{"id":2927,"date":"2025-10-30T07:59:00","date_gmt":"2025-10-30T07:59:00","guid":{"rendered":"https:\/\/www.focusherb.com\/kr\/?post_type=blog&p=2927"},"modified":"2025-11-04T01:09:29","modified_gmt":"2025-11-04T01:09:29","slug":"%ec%b2%9c%ec%97%b0-%ed%94%8c%eb%9d%bc%eb%b3%b4%eb%85%b8%ec%9d%b4%eb%93%9c-%ec%95%84%ed%94%bc%ec%a0%9c%eb%8b%8c-%ec%84%b8%ed%8f%ac-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80-%eb%b0%8f-%ec%a0%84%eb%b0%98","status":"publish","type":"blog","link":"https:\/\/www.focusherb.com\/kr\/blog\/%ec%b2%9c%ec%97%b0-%ed%94%8c%eb%9d%bc%eb%b3%b4%eb%85%b8%ec%9d%b4%eb%93%9c-%ec%95%84%ed%94%bc%ec%a0%9c%eb%8b%8c-%ec%84%b8%ed%8f%ac-%eb%85%b8%ed%99%94-%eb%b0%a9%ec%a7%80-%eb%b0%8f-%ec%a0%84%eb%b0%98\/","title":{"rendered":"\ucc9c\uc5f0 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc \uc544\ud53c\uc81c\ub2cc: \uc138\ud3ec \ub178\ud654 \ubc29\uc9c0 \ubc0f \uc804\ubc18\uc801\uc778 \ud68c\ucd98\uc758 \uacfc\ud559\uc801 \ube44\ubc00"},"content":{"rendered":"

\uc601\uc6d0\ud55c \uc80a\uc74c\uc744 \ud5a5\ud55c \uae34 \uc5ec\uc815 \uc18d\uc5d0\uc11c \uacfc\ud559\uacc4\ub294 \ub04a\uc784\uc5c6\uc774 \ud0d0\uad6c\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc \ub4e4\uc5b4 \uc544\ud53c\uc81c\ub2cc\uc774\ub77c\ub294 \ucc9c\uc5f0 \ud654\ud569\ubb3c\uc774 \uc8fc\ubaa9\uc744 \ubc1b\uc73c\uba70 \ud56d\ub178\ud654 \ubd84\uc57c\uc758 \uc5f0\uad6c \ucd08\uc810\uc774 \ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uacfc\uc77c\uacfc \ucc44\uc18c\uc5d0 \ub110\ub9ac \ubd84\ud3ec\ud558\ub294 \ud50c\ub77c\ubcf4\ub178\uc774\ub4dc\uc778 \uc544\ud53c\uc81c\ub2cc\uc740 2-\ud398\ub2d0\ud06c\ub85c\ubaac\uc744 \uc911\uc2ec\uc73c\ub85c 4′, 5′, 7′ \uc704\uce58\uc5d0 \ud788\ub4dc\ub85d\uc2dc\uae30\uac00 \uc815\ud655\ud558\uac8c \uacb0\ud569\ub418\uc5b4 \ub3c5\ud2b9\ud55c \ud654\ud559\uc801 \ud65c\uc131\uc744 \ubcf4\uc785\ub2c8\ub2e4. \uc140\ub7ec\ub9ac\uc758 \uc904\uae30\uc640 \uc78e\uc5d0 \ud48d\ubd80\ud558\uac8c \ud568\uc720\ub418\uc5b4 \uc788\uc5b4, \uc774 \ud754\ud55c \ucc44\uc18c\uc5d0 \ud2b9\ubcc4\ud55c \uc0dd\ubb3c\ud559\uc801 \ud6a8\ub2a5\uc744 \ubd80\uc5ec\ud558\uace0 \uc140\ub7ec\ub9ac\uac00 \uac00\uc9c4 \ub2e4\uc591\ud55c \uac74\uac15\uc0c1\uc758 \uc774\uc810\uc744 \uc774\ub8e8\ub294 \ud575\uc2ec \uc694\uc18c\uc785\ub2c8\ub2e4.\"\"<\/p>\n

\ud575\uc2ec \uba54\ucee4\ub2c8\uc998: \uc544\ud53c\uc81c\ub2cc\uc774 \uc138\ud3ec \ub178\ud654 \uacfc\uc815\uc744 \uc7ac\uad6c\uc131\ud558\ub294 \ubc29\uc2dd<\/h2>\n

(I) PRDX6 \ub2e8\ubc31\uc9c8 \ud45c\uc801: \ub178\ud654 “\uc2a4\uc704\uce58” \ucc28\ub2e8<\/h3>\n

\ubcf5\uc7a1\ud55c \uc138\ud3ec \ub178\ud654 \uc870\uc808 \ub124\ud2b8\uc6cc\ud06c\uc5d0\uc11c \uc544\ud53c\uc81c\ub2cc<\/strong><\/a>\uc740 \uc815\ubc00\ud55c “\ub0b4\ube44\uac8c\uc774\ud130”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ud575\uc2ec \ud45c\uc801\uc778 \ud37c\uc625\uc2dc\ub808\ub3c5\uc2e0 6(PRDX6)\uc744 \ud3ec\ucc29\ud569\ub2c8\ub2e4. \ud37c\uc625\uc2dc\ub808\ub3c5\uc2e0 \uacc4\uc5f4\uc758 \ud575\uc2ec \uad6c\uc131\uc6d0\uc778 PRDX6\ub294 \ub2e4\uc591\ud55c \uae30\ub2a5\uc744 \uc218\ud589\ud569\ub2c8\ub2e4. PRDX6\uc758 \ud3ec\uc2a4\ud3ec\ub9ac\ud30c\uc544\uc81c A2(PLA2) \ud65c\uc131\uc740 \uc138\ud3ec \uc9c0\uc9c8 \ub300\uc0ac, \uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec \ubc0f \uae30\ud0c0 \uacfc\uc815\uc5d0\uc11c \uc911\ucd94\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc138\ud3ec\uac00 \ub178\ud654\uc758 \uc704\ud611\uc5d0 \uc9c1\uba74\ud558\uba74 PRDX6\uc758 \ube44\uc815\uc0c1\uc801\uc778 \ud65c\uc131\ud654\ub294 \ub9c8\uce58 \uc798\ubabb\ub41c “\uc2a4\uc704\uce58”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc77c\ub828\uc758 \uc720\ud574\ud55c \ubc18\uc751\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \ucca8\ub2e8 \ubc14\uc774\uc624\ud2f4 \ud45c\uc9c0 \ud504\ub85c\ube0c \uae30\uc220\uacfc \uc57d\ubb3c \uce5c\ud654\ub3c4 \ud45c\uc801 \uc548\uc815\ud654(DARTS) \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc544\ud53c\uc81c\ub2cc\uc774 PRDX6\uc5d0 \uc9c1\uc811 \uacb0\ud569\ud558\ub294 \uacfc\uc815\uc744 \uba85\ud655\ud558\uac8c \ud3ec\ucc29\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uacb0\ud569\uc740 \uacfc\ud65c\uc131 PRDX6\uc5d0 “\uc871\uc1c4”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec PLA2 \ud65c\uc131\uc744 \ud2b9\uc774\uc801\uc73c\ub85c \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc774 \uc5b5\uc81c \ud6a8\uacfc\ub294 \uc5f4\ucda9\uaca9 \ub2e8\ubc31\uc9c8 A8(HSPA8)\uc758 \ud65c\uc131\ud654\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ucc28\ub2e8\ud558\uc5ec ATM(Ataxia telangiectasia mutated) \ub2e8\ubc31\uc9c8 \ubc0f p38 mitogen-activated protein kinase(p38MAPK) \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc640\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uc1c4 \ubc18\uc751\uc740 \uae09\uc131 \uc2a4\ud2b8\ub808\uc2a4 \uad00\ub828 \ud45c\ud604\ud615(ASAP)\uc5d0\uc11c \ub178\ud654 \uad00\ub828 \ubd84\ube44 \ud45c\ud604\ud615(SASP)\uc73c\ub85c\uc758 \uc804\uc774\ub97c \uc131\uacf5\uc801\uc73c\ub85c \ubc29\uc9c0\ud558\uc5ec \ub178\ud654 \uc138\ud3ec\uc758 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \ubd84\ube44\ub97c \uadfc\ubcf8\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uace0 \uc138\ud3ec \ub178\ud654\uc5d0 \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\ub3d9\uc744 \uac81\ub2c8\ub2e4.<\/p>\n

(II) \uc774\uc911 \uc870\uc808: \uc2dc\ub108\uc9c0 \ud6a8\uacfc\uc758 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud6a8\uacfc<\/h3>\n

\uc720\ub9ac\uae30 \uc18c\uac70: “\uc774\ub3d9\uc2dd \ud3ed\ud0c4”\ucc98\ub7fc \uc720\ub9ac\uae30\ub294 \uc138\ud3ec \ub0b4\uc5d0\uc11c \uc790\uc720\ub86d\uac8c \ub3cc\uc544\ub2e4\ub2c8\uba70 \ub04a\uc784\uc5c6\uc774 \uac74\uac15\uc744 \uc704\ud611\ud569\ub2c8\ub2e4. \ud2b9\ud788 \uc288\ud37c\uc625\uc0ac\uc774\ub4dc \uc74c\uc774\uc628\uacfc \ud788\ub4dc\ub85d\uc2e4 \ub77c\ub514\uce7c\uc740 \uc138\ud3ec \ub0b4 \uc8fc\uc694 \uc0dd\uccb4 \ubd84\uc790\ub97c \uacf5\uaca9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud65c\uc131\uc0b0\uc18c\ub294 DNA \uc774\uc911\ub098\uc120 \uad6c\uc870\ub97c \ud30c\uad34\ud558\uace0 \uc5fc\uae30\ub97c \uc190\uc0c1\uc2dc\ucf1c \uc720\uc804\uc790 \uc804\ub2ec\uc5d0 \uc624\ub958\ub97c \uc77c\uc73c\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc138\ud3ec\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \ub610\ud55c \ud65c\uc131\uc0b0\uc18c\uc5d0 \uc758\ud55c \uc190\uc0c1\uc5d0 \ucde8\uc57d\ud558\uc5ec \uc138\ud3ec\ub9c9\uacfc \ud638\ud761 \uc0ac\uc2ac \ub2e8\ubc31\uc9c8\uc744 \uc190\uc0c1\uc2dc\ud0a4\uace0 \uc5d0\ub108\uc9c0 \uc0dd\uc131\uc744 \ubc29\ud574\ud569\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \ubd84\uc790 \uad6c\uc870\ub97c \uac00\uc9c4 \uc544\ud53c\uc81c\ub2cc\uc740 “\uc815\ubc00 \uc800\uaca9\ucd1d”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc774\ub7ec\ud55c \ud65c\uc131\uc0b0\uc18c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc911\ud654\ud569\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \ub0b4 \uc138\ud3ec \ubc30\uc591 \uc2e4\ud5d8 \uacb0\uacfc, \ud2b9\uc815 \ub18d\ub3c4\uc758 \uc544\ud53c\uc81c\ub2cc\uc73c\ub85c \uc138\ud3ec\ub97c \ucc98\ub9ac\ud588\uc744 \ub54c \ud615\uad11 \ud504\ub85c\ube0c \uae30\uc220\ub85c \uce21\uc815\ud588\uc744 \ub54c \uc138\ud3ec \ub0b4 \ud65c\uc131\uc0b0\uc18c(ROS) \uc218\uce58\uac00 30~50% \uac10\uc18c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc544\ud53c\uc81c\ub2cc\uc758 \uac15\ub825\ud55c \ud65c\uc131\uc0b0\uc18c \uc81c\uac70 \ub2a5\ub825\uc744 \uac15\ub825\ud558\uac8c \uc785\uc99d\ud558\uba70, \uc138\ud3ec\uc5d0 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ubc29\uc5b4\ub825\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

\uc5fc\uc99d \uc5f0\uc1c4 \ubc18\uc751 \uc5b5\uc81c: \uc5fc\uc99d\uc740 \uc2e0\uccb4 \ub0b4 \ub0b4\uc804\uacfc \uac19\uc73c\uba70, \ub9cc\uc131 \uc5fc\uc99d\uc740 \ub178\ud654\ub97c \ucd09\uc9c4\ud558\ub294 \ucd09\ub9e4\uc81c\uc785\ub2c8\ub2e4. \uc5fc\uc99d \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc5d0\uc11c \ud575\uc778\uc790 \u03baB(NF-\u03baB)\ub294 “\uc9c0\ud718\uad00”\ucc98\ub7fc \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ud65c\uc131\ud654\ub418\uba74 \uba85\ub839\uc744 \ub0b4\ub824 \uc138\ud3ec\uac00 \uc778\ud130\ub8e8\ud0a8-6(IL-6)\uacfc \uc885\uc591\uad34\uc0ac\uc778\uc790 \u03b1(TNF-\u03b1)\uc640 \uac19\uc740 \uc218\ub9ce\uc740 \uc5fc\uc99d \uc720\ubc1c \uc778\uc790\ub97c \ubd84\ube44\ud558\ub3c4\ub85d \uc720\ub3c4\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc778\uc790\ub294 \uc5fc\uc99d \uc5f0\uc1c4 \ubc18\uc751\uc744 \uc720\ubc1c\ud558\uc5ec \uc870\uc9c1 \uc12c\uc720\ud654\uc640 \uc7a5\uae30 \uae30\ub2a5 \uc7a5\uc560\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 NF-\u03baB \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud558\uc5ec “\uc9c0\ud718\uad00”\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uce68\ubb35\uc2dc\ud0a4\uace0 \uc5fc\uc99d \uc720\ubc1c \uc778\uc790\uc758 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \ud6a8\uacfc\uc801\uc73c\ub85c \uac1c\uc785\ud569\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \uc5fc\uc99d\uc774 \uc788\ub294 \uc0dd\uc950\uc5d0\uac8c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ud608\uccad\uacfc \uc870\uc9c1\uc5d0\uc11c IL-6\uc640 TNF-\u03b1 \uc218\uce58\uac00 \ud604\uc800\ud788 \uac10\uc18c\ud558\uc5ec \uc5fc\uc99d \uc99d\uc0c1\uc774 \ud604\uc800\ud788 \uc644\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc544\ud53c\uc81c\ub2cc\uc774 \uc5fc\uc99d \uc5f0\uc1c4 \ubc18\uc751\uc744 \uc5b5\uc81c\ud558\uace0 \ub178\ud654 \uc9c0\uc5f0\uc5d0 \uc720\ub9ac\ud55c \ub0b4\ubd80 \ud658\uacbd\uc744 \uc870\uc131\ud558\ub294 \ub370 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

(III) \ub178\ud654 \uc138\ud3ec \ubbf8\uc138\ud658\uacbd \uc7ac\uad6c\uc131<\/h3>\n

\ub178\ud654 \uc138\ud3ec\ub294 \uc790\uc2e0\uc758 \uae30\ub2a5\uc744 \uc800\ud558\uc2dc\ud0ac \ubfd0\ub9cc \uc544\ub2c8\ub77c, \ub9c8\uce58 \uc791\uc740 \uc950\uc758 \ubc30\uc124\ubb3c\uc774 \ud1b5 \uc804\uccb4\ub97c \ub9dd\uac00\ub728\ub9ac\ub294 \uac83\ucc98\ub7fc \uc8fc\ubcc0 \uc138\ud3ec \ubbf8\uc138\ud658\uacbd\uc5d0\ub3c4 \ubd80\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \uadf8\ub4e4\uc774 \ubd84\ube44\ud558\ub294 SASP\uc5d0\ub294 \uc5ec\ub7ec \uae30\uc9c8 \uae08\uc18d\ub2e8\ubc31\ubd84\ud574\ud6a8\uc18c(MMP)\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\ub4e4\uc740 \ub9c8\uce58 “\uac00\uc704”\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc138\ud3ec\uc678\uae30\uc9c8(ECM) \ub0b4\uc758 \ucf5c\ub77c\uac90\uacfc \ud0c4\ub825\uc12c\uc720 \ub124\ud2b8\uc6cc\ud06c\ub97c \ud30c\uad34\ud558\uc5ec \ud53c\ubd80 \ucc98\uc9d0, \uc8fc\ub984, \uadf8\ub9ac\uace0 \uc7a5\uae30 \ubc0f \uc870\uc9c1\uc758 \uad6c\uc870\uc801 \uc548\uc815\uc131 \uc800\ud558\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4.<\/p>\n

\ub3c5\ud2b9\ud55c “\uc138\ub178\ubaa8\ud53d \uc791\uc6a9\uc81c(senomorphic agent)”\uc778 \uc544\ud53c\uc81c\ub2cc\uc740 \uae30\uc874\uacfc\ub294 \ub2e4\ub978 \uc811\uadfc \ubc29\uc2dd\uc744 \ucde8\ud569\ub2c8\ub2e4. \ub178\ud654 \uc138\ud3ec\ub97c \uc9c1\uc811 \uc81c\uac70\ud558\ub294 \ub300\uc2e0, \ub354 \ubd80\ub4dc\ub7fd\uace0 \ubbf8\ubb18\ud55c \ubc29\uc2dd\uc73c\ub85c \ubd84\ube44 \uae30\ub2a5\uc744 \uc870\uc808\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc740 SASP \uad00\ub828 MMP\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uac00\uc704\uc758 \ubcf4\ud638\ub9c9 \uc5ed\ud560\uc744 \ud558\uace0, ECM \uc190\uc0c1\uc744 \uc904\uc774\uba70, \ud53c\ubd80 \ubc0f \uc7a5\uae30 \uc870\uc9c1\uc758 \uad6c\uc870\uc801 \uc628\uc804\uc131\uacfc \uc548\uc815\uc131\uc744 \uc720\uc9c0\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uc138\ud3ec \ubaa8\ub378\uc5d0\uc11c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \ub178\ud654 \uc138\ud3ec\ub294 MMP \ubd84\ube44\ub97c \uc904\uc774\uace0, \ucf5c\ub77c\uac90\uacfc \ud0c4\ub825\uc12c\uc720\uc758 \ubd84\ud574\ub97c \uc5b5\uc81c\ud558\uba70, ECM \uad6c\uc870\ub97c \uc720\uc9c0\ud558\uc5ec \ud53c\ubd80 \ud0c4\ub825\uacfc \ud0c4\ub825\uc744 \uac15\ub825\ud558\uac8c \uc720\uc9c0\ud588\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc138\ud3ec \ubbf8\uc138\ud658\uacbd \uc218\uc900\uc5d0\uc11c \uc544\ud53c\uac8c\ub2cc\uc758 \ub178\ud654 \ubc29\uc9c0 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n

 <\/p>\n

\ub2e4\uc911 \uc2dc\uc2a4\ud15c \ud56d\ub178\ud654 \ud6a8\uacfc: \ubd84\uc790\uc801 \uad00\uc810\uc5d0\uc11c \uc720\uae30\uccb4\uc801 \uad00\uc810\uae4c\uc9c0, \ud53c\ubd80 \ub178\ud654 \ubc29\uc9c0\ub97c \uc704\ud55c \uac1c\uc785\"\"<\/h2>\n

(I) \ud53c\ubd80 \ud56d\ub178\ud654: “\uc80a\uc74c\uc758 \ube44\uacc4” \ubcf4\ud638<\/h3>\n

\uc778\uccb4\uc5d0\uc11c \uac00\uc7a5 \ud070 \uae30\uad00\uc778 \ud53c\ubd80\ub294 \ub178\ud654\uc758 \uac00\uc7a5 \ub208\uc5d0 \ub744\ub294 \uc9d5\ud6c4\uc785\ub2c8\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ud53c\ubd80\uc758 \ucf5c\ub77c\uac90\uacfc \ud0c4\ub825 \uc12c\uc720\ub294 \uac74\ubb3c\uc758 \ube44\uacc4\uac00 \ucc9c\ucc9c\ud788 \ubd80\uc2dd\ub418\uace0 \uc57d\ud574\uc9c0\ub4ef\uc774 \uc810\ucc28 \uac10\uc18c\ud558\uc5ec \ud53c\ubd80 \ucc98\uc9d0\uacfc \uc8fc\ub984\uc744 \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ud53c\ubd80 \ud56d\ub178\ud654\uc5d0 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \ubcf4\uc774\uba70 \ud53c\ubd80\uc758 \uc80a\uc74c\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n

\ucf5c\ub77c\uac90 \ubcf4\ud638\uc5d0 \uc788\uc5b4 \uc790\uc678\uc120\uc740 \ud53c\ubd80\uc758 \ucd5c\ub300 \uc0b4\uc778\uc790\ub85c \uc5ec\uaca8\uc9d1\ub2c8\ub2e4. \uc790\uc678\uc120\uc740 \ub9e4\ud2b8\ub9ad\uc2a4 \uba54\ud0c8\ub85c\ud504\ub85c\ud14c\uc544\uc81c-1(MMP-1)\uacfc \uac19\uc740 \ucf5c\ub77c\uac90 \ubd84\ud574 \ud6a8\uc18c\ub97c \ud65c\uc131\ud654\uc2dc\ud0b5\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\ub4e4\uc740 \ub9c8\uce58 \uac00\uc704\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \ucf5c\ub77c\uac90 \uc12c\uc720\ub97c \ubb34\uc790\ube44\ud558\uac8c \uc808\ub2e8\ud558\uace0 \ud53c\ubd80\uc758 \ud0c4\ub825\uc744 \uc783\uac8c \ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ucda9\uc131\uc2a4\ub7ec\uc6b4 \uc218\ud638\uc790 \uc5ed\ud560\uc744 \ud558\uba70, MMP-1\uacfc \uac19\uc740 \ucf5c\ub77c\uac8c\ub098\uc544\uc81c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uc774\ub7ec\ud55c \ud30c\uad34\uc801\uc778 \ud589\ub3d9\uc744 \uc5b5\uc81c\ud569\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \uc2e4\ud5d8\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 \uc790\uc678\uc120\uc73c\ub85c \uc190\uc0c1\ub41c \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ub180\ub78d\uac8c\ub3c4 \ucf5c\ub77c\uac90 \ud569\uc131\uc774 20~30% \uc99d\uac00\ud558\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uc774\uc804\uc5d0 \uc190\uc0c1\ub418\uc5c8\ub358 \ucf5c\ub77c\uac90 \uc12c\uc720\uac00 \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf5\uad6c\ub418\uc5b4 \ud53c\ubd80 \ud0c4\ub825\uacfc \ud0c4\ub825\uc744 \uc704\ud55c \ud0c4\ud0c4\ud55c \ud1a0\ub300\ub97c \ub9c8\ub828\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

\ud53c\ubd80 \uc7a5\ubcbd\uc758 \uac74\uac15\uc740 \ud53c\ubd80 \uac74\uac15 \uc720\uc9c0\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \ud53c\ubd80 \uc7a5\ubcbd\uc740 \ubcf4\uc774\uc9c0 \uc54a\ub294 \ubcf4\ud638\ub9c9\ucc98\ub7fc \uc791\uc6a9\ud558\uc5ec \uc218\ubd84 \uc190\uc2e4\uc744 \ub9c9\uace0 \uc720\ud574 \ubb3c\uc9c8\uc758 \uce68\ud22c\ub97c \ucc28\ub2e8\ud569\ub2c8\ub2e4. \ub098\uc774\uac00 \ub4e4\uba74\uc11c \ud53c\ubd80 \uc7a5\ubcbd \uae30\ub2a5\uc774 \uc810\ucc28 \uc57d\ud574\uc9c0\uace0, \uac01\uc9c8\uc138\ud3ec \uc99d\uc2dd\uc774 \uac10\uc18c\ud558\uba70, \uc138\ub77c\ub9c8\uc774\ub4dc \uc0dd\uc131\uc774 \uac10\uc18c\ud558\uc5ec \ud53c\ubd80\uac00 \uac74\uc870\ud558\uace0 \uac70\uce60\uc5b4\uc9d1\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uac01\uc9c8\uc138\ud3ec \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud558\uace0 \ud53c\ubd80 \uc2e0\uc9c4\ub300\uc0ac\ub97c \ucd09\uc9c4\ud558\uc5ec \ud53c\ubd80\uc5d0 “\ud65c\ub825”\uc744 \ubd88\uc5b4\ub123\uc5b4 \uc774\ub7ec\ud55c \ubb38\uc81c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ud574\uacb0\ud569\ub2c8\ub2e4. \ub610\ud55c, \uc544\ud53c\uc81c\ub2cc\uc740 \uc138\ub77c\ub9c8\uc774\ub4dc \ud569\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ucf1c \uc138\ub77c\ub9c8\uc774\ub4dc \ud569\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \ud53c\ubd80\uc758 \uc218\ubd84 \ubcf4\uc720\ub825\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \ub178\ud654\ub41c \uc950\uc5d0\uac8c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ud53c\ubd80 \uc218\ubd84 \ud568\ub7c9\uc774 \ud06c\uac8c \uc99d\uac00\ud558\uc5ec \uac74\uc870\ud568\uacfc \uac70\uce60\uae30\uac00 \ud604\uc800\ud788 \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uc7a5\ubcbd \uae30\ub2a5\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \ud68c\ubcf5\ub418\uc5b4 \ud53c\ubd80\uac00 \ucd09\ucd09\ud558\uace0 \uc724\uae30 \uc788\ub294 \ubaa8\uc2b5\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc7a5\uae30 \ud68c\ucd98: \uae30\ub2a5 \uc800\ud558 \uc9c0\uc5f0<\/h3>\n

\uc2ec\ud608\uad00 \ubcf4\ud638: \uc2ec\ud608\uad00\uacc4\ub294 \uc778\uccb4\uc758 “\uc0dd\uba85\uc758 \uac15”\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ub178\ud654\uac00 \uc9c4\ud589\ub428\uc5d0 \ub530\ub77c \uc774 “\uac15”\uc740 \uc810\uc9c4\uc801\uc73c\ub85c \ubb38\uc81c\ub97c \uc77c\uc73c\ucf1c \uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d\uc774\ub098 \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uacfc \uac19\uc740 \uc9c8\ubcd1\uc73c\ub85c \uc774\uc5b4\uc9c0\uace0, \uc774\ub294 \uc0dd\uba85\uacfc \uac74\uac15\uc5d0 \uc2ec\uac01\ud55c \uc704\ud611\uc774 \ub429\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uc2ec\ud608\uad00\uacc4\uc5d0 \uc0c8\ub85c\uc6b4 \ud65c\ub825\uacfc \ud65c\ub825\uc744 \ubd88\uc5b4\ub123\uc2b5\ub2c8\ub2e4. \ud608\uc911 \uc9c0\uc9c8 \uc870\uc808\uacfc \uad00\ub828\ud558\uc5ec, \uc544\ud53c\uc81c\ub2cc\uc740 \uc9c0\ubc29\uc0b0 \ud569\uc131\ud6a8\uc18c(FAS)\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uc5ec \uc9c0\ubc29\uc0b0 \ud569\uc131\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0, \uc9c0\ubc29\uc0b0 \ud569\uc131 “\uc0dd\uc0b0 \ub77c\uc778”\uc744 \ubcf8\uc9c8\uc801\uc73c\ub85c \uc911\ub2e8\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c \uc9c0\ub2e8\ubc31\uc9c8 \ub9ac\ud30c\uc544\uc81c(LPL)\uc640 \uac04 \ub9ac\ud30c\uc544\uc81c(HL)\uc758 \ud65c\uc131\uc744 \uc870\uc808\ud558\uc5ec \uc911\uc131\uc9c0\ubc29 \ubd84\ud574\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \uace0\uc9c0\ubc29 \uc2dd\uc774\ub85c \uc720\ubc1c\ub41c \ube44\ub9cc \ub9c8\uc6b0\uc2a4\uc5d0\uac8c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ud608\uccad \ucd1d \ucf5c\ub808\uc2a4\ud14c\ub864, \uc911\uc131\uc9c0\ubc29, \uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864(LDL-C) \uc218\uce58\uac00 \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\ud558\ub294 \ubc18\uba74, \uace0\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864(HDL-C) \uc218\uce58\ub294 \uc99d\uac00\ud558\uc5ec \ud608\uc911 \uc9c0\uc9c8 \uc218\uce58\uac00 \uc720\uc758\ubbf8\ud558\uac8c \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud608\uad00 \ub0b4\ubcbd\uc758 \uc218\ud638\uc790\uc778 \ub0b4\ud53c \uc138\ud3ec\ub294 \uc2ec\ud608\uad00 \uac74\uac15\uacfc \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ub0b4\ud53c \uae30\ub2a5 \uc7a5\uc560\ub294 \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc758 \ucd08\uae30 \uc9d5\ud6c4\ub85c, \ube44\uc815\uc0c1\uc801\uc778 \ud608\uad00 \uc218\ucd95 \ubc0f \ud655\uc7a5, \uc5fc\uc99d \uc138\ud3ec \ubd80\ucc29 \ub4f1\uc758 \ubb38\uc81c\ub97c \uc720\ubc1c\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \uc791\uc6a9\uc744 \ud1b5\ud574 \ub0b4\ud53c \uc138\ud3ec\ub97c \ubcf4\ud638\ud558\uace0, \uc0b0\ud654\uc9c8\uc18c(NO)\uc758 \ud569\uc131\uacfc \ubc29\ucd9c\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. NO\ub294 \ud608\uad00\uc744 \ud655\uc7a5\ud558\uace0 \ud608\uc555\uc744 \ub0ae\ucd94\uba70 \ud608\uc18c\ud310 \uc751\uc9d1\uacfc \ud608\uc804 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uc8fc\uc694 \ud608\uad00 \ud655\uc7a5\uc81c\uc785\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc73c\ub85c \ucc98\ub9ac\ub41c \ub0b4\ud53c\uc138\ud3ec\ub294 \uc77c\uc0b0\ud654\uc9c8\uc18c(NO) \ubd84\ube44\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \ub0b4\ud53c \uc0b0\ud654\uc9c8\uc18c \ud569\uc131\ud6a8\uc18c(eNOS) \ud65c\uc131\uc744 \uc99d\uc9c4\uc2dc\ucf1c \ub0b4\ud53c \uae30\ub2a5\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uac1c\uc120\ud558\uace0 \uc8fd\uc0c1\uacbd\ud654\ubc18 \ud615\uc131 \uc704\ud5d8\uc744 \uac10\uc18c\uc2dc\ucf1c \uc2ec\ud608\uad00 \uac74\uac15\uc5d0 \uac15\ub825\ud55c \ubc29\uc5b4 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc2e0\uacbd\uc778\uc9c0 \uae30\ub2a5 \ud5a5\uc0c1: \uc778\uccb4\uc758 “\ubcf8\ubd80”\uc778 \ub1cc\ub294 \ub178\ud654\uc640 \ud568\uaed8 \uc810\uc9c4\uc801\uc73c\ub85c \uc190\uc0c1\ub418\uc5b4 \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8 \ubd88\uade0\ud615\uacfc \uc5fc\uc99d \ubc18\uc751 \uc99d\uac00\ub97c \ucd08\ub798\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc190\uc0c1\uc740 \uae30\uc5b5\ub825 \uac10\ud1f4, \uc778\uc9c0 \uc7a5\uc560, \uadf8\ub9ac\uace0 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uac19\uc740 \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \ubc1c\ubcd1\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uc2e0\uacbd \ubcf4\ud638\uc5d0 \ud070 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc600\uc73c\uba70, \ub1cc \ub178\ud654\ub97c \ub2a6\ucd9c \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 \ub178\ud654\ub41c \uc0dd\uc950\uc5d0\uac8c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \ubaa8\ub9ac\uc2a4 \uc218\uc911 \ubbf8\ub85c\uc640 Y\uc790 \ubbf8\ub85c\uc640 \uac19\uc740 \ud589\ub3d9 \uac80\uc0ac\ub97c \ud1b5\ud574 \uc0dd\uc950\uc758 \ud559\uc2b5 \ubc0f \uae30\uc5b5 \ub2a5\ub825\uc774 \ud06c\uac8c \ud5a5\uc0c1\ub418\uc5c8\uc74c\uc744 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc0dd\uc950\ub294 \uc228\uaca8\uc9c4 \ud50c\ub7ab\ud3fc\uc744 \ub354 \ube68\ub9ac \ucc3e\uace0 Y\uc790 \ubbf8\ub85c\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \ud314\ub85c \ud6e8\uc52c \ub354 \uc790\uc8fc \uc9c4\uc785\ud558\uc5ec \uae30\uc5b5\ub825\uacfc \uacf5\uac04 \uc778\uc9c0 \ub2a5\ub825\uc774 \ud5a5\uc0c1\ub418\uc5c8\uc74c\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc544\ud53c\uc81c\ub2cc\uc758 \uc791\uc6a9 \uae30\uc804\uc5d0 \ub300\ud55c \uc2ec\uce35\uc801\uc778 \uc5f0\uad6c \uacb0\uacfc, \uc544\ud53c\uc81c\ub2cc\uc740 \ub178\ud654\ub41c \uc0dd\uc950\uc758 \ub1cc\uc5d0\uc11c \uc5fc\uc99d \ubc18\uc751\uc744 \uc644\ud654\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4 \uc778\ud130\ub8e8\ud0a8-1\u03b2(IL-1\u03b2) \ubc0f \uc885\uc591\uad34\uc0ac\uc778\uc790 \u03b1(TNF-\u03b1)\uc640 \uac19\uc740 \uc2e0\uacbd\uc5fc\uc99d \uc778\uc790\uc758 \ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\uc5ec \ub1cc\uc758 “\uc5fc\uc99d \ud3ed\ud48d”\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc9c4\uc815\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, \uc544\ud53c\uc81c\ub2cc\uc740 \uc2dc\ub0c5\uc2a4\uc758 \uad6c\uc870\uc801 \ubc0f \uae30\ub2a5\uc801 \ubb34\uacb0\uc131\uc744 \ubcf4\ud638\ud558\uace0, \uc2e0\uacbd\uc804\ub2ec\ubb3c\uc9c8\uc758 \ud569\uc131 \ubc0f \ubc29\ucd9c\uc744 \ucd09\uc9c4\ud558\uba70, \ub274\ub7f0 \uac04 \uc2e0\ud638\uc804\ub2ec\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub354 \ub098\uc544\uac00, \uc544\ud53c\uc81c\ub2cc\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uad00\ub828\ub41c \ubcd1\ub9ac\ud559\uc801 \uacfc\uc815\uc744 \uc5b5\uc81c\ud558\ub294 \ud6a8\uacfc\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ubca0\ud0c0-\uc544\ubc00\ub85c\uc774\ub4dc \ub2e8\ubc31\uc9c8(A\u03b2)\uc758 \ucd95\uc801\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \ud0c0\uc6b0 \ub2e8\ubc31\uc9c8\uc758 \uacfc\uc778\uc0b0\ud654\ub97c \uc5b5\uc81c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ub450 \uac00\uc9c0 \ubcd1\ub9ac\ud559\uc801 \ubcc0\ud654\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ud575\uc2ec \ud2b9\uc9d5\uc785\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \uc9c4\ud589\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ub2a6\ucdb0 \ub1cc\uc758 “\uc9c0\ud718 \uc13c\ud130”\uac00 \ub354 \uc624\ub7ab\ub3d9\uc548 \ud6a8\uc728\uc801\uc73c\ub85c \uae30\ub2a5\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4.<\/p>\n

(III) \ub300\uc0ac \ubc0f \uba74\uc5ed \uc870\uc808<\/h3>\n

\ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac \uac1c\uc120: \ub300\uc0ac \uc2dc\uc2a4\ud15c\uc740 \uc2e0\uccb4\uc758 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc785\ub2c8\ub2e4. \ub178\ud654\uc5d0 \ub530\ub77c \ub300\uc0ac \uae30\ub2a5\uc774 \uc810\ucc28 \uc800\ud558\ub418\uace0, \ube44\uc815\uc0c1\uc801\uc778 \ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uac74\uac15 \ubb38\uc81c\ub97c \uc57c\uae30\ud558\uc5ec \ube44\ub9cc\uacfc \ub2f9\ub1e8\ubcd1\uacfc \uac19\uc740 \uc9c8\ubcd1\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ud3ec\ub3c4\ub2f9 \ubc0f \uc9c0\uc9c8 \ub300\uc0ac \uc870\uc808\uc5d0 \uae0d\uc815\uc801\uc778 \uc5ed\ud560\uc744 \ud558\uba70, \uc774 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5”\uc758 \uc815\uc0c1\uc801\uc778 \uc791\ub3d9\uc744 \uac15\ub825\ud558\uac8c \uc9c0\uc6d0\ud569\ub2c8\ub2e4. \uc5d0\ub108\uc9c0 \ub300\uc0ac\uc640 \uad00\ub828\ud558\uc5ec, \uc544\ud53c\uc81c\ub2cc\uc740 \uc544\ub370\ub178\uc2e0 \ubaa8\ub178\ud3ec\uc2a4\ud398\uc774\ud2b8-\ud65c\uc131\ud654 \ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c(AMPK) \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. AMPK\ub294 \uc138\ud3ec \ub0b4 “\uc5d0\ub108\uc9c0 \uc13c\uc11c” \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc138\ud3ec \uc5d0\ub108\uc9c0 \uc218\uc900\uc774 \uac10\uc18c\ud558\uba74 AMPK\uac00 \ud65c\uc131\ud654\ub429\ub2c8\ub2e4. AMPK\ub294 \uc77c\ub828\uc758 \ub300\uc0ac \ud6a8\uc18c\uc640 \ub2e8\ubc31\uc9c8\uc744 \uc870\uc808\ud558\uc5ec \uc9c0\ubc29\uc0b0 \uc0b0\ud654\ub97c \ucd09\uc9c4\ud558\uace0, \uc9c0\ubc29 \ud569\uc131\uc744 \uc5b5\uc81c\ud558\uba70, \ud3ec\ub3c4\ub2f9 \ud761\uc218 \ubc0f \uc774\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc73c\ub85c \ucc98\ub9ac\ub41c \uc138\ud3ec\ub294 AMPK \uc778\uc0b0\ud654\uac00 \uc99d\uac00\ud558\uace0, \uc9c0\ubc29\uc0b0 \uc0b0\ud654 \uad00\ub828 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc774 \uc99d\uac00\ud558\uba70, \uc9c0\ubc29 \ud569\uc131 \uad00\ub828 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc774 \uac10\uc18c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc138\ud3ec \ub0b4 \uc9c0\ubc29 \ucd95\uc801\uc744 \ud604\uc800\ud788 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc5d0\ub108\uc9c0 \ub300\uc0ac\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4.<\/p>\n

\uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc740 \uc81c2\ud615 \ub2f9\ub1e8\ubcd1\uc758 \uc8fc\uc694 \ubc1c\ubcd1 \uae30\uc804\uc73c\ub85c, \uc778\uc290\ub9b0\uc758 \ud608\ub2f9 \uac15\ud558 \ud6a8\uacfc\ub97c \uc57d\ud654\uc2dc\ud0a4\uace0 \ud608\ub2f9\uc744 \uc0c1\uc2b9\uc2dc\ud0b5\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ub2e4\uc591\ud55c \uacbd\ub85c\ub97c \ud1b5\ud574 \uc778\uc290\ub9b0 \uc800\ud56d\uc131\uc744 \uac1c\uc120\ud558\uace0 \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \uccab\uc9f8, \uc544\ud53c\uc81c\ub2cc\uc740 \uc778\uc290\ub9b0 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub97c \uc870\uc808\ud558\uc5ec \uc778\uc290\ub9b0 \uc218\uc6a9\uccb4 \uae30\uc9c8-1(IRS-1)\uc758 \uc778\uc0b0\ud654\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \ud558\uc704 \ub2e8\uacc4\uc778 \ud3ec\uc2a4\ud30c\ud2f0\ub51c\uc774\ub178\uc2dc\ud1a8 3-\ud0a4\ub098\uc544\uc81c(PI3K)\/\ub2e8\ubc31\uc9c8 \ud0a4\ub098\uc544\uc81c B(Akt) \uc2e0\ud638\uc804\ub2ec\uc744 \ucd09\uc9c4\ud558\uc5ec \uc138\ud3ec\uc758 \ud3ec\ub3c4\ub2f9 \ud761\uc218 \ubc0f \ud65c\uc6a9\uc744 \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub458\uc9f8, \uc544\ud53c\uc81c\ub2cc\uc740 \uc5fc\uc99d \uc778\uc790 \uc218\uce58\ub97c \uac10\uc18c\uc2dc\ucf1c \uc778\uc290\ub9b0 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc5d0 \ub300\ud55c \uc5fc\uc99d\uc758 \uac04\uc12d\uc744 \uc644\ud654\ud569\ub2c8\ub2e4. \ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \ub2f9\ub1e8\ubcd1 \ub9c8\uc6b0\uc2a4\uc5d0\uac8c \uc544\ud53c\uc81c\ub2cc\uc744 \ud22c\uc5ec\ud55c \uacb0\uacfc, \ud608\ub2f9 \uc218\uce58\uac00 \ud604\uc800\ud788 \uac10\uc18c\ud558\uace0 \uc778\uc290\ub9b0 \ubbfc\uac10\ub3c4\uac00 \uc99d\uac00\ud558\uba70 \ub2f9 \ub0b4\uc131\uc774 \uac1c\uc120\ub418\uc5b4 \ub2f9\ub1e8\ubcd1 \uc99d\uc0c1\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \uc644\ud654\ub418\uace0 “\uc5d0\ub108\uc9c0 \uacf5\uc7a5” \ub0b4\uc5d0\uc11c \uc5d0\ub108\uc9c0 \ubd84\ubc30\uac00 \ub354\uc6b1 \ud6a8\uc728\uc801\uc73c\ub85c \uc774\ub8e8\uc5b4\uc84c\uc2b5\ub2c8\ub2e4.<\/p>\n

\uba74\uc5ed \uac10\uc2dc \uac15\ud654: \uc2e0\uccb4\uc758 \ubc29\uc5b4\ub825\uc778 \uba74\uc5ed \uccb4\uacc4\ub294 \ub178\ud654\uc640 \ud568\uaed8 \uc810\ucc28 \uc57d\ud654\ub418\uc5b4 \ub178\ud654 \uc138\ud3ec\uac00 \ucd95\uc801\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc138\ud3ec\ub294 \ub9c8\uce58 \uc228\uc740 \uc801\ucc98\ub7fc \uba74\uc5ed \uc81c\uac70\ub97c \ud68c\ud53c\ud558\uace0 \ub2e4\uc591\ud55c \uc0ac\uc774\ud1a0\uce74\uc778\uc744 \ubd84\ube44\ud558\uc5ec \uc5fc\uc99d\uc131 \ubbf8\uc138\ud658\uacbd\uc744 \ud615\uc131\ud558\uace0 \ub178\ud654\uc640 \uc9c8\ubcd1\uc744 \ub354\uc6b1 \uac00\uc18d\ud654\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uba74\uc5ed \uac10\uc2dc \uac15\ud654\uc5d0 \uc788\uc5b4 \ub3c5\ud2b9\ud55c \uc5ed\ud560\uc744 \ud558\uba70, \uba74\uc5ed \uccb4\uacc4\uac00 \ub178\ud654 \uc138\ud3ec\ub97c \ub354 \uc798 \uc2dd\ubcc4\ud558\uace0 \uc81c\uac70\ud558\ub3c4\ub85d \ub3d5\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc740 \ub178\ud654 \uc138\ud3ec\uac00 \uba74\uc5ed \uc81c\uac70\ub97c \ud68c\ud53c\ud558\ub294 \uae30\uc804\uc744 \uc5b5\uc81c\ud558\uc5ec \uba74\uc5ed \uccb4\uacc4\uc758 \ube44\uc815\uc0c1 \uc138\ud3ec \uc778\uc2dd \ubc0f \uc81c\uac70 \ub2a5\ub825\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \uba74\uc5ed \uc138\ud3ec \uae30\ub2a5\uc744 \uc870\uc808\ud558\uc5ec \ub178\ud654 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc790\uc5f0\uc0b4\ud574\uc138\ud3ec(NK \uc138\ud3ec)\uc640 \uc138\ud3ec\ub3c5\uc131 T \ub9bc\ud504\uad6c(CTL)\uc758 \uc138\ud3ec\ub3c5\uc131 \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \ub610\ud55c, \uc544\ud53c\uc81c\ub2cc\uc740 \uba74\uc5ed \ubbf8\uc138\ud658\uacbd\uc744 \uc870\uc808\ud558\uc5ec \ub178\ud654 \uc138\ud3ec\uc758 \uba74\uc5ed\uc5b5\uc81c \uc778\uc790 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uba74\uc5ed \ud65c\uc131\ud654 \uc778\uc790\uc758 \ubc1c\ud604\uc744 \uc99d\uac00\uc2dc\ud0b5\ub2c8\ub2e4. \uc2dc\ud5d8\uad00 \ub0b4 \uc2e4\ud5d8\uc5d0\uc11c \uc544\ud53c\uc81c\ub2cc\uc744 \ub178\ud654 \uc138\ud3ec \ubc0f \uba74\uc5ed \uc138\ud3ec\uc640 \ud568\uaed8 \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \uba74\uc5ed \uc138\ud3ec\uc758 \ub178\ud654 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc0b4\uc0c1 \ud6a8\uacfc\uac00 \ud604\uc800\ud788 \ud5a5\uc0c1\ub418\uace0, \ub178\ud654 \uc138\ud3ec\uc758 \uc218\uac00 \uac10\uc18c\ud558\uba70, \uba74\uc5ed \uccb4\uacc4\uc758 “\uc804\ud22c\ub825”\uc774 \ud6a8\uacfc\uc801\uc73c\ub85c \uc720\uc9c0\ub418\uc5b4 \uc2e0\uccb4\uc758 “\ubc29\uc5b4\ub825”\uc774 \ud56d\uc0c1 \uacbd\uacc4 \uc0c1\ud0dc\ub97c \uc720\uc9c0\ud558\uc5ec \ub178\ud654\uc640 \uc9c8\ubcd1\uc758 \uce68\uc785\uc5d0 \uc800\ud56d\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc751\uc6a9 \uc804\ub9dd: \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\ubd80\ud130 \uc815\ubc00 \ud56d\ub178\ud654 \uc694\ubc95\uae4c\uc9c0<\/h2>\n

(I) \uc77c\uc0c1 \ud56d\ub178\ud654: \uc2dd\uc774 \uc12d\ucde8\uc640 \uae30\ub2a5\uc131 \uc2dd\ud488<\/h3>\n

\uc140\ub7ec\ub9ac, \uce90\ubaa8\ub9c8\uc77c, \uac10\uade4\ub958\ub294 \uc77c\uc0c1\uc0dd\ud65c\uc5d0\uc11c \uc544\ud53c\uc81c\ub2cc\uc758 \ud6cc\ub96d\ud55c \ucc9c\uc5f0 \uacf5\uae09\uc6d0\uc785\ub2c8\ub2e4. \uc140\ub7ec\ub9ac 100g\uc5d0\ub294 10~20mg\uc758 \uc544\ud53c\uc81c\ub2cc\uc774 \ud568\uc720\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \ubcf6\uc74c, \uc0d0\ub7ec\ub4dc, \uc8fc\uc2a4 \ub4f1 \uc140\ub7ec\ub9ac\ub97c \uaddc\uce59\uc801\uc73c\ub85c \uc12d\ucde8\ud558\uba74 \uc77c\uc815\ub7c9\uc758 \uc544\ud53c\uc81c\ub2cc\uc744 \uc12d\ucde8\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uce90\ubaa8\ub9c8\uc77c\uc740 \ucc28\ub85c \ub9c8\uc2dc\ub294 \uac83 \uc678\uc5d0\ub3c4 \uc77c\ubd80 \uace0\uae09 \uc2a4\ud0a8\ucf00\uc5b4 \ubc0f \uc544\ub85c\ub9c8\ud14c\ub77c\ud53c \uc81c\ud488\uc5d0\ub3c4 \uc0ac\uc6a9\ub418\uc5b4 \uc544\ud53c\uc81c\ub2cc\uc758 \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \ub204\ub9ac\uba74\uc11c \ud3b8\uc548\ud55c \ud734\uc2dd\uc744 \ucde8\ud560 \uc218 \uc788\ub3c4\ub85d \ub3c4\uc640\uc90d\ub2c8\ub2e4.<\/p>\n

\uc55e\uc73c\ub85c \uac74\uac15\uc5d0 \ub300\ud55c \uad00\uc2ec\uc774 \ub192\uc544\uc9d0\uc5d0 \ub530\ub77c \uac15\ud654 \uc2dd\ud488\uacfc \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc774 \uc544\ud53c\uc81c\ub2cc\uc744 \uc12d\ucde8\ud558\ub294 \ud3b8\ub9ac\ud55c \ubc29\ubc95\uc774 \ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \ube75\uc774\ub098 \uc694\uad6c\ub974\ud2b8\uc640 \uac19\uc740 \uc77c\uc0c1 \uc2dd\ud488\uc5d0 \uc544\ud53c\uc81c\ub2cc\uc744 \ucca8\uac00\ud558\uba74 \ub9db\uc788\ub294 \uc74c\uc2dd\uc744 \uc990\uae30\uba74\uc11c \uc774 \uc720\uc775\ud55c \uc131\ubd84\uc744 \uc27d\uac8c \uc12d\ucde8\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubc18\uba74, \uac74\uac15 \ubcf4\uc870 \uc2dd\ud488\uc740 \ub2e4\uc591\ud55c \uadf8\ub8f9\uc758 \ud544\uc694\uc5d0 \ub530\ub77c \uc544\ud53c\uc81c\ub2cc\uc758 \ubcf5\uc6a9\ub7c9\uc744 \uc815\ubc00\ud558\uac8c \uc870\uc808\ud558\uc5ec \ud3b8\ub9ac\ud568\uacfc \ube60\ub978 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc758 \ub178\ud654 \ubc29\uc9c0 \ud6a8\uacfc\ub97c \ub354\uc6b1 \uac15\ud654\ud558\uae30 \uc704\ud574 \ube44\ud0c0\ubbfc C\uc640 \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uacfc \uac19\uc740 \uc131\ubd84\uacfc \ubcd1\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ube44\ud0c0\ubbfc C\uc758 \uac15\ub825\ud55c \ud56d\uc0b0\ud654 \ud6a8\uacfc\ub294 \uc544\ud53c\uc81c\ub2cc\uacfc \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \uc790\uc720 \ub77c\ub514\uce7c \uc18c\uac70\ub97c \ud5a5\uc0c1\uc2dc\ud0b5\ub2c8\ub2e4. \ub808\uc2a4\ubca0\ub77c\ud2b8\ub864\uc740 \ud56d\uc0b0\ud654, \ud56d\uc5fc\uc99d, \uc138\ud3ec \ub300\uc0ac \uc870\uc808 \ud6a8\uacfc\ub3c4 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \uc544\ud53c\uc81c\ub2cc\uacfc \ud568\uaed8 \uc0ac\uc6a9\ud558\uba74 \ub2e4\ucc28\uc6d0\uc801\uc73c\ub85c \ub178\ud654 \uacfc\uc815\uc744 \uc9c0\uc5f0\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(II) \uc81c\uc57d \ubc0f \ubbf8\uc6a9 \uc758\ud559 \ubd84\uc57c\uc758 \uc7a0\uc7ac\ub825<\/h3>\n

\uc9c8\ubcd1 \uc911\uc7ac: \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc774\ub098 \uace8\uad00\uc808\uc5fc\uacfc \uac19\uc740 \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc740 \uc0ac\ub78c\ub4e4\uc758 \uc0b6\uc758 \uc9c8\uacfc \uac74\uac15\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ub3c5\ud2b9\ud55c \uc791\uc6a9 \uae30\uc804\uc744 \uac00\uc9c4 \uc544\ud53c\uc81c\ub2cc\uc740 \uc774\ub7ec\ud55c \uc9c8\ud658\uc5d0 \ub300\ud55c \ud45c\uc801 \uc57d\ubb3c \uac1c\ubc1c\uc5d0 \ud070 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc758 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \uc788\uc5b4, \uc544\ud53c\uc81c\ub2cc\uc740 \ud608\uc911 \uc9c0\uc9c8 \uc870\uc808, \uc5fc\uc99d \ubc18\uc751 \uc5b5\uc81c, \ud608\uad00 \ub0b4\ud53c\uc138\ud3ec \ubcf4\ud638 \ub4f1 \ub2e4\uc591\ud55c \ud6a8\uacfc\ub97c \ud1b5\ud574 \uc0c8\ub85c\uc6b4 \ud56d\uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc81c\ub85c\uc11c \uae30\ub300\ub97c \ubaa8\uc73c\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc804\uc784\uc0c1 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc740 \uc2e4\ud5d8 \ub3d9\ubb3c\uc758 \ud608\uc911 \ucf5c\ub808\uc2a4\ud14c\ub864 \ubc0f \uc911\uc131\uc9c0\ubc29 \uc218\uce58\ub97c \uc720\uc758\ubbf8\ud558\uac8c \uac10\uc18c\uc2dc\ud0a4\uace0, \ud608\uad00\ubcbd\uc758 \uc9c0\uc9c8 \uce68\ucc29\uc744 \uc904\uc774\uba70, \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\ubc18 \ud615\uc131\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \uc9c0\uc5f0\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uace8\uad00\uc808\uc5fc\uc740 \ud754\ud55c \ud1f4\ud589\uc131 \uad00\uc808 \uc9c8\ud658\uc774\uba70, \uadf8 \ubc1c\ubcd1 \uae30\uc804\uc740 \uad00\uc808 \uc5f0\uace8\uc758 \ubd84\ud574 \ubc0f \uc5fc\uc99d \ubc18\uc751\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uae30\uc9c8 \uae08\uc18d\ub2e8\ubc31\ubd84\ud574\ud6a8\uc18c(MMP)\uc5d0 \uc758\ud55c \uad00\uc808 \uc5f0\uace8\uc758 \ud30c\uad34\ub97c \uc5b5\uc81c\ud558\uace0, \uc5fc\uc99d\uc744 \uac10\uc18c\uc2dc\ud0a4\uba70, \uc5f0\uace8\uc138\ud3ec\uc758 \uc99d\uc2dd \ubc0f \ubcf5\uad6c\ub97c \ucd09\uc9c4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc544\ud53c\uc81c\ub2cc\uc740 \uc5f0\uace8\uc138\ud3ec\uc5d0\uc11c \uc81c2\ud615 \ucf5c\ub77c\uac90\uacfc \ud504\ub85c\ud14c\uc624\uae00\ub9ac\uce78\uc758 \ubc1c\ud604\uc744 \uc0c1\ud5a5 \uc870\uc808\ud558\uc5ec \uc5f0\uace8\uc758 \uad6c\uc870\uc801 \uc548\uc815\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uace8\uad00\uc808\uc5fc \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\ub825\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub610\ud55c, \uc544\ud53c\uc81c\ub2cc\uacfc \uc138\ub180\ub9ac\ud2f1\uc2a4\ub97c \ubcd1\uc6a9\ud558\uba74 \uccb4\ub0b4 \ub178\ud654 \uc138\ud3ec\ub97c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc73c\ub85c \uc81c\uac70\ud558\uc5ec \ub178\ud654 \uad00\ub828 \uc9c8\ud658\uc758 \uce58\ub8cc \ud6a8\uacfc\ub97c \ub354\uc6b1 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc758\ub8cc \ubbf8\uc6a9 \ubd84\uc57c: \uc758\ub8cc \ubbf8\uc6a9 \ubd84\uc57c\uc5d0\uc11c\ub3c4 \uc544\ud53c\uc81c\ub2cc\uc740 \ub9e4\uc6b0 \uc120\ud638\ub429\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc \uc720\ub3c4\uccb4\ub294 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc5d0 \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \uacbd\ud53c \ud761\uc218\ub97c \ud1b5\ud574 \ud53c\ubd80 \uae4a\uc219\uc774 \uce68\ud22c\ud558\uc5ec \ud56d\uc0b0\ud654 \ubc0f \ud56d\uc5fc \ud6a8\uacfc\ub97c \ubc1c\ud718\ud558\uc5ec \uc8fc\ub984 \ubc0f \ucc98\uc9d0\uacfc \uac19\uc740 \ud53c\ubd80 \ub178\ud654 \ubb38\uc81c\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uac1c\uc120\ud569\ub2c8\ub2e4. \ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc544\ud53c\uc81c\ub2cc \uc720\ub3c4\uccb4\uac00 \ud568\uc720\ub41c \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc744 8\uc8fc \ub3d9\uc548 \uc0ac\uc6a9\ud55c \ud6c4, \ud53c\ud5d8\uc790 \ud53c\ubd80\uc758 \ud3c9\uade0 \uc8fc\ub984 \uae4a\uc774\uac00 15~20% \uac10\uc18c\ud558\uace0 \ud53c\ubd80 \ud0c4\ub825\uacfc \ud0c4\ub825\uc774 \ud06c\uac8c \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uc740 \ub610\ud55c \uc9c4\ud53c \ubbf8\uc138 \ud658\uacbd\uc744 \uc870\uc808\ud558\uace0, \ucf5c\ub77c\uac90\uacfc \uc5d8\ub77c\uc2a4\ud2f4 \uc12c\uc720\uc758 \ud569\uc131\uc744 \ucd09\uc9c4\ud558\uba70, \ub9e4\ud2b8\ub9ad\uc2a4 \uba54\ud0c8\ub85c\ud504\ub85c\ud14c\uc544\uc81c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\uace0, \uc138\ud3ec\uc678 \uae30\uc9c8\uc758 \ubd84\ud574\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \ud6a8\uacfc\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc77c\ub828\uc758 \ud6a8\uacfc\ub294 \ud53c\ubd80\uc758 \uad6c\uc870\uc640 \uae30\ub2a5\uc744 \uc885\ud569\uc801\uc73c\ub85c \uac1c\uc120\ud558\uc5ec \ud53c\ubd80 \uc18d\ubd80\ud130 \uc80a\uc5b4\uc9c0\ub294 \ud6a8\uacfc\ub97c \uac00\uc838\uc635\ub2c8\ub2e4. \uae30\ubcf8 \ubcf4\uc2b5 \ub85c\uc158\ubd80\ud130 \uace0\uae09 \uc138\ub7fc\uae4c\uc9c0, \uc810\uc810 \ub354 \ub9ce\uc740 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc774 \uc544\ud53c\uc81c\ub2cc\uc744 \ud568\uc720\ud558\uace0 \uc788\uc73c\uba70, \uc18c\ube44\uc790\ub4e4\uc5d0\uac8c \ub354\uc6b1 \ud6a8\uc728\uc801\uc778 \uc548\ud2f0\uc5d0\uc774\uc9d5 \uc2a4\ud0a8\ucf00\uc5b4 \uacbd\ud5d8\uc744 \uc120\uc0ac\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

(III) \ud5a5\ud6c4 \uc5f0\uad6c \ubc29\ud5a5<\/h3>\n

\ud5a5\ud6c4 \uc544\ud53c\uc81c\ub2cc \uc5f0\uad6c\ub294 \ub354\uc6b1 \uc2ec\uce35\uc801\uc774\uace0 \uc815\ud655\ud55c \ubc29\ud5a5\uc73c\ub85c \ub098\uc544\uac08 \uac83\uc785\ub2c8\ub2e4. \uc544\ud53c\uc81c\ub2cc\uacfc \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\ucd1d\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \ud0d0\uad6c\ud558\uba74\uc11c, \uc5f0\uad6c\uc790\ub4e4\uc740 \uc544\ud53c\uc81c\ub2cc\uc774 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\ucd1d\uc758 \uad6c\uc131\uacfc \uae30\ub2a5\uc744 \uc5b4\ub5bb\uac8c \uc870\uc808\ud558\ub294\uc9c0, \uadf8\ub9ac\uace0 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\ucd1d\uc758 \ubcc0\ud654\uac00 \uc544\ud53c\uc81c\ub2cc\uc758 \ub300\uc0ac\uc640 \uc0dd\uccb4\uc774\uc6a9\ub960\uc5d0 \uc5b4\ub5bb\uac8c \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \uc2ec\uce35\uc801\uc73c\ub85c \uc5f0\uad6c\ud560 \uac83\uc785\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\ucd1d \uc870\uc808\uc5d0 \uae30\ubc18\ud55c \uc544\ud53c\uc81c\ub2cc \uc99d\uac15 \uc804\ub7b5\uc744 \uac1c\ubc1c\ud558\uc5ec \uc544\ud53c\uc81c\ub2cc\uc758 \ud56d\ub178\ud654 \ud6a8\uacfc\ub97c \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uae30\ub97c \uae30\ub300\ud569\ub2c8\ub2e4. \ud45c\uc801 \uc804\ub2ec \uc2dc\uc2a4\ud15c \ucd5c\uc801\ud654 \ub610\ud55c \uc5f0\uad6c\uc758 \ucd08\uc810 \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. \ud604\uc7ac \uc544\ud53c\uc81c\ub2cc\uc758 \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud55c \ub098\ub178\uae30\uc220 \ubc0f \uae30\ud0c0 \ubc29\ubc95\ub4e4\uc774 \uc874\uc7ac\ud558\uc9c0\ub9cc, \uc815\ud655\ud55c \ud45c\uc801 \uc804\ub2ec\uc744 \ub2ec\uc131\ud558\ub294 \uac83\uc740 \uccb4\ub0b4\uc5d0\uc11c \ud2b9\uc815 \uc870\uc9c1\uacfc \uc138\ud3ec\uc5d0 \ud6a8\uc728\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc544\ud53c\uc81c\ub2cc\uc758 \uae30\ub2a5\uc740 \uc5ec\uc804\ud788 \u200b\u200b\uacfc\uc81c\ub85c \ub0a8\uc544 \uc788\uc73c\uba70, \ucd94\uac00\uc801\uc778 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \ub178\ud654 \uc138\ud3ec \uc751\uc9d1 \ubd80\uc704\uc5d0 \uc544\ud53c\uc81c\ub2cc\uc744 \uc815\ud655\ud558\uac8c \uc804\ub2ec\ud558\uace0 \uc870\uc9c1 \ud2b9\uc774\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \uc0c8\ub85c\uc6b4 \uc6b4\ubc18\uccb4 \ubb3c\uc9c8\uacfc \uc804\ub2ec \uae30\uc220\uc744 \uac1c\ubc1c\ud558\ub294 \uac83\uc740 \ubbf8\ub798 \uc5f0\uad6c\uc758 \uc911\uc694\ud55c \ubaa9\ud45c\uc785\ub2c8\ub2e4. \uc7a5\uae30\uc801\uc778 \uc548\uc804\uc131 \ud3c9\uac00 \ub610\ud55c \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \ud604\uc7ac \uc5f0\uad6c\uc5d0\uc11c \uc544\ud53c\uc81c\ub2cc\uc758 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc774 \uc6b0\uc218\ud558\ub2e4\ub294 \uac83\uc774 \ubc1d\ud600\uc84c\uc9c0\ub9cc, \uadf8 \uc801\uc6a9 \ubd84\uc57c\uac00 \ud655\ub300\ub428\uc5d0 \ub530\ub77c \uc7a5\uae30\uc801\uc778 \ub300\uaddc\ubaa8 \uc548\uc804\uc131 \ud3c9\uac00\uac00 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \ub2e4\uc591\ud55c \uc9d1\ub2e8, \uc6a9\ub7c9 \ubc0f \uc0ac\uc6a9 \uae30\uac04\uc744 \ud3ec\ud568\ud558\ub294 \uc5f0\uad6c\ub294 \uc544\ud53c\uc81c\ub2cc\uc758 \uc548\uc804\uc131\uacfc \uc7a0\uc7ac\uc801 \ubd80\uc791\uc6a9\uc5d0 \ub300\ud55c \ud3ec\uad04\uc801\uc778 \uc774\ud574\ub97c \uc81c\uacf5\ud558\uc5ec \uad11\ubc94\uc704\ud55c \uc801\uc6a9\uc5d0 \ub300\ud55c \ud655\uc2e4\ud55c \uc548\uc804\uc131\uc744 \ubcf4\uc7a5\ud560 \uac83\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c \ubc29\ud5a5\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uc804\uc740 \uc544\ud53c\uc81c\ub2cc\uc744 \ub2e8\uc21c\ud55c \ucc9c\uc5f0 \uc131\ubd84\uc5d0\uc11c \uc815\ubc00\ud55c \ub178\ud654 \ubc29\uc9c0\uc81c\ub85c \ubc1c\uc804\uc2dc\ucf1c \uc778\uac04\uc758 \uac74\uac15\uacfc \ub178\ud654 \ubc29\uc9c0 \ub178\ub825\uc5d0 \ub354 \ud070 \uc774\uc810\uc744 \uc81c\uacf5\ud560 \uac83\uc785\ub2c8\ub2e4.\"\"<\/p>\n

\uc544\ud53c\uc81c\ub2cc, \ucc9c\uc5f0 \ud56d\ub178\ud654\uc758 \uc0c8\ub85c\uc6b4 \ud328\ub7ec\ub2e4\uc784\uc744 \uc5f4\ub2e4<\/h2>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

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