\uc870 \ub2ec\ub7ec \uaddc\ubaa8\uc758 \ud56d\ub178\ud654 \uc2dc\uc7a5\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc5d4\uc9c4<\/h3>\n

\uc138\uacc4\uc801\uc73c\ub85c \uace0\ub839\ud654\uac00 \uac00\uc18d\ud654\ub428\uc5d0 \ub530\ub77c \ud56d\ub178\ud654 \uc2dc\uc7a5\uc740 \uc804\ub840 \uc5c6\ub294 \uc18d\ub3c4\ub85c \uc131\uc7a5\ud558\uba70 \ub9e4\uc6b0 \uc720\ub9dd\ud55c \uc218\uc870 \ub2ec\ub7ec \uaddc\ubaa8\uc758 \uc2dc\uc7a5\uc73c\ub85c \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae30\ud68c\uc758 \uc2dc\uc7a5\uc5d0\uc11c, \ub3c5\ubcf4\uc801\uc778 \ud56d\ub178\ud654 \ud6a8\uacfc\ub97c \uc9c0\ub2cc NR \uad00\ub828 \uc81c\ud488\ub4e4\uc774 \uc810\ucc28 \uc8fc\ubaa9\uc744 \ubc1b\uc73c\uba70 \uc5c5\uacc4\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\ub85c \ub5a0\uc624\ub974\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2dc\uc7a5 \uc870\uc0ac \uae30\uad00\ub4e4\uc740 2030\ub144\uae4c\uc9c0 NR \uad00\ub828 \uc81c\ud488 \uc2dc\uc7a5 \uaddc\ubaa8\uac00 500\uc5b5 \ub2ec\ub7ec\ub97c \ub3cc\ud30c\ud560 \uac83\uc73c\ub85c \uc804\ub9dd\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub294 \ud56d\ub178\ud654 \uc2dc\uc7a5\uc5d0\uc11c NR\uc758 \ub9c9\ub300\ud55c \uc7a0\uc7ac\ub825\uc744 \uc5ec\uc2e4\ud788 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc601\uc591 \ubcf4\ucda9\uc81c \ubd84\uc57c\uc5d0\uc11c NR\uc740 \ube60\ub974\uac8c \uc131\uc7a5\ud558\uba70 \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \ubd84\uc57c \uc911 \ud558\ub098\ub85c \uc790\ub9ac\ub9e4\uae40\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc810\uc810 \ub354 \ub9ce\uc740 \uc18c\ube44\uc790\ub4e4\uc774 \uac74\uac15\uacfc \ud56d\ub178\ud654\uc5d0 \uad00\uc2ec\uc744 \uae30\uc6b8\uc774\uace0 \uc788\uc73c\uba70, \ud6a8\uacfc\uc801\uc778 \ud56d\ub178\ud654 \uc81c\ud488\uc744 \uc801\uadf9\uc801\uc73c\ub85c \ucc3e\uace0 \uc788\uc2b5\ub2c8\ub2e4. NR \ubcf4\ucda9\uc81c\ub294 \uc774\ub7ec\ud55c \uc2dc\uc7a5 \uc218\uc694\ub97c \uc644\ubcbd\ud558\uac8c \ucda9\uc871\ud558\uba70 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc758 \uc0ac\ub791\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

NR\uc774 \uc2dc\uc7a5\uc5d0\uc11c \uc774\ucc98\ub7fc \ub192\uc740 \uad00\uc2ec\uc744 \ubc1b\ub294 \uac83\uc740 \uc8fc\ub85c \ucc9c\uc5f0 \uc548\uc804\uc131\uacfc \ub2e4\uc911 \ud45c\uc801 \ud56d\ub178\ud654 \ud6a8\uacfc \ub355\ubd84\uc785\ub2c8\ub2e4. \ucc9c\uc5f0 \ubb3c\uc9c8\uc778 NR\uc740 \ubbf8\uad6d FDA\ub85c\ubd80\ud130 GRAS(Generally Recognized As Safe, \uc77c\ubc18\uc801\uc73c\ub85c \uc548\uc804\ud558\ub2e4\uace0 \uc778\uc815\ub418\ub294 \ubb3c\uc9c8) \uc778\uc99d\uc744 \ubc1b\uc558\uc73c\uba70, \uc774\ub294 \uc2dd\ud488 \ubc0f \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488 \uc0b0\uc5c5\uc5d0\uc11c NR\uc744 \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 \ud0c4\ud0c4\ud55c \uae30\ubc18\uc744 \ub9c8\ub828\ud574 \uc90d\ub2c8\ub2e4. \uc18c\ube44\uc790\ub4e4\uc740 \ud56d\ub178\ud654 \uc81c\ud488\uc744 \uc120\ud0dd\ud560 \ub54c \uc548\uc804\uc131\uc744 \uc6b0\uc120\uc2dc\ud558\ub294 \uacbd\ud5a5\uc774 \uc788\uc73c\uba70, NR\uc758 GRAS \uc778\uc99d\uc740 \uc758\uc2ec\ud560 \uc5ec\uc9c0 \uc5c6\uc774 \uadf8\ub4e4\uc758 \uc2e0\ub8b0\ub97c \uc5bb\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

NR\uc758 \ub2e4\uc911 \ud45c\uc801 \ud56d\ub178\ud654 \ud6a8\uacfc\ub294 \uc218\ub9ce\uc740 \ud56d\ub178\ud654 \uc81c\ud488 \uc911\uc5d0\uc11c\ub3c4 \ub2e8\uc5f0 \ub3cb\ubcf4\uc785\ub2c8\ub2e4. NR\uc740 \uc7a5\uc218 \ub2e8\ubc31\uc9c8(\uc2dc\ub974\ud22c\uc778)\uc744 \ud65c\uc131\ud654\ud558\uace0, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5\uc744 \uac1c\uc120\ud558\uba70, \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc5fc\uc99d\uc744 \uc870\uc808\ud558\uc5ec \ub178\ud654 \uacfc\uc815\uc744 \ud3ec\uad04\uc801\uc73c\ub85c \ub2a6\ucd9c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc885\ud569\uc801\uc778 \ud56d\ub178\ud654 \ud6a8\uacfc \ub355\ubd84\uc5d0 NR\uc740 \uc2e0\uc9c4\ub300\uc0ac \uae30\ub2a5 \uac1c\uc120, \uba74\uc5ed\ub825 \uac15\ud654, \ud53c\ubd80 \ub178\ud654 \uc9c0\uc5f0, \uc2ec\ud608\uad00 \uac74\uac15 \ubcf4\ud638 \ub4f1 \ub2e4\uc591\ud55c \uc18c\ube44\uc790\uc758 \uc694\uad6c\ub97c \ucda9\uc871\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NR\uc740 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n

NR\uc758 \uc7a0\uc7ac\ub825\uc740 \uc601\uc591 \ubcf4\ucda9\uc81c\ub97c \ub118\uc5b4 \uc81c\uc57d \ubc0f \ud654\uc7a5\ud488 \uc5c5\uacc4\uc758 \uc8fc\ubaa9\uc744 \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc81c\uc57d \ubd84\uc57c\uc5d0\uc11c\ub294 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc774\ub098 \uc2ec\ud608\uad00 \uc9c8\ud658\uacfc \uac19\uc740 \ub178\ud654 \uad00\ub828 \uc9c8\ud658 \uce58\ub8cc\uc5d0 NR\uc744 \ud65c\uc6a9\ud558\ub294 \ubc29\uc548\uc744 \uc801\uadf9\uc801\uc73c\ub85c \ubaa8\uc0c9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ube44 \uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 NR\uc740 \uc774\ub7ec\ud55c \uc9c8\ud658\uc758 \uc99d\uc0c1\uacfc \uc608\ud6c4\ub97c \uac1c\uc120\ud558\ub294 \ub370 \uc7a0\uc7ac\ub825\uc774 \uc788\uc73c\uba70, \ud5a5\ud6c4 \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \ub3cc\ud30c\uad6c\ub97c \uac00\uc838\uc62c \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4.<\/p>\n

\ubdf0\ud2f0 \uc5c5\uacc4\uc5d0\uc11c\ub3c4 NR\uc740 \ub3c5\ubcf4\uc801\uc778 \ub9e4\ub825\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uac74\uac15\uacfc \ud56d\ub178\ud654\uc5d0 \ub300\ud55c \uad00\uc2ec\uc774 \ub192\uc544\uc9d0\uc5d0 \ub530\ub77c, \ubdf0\ud2f0 \uc5c5\uacc4\ub294 \ud601\uc2e0\uc801\uc778 \uc131\ubd84\uacfc \uae30\uc220\uc744 \ub04a\uc784\uc5c6\uc774 \ubaa8\uc0c9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. NR\uc740 \ud53c\ubd80 \uc138\ud3ec \ud65c\ub825\uc744 \uc99d\uc9c4\ud558\uace0, \ucf5c\ub77c\uac90 \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uba70, \ud53c\ubd80 \ud0c4\ub825\uacfc \uc724\uae30\ub97c \uac1c\uc120\ud558\uace0, \uc8fc\ub984\uc774\ub098 \ucc98\uc9d0\uacfc \uac19\uc740 \ub178\ud654 \uc9d5\ud6c4\ub97c \uc644\ud654\ud558\ub294 \ub370 \ub3c4\uc6c0\uc744 \uc90d\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc810\uc810 \ub354 \ub9ce\uc740 \ubdf0\ud2f0 \ube0c\ub79c\ub4dc\ub4e4\uc774 NR\uc744 \uc81c\ud488 \uc81c\ud615\uc5d0 \ud1b5\ud569\ud558\uc5ec \ud56d\ub178\ud654 \ud6a8\uacfc\ub97c \uac00\uc9c4 \ub2e4\uc591\ud55c \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc744 \ucd9c\uc2dc\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub294 \uc18c\ube44\uc790\ub4e4\uc758 \ud070 \ud638\uc751\uc744 \uc5bb\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uacfc\ud559 \uc5f0\uad6c\uc758 \ucd5c\uc804\uc120: \ub2e8\uc77c \uc131\ubd84\uc5d0\uc11c \uc804\uc2e0 \ud56d\ub178\ud654 \uc194\ub8e8\uc158\uae4c\uc9c0<\/h3>\n

\uacfc\ud559\uc790\ub4e4\uc740 NR \ud56d\ub178\ud654 \uc5f0\uad6c\uc758 \uae38\uc744 \ub04a\uc784\uc5c6\uc774 \ud0d0\uad6c\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ud604\uc7ac \uc5f0\uad6c\uc758 \ucd08\uc810\uc740 \ub2e8\uc77c NR \uc131\ubd84 \uc5f0\uad6c\uc5d0\uc11c \ub2e4\ub978 \ucc9c\uc5f0 \uc131\ubd84\uacfc\uc758 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ud0d0\uad6c\ud558\uace0 \uc804\uc2e0 \ud56d\ub178\ud654 \uc194\ub8e8\uc158\uc744 \uac1c\ubc1c\ud558\ub294 \ubc29\ud5a5\uc73c\ub85c \uc810\ucc28 \uc774\ub3d9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uacfc\ud559\uc790\ub4e4\uc740 NR\uc774 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uacfc \ud018\ub974\uc138\ud2f4\uacfc \uac19\uc740 \ucc9c\uc5f0 \uc131\ubd84\uacfc \uc0c1\ub2f9\ud55c \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b8\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc740 \ud3ec\ub3c4\uc640 \ube14\ub8e8\ubca0\ub9ac\uc640 \uac19\uc740 \uc2dd\ubb3c\uc5d0\uc11c \ub110\ub9ac \ubc1c\uacac\ub418\ub294 \ucc9c\uc5f0 \ud3f4\ub9ac\ud398\ub180 \ud654\ud569\ubb3c\uc785\ub2c8\ub2e4. \ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d, \uc9c0\uc9c8 \uc870\uc808 \ud6a8\uacfc\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc740 SIRT1 \ub2e8\ubc31\uc9c8\uc744 \ud65c\uc131\ud654\uc2dc\ucf1c NR\uacfc \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \uc138\ud3ec\uc758 \ud56d\uc0b0\ud654 \ub2a5\ub825\uacfc DNA \ubcf5\uad6c \ub2a5\ub825\uc744 \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ucf1c \ub178\ud654\ub97c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc73c\ub85c \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud018\ub974\uc138\ud2f4\uc740 \ub610\ud55c \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \uac00\uc9c4 \uc77c\ubc18\uc801\uc778 \ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \ud654\ud569\ubb3c\uc785\ub2c8\ub2e4. \uc5fc\uc99d \uc778\uc790 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\uace0 \uc138\ud3ec\uc758 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc190\uc0c1\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud018\ub974\uc138\ud2f4\uc774 NR\uacfc \uacb0\ud569\ud558\uba74 “\ub2e4\uc911 \uacbd\ub85c \uac1c\uc785” \uc804\ub7b5\uc744 \ud615\uc131\ud558\uc5ec \uc5ec\ub7ec \uc218\uc900\uc5d0\uc11c \uc0dd\ub9ac \uae30\ub2a5\uc744 \uc870\uc808\ud558\uace0 \ud56d\ub178\ud654 \ud6a8\uacfc\ub97c \uc885\ud569\uc801\uc73c\ub85c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub178\ud654\ub41c \uc0dd\uc950\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c NR\uacfc \ud018\ub974\uc138\ud2f4\uc744 \ub3d9\uc2dc\uc5d0 \ud22c\uc5ec\ud588\uc744 \ub54c \uc778\uc9c0 \uae30\ub2a5, \uc6b4\ub3d9 \ub2a5\ub825, \ub300\uc0ac \uc9c0\ud45c\uac00 \uc720\uc758\ubbf8\ud558\uac8c \uac1c\uc120\ub418\uc5c8\uc73c\uba70, NR \ub610\ub294 \ud018\ub974\uc138\ud2f4\uc744 \ub2e8\ub3c5\uc73c\ub85c \ud22c\uc5ec\ud588\uc744 \ub54c\ubcf4\ub2e4 \ub354 \ub69c\ub837\ud55c \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc720\uc804\uc790 \uc2dc\ud000\uc2f1 \uae30\uc220\uc758 \uae09\uc18d\ud55c \ubc1c\uc804\uc73c\ub85c \uac1c\uc778 \ub9de\ucda4\ud615 \ud56d\ub178\ud654 \ud504\ub85c\uadf8\ub7a8 \uac1c\ubc1c\uc774 \uac00\ub2a5\ud574\uc84c\uc2b5\ub2c8\ub2e4. \uc720\uc804\uc790 \uc2dc\ud000\uc2f1 \uae30\uc220\uc740 \uac1c\uc778\uc758 \uc720\uc804 \uc815\ubcf4\ub97c \uc2ec\uce35\uc801\uc73c\ub85c \ubd84\uc11d\ud558\uc5ec \uc720\uc804\uc801 \ud2b9\uc131\uacfc \uc7a0\uc7ac\uc801 \uac74\uac15 \uc704\ud5d8\uc744 \ubc1d\ud600\ub0bc \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc720\uc804\uc790 \uc2dc\ud000\uc2f1\uc744 \ud1b5\ud574 \uacfc\ud559\uc790\ub4e4\uc740 \uac1c\uc778\uc774 \ub300\uc0ac\ud558\uace0 \uc7ac\uc0dd\ud558\ub294 \ubc29\uc2dd\uc758 \ucc28\uc774\ub97c \uc774\ud574\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4 NR\uc5d0 \ubc18\uc751\ud558\uc5ec \uac1c\uc778\uc758 NR \ud544\uc694\ub7c9\uc744 \uc815\ud655\ud558\uac8c \ud3c9\uac00\ud569\ub2c8\ub2e4.<\/p>\n

\ud2b9\uc815 \uc720\uc804\uc790 \ubcc0\uc774\ub97c \uac00\uc9c4 \uac1c\uc778\uc758 \uacbd\uc6b0, NR\uc758 \ud761\uc218 \ubc0f \uc774\uc6a9 \ud6a8\uc728\uc774 \ub0ae\uc544 NR \ubcf4\ucda9\ub7c9\uc744 \uc801\uc808\ud788 \ub298\ub824\uc57c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\ub978 \uac1c\uc778\uc758 \uacbd\uc6b0, \ucd5c\uc0c1\uc758 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub97c \uc5bb\uae30 \uc704\ud574 NR \ubcf4\ucda9\uacfc \ub2e4\ub978 \ud2b9\uc815 \uc601\uc591\uc18c \ub610\ub294 \uac1c\uc785\uc744 \ubcd1\ud589\ud574\uc57c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uac1c\uc778\uc758 \uc720\uc804\uc801 \ud2b9\uc131\uacfc \uac74\uac15 \uc0c1\ud0dc\uc5d0 \uae30\ubc18\ud55c \ub9de\ucda4\ud615 \ub178\ud654 \ubc29\uc9c0 \uacc4\ud68d\uc744 \uc218\ub9bd\ud558\uba74 \ub354\uc6b1 \uc815\ud655\ud558\uace0 \ud6a8\uc728\uc801\uc778 \ub178\ud654 \ubc29\uc9c0 \ubaa9\ud45c\ub97c \ub2ec\uc131\ud558\uc5ec \uac01 \uac1c\uc778\uc5d0\uac8c \uac00\uc7a5 \uc801\ud569\ud55c \uac74\uac15 \uad00\ub9ac \uacc4\ud68d\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(III) \ub178\ud654 \ubc29\uc9c0\uc5d0 \ub300\ud55c \ud569\ub9ac\uc801 \uad00\uc810: \uacfc\ud559\uc801 \uadfc\uac70\uc640 \uc724\ub9ac\uc801 \uacbd\uacc4<\/h3>\n

NR\uc740 \ub178\ud654 \ubc29\uc9c0 \ubd84\uc57c\uc5d0\uc11c \ud765\ubbf8\ub85c\uc6b4 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc654\uc9c0\ub9cc, \uc5ec\uc804\ud788 \uacfc\ud559\uc801\uc774\uace0 \ud569\ub9ac\uc801\uc778 \uad00\uc810\uc744 \uac00\uc838\uc57c \ud569\ub2c8\ub2e4. \ud604\uc7ac NR\uc758 \uc7a5\uae30\uc801\uc778 \uc548\uc804\uc131\uc744 \ub4b7\ubc1b\uce68\ud558\uae30 \uc704\ud574\uc11c\ub294 \ub354 \ub9ce\uc740 \uc784\uc0c1 \ub370\uc774\ud130\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uae30\uc874 \uc5f0\uad6c\uc5d0\uc11c\ub294 NR(\ubc18\uc751\uc131 \ub2e8\ubc31\uc9c8)\uc774 \uc801\uc808\ud55c \uc6a9\ub7c9\uc5d0\uc11c \uc6b0\uc218\ud55c \ub0b4\uc57d\uc131\uacfc \uc548\uc804\uc131\uc744 \ubcf4\uc778\ub2e4\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc9c0\ub9cc, 2000mg\/\uc77c\uc744 \ucd08\uacfc\ud558\ub294 \uc6a9\ub7c9\uc758 \uc7a5\uae30\uc801\uc778 \ud6a8\uacfc\uc5d0 \ub300\ud574\uc11c\ub294 \uc544\uc9c1 \ub9ce\uc740 \uac83\uc774 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. NR\uc744 \uace0\uc6a9\ub7c9\uc73c\ub85c \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uac04\uc774\ub098 \uc2e0\uc7a5\uacfc \uac19\uc740 \uc7a5\uae30 \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub4f1 \uc7a0\uc7ac\uc801\uc778 \ubd80\uc791\uc6a9\uc774 \ubc1c\uc0dd\ud560\uc9c0 \uc5ec\ubd80, \uadf8\ub9ac\uace0 \ub2e4\ub978 \uc57d\ubb3c\uc774\ub098 \uc601\uc591\uc18c\uc640 \uc0c1\ud638\uc791\uc6a9\ud560\uc9c0 \uc5ec\ubd80\ub294 \ucd94\uac00\uc801\uc778 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n

\uacfc\ud559\uacc4\ub294 \uc77c\ubc18\uc801\uc73c\ub85c NR\uc744 “\uae30\uc801\uc758 \ub178\ud654 \ubc29\uc9c0\uc81c”\uac00 \uc544\ub2cc \uac74\uac15\ud55c \uc0dd\ud65c \uc2b5\uad00\uc744 \uc704\ud55c \ubcf4\ucda9\uc81c\ub85c \uac04\uc8fc\ud574\uc57c \ud55c\ub2e4\uace0 \uc8fc\uc7a5\ud569\ub2c8\ub2e4. \uade0\ud615 \uc7a1\ud78c \uc2dd\ub2e8, \uc801\ub2f9\ud55c \uc6b4\ub3d9, \ucda9\ubd84\ud55c \uc218\uba74, \uadf8\ub9ac\uace0 \uac74\uac15\ud55c \uc815\uc2e0 \uc0c1\ud0dc\ub97c \ud3ec\ud568\ud55c \uac74\uac15\ud55c \uc0dd\ud65c \uc2b5\uad00\uc740 \uc2e0\uccb4 \uac74\uac15\uc744 \uc720\uc9c0\ud558\uace0 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \uae30\ucd08\uc785\ub2c8\ub2e4. NR\uc740 \uc0dd\ub9ac \uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ub178\ud654 \uacfc\uc815\uc744 \uc5b4\ub290 \uc815\ub3c4 \ub2a6\ucd9c \uc218 \uc788\uc9c0\ub9cc, \uac74\uac15\ud55c \uc0dd\ud65c \uc2b5\uad00\uc744 \ub300\uccb4\ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. NR\uc774 \uc788\ub2e4\uace0 \ud574\uc11c \uc77c\uc0c1\uc801\uc778 \uac74\uac15 \uad00\ub9ac\ub97c \uc18c\ud640\ud788 \ud560 \uc218\ub294 \uc5c6\uc2b5\ub2c8\ub2e4. NR\uacfc \uac74\uac15\ud55c \uc0dd\ud65c \uc2b5\uad00\uc744 \ubcd1\ud589\ud574\uc57c\ub9cc \uc9c4\uc815\uc73c\ub85c \uac74\uac15\ud55c \ub178\ud654\ub77c\ub294 \ubaa9\ud45c\ub97c \ub2ec\uc131\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. NR\uc758 \uac1c\ubc1c\uc740 \uc724\ub9ac\uc801 \ubb38\uc81c \ub610\ud55c \uc81c\uae30\ud588\uc2b5\ub2c8\ub2e4. NR\uacfc \uac19\uc740 \ud56d\ub178\ud654 \uae30\uc220\uc774 \uc778\uac04\uc758 \uc218\uba85\uc744 \ud06c\uac8c \uc5f0\uc7a5\ud560 \uc218 \uc788\ub2e4\uba74, \uc6b0\ub9ac\ub294 \uc77c\ub828\uc758 \uc0ac\ud68c\uc801, \uc724\ub9ac\uc801 \ubb38\uc81c\uc5d0 \uc9c1\uba74\ud558\uac8c \ub420 \uac83\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc81c\ud55c\ub41c \uc758\ub8cc \uc790\uc6d0\uc744 \uc5b4\ub5bb\uac8c \ubc30\ubd84\ud560 \uac83\uc778\uac00, \uc778\uad6c \uace0\ub839\ud654\uac00 \ucd08\ub798\ud558\ub294 \uc0ac\ud68c\uc801 \uc555\ub825\uc5d0 \uc5b4\ub5bb\uac8c \ub300\ucc98\ud560 \uac83\uc778\uac00, \uadf8\ub9ac\uace0 \uac1c\uc778\uc758 \uc7a5\uc218 \uad8c\ub9ac\uc640 \uc9c0\uc18d \uac00\ub2a5\ud55c \uc0ac\ud68c \ubc1c\uc804\uc758 \uade0\ud615\uc744 \uc5b4\ub5bb\uac8c \ub9de\ucd9c \uac83\uc778\uac00 \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubb38\uc81c\ub4e4\uc740 NR \uae30\uc220 \uac1c\ubc1c\uc744 \ucd09\uc9c4\ud558\uace0, \uae30\uc220 \uac1c\ubc1c\uc774 \uc778\ub958 \uc804\uccb4\uc758 \uc774\uc775\uc5d0 \ubd80\ud569\ud558\ub3c4\ub85d \uad00\ub828 \uc815\ucc45 \ubc0f \uc724\ub9ac \uc9c0\uce68\uc744 \uc218\ub9bd\ud558\ub294 \uacfc\uc815\uc5d0\uc11c \uc2ec\ub3c4 \uc788\ub294 \uace0\ub824\uc640 \ub17c\uc758\ub97c \ud544\uc694\ub85c \ud569\ub2c8\ub2e4.<\/p>\n

NR\uc758 \ub4f1\uc7a5\uc740 \uc758\uc2ec\ud560 \uc5ec\uc9c0 \uc5c6\uc774 \uc778\ub958\uc758 \ub178\ud654 \ud1f4\uce58\uc5d0 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uacfc \uac00\ub2a5\uc131\uc744 \uac00\uc838\ub2e4\uc90d\ub2c8\ub2e4. \ubd84\uc790 \uc218\uc900\uc5d0\uc11c \ub178\ud654 \uacfc\uc815\uc744 \uae4a\uc774 \uc774\ud574\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \uac1c\uc785 \ubc29\ubc95\uc744 \uc81c\uc2dc\ud569\ub2c8\ub2e4. \ub04a\uc784\uc5c6\ub294 \uae30\uc220 \ubc1c\uc804\uacfc \uc2ec\ud654 \uc5f0\uad6c\ub97c \ud1b5\ud574 NR\uc740 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ub300\uc911\uc5d0\uac8c \uc810\ucc28 \ub2e4\uac00\uac00 \uac74\uac15\ud55c \uc0b6\uc744 \uc704\ud55c \uc0c8\ub85c\uc6b4 \uc7a5\uc744 \uc5f4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uacfc\ud559\uacfc \uc0b0\uc5c5\uc758 \ubc1c\uc804\uc5d0 \ud798\uc785\uc5b4 \ub178\ud654\ub294 \ub354 \uc774\uc0c1 \ub3cc\uc774\ud0ac \uc218 \uc5c6\ub294 \uc790\uc5f0 \ubc95\uce59\uc774 \uc544\ub2c8\ub77c, \uac1c\uc785\ud558\uace0 \uad00\ub9ac\ud560 \uc218 \uc788\ub294 \uac74\uac15 \ubb38\uc81c\ub85c \uc790\ub9ac\ub9e4\uae40\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uacfc\ud559\uc801 \ud0dc\ub3c4\ub97c \ucde8\ud558\uace0 NR\uc774 \ub178\ud654 \ubc29\uc9c0 \ubd84\uc57c\uc5d0\uc11c \ub354 \ud070 \uc5ed\ud560\uc744 \uc218\ud589\ud558\uace0 \uc778\uac04\uc758 \uac74\uac15\uacfc \uc6f0\ube59\uc5d0 \ub354 \ud06c\uac8c \uae30\uc5ec\ud558\uae30\ub97c \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

\uc0b6\uc758 \uacfc\uc815\uc5d0\uc11c \ub178\ud654\ub294 \ud53c\ud560 \uc218 \uc5c6\ub294 \ud669\ud63c\ucc98\ub7fc \uc870\uc6a9\ud788 \ucc3e\uc544\uc635\ub2c8\ub2e4. \uadf8\ub807\ub2e4\uba74 \ub178\ud654\ub780 \uc815\ud655\ud788 \ubb34\uc5c7\uc77c\uae4c\uc694? \uc138\ud3ec\uc640 \ubd84\uc790 \uc218\uc900\uc744 \uae4a\uc774 \ub4e4\uc5ec\ub2e4\ubcf4\uba74, \ub178\ud654\uc758 \ubcf8\uc9c8\uc740 NAD+ \uc218\uce58 \uac10\uc18c\ub85c \ucd09\ubc1c\ub418\ub294 \ub3c4\ubbf8\ub178 \ud6a8\uacfc\ub77c\ub294 \uac83\uc744 \uc54c \uc218 \uc788\uc2b5\ub2c8\ub2e4. NAD+, \uc989 \ub2c8\ucf54\ud2f4\uc544\ubbf8\ub4dc \uc544\ub370\ub2cc \ub514\ub274\ud074\ub808\uc624\ud2f0\ub4dc\ub294 \uc0dd\uc18c\ud558\uac8c \ub4e4\ub9b4\uc9c0 \ubaa8\ub974\uc9c0\ub9cc, \uc6b0\ub9ac \ubab8\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc138\ud3ec \uc5d0\ub108\uc9c0 \ub300\uc0ac, DNA \ubcf5\uad6c, \uadf8\ub9ac\uace0 \uc7a5\uc218 \ub2e8\ubc31\uc9c8 \ud65c\uc131\ud654\uc5d0 \ud544\uc218\uc801\uc778 \uc870\ud6a8\uc18c\uc785\ub2c8\ub2e4. \uac04\ub2e8\ud788 … Continue reading NR\uc740 \uc0dd\ub9ac\uc801 \ub178\ud654\ub97c \uc9c0\uc5f0\uc2dc\ud0b5\ub2c8\ub2e4: \uacfc\ud559\uc801 \uc6d0\ub9ac\uc5d0\uc11c \ub178\ud654 \ubc29\uc9c0 \uc2e4\ucc9c\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ud3ec\uad04\uc801\uc778 \ubd84\uc11d<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":2922,"parent":0,"menu_order":23,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-2921","blog","type-blog","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/types\/blog"}],"author":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/comments?post=2921"}],"version-history":[{"count":0,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/blog\/2921\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media\/2922"}],"wp:attachment":[{"href":"https:\/\/www.focusherb.com\/kr\/wp-json\/wp\/v2\/media?parent=2921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}