Food and Nutrition Ingredients
Formononetin
Formononetin (CAS: 485-72-3) is a natural lipophilic isoflavone extracted from red clover and astragalus root. Pale yellow crystalline powder with typical phytoestrogen activity. It features bidirectional hormone regulation, strong antioxidant and anti-inflammatory effects. Food-grade formononetin is widely used in menopause relief, female endocrine conditioning, bone health oral capsules and tablets. Cosmetic grade is applied in anti-wrinkle firming cream, anti-photoaging oil serum and mature skin repair skincare.
We supply 98%/99% high-purity formononetin crystal powder and 80% standardized red clover total isoflavone powder. Strictly control pesticide residues, heavy metals, residual solvents and microbiology, compliant with FDA GRAS, CosIng, ISO22716, GMP, HALAL & KOSHER. Free testing samples and complete COA & SDS documents are offered for brand formula development.
Formononetin
Red Clover Isoflavone
Phytoestrogen
Oil Soluble
HALAL & KOSHER Certified
Red Clover Isoflavone
Phytoestrogen
Oil Soluble
HALAL & KOSHER Certified
PRODUCT INTRODUCTION
| Product Name | Formononetin, Red Clover / Astragalus Isoflavone Extract |
| CAS No. | 485-72-3 |
| Molecular Formula | C₁₆H₁₂O₄ |
| Molecular Weight | 268.26 g/mol |
| Appearance | Off-white to pale yellow fine crystalline powder, slight herbal odor |
| Formononetin Content (HPLC) | 80% / 98% / 99% |
| Related Impurities | Single unknown impurity ≤0.1%, total isoflavone impurities ≤0.5% |
| Solubility | Soluble in ethanol, vegetable oil, acetone; slightly soluble in methanol; insoluble in pure water |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metals | Pb ≤0.1ppm, As ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm |
| Microbiological Index | TPC ≤100cfu/g, Mold & Yeast ≤10cfu/g, Pathogens Negative |
| Allergen Description | Non-GMO, Vegan, Gluten-Free, No artificial additives |
| Storage Requirements | Sealed nitrogen-filled light-proof vacuum packaging, store at 2~20℃; avoid light, high temperature and air oxidation |
| Unopened Shelf Life | 24 months under specified storage conditions |
| MOQ | 5g sample available; bulk: 50g/1kg/5kg/25kg vacuum light-proof packing |
Core Benefits & Functional Mechanism of Formononetin
Formononetin is a typical natural phytoestrogen isoflavone with bidirectional regulation capacity. It binds weakly to human estrogen receptors; when human estrogen is insufficient, it supplements mild estrogen activity; when estrogen is excessive, it competitively inhibits excess hormone effects. Oral intake relieves menopausal hot flashes, insomnia, mood swings, protects bone density, supports cardiovascular health and improves long-term aging oxidation. Externally, it inhibits matrix metalloproteinase to reduce collagen loss, resists UV oxidative aging, tightens sagging mature skin, fades static fine lines and alleviates inflammatory redness.
Raw formononetin is oil-soluble and easy to oxidize under light/heat; microcapsule modification realizes water dispersion and greatly improves stability. Classic compound schemes: oral Formononetin + Genistein + Calcium + Vitamin D; skincare Formononetin + Vitamin E + Squalane anti-aging oil formula.
- Bidirectional phytoestrogen balance: gently regulate female endocrine without hormone side effects
- Menopause comprehensive care: ease hot flashes, sleep disorder, maintain bone & blood vessel health
- Strong antioxidant anti-aging: clear free radicals, delay systemic and skin oxidative aging
- Dermal anti-aging: inhibit collagen degradation, firm skin, smooth fine lines, resist photoaging
- Dual delivery: oil-soluble crystal for oil formulas; microcapsule for water-phase products & tablets
- Dual-grade separation: independent production of food and cosmetic grades to meet compliance rules
Formulation Tips: Oral daily dosage 20–100mg; skincare recommended addition 0.02%~0.15%. Use amber opaque packaging, avoid high-temperature heating; pregnant women, hormone-dependent tumor patients cannot take orally; finished products need anti-oxidant auxiliary.
Formononetin Low-Temp Extraction & Purification & Microencapsulation Process
Full Production Process Steps
- Red clover/astragalus raw material screening, pesticide and heavy metal pre-inspection
- Closed low-temperature ethanol reflux extraction under light-shielded nitrogen protection
- Macroporous resin enrichment to concentrate total isoflavone components
- Multi-gradient solvent recrystallization to purify high-purity formononetin monomer
- Activated carbon decolorization and membrane filtration to remove plant impurities
- Optional microcapsule homogenization + spray drying to prepare water-dispersible powder
- HPLC full inspection, nitrogen-filled light-proof vacuum sealed packaging
GMP plant extract closed clean workshop, full-process low temperature and light avoidance operation, strictly control solvent residues and oxidation discoloration. All batches have stable purity and solubility, fully meet global food and cosmetic raw material safety standards.
Factory Supply Capacity & Global Export Certifications
Specialized isoflavone GMP production base, annual total output of formononetin reaches 3.5 tons, regular spot inventory 200kg. Independent constant temperature dark nitrogen storage warehouse prevents oxidation deterioration, stably supplies bulk goods to global female endocrine health supplements and mature anti-aging skincare OEM factories.
Stable Bulk Supply Advantages
- Annual capacity: 3.5 tons full-spec formononetin crystal & microcapsule powder
- In-stock inventory: 200kg conventional specifications support fast delivery
- Custom microcapsule, multi-isoflavone compound premix powder
- 4~7 working days bulk delivery, long-term framework order preferential price
Batch COA & SDS Full Official Documents
- ISO22716 / GMP unified production standard for food and cosmetic raw materials
- US FDA GRAS certified, EU food safety + CosIng cosmetic filing compliant
- Dual HALAL & KOSHER certification to cover global religious market exports
- Third-party full safety testing + complete batch traceability management system
- Provide REACH, CPNP documents to support overseas brand registration and customs clearance
6 Core Competitive Advantages of Our Formononetin
Natural Plant Source
Extracted from red clover/astragalus, natural plant phytoestrogen, clean label compliant.
Bidirectional Hormone Regulation
Safe mild phytoestrogen, no hormone side effects, targeted for female endocrine care.
Menopause Differentiated Value
Unique hot flash and sleep relief efficacy, differentiated from ordinary antioxidant ingredients.
Oil & Water Dual Applicability
Oil crystal for oil formulas; microcapsule adapts to water formulas, tablets and drinks.
Global Food & Cosmetic Compliance
Dual certification system, complete filing documents for EU and US cross-border brands.
Custom Compound Support
Custom purity, microcapsule, multi-isoflavone blends and packaging customization.
Request Free Sample & Bulk Quotation
Looking for a reliable supplier of high purity Formononetin raw material for phytoestrogen supplements, women’s wellness capsules and plant-based functional nutritional formulations?
Contact our team today to receive free samples, full COA specifications, global export certification documents and customized bulk pricing for your isoflavone health raw material project.
Main Industrial Application Fields for Formononetin
Menopause Relief Oral Capsules
Improve hot flashes, insomnia, female midlife conditioning capsules
Bone & Vascular Nutritional Tablets
Calcium compound bone density maintenance, cardiovascular care tablets
Hormone Balance Solid Beverage
Microcapsule formononetin instant powder drink for daily care
Mature Skin Anti-Aging Oil Serum
Oil-soluble anti-wrinkle essence for sagging aging skin
Firming Anti-Aging Face Cream
Collagen protection cream to smooth wrinkles and firm skin
Compound Isoflavone Series
Formononetin+Genistein multi-isoflavone internal and external anti-aging line
Strict QC Testing & Official Batch Compliance Documents
Each batch of formononetin undergoes full HPLC content detection, moisture, ignition residue, heavy metals, pesticide residues, solvent residues and microbial comprehensive testing, fully compliant with ISO22716, FDA GRAS, CosIng global raw material standards.
We provide exclusive batch COA, HPLC chromatogram report, SDS safety data sheet, HALAL/KOSHER/ISO/GMP certificate copies, food/cosmetic safety assessment reports and full batch traceability archives, supporting factory audits, global health products and cosmetics registration and customs clearance.
Full Batch Traceability Management
Unique batch number records all extraction, purification and testing procedures, permanently traceable for compliance audit
OEM & Custom Formulation Service for Formononetin
Customizable Service List
- Formononetin content customization:80%/98%/99%, powder particle fineness adjustment
- Custom cold-water dispersible microcapsule powder with wall material formula adjustment
- Compound isoflavone premix: Formononetin + Genistein + Daidzein blended powder
- Bulk nitrogen-filled light-proof vacuum packaging:50g/1kg/5kg/25kg, customizable outer private label
- Capsule, tablet, oil essence, cream formula guidance and stability testing support
We support long-term framework bulk orders with stable purity and low impurity indicators. Provide complete certification documents including batch COA, SDS, safety evaluation report, helping cross-border health food and cosmetic brands smoothly complete regional filing and customs clearance.
How to buy Formononetin?
Please feel free to contact us for any of your needs. You can send an email to admin@focusherb.com or submit your request at the bottom of the page. We will be happy to assist you!
Have any questions?
Let's get in touch!
Contact us if your are thinking of purchasing highquality ingredients, develop new products, or justsolving a manufacturing challenge in your rawmaterials.
