Cosmetic Ingredients
PDRN (Polydeoxyribonucleotide)
PDRN, full name Polydeoxyribonucleotide (CAS:100403-24-5), is high-molecular long-chain polynucleotide complex extracted and refined from deep-sea salmon gonad. It features excellent skin cell biological homology, effectively promotes keratinocyte proliferation, inhibits inflammatory factors, accelerates micro-wound healing after laser, microneedle and peeling aesthetic operations.
Our PDRN adopts low-endotoxin purification process, 99% HPLC purity powder and customized concentration aqueous solutions (0.1%~1%) are available, compliant with CosIng, FDA, ISO22716, GMP, HALAL & KOSHER standards. Widely used in post-procedure repair gel, sensitive anti-redness serum and barrier recovery mask. Stable batch supply, factory direct price, free samples and complete COA & SDS documents provided.
Medical Beauty Raw
Low Endotoxin Standard
HPLC Verified
Clean Beauty Raw
HALAL & KOSHER Certified
Low Endotoxin Standard
HPLC Verified
Clean Beauty Raw
HALAL & KOSHER Certified
PRODUCT INTRODUCTION
| Product Name | PDRN / Polydeoxyribonucleotide – Salmon Gonad DNA Extract |
| CAS No. | 100403-24-5 |
| Source | Deep-sea salmon gonad (Oncorhynchus keta) |
| Appearance (Powder) | White to off-white fine crystalline powder, odorless |
| Appearance (Solution) | Transparent colorless aqueous solution |
| Purity (HPLC) | 99% PDRN pure powder; 0.1% / 0.5% / 1% solutions |
| Endotoxin Level | <0.5 EU/mg (medical aesthetic grade standard) |
| Solubility | Fully soluble in purified water; insoluble in oil & ethanol |
| pH (1% solution) | 5.0 – 6.8 |
| Moisture | ≤3.0% |
| Heavy Metals | Pb ≤0.1ppm, As ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm |
| Microbiological | TPC ≤100cfu/g, Yeast/Mold ≤10cfu/g, Pathogens negative |
| Allergen / Dietary Status | Vegan · Gluten-Free · Non-GMO · No parabens or additives |
| Storage | Sealed, cool & dark below 40°C; avoid high temperature & direct sunlight |
| Shelf Life (unopened) | 24 months powder; 6–12 months solution (preserved system dependent) |
| MOQ | 10g R&D sample; 1kg / 5kg / 25kg bulk |
| Available Grades | Cosmetic Grade (Medical Aesthetic / Sensitive Skincare) |
| Certifications | ISO22716, GMP, EU CosIng, SCCS assessed, HALAL, KOSHER |
| Packaging Options | 1g–10g foil bag, 1kg / 5kg vacuum drum, neutral private labeling |
Formulation Benefits: Why PDRN Is the Gold Standard for Repair Skincare
Biologically homologous repair. PDRN’s long-chain polynucleotides share high homology with human skin cells – acting as a repair signaling molecule that accelerates keratinocyte proliferation and collagen synthesis.
Dual-action efficacy: Suppresses TNF-α and IL-6 inflammatory cytokines to reduce post-procedure redness and burning within hours. Simultaneously, it stimulates fibroblast activity to rebuild the damaged lipid barrier – lightening post-inflammatory hyperpigmentation and smoothing fine lines.
Ultra-mild profile: Unlike retinol or high-concentration acids, PDRN causes zero irritation – safe for rosacea, thin sensitive skin, and fragile post-procedure skin. Ideal for chronic repair formulas.
- Barrier reconstruction: Promotes epidermal regeneration – reduces TEWL (transepidermal water loss).
- Fast anti-inflammatory: Suppresses cytokines – laser/microneedle recovery in days, not weeks.
- Micro-wound healing: Accelerates re-epithelialization – lowers pigmentation & scabbing risk.
- Anti-photoaging: Stimulates collagen – smooths fine lines & post-acne marks.
- Zero irritation: Safe for rosacea, sensitive & chronic repair use.
- Full water solubility: Compatible with HA, centella, ectoin, tranexamic acid.
Formulation Tips: For serums, use 0.02%–0.1% PDRN with 0.1%–0.5% HA. For post-procedure gels, use 0.1%–0.3% PDRN with centella and ectoin. Add at 40°C post-emulsification to preserve polynucleotide activity. Avoid prolonged heating above 60°C.
Controlled Extraction Process for Low-Endotoxin PDRN
Manufacturing Highlights
- Premium salmon gonad raw material screening – remove impurities & connective tissue.
- Low-temperature enzymatic hydrolysis – releases high-molecular polynucleotide fragments.
- Multi-stage membrane filtration + macroporous resin purification – removes proteins & endotoxins.
- Desalting & low-endotoxin removal – achieves <0.5EU/mg standard.
- Low-temperature vacuum concentration – prevents nucleic acid degradation.
- Aseptic freeze-drying – yields pure white PDRN powder.
- Microbial & endotoxin testing – light-proof vacuum sealed packaging.
Operated in ISO22716 Grade 100,000 GMP clean workshop. Strict temperature control throughout hydrolysis and drying preserves the complete long-chain PDRN structure – the key to its biological repair efficacy. Low endotoxin index meets medical aesthetic raw material standards.
Supply Chain Stability & Export Readiness
350kg annual pure powder capacity with 30kg powder ready stock and pre-made standard solutions. Dedicated low-temperature dark warehouse preserves nucleic acid activity. Bulk tier pricing available for long-term framework agreements.
Logistics & Compliance Advantages
- Lead time: 3–7 working days (sample & bulk)
- Low endotoxin (<0.5EU/mg) – medical aesthetic grade
- Custom concentration solutions & preservative-free options
- Full dossier: COA, endotoxin test, MSDS, SCCS, HALAL/KOSHER
- EU CPNP & REACH filing support documents
Batch COA, SDS & SCCS
Full Documentation Ready
- ISO22716 GMP certified cosmetic workshop
- EU CosIng listed & SCCS safety assessed
- HALAL & KOSHER certified for global brand acceptance
- Third-party endotoxin & HPLC testing available
6 Reasons to Source PDRN from Focusherb
Low Endotoxin <0.5EU/mg
Medical aesthetic grade – meets the strictest standards for post-procedure applications. Safe for compromised skin.
Dual Repair + Anti-Redness
Accelerates wound healing while suppressing inflammation – two benefits, one active ingredient.
350kg Capacity + 30kg Stock
Reliable supply for both small-batch prestige brands and large-volume medical aesthetic lines.
Powder + Custom Solutions
99% pure powder or 0.1%–1% pre-dissolved solutions – choose the form that fits your production workflow.
Full Dossier Per Batch
COA, endotoxin report, SDS, SCCS, and HALAL/KOSHER certificates – complete documentation for global registration.
Globally Compliant
EU CosIng, SCCS assessed, FDA cosmetic standard, HALAL & KOSHER – ready for cross-border brand launch.
Request Free Sample & Bulk Quotation
Looking for a reliable supplier of high purity PDRN (polydeoxyribonucleotide) powder raw material for wound repair serums, sensitive soothing creams, post-procedure skincare and regenerative cosmetic formulations?
Contact our team today to receive free samples, full COA specifications, global export certification documents and customized bulk pricing for your skin repair cosmetic raw material project.
Where Medical Aesthetic & Skincare Brands Use PDRN
Post-Laser Repair Serums
Aesthetic clinic recovery essentials
Barrier Repair Masks
Sensitive anti-redness sheet masks
Soothing Repair Creams
Rosacea & chronic sensitive daily care
Microneedle Recovery Gels
Professional medical beauty line actives
Post-Acne Repair Essences
Inflammatory mark fading treatments
Clean Beauty Repair Lines
Vegan · Sensitive · Minimalist skincare
Batch Traceability & Full Documentation Package
Every batch of PDRN undergoes rigorous QC: HPLC PDRN content assay, low endotoxin test (<0.5EU/mg), moisture, heavy metals, and full microbiological screening. All results meet or exceed EU CosIng and medical aesthetic raw material standards.
With every shipment, you receive:
- Batch-specific COA (Certificate of Analysis)
- Endotoxin Test Report (LAL method)
- 16-section MSDS (Material Safety Data Sheet)
- SCCS safety assessment summary
- HALAL & KOSHER certificates
- EU CPNP / REACH filing support documents
100% Batch Traceability
Salmon source → Extraction → Purification → Drying → QC → Packaging – all recorded under a unique batch number for full accountability.
Tailored OEM Solutions for Your Brand
Customization Options
- 99% pure powder with custom particle fineness
- Pre-dissolved solutions: 0.1% / 0.5% / 1% in water, glycerin, or BG
- Preservative-free or mild preservative system options
- Premix blends: PDRN + HA / Centella / Ectoin / Tranexamic Acid
- Neutral export packaging (no brand logo) available
- Formula support: Post-procedure repair & sensitive skincare formulation guidance
ong-term supply agreements with fixed pricing available. We support your overseas brand registration with full regulatory documentation.
Why Medical Aesthetic & Sensitive Skincare Brands Choose Focusherb PDRN?
For Brand Owners & Product Managers
Looking for a premium repair ingredient that justifies a high-price positioning? PDRN is the “gold standard” in post-procedure recovery. Our low-endotoxin (<0.5EU/mg) salmon-derived polynucleotide delivers clinically credible repair efficacy – the hero ingredient your sensitive skin or medical aesthetic line needs.
For R&D Chemists
Need a repair active that’s water-soluble, heat-stable, and compatible with HA, centella, ectoin, and tranexamic acid? Our PDRN integrates seamlessly into serums, gels, masks, and creams. Available as 99% pure powder or pre-dissolved solutions (0.1%–1%) – skip the dissolution headaches and focus on formulation performance.
For Compliance & Regulatory Teams
EU CosIng listed · Low endotoxin certified · HALAL & KOSHER · Full SCCS safety assessment · CPNP & REACH filing support. We provide complete documentation for cross-border medical beauty brand registration.
How to buy PDRN Polydeoxyribonucleotide Powder ?
Please feel free to contact us for any of your needs. You can send an email to admin@focusherb.com or submit your request at the bottom of the page. We will be happy to assist you!
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