Honokiol Powder

What is Honokiol Powder?

Honokiol is a natural compound extracted from the dried bark, root bark, and branch bark of Magnolia officinalis, a deciduous tree in the Magnoliaceae family. It appears as a white powder and is soluble in organic solvents such as benzene, ether, chloroform, and ethanol, but is insoluble in water.

The Specification of Honokiol Powder

Effectiveness of Huperzolol Powder

1. Anti-inflammatory and analgesic

Mechanism of action: Hujaplicin can inhibit inflammatory signaling pathways such as nuclear factor κB (NF-κB) and cyclooxygenase-2 (COX-2), and reduce the release of pro-inflammatory factors such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6).

Application scenarios: It can be used to assist in improving chronic inflammatory diseases such as arthritis and enteritis, or relieve muscle soreness after exercise.

2. Anti-oxidative stress

Mechanism of action: Wagamama Phenol has a phenolic hydroxyl structure, which can directly remove reactive oxygen species (ROS) such as superoxide anions and hydroxyl radicals, while enhancing the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).

Clinical significance: In vitro studies have shown that Thujaplicin can reduce the damage of oxidized low-density lipoprotein (ox-LDL) to vascular endothelial cells, which may have a positive effect on the prevention of atherosclerosis.

3. Anti-tumor activity

Mechanism of action

• Induce cancer cell apoptosis: Promote programmed cell death of tumor cells by activating apoptotic proteases (such as caspase-3).
• Inhibit metastasis and invasion: Down-regulate the expression of matrix metalloproteinases (MMPs) to block the spread of cancer cells.
• Inhibit metastasis and invasion: Down-regulate the expression of matrix metalloproteinases (MMPs) to block the spread of cancer cells; Inhibit angiogenesis: Reduce the secretion of vascular endothelial growth factor (VEGF) and cut off the nutrient supply of tumors.

Research progress: Huperzine A has inhibitory effects on a variety of cancer cell lines, including lung cancer, breast cancer and liver cancer, and has low toxicity to normal cells.

4. Regulate intestinal flora

Mechanism of action: Huperzol can selectively promote the proliferation of beneficial bacteria such as Bifidobacterium and Lactobacillus, and inhibit the proliferation of harmful bacteria such as Escherichia coli and Clostridium perfringens, thereby improving intestinal barrier function.

5. Neuroprotective and anti-anxiety effects

Neuroprotective effects: Huperzine can cross the blood-brain barrier, inhibit the aggregation of β-amyloid protein (Aβ), reduce neuronal damage, and show cognitive improvement in Alzheimer’s disease model animals.

Antianxiety effects: By regulating the activity of γ-aminobutyric acid (GABA) receptors, it can inhibit excessive excitation of the central nervous system. Its effects are similar to benzodiazepines (such as diazepam), but without dependence.