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Cosmetic Ingredients

Alpha Arbutin (α-Arbutin)


Alpha Arbutin (α-Arbutin, CAS:84380-01-8) is a high-activity stereoisomer arbutin, a superior tyrosinase inhibitor compared to regular β-Arbutin. It is white crystalline powder, water-soluble, stable structure, effectively blocks melanin synthesis, fades pigmentation, brightens uneven skin tone, widely used in brightening serums, masks, creams and hyperpigmentation repair skincare.

Our Alpha Arbutin is 99% HPLC verified purity, compliant with CosIng, FDA, ISO22716, GMP, HALAL & KOSHER standards, better inhibitory effect, low irritation, good formulation stability, ideal for daily brightening, post-sun repair, acne mark & melasma care formulas. Stable batches, bulk factory price, full COA & SDS available, free samples offered.

Alpha Arbutin
α-Arbutin
99% High Purity
HPLC Verified
HALAL & KOSHER Certified

PRODUCT INTRODUCTION

Complete Technical Specification (Alpha Arbutin / α-Arbutin)


Product Name Alpha Arbutin / α-Arbutin
CAS No. 84380-01-8
Molecular Formula C₁₂H₁₆O₇
Molecular Weight 272.25 g/mol
Appearance White fine crystalline powder, odorless
α-Arbutin Purity (HPLC) ≥99.0%
Solubility Freely soluble in water, soluble in ethanol, stable in water-based formulations
pH (1% aqueous solution) 5.0 ~ 7.0
Moisture ≤0.5%
Residue on Ignition ≤0.1%
Heavy Metals Pb ≤0.1ppm, As ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm, compliant with cosmetic standards
Microbiology TPC ≤100cfu/g, Yeast & Mold ≤10cfu/g, E.Coli / Salmonella / Pseudomonas aeruginosa: Negative
Allergen Status Vegan, Gluten-Free, Non-GMO, no parabens / artificial fragrances
Storage Condition Sealed, cool dry dark warehouse, avoid high temperature, strong light and extreme pH environments
Shelf Life 24 months unopened original packaging
MOQ 100g sample order, 1kg / 5kg / 25kg bulk export packagin

Core Benefits & Functional Mechanism


Alpha Arbutin is a stereochemically optimized form of arbutin, which directly binds to and inhibits tyrosinase, the key enzyme responsible for melanin synthesis, blocking the conversion of tyrosine to melanin, reducing excess pigment formation, fading existing pigmentation, and preventing new dark spots. Its spatial structure gives it stronger inhibitory activity than regular β-Arbutin, while maintaining mild skin compatibility.

It works well with niacinamide, tranexamic acid, vitamin C derivatives, centella asiatica extract to create multi-dimensional brightening formulas, reducing uneven tone, post-acne marks, sun pigmentation and melasma, without harsh irritation like hydroquinone or high-concentration acids. It maintains formulation clarity and color stability in water-based serums, toners and creams.

  • Potent tyrosinase inhibition: superior to β-arbutin, suppress melanin production at source
  • Spot & pigment fading: improve sun spots, melasma, acne marks, post-inflammatory hyperpigmentation
  • Uniform overall tone: reduce dullness, yellow tone, sallow complexion, restore translucent skin tone
  • Good formulation stability: resistant to common cosmetic pH ranges, less prone to discoloration
  • Mild brightening: lower irritation than strong depigmenting ingredients, suitable for daily long-term use
  • Broad formulation adaptability: water-soluble, compatible with most water-based cosmetic systems
Alpha Arbutin tyrosinase inhibition brightening mechanism diagram

Alpha Arbutin Synthesis & Purification Process


Full Manufacturing Steps

  1. Raw material selection: high-purity glucose & hydroquinone derivatives, strict impurity control
  2. Stereoselective enzymatic/catalytic synthesis: directional synthesis of alpha configuration arbutin
  3. Intermediate purification: remove beta-arbutin isomers, residual raw materials and reaction by-products
  4. Recrystallization & high-purity refining: repeated recrystallization to reach ≥99% α-Arbutin purity
  5. Filtration & drying: vacuum drying to form uniform fine crystal powder
  6. HPLC isomer verification: confirm alpha configuration ratio, exclude beta isomer impurities
  7. Full quality inspection & sealed moisture-proof packaging

GMP clean plant extract workshop, low-temperature purification technology to preserve natural triterpene activity, ECOCERT organic traceable raw material options, consistent total triterpenes content, compliant with global cosmetic raw material standards.

Alpha Arbutin GMP synthesis purification production line

Factory Supply Capacity & Global Certifications


Functional cosmetic ingredient GMP production base, annual Alpha Arbutin output reaches 30 tons, 3 tons+ regular spot inventory, controlled dry warehouse storage to prevent moisture clumping and ensure long-term stability.

Stable Bulk Supply Advantages

  • Annual production capacity: 30 tons 99% Alpha Arbutin
  • Regular spot inventory: 3 tons standard 99% α-Arbutin powder
  • Custom mesh size, pre-blended brightening complex formulas available
  • 3~5 working days fast delivery for standard bulk orders
halal

Batch COA & SDS Full Documents

  • ISO22716 / GMP Cosmetic Good Manufacturing Practice
  • CosIng EU cosmetic raw material compliance, FDA cosmetic ingredient compliance
  • HALAL & KOSHER global religious export certification
  • Third-party cosmetic safety testing & full batch traceability system
  • REACH, CPNP & regional cosmetic filing supporting documents

6 Core Competitive Advantages of Our Alpha Arbutin


99% High Purity Alpha Configuration

Strict isomer control, high α-Arbutin ratio, minimal β-Arbutin impurity, verified by HPLC, consistent brightening efficacy across batches.

Stronger Tyrosinase Inhibition

Superior melanin inhibition compared to regular beta arbutin, targeted fading stubborn pigment, melasma and inflammatory marks efficiently.

Excellent Formulation Stability

Resists discoloration in daily cosmetic pH range, maintains formula clarity, compatible with most water-based brightening formulations.

Mild & Daily-Use Friendly

Non-irritating compared to harsh depigmenting agents, suitable for long-term daily brightening routines and sensitive skin brightening formulas

Global Cosmetic Compliance

Compliant with EU CosIng, US FDA, ISO22716, HALAL & KOSHER, supports global cosmetic registration, filing and customs clearance documents.

Custom Formulation Service

Custom particle size, pre-blended multi-brightening complexes, bulk & private label packaging, cosmetic formulation technical guidance.

Request Free Sample & Bulk Quotation

Looking for a reliable supplier of high purity Alpha Arbutin (α-Arbutin) raw material for brightening skincare serums, facial lotions, spot fading creams and cosmetic formulations?

Contact our team today to receive free samples, full COA specifications, global export certification documents and customized bulk pricing for your skin whitening cosmetic raw material project.

Get Free Sample & Quote

Main Industrial Application Fields


Brightening Essence & Serums

Daily whitening serums, essence toners, reduce dullness and even overall skin tone

Brightening Facial Masks

Whitening sheet masks, sleeping masks, fade post-acne marks and sun discoloration

Spot & Melasma Creams

Targeted spot creams, night repair creams, improve stubborn pigmentation

After-Sun Repair Products

Post-sun soothing lotions, prevent UV-induced pigmentation and darkening

Medical Beauty Repair Skincare

Post-treatment hyperpigmentation repair formulas, gentle brightening care

Clean Beauty & Daily Skincare

Vegan & clean label whitening formulas, long-term daily brightening care

Strict QC Testing & Official Batch Documents


Every batch of Alpha Arbutin is tested via HPLC for α-Arbutin purity, isomer ratio, moisture, heavy metals, residual solvents and full microbiology testing, complying with ISO22716, CosIng, FDA cosmetic raw material specifications.

We provide official batch COA, HPLC test reports, SDS safety data sheets, HALAL/KOSHER/ISO/GMP certificates, third-party cosmetic safety assessment reports, full batch traceability records, supporting cosmetic factory audits, global cosmetic registration and customs clearance.

Full Batch Traceability System

Unique batch number, full synthesis & testing records, permanent batch traceability for cosmetic compliance audits

OEM & Custom Formulation Service


Customizable Service Range

  • 99% Alpha Arbutin powder mesh size customization (fine powder for liquid formulations)
  • Multi-ingredient brightening pre-mix blends (Alpha Arbutin + Niacinamide / Tranexamic Acid / VC derivatives)
  • Aqueous/glycerin liquid formulations with specified concentrations
  • Bulk packaging: 1kg / 5kg / 25kg neutral drums/bags, private label custom packaging
  • Cosmetic formulation technical support, dosage guide, pH & stability testing guidance

Support long-term framework bulk orders, consistent purity & crystal properties, provide full cosmetic regulatory documents (COA, SDS, test reports, certification copies) for global cosmetic brands to complete regional filing and compliance verification.

Alpha Arbutin custom cosmetic raw material packaging

How to buy Alpha Arbutin / α-Arbutin ?

Please feel free to contact us for any of your needs. You can send an email to admin@focusherb.com or submit your request at the bottom of the page. We will be happy to assist you!

Top Frequently Asked Questions about Alpha Arbutin (α-Arbutin)


What is the CAS number and specification of your Alpha Arbutin?

Our Alpha Arbutin is pure α-configuration arbutin with CAS: 84380-01-8, distinct from Beta-Arbutin (CAS: 497-76-7).

Standard purity: ≥99% HPLC verified white crystalline powder.
We provide full batch COA, HPLC test reports, and key impurity data including hydroquinone residual testing. Custom formulations (aqueous solutions, serum bases) are available upon request.

What safety tests have been completed?

Each batch is tested for heavy metals (Pb, As, Cd, Hg), residual solvents, microbial contamination (TPC, yeast & mold, E.Coli, Pseudomonas aeruginosa, Salmonella), hydroquinone residues, and allergen screening.

Compliant with CosIng, FDA, ISO22716, GMP and EU SCCS cosmetic regulations. Full test documents are available for global cosmetic registration, audits and customs clearance.

What is the recommended dosage and suitable formulation pH range?

General recommended dosage: 0.5%–2% for facial serums, toners, creams and masks (follow regional regulatory limits, e.g. EU SCCS 2% maximum for facial products).

Ideal pH range: 4.0–6.5. Avoid extreme high pH, strong alkaline formulas to prevent degradation and discoloration.

Compatible with hyaluronic acid, panthenol, centella asiatica extract, niacinamide (pre-formulation compatibility testing is advised).

What is the shelf life and correct storage method?

  • Unopened powder: 24 months when sealed, stored in cool, dry, dark conditions (recommended 2-8°C), away from direct sunlight, heat and moisture.
  • Liquid formulations: 6–12 months (depends on preservative system).
  • Keep tightly sealed after opening to prevent moisture contamination and active ingredient degradation.

What is the difference between Alpha Arbutin and Beta Arbutin?

They are two different stereoisomers with different CAS numbers and molecular structures:

  • Alpha Arbutin (α-Arbutin, CAS:84380-01-8): Stronger tyrosinase inhibition, better stability, superior brightening effect, milder, premium cosmetic grade.
  • Beta Arbutin (β-Arbutin, CAS:497-76-7): Traditional basic arbutin with lower whitening activity and lower cost.They cannot be mixed or substituted directly in formulations.

Is Alpha Arbutin vegan, cruelty-free, allergen-free, and clean beauty compliant?

Our standard Alpha Arbutin is vegan, cruelty-free, non-GMO, gluten-free, parabens-free and free of artificial fragrances.

HALAL, KOSHER and clean beauty documentation can be provided for export brands upon request. It is not a common cosmetic allergen, though patch testing is recommended for sensitive skin finished products.

What is the MOQ, packaging and delivery time?

  • Sample MOQ: 100g for formulation trials
  • Bulk MOQ: 1kg / 5kg / 25kg export packaging (aluminum foil bags, drums)
  • In-stock orders: 3–7 working days delivery
  • Custom liquid formulations: 7–14 working days
  • Long-term framework bulk orders are supported for consistent batch quality and price.

Can I get free samples and full compliance documents?

Yes, qualified bulk buyers can apply for free test samples for formulation stability and compatibility testing.

We provide COA, SDS (MSDS), HPLC reports, GMP/ISO certificates, traceability records, and support REACH, CPNPF, CPNP and other regional cosmetic filings and import clearance.

Does Alpha Arbutin cause skin irritation, discoloration or discoloration in finished products?

High-purity Alpha Arbutin has very low irritation risk and good color stability under proper pH and storage conditions.

The risk of yellowing/discoloration can be minimized by avoiding high pH, excessive heat and prolonged light exposure. We strongly suggest pre-formulation stability testing for your base formula.

Do you support factory audits and third-party testing?

Our factory follows GMP & ISO22716 cosmetic raw material standards. On-site factory visits, customer audits and independent third-party testing are welcome. We provide complete batch traceability records for quality verification.

Have any questions?
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